Animal models of neurodegenerative diseases

Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy

Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359 · see citing works

α-Synuclein in Lewy bodies

Spillantini, M. G., Schmidt, M. L., Lee, V. M.-Y., Trojanowski, J. Q., Jakes, R., & Goedert, M. (1997) · Nature · doi:10.1038/42166 · Cited by 8,382 · see citing works

Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis

Neumann, M., Sampathu, D. M., Kwong, L. K., Truax, A. C., Micsenyi, M. C., Chou, T. T., Bruce, J., Schuck, T., Grossman, M., Clark, C. M., et al. (2006) · Science · doi:10.1126/science.1134108 · Cited by 6,576 · see citing works

Prions

Prusiner, S. B. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.23.13363 · Cited by 5,373 · see citing works

Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

DeJesus-Hernandez, M., Mackenzie, I. R., Boeve, B. F., Boxer, A. L., Baker, M., Rutherford, N. J., Nicholson, A. M., Finch, N. A., Flynn, H., Adamson, J., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.011 · Cited by 4,936 · see citing works

A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD

Renton, A. E., Majounie, E., Waite, A., Simón-Sánchez, J., Rollinson, S., Gibbs, J. R., Schymick, J. C., Laaksovirta, H., van Swieten, J. C., Myllykangas, L., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.010 · Cited by 4,409 · see citing works

Meta-Analysis of 74,046 Individuals Identifies 11 New Susceptibility Loci for Alzheimer’s Disease

(EADI), E. A. D. I., Lambert, J.-C., (GERAD), G. A. E. R. I. A. D., Alzheimer's Disease Genetic Consortium (ADGC), (CHARGE), C. F. H. A. A. R. I. G. E., Ibrahim-Verbaas, C. A., Harold, D., Naj, A. C., Sims, R., Bellenguez, C., et al. (2013) · Nature Genetics · doi:10.1038/ng.2802 · Cited by 4,336 · see citing works

Motor Neuron Degeneration in Mice that Express a Human Cu,Zn Superoxide Dismutase Mutation

Gurney, M. E., Pu, H., Chiu, A. Y., Dal Canto, M. C., Polchow, C. Y., Alexander, D. D., Caliendo, J., Hentati, A., Kwon, Y. W., Deng, H.-X., et al. (1994) · Science · doi:10.1126/science.8209258 · Cited by 4,143 · see citing works

Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles

Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., & LaFerla, F. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00434-3 · Cited by 4,126 · see citing works

Statistical tests, P values, confidence intervals, and power: a guide to misinterpretations

Greenland, S., Senn, S. J., Rothman, K. J., Carlin, J. B., Poole, C., Goodman, S. N., & Altman, D. G. (2016) · European Journal of Epidemiology · doi:10.1007/s10654-016-0149-3 · Cited by 3,200 · see citing works

Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

Luk, K. C., Kehm, V., Carroll, J., Zhang, B., O’Brien, P., Trojanowski, J. Q., & Lee, V. M.-Y. (2012) · Science · doi:10.1126/science.1227157 · Cited by 2,563 · see citing works

Decoding ALS: from genes to mechanism

Taylor, J. P., Brown, R. H., & Cleveland, D. W. (2016) · Nature · doi:10.1038/nature20413 · Cited by 2,047 · see citing works

Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function

SantaCruz, K., Lewis, J., Spires, T., Paulson, J., Kotilinek, L., Ingelsson, M., Guimaraes, A., DeTure, M., Ramsden, M., McGowan, E., et al. (2005) · Science · doi:10.1126/science.1113694 · Cited by 2,014 · see citing works

A/T/N: An unbiased descriptive classification scheme for Alzheimer disease biomarkers

Jack, C. R., Bennett, D. A., Blennow, K., Carrillo, M. C., Feldman, H. H., Frisoni, G. B., Hampel, H., Jagust, W. J., Johnson, K. A., Knopman, D. S., et al. (2016) · Neurology · doi:10.1212/wnl.0000000000002923 · Cited by 1,864 · see citing works

Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP

Lewis, J., Dickson, D. W., Lin, W.-L., Chisholm, L., Corral, A., Jones, G., Yen, S.-H., Sahara, N., Skipper, L., Yager, D., et al. (2001) · Science · doi:10.1126/science.1058189 · Cited by 1,611 · see citing works

Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Aβ42 Fibrils

Götz, J., Chen, F., van Dorpe, J., & Nitsch, R. M. (2001) · Science · doi:10.1126/science.1062097 · Cited by 1,526 · see citing works

Single App knock-in mouse models of Alzheimer’s disease

Saito, T., Matsuba, Y., Mihira, N., Takano, J., Nilsson, P., Itohara, S., Iwata, N., & Saido, T. C. (2014) · Nature Neuroscience · doi:10.1038/nn.3697 · Cited by 1,447 · see citing works

Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

de Calignon, A., Polydoro, M., Suárez-Calvet, M., William, C., Adamowicz, D. H., Kopeikina, K. J., Pitstick, R., Sahara, N., Ashe, K. H., Carlson, G. A., et al. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.033 · Cited by 1,427 · see citing works

ALS: A Disease of Motor Neurons and Their Nonneuronal Neighbors

Boillée, S., Velde, C. V., & Cleveland, D. W. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.018 · Cited by 1,426 · see citing works

Alzheimer’s Disease: The Challenge of the Second Century

Holtzman, D. M., Morris, J. C., & Goate, A. M. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002369 · Cited by 1,424 · see citing works

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

Lewis, J., McGowan, E., Rockwood, J., Melrose, H., Nacharaju, P., Van Slegtenhorst, M., Gwinn-Hardy, K., Murphy, M. P., Baker, M., Yu, X., et al. (2000) · Nature Genetics · doi:10.1038/78078 · Cited by 1,371 · see citing works

Genetics of Parkinson's DiseasePreprint

Klein, C., & Westenberger, A. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a008888 · Cited by 1,370 · see citing works

Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

Reaume, A. G., Elliott, J. L., Hoffman, E. K., Kowall, N. W., Ferrante, R. J., Siwek, D. F., Wilcox, H. M., Flood, D. G., Beal, M. F., Brown, R. H., et al. (1996) · Nature Genetics · doi:10.1038/ng0596-43 · Cited by 1,285 · see citing works

3,4-Dihydroxyphenylalanine and 5-Hydroxytryptophan as Reserpine Antagonists

Carlsson, A., Lindqvist, M., & Magnusson, T. (1957) · Nature · doi:10.1038/1801200a0 · Cited by 1,272 · see citing works

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease

Yun, S. P., Kam, T.-I., Panicker, N., Kim, S., Oh, Y., Park, J.-S., Kwon, S.-H., Park, Y. J., Karuppagounder, S. S., Park, H., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0051-5 · Cited by 1,123 · see citing works

A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci

Chang, D., Nalls, M. A., Hallgrímsdóttir, I. B., Hunkapiller, J., van der Brug, M., Cai, F., International Parkinson's Disease Genomics Consortium, 23andMe Research Team, Kerchner, G. A., Ayalon, G., et al. (2017) · Nature Genetics · doi:10.1038/ng.3955 · Cited by 1,112 · see citing works

TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration

Lagier-Tourenne, C., Polymenidou, M., & Cleveland, D. W. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq137 · Cited by 1,021 · see citing works

Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond

Ilieva, H., Polymenidou, M., & Cleveland, D. W. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200908164 · Cited by 1,008 · see citing works

PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease

Shin, J.-H., Ko, H. S., Kang, H., Lee, Y., Lee, Y.-I., Pletinkova, O., Troconso, J. C., Dawson, V. L., & Dawson, T. M. (2011) · Cell · doi:10.1016/j.cell.2011.02.010 · Cited by 953 · see citing works

Genetic Animal Models of Parkinson's Disease

Dawson, T. M., Ko, H. S., & Dawson, V. L. (2010) · Neuron · doi:10.1016/j.neuron.2010.04.034 · Cited by 825 · see citing works

APP mouse models for Alzheimer’s disease preclinical studies.

Sasaguri, H., Nilsson, P., Hashimoto, S., Nagata, K., Saito, T., De Strooper, B., Hardy, J., Vassar, R., Winblad, B., & Saido, T. C. (2017) · The EMBO Journal · doi:10.15252/embj.201797397 · Cited by 793 · see citing works

Spreading of pathology in neurodegenerative diseases: a focus on human studies

Brettschneider, J., Tredici, K. D., Lee, V. M.-Y., & Trojanowski, J. Q. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3887 · Cited by 790 · see citing works

Prion-like transmission of protein aggregates in neurodegenerative diseases

Brundin, P., Melki, R., & Kopito, R. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2873 · Cited by 778 · see citing works

The A4 Study: Stopping AD Before Symptoms Begin?

Sperling, R. A., Rentz, D. M., Johnson, K. A., Karlawish, J. H., Donohue, M., Salmon, D. P., & Aisen, P. S. S. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3007941 · Cited by 756 · see citing works

Clinical genetics of amyotrophic lateral sclerosis: what do we really know?

Andersen, P. M., & Al-Chalabi, A. (2011) · Nature Reviews Neurology · doi:10.1038/nrneurol.2011.150 · Cited by 687 · see citing works

Diagnosis and treatment of Parkinson disease: molecules to medicine

Savitt, J. M. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29178 · Cited by 649 · see citing works

Benefit of vitamin E, riluzole, and gababapentin in a transgenic model of familial amyotrophic lateral sclerosis

Gurney, M. E., Cutting, F. B., Zhai, P., Doble, A., Taylor, C. P., Andrus, P. K., & Hall, E. D. (1996) · Annals of Neurology · doi:10.1002/ana.410390203 · Cited by 647 · see citing works

Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation

He, Z., Guo, J. L., McBride, J. D., Narasimhan, S., Kim, H., Changolkar, L., Zhang, B., Gathagan, R. J., Yue, C., Dengler, C., et al. (2018) · Nature Medicine · doi:10.1038/nm.4443 · Cited by 645 · see citing works

Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases

Guo, J. L., & Lee, V. M. Y. (2014) · Nature Medicine · doi:10.1038/nm.3457 · Cited by 641 · see citing works

Propagation of Tau aggregates and neurodegeneration

Goedert, M., Eisenberg, D. S., & Crowther, R. A. (2017) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-072116-031153 · Cited by 632 · see citing works

An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: a phase 1, randomised, first-in-man study

Miller, T. M., Pestronk, A., David, W., Rothstein, J., Simpson, E., Appel, S. H., Andres, P. L., Mahoney, K., Allred, P., Alexander, K., et al. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70061-9 · Cited by 617 · see citing works

Peripherally Applied Aβ-Containing Inoculates Induce Cerebral β-Amyloidosis

Eisele, Y. S., Obermüller, U., Heilbronner, G., Baumann, F., Kaeser, S. A., Wolburg, H., Walker, L. C., Staufenbiel, M., Heikenwalder, M., & Jucker, M. (2010) · Science · doi:10.1126/science.1194516 · Cited by 568 · see citing works

Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons

Shi, Y., Lin, S., Staats, K. A., Li, Y., Chang, W.-H., Hung, S.-T., Hendricks, E., Linares, G. R., Wang, Y., Son, E. Y., et al. (2018) · Nature Medicine · doi:10.1038/nm.4490 · Cited by 566 · see citing works

Aβ42 Is Essential for Parenchymal and Vascular Amyloid Deposition in Mice

McGowan, E., Pickford, F., Kim, J., Onstead, L., Eriksen, J., Yu, C., Skipper, L., Murphy, M. P., Beard, J., Das, P., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.06.030 · Cited by 565 · see citing works

<i>C9orf72</i> is required for proper macrophage and microglial function in mice

O’Rourke, J. G., Bogdanik, L., Yáñez, A., Lall, D., Wolf, A. J., Muhammad, A. K. M. G., Ho, R., Carmona, S., Vit, J. P., Zarrow, J., et al. (2016) · Science · doi:10.1126/science.aaf1064 · Cited by 550 · see citing works

Gain of toxicity from ALS/FTD-linked repeat expansions in C9ORF72 is alleviated by antisense oligonucleotides targeting GGGGCC-containing RNAs

Jiang, J., Zhu, Q., Gendron, T. F., Saberi, S., McAlonis-Downes, M., Seelman, A., Stauffer, J. E., Jafar-nejad, P., Drenner, K., Schulte, D., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.04.006 · Cited by 536 · see citing works

Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms

Andorfer, C., Acker, C. M., Kress, Y., Hof, P. R., Duff, K., & Davies, P. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4637-04.2005 · Cited by 511 · cited 1× · see citing works

Design, power, and interpretation of studies in the standard murine model of ALS

Scott, S., Kranz, J. E., Cole, J., Lincecum, J. M., Thompson, K., Kelly, N., Bostrom, A., Theodoss, J., Al‐Nakhala, B. M., Vieira, F. G., et al. (2008) · Amyotrophic Lateral Sclerosis · doi:10.1080/17482960701856300 · Cited by 504 · see citing works

ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43

Arnold, E. S., Ling, S., Huelga, S. C., Lagier‐Tourenne, C., Polymenidou, M., Ditsworth, D., Kordasiewicz, H. B., McAlonis‐Downes, M., Platoshyn, O., Parone, P. A., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1222809110 · Cited by 494 · see citing works

Parkinson’s disease: animal models and dopaminergic cell vulnerability

Blesa, J., & Przedborski, S. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00155 · Cited by 483 · see citing works

LRRK2 Inhibition Attenuates Microglial Inflammatory Responses

Moehle, M. S., Webber, P. J., Tse, T., Sukar, N., Standaert, D. G., DeSilva, T. M., Cowell, R. M., & West, A. B. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.5601-11.2012 · Cited by 463 · see citing works

Tau prion strains dictate patterns of cell pathology, progression rate, and regional vulnerability in vivo

Kaufman, S. K., Sanders, D. W., Thomas, T. L., Ruchinskas, A. J., Vaquer-Alicea, J., Sharma, A. M., Miller, T. M., & Diamond, M. I. (2016) · Neuron · doi:10.1016/j.neuron.2016.09.055 · Cited by 450 · see citing works

Recent Advances in the Genetics of Parkinson's Disease

Martin, I., Dawson, V. L., & Dawson, T. M. (2011) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-082410-101440 · Cited by 438 · see citing works

Drosophila as a Model for Human Neurodegenerative Disease

Bilen, J., & Bonini, N. M. (2005) · Annual Review of Genetics · doi:10.1146/annurev.genet.39.110304.095804 · Cited by 420 · see citing works

Animal Models of Alzheimer Disease

LaFerla, F. M., & Green, K. N. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006320 · Cited by 419 · see citing works

Probing the biology of Alzheimer’s disease in mice

Ashe, K. H., & Zahs, K. R. (2010) · Neuron · doi:10.1016/j.neuron.2010.04.031 · Cited by 413 · see citing works

C9ORF72 repeat expansions in mice cause TDP-43 pathology, neuronal loss, and behavioral deficits

Chew, J., Gendron, T. F., Prudencio, M., Sasaguri, H., Zhang, Y., Castanedes‐Casey, M., Lee, C. W., Jansen‐West, K. R., Kurti, A., Murray, M. E., et al. (2015) · Science · doi:10.1126/science.aaa9344 · Cited by 410 · see citing works

ALZHEIMER'S DISEASE: Genetic Studies and Transgenic Models

Price, D. L., Tanzi, R. E., Borchelt, D. R., & Sisodia, S. S. (1998) · Annual Review of Genetics · doi:10.1146/annurev.genet.32.1.461 · Cited by 406 · see citing works

The Presenilins in Alzheimer's Disease--Proteolysis Holds the Key

Haass, C., & Strooper, B. D. (1999) · Science · doi:10.1126/science.286.5441.916 · Cited by 388 · see citing works

Anti-Aβ Therapeutics in Alzheimer's Disease: The Need for a Paradigm Shift

Golde, T. E., Schneider, L. S., & Koo, E. H. (2011) · Neuron · doi:10.1016/j.neuron.2011.01.002 · Cited by 382 · see citing works

Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease

Lee, B. D., Shin, J., VanKampen, J., Petrucelli, L., West, A. B., Ko, H. S., Lee, Y.-I., Maguire‐Zeiss, K. A., Bowers, W. J., Federoff, H. J., et al. (2010) · Nature Medicine · doi:10.1038/nm.2199 · Cited by 376 · see citing works

Neuropathological Staging of Brain Pathology in Sporadic Parkinson’s disease: Separating the Wheat from the Chaff

Braak, H., & Del Tredici, K. (2017) · Journal of Parkinson’s Disease · doi:10.3233/jpd-179001 · Cited by 372 · see citing works

TDP-43 Is a Developmentally Regulated Protein Essential for Early Embryonic Development

Sephton, C. F., Good, S. K., Atkin, S., Dewey, C. M., Mayer, P., Herz, J., & Yu, G. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.061846 · Cited by 370 · see citing works

C9orf72 BAC Mouse Model with Motor Deficits and Neurodegenerative Features of ALS/FTD

Liu, Y., Pattamatta, A., Zu, T., Reid, T. S., Bardhi, O., Borchelt, D., Yachnis, A. T., & Ranum, L. P. W. (2016) · Neuron · doi:10.1016/j.neuron.2016.04.005 · Cited by 368 · see citing works

Comparative transcriptomics in human and mouse

Breschi, A., Gingeras, T., & Guigó, R. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.19 · Cited by 368 · see citing works

Neurodegenerative Diseases: Expanding the Prion Concept

Walker, L. C., & Jucker, M. (2015) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071714-033828 · Cited by 361 · see citing works

Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis

Kraemer, B. C., Schuck, T., Wheeler, J. M., Robinson, L. C., Trojanowski, J. Q., Lee, V. M. Y., & Schellenberg, G. D. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0659-0 · Cited by 350 · see citing works

Functional recovery in new mouse models of ALS/FTLD after clearance of pathological cytoplasmic TDP-43

Walker, A. K., Spiller, K. J., Ge, G., Zheng, A., Xu, Y., Zhou, M. S., Tripathy, K., Kwong, L. K., Trojanowski, J. Q., & Lee, V. M. ‐. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1460-x · Cited by 338 · see citing works

Pathological Changes in Dopaminergic Nerve Cells of the Substantia Nigra and Olfactory Bulb in Mice Transgenic for Truncated Human α-Synuclein(1–120): Implications for Lewy Body Disorders

Tofaris, G. K., Garcia-Reitboeck, P., Humby, T., Lambourne, S. L., O’Connell, M. T., Ghetti, B. F., Gossage, H., Emson, P. C., Wilkinson, L. S., Goedert, M., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4965-05.2006 · Cited by 325 · see citing works

Guidelines for preclinical animal research in ALS/MND: A consensus meeting

Ludolph, A. C., Bendotti, C., Blaugrund, E., Chiò, A., Greensmith, L., Loeffler, J., Mead, R. J., Niessen, H. G., Petri, S., Pradat, P., et al. (2010) · Amyotrophic Lateral Sclerosis · doi:10.3109/17482960903545334 · Cited by 315 · see citing works

C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins

Zhang, Y., Gendron, T. F., Grima, J. C., Sasaguri, H., Jansen‐West, K. R., Xu, Y.-F., Katzman, R. B., Gass, J. M., Murray, M. E., Shinohara, M., et al. (2016) · Nature Neuroscience · doi:10.1038/nn.4272 · Cited by 315 · see citing works

Cell-to-cell transmission of non-prion protein aggregates

Lee, S., Desplats, P., Sigurdson, C. J., Tsigelny, I. F., & Masliah, E. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.145 · Cited by 307 · see citing works

Poly(GR) impairs protein translation and stress granule dynamics in C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis

Zhang, Y., Gendron, T. F., Ebbert, M., O’Raw, A. D., Yue, M., Jansen‐West, K. R., Zhang, X., Prudencio, M., Chew, J., Cook, C. N., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0071-1 · Cited by 307 · see citing works

The DIAN‐TU Next Generation Alzheimer's prevention trial: Adaptive design and disease progression model

Bateman, R. J., Benzinger, T. L., Berry, S., Clifford, D. B., Duggan, C., Fagan, A. M., Fanning, K., Farlow, M. R., Hassenstab, J., McDade, E. M., et al. (2017) · Alzheimer's &amp; Dementia · doi:10.1016/j.jalz.2016.07.005 · Cited by 303 · see citing works

Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy

Spiller, K. J., Restrepo, C. R., Khan, T., Dominique, M. A., Fang, T. C., Canter, R. G., Roberts, C. J., Miller, K. R., Ransohoff, R. M., Trojanowski, J. Q., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0083-7 · Cited by 301 · see citing works

C9orf72 BAC Transgenic Mice Display Typical Pathologic Features of ALS/FTD

O’Rourke, J. G., Bogdanik, L., Muhammad, A. K. M. G., Gendron, T. F., Kim, K. J., Austin, A., Cady, J., Liu, E. Y., Zarrow, J., Grant, S., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.10.027 · Cited by 298 · see citing works

Rodent Models of Amyotrophic Lateral Sclerosis

Philips, T., & Rothstein, J. D. (2015) · Current Protocols in Pharmacology · doi:10.1002/0471141755.ph0567s69 · Cited by 292 · see citing works

A decade of modeling Alzheimer's disease in transgenic mice

MCGOWAN, E., ERIKSEN, J., & HUTTON, M. (2006) · Trends in Genetics · doi:10.1016/j.tig.2006.03.007 · Cited by 287 · see citing works

Induction of Tau Pathology by Intracerebral Infusion of Amyloid-β-Containing Brain Extract and by Amyloid-β Deposition in APP × Tau Transgenic Mice

Bolmont, T., Clavaguera, F., Meyer-Luehmann, M., Herzig, M. C., Radde, R., Staufenbiel, M., Lewis, J., Hutton, M., Tolnay, M., & Jucker, M. (2007) · The American Journal of Pathology · doi:10.2353/ajpath.2007.070403 · Cited by 281 · see citing works

Serial propagation of distinct strains of Aβ prions from Alzheimer’s disease patients

Watts, J. C., Condello, C., Stöhr, J., Oehler, A., Lee, J., DeArmond, S. J., Lannfelt, L., Ingelsson, M., Giles, K., & Prusiner, S. B. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408900111 · Cited by 279 · see citing works

Drosophila melanogaster as a model organism for Alzheimer’s disease

Prüßing, K., Voigt, A., & Schulz, J. B. (2013) · Molecular Neurodegeneration · doi:10.1186/1750-1326-8-35 · Cited by 271 · see citing works

Modeling human diseases with induced pluripotent stem cells: from 2D to 3D and beyond

Liu, C., Oikonomopoulos, A., Sayed, N., & Wu, J. C. (2018) · Development · doi:10.1242/dev.156166 · Cited by 271 · see citing works

Loss-of-function mutations in the <i>C9ORF72</i> mouse ortholog cause fatal autoimmune disease

Burberry, A., Suzuki, N., Wang, J.-Y., Moccia, R., Mordes, D. A., Stewart, M. H., Suzuki-Uematsu, S., Ghosh, S., Singh, A., Merkle, F. T., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf6038 · Cited by 269 · see citing works

TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD

White, M. A., Kim, E., Duffy, A., Adalbert, R., Phillips, B. U., Peters, O. M., Stephenson, J., Yang, S., Massenzio, F., Lin, Z., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0113-5 · Cited by 267 · see citing works

Pathological hallmarks of amyotrophic lateral sclerosis/frontotemporal lobar degeneration in transgenic mice produced with TDP-43 genomic fragments

Swarup, V., Phaneuf, D., Bareil, C., Robertson, J., Rouleau, G. A., Križ, J., & Julien, J. (2011) · Brain · doi:10.1093/brain/awr159 · Cited by 264 · see citing works

Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer’s Disease

Fu, H., Rodriguez, G. A., Herman, M., Emrani, S., Nahmani, E., Barrett, G., Figueroa, H. Y., Goldberg, E., Hussaini, S. A., & Duff, K. E. (2017) · Neuron · doi:10.1016/j.neuron.2016.12.023 · Cited by 264 · see citing works

C9orf72 ablation causes immune dysregulation characterized by leukocyte expansion, autoantibody production and glomerulonephropathy in mice

Atanasio, A., Decman, V., White, D., Ramos, M., Ikiz, B., Lee, H.-C., Siao, C.-J., Brydges, S., LaRosa, E., Bai, Y., et al. (2016) · Scientific Reports · doi:10.1038/srep23204 · Cited by 263 · see citing works

Absence of nigral degeneration in aged parkin/DJ‐1/PINK1 triple knockout mice

Kitada, T., Tong, Y., Gautier, C., & Shen, J. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06350.x · Cited by 260 · see citing works

Human C9ORF72 Hexanucleotide Expansion Reproduces RNA Foci and Dipeptide Repeat Proteins but Not Neurodegeneration in BAC Transgenic Mice

Peters, O. M., Cabrera, G. T., Tran, H., Gendron, T. F., McKeon, J. E., Metterville, J., Weiss, A., Wightman, N., Salameh, J. S., Kim, J., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.11.018 · Cited by 259 · see citing works

TDP‐43, a neuro‐pathosignature factor, is essential for early mouse embryogenesis

Wu, L., Cheng, W., Hou, S., Yan, Y., Jiang, S., & Shen, C. ‐. J. (2010) · genesis · doi:10.1002/dvg.20584 · Cited by 256 · see citing works

Animal models of α-synucleinopathy for Parkinson disease drug development

Koprich, J. B., Kalia, L. V., & Brotchie, J. M. (2017) · Nature reviews. Neuroscience · doi:10.1038/nrn.2017.75 · Cited by 235 · see citing works

Mammalian prions and their wider relevance in neurodegenerative diseases

Collinge, J. (2016) · Nature · doi:10.1038/nature20415 · Cited by 231 · see citing works

Mechanisms of Protein Seeding in Neurodegenerative Diseases

Walker, L. C., Diamond, M. I., Duff, K. E., & Hyman, B. T. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.1453 · Cited by 226 · see citing works

Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss

Lee, Y., Karuppagounder, S. S., Shin, J.-H., Lee, Y.-I., Ko, H. S., Swing, D., Jiang, H., Kang, S.-U., Lee, B. D., Kang, H. C., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3500 · Cited by 214 · see citing works

PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival

Lee, Y., Stevens, D. A., Kang, S.-U., Jiang, H., Lee, Y.-I., Ko, H. S., Scarffe, L. A., Umanah, G. K. E., Kang, H., Ham, S., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2016.12.090 · Cited by 207 · see citing works

Treatment with edaravone, initiated at symptom onset, slows motor decline and decreases SOD1 deposition in ALS mice

Ito, H., Wate, R., Zhang, J., Ohnishi, S., Kaneko, S., Ito, H., Nakano, S., & Kusaka, H. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.07.017 · Cited by 205 · see citing works

Conditional Expression of Parkinson's Disease-Related Mutant -Synuclein in the Midbrain Dopaminergic Neurons Causes Progressive Neurodegeneration and Degradation of Transcription Factor Nuclear Receptor Related 1

Lin, X. Z., Parisiadou, L., Sgobio, C., Liu, G., Yu, J. H., Sun, L., Shim, H., Gu, X., Luo, J., Long, C., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1731-12.2012 · Cited by 188 · see citing works

Bacterial Artificial Chromosome Transgenic Mice Expressing a Truncated Mutant Parkin Exhibit Age-Dependent Hypokinetic Motor Deficits, Dopaminergic Neuron Degeneration, and Accumulation of Proteinase K-Resistant α-Synuclein

Lu, X., Fleming, S. M., Meurers, B. H., Ackerson, L. C., Mortazavi, F., Lo, V., Hernandez, D., Sulzer, D., Jackson, G. R., Maidment, N. T., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5351-08.2009 · Cited by 177 · see citing works

Animal models of Parkinson's disease: Limits and relevance to neuroprotection studies

Bézard, E., Yue, Z., Kirik, D., & Spillantini, M. G. (2012) · Movement Disorders · doi:10.1002/mds.25108 · Cited by 176 · see citing works

Nonhuman Primate Models of Alzheimer-Like Cerebral Proteopathy

Heuer, E., F. Rosen, R., Cintron, A., & C. Walker, L. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212799315885 · Cited by 169 · see citing works

Evaluation of Potential Infectivity of Alzheimer and Parkinson Disease Proteins in Recipients of Cadaver-Derived Human Growth Hormone

Irwin, D. J., Abrams, J. Y., Schonberger, L. B., Leschek, E., Mills, J. L., Lee, V. M. ‐., & Trojanowski, J. Q. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.1933 · Cited by 167 · see citing works

Modelling neurodegenerative diseases in Drosophila: a fruitful approach?

Muqit, M. M. K., & Feany, M. Β. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn751 · Cited by 165 · see citing works

α-Synuclein-Based Animal Models of Parkinson's Disease: Challenges and Opportunities in a New Era

Visanji, N. P., Brotchie, J. M., Kalia, L. V., Koprich, J. B., Tandon, A., Watts, J. C., & Lang, A. E. (2016) · Trends in Neurosciences · doi:10.1016/j.tins.2016.09.003 · Cited by 161 · see citing works

Animal models of the non-motor features of Parkinson's disease

McDowell, K. A., & Chesselet, M. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.12.040 · Cited by 158 · see citing works

Toward more predictive genetic mouse models of Alzheimer’s disease

Onos, K. D., Sukoff Rizzo, S. J., Howell, G. R., & Sasner, M. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2015.12.003 · Cited by 156 · see citing works

Alzheimer's Prevention Initiative: A Proposal to Evaluate Presymptomatic Treatments as Quickly as Possible

Reiman, E. M., Langbaum, J. B. S., & Tariot, P. N. (2010) · Biomarkers in Medicine · doi:10.2217/bmm.09.91 · Cited by 156 · see citing works

From animal models to human disease: a genetic approach for personalized medicine in ALS

Picher‐Martel, V., Valdmanis, P. N., Gould, P. V., Julien, J., & Dupré, N. (2016) · Acta Neuropathologica Communications · doi:10.1186/s40478-016-0340-5 · Cited by 150 · see citing works

Distinct differences in prion-like seeding and aggregation between Tau protein variants provide mechanistic insights into tauopathies

Strang, K. H., Croft, C. L., Sorrentino, Z. A., Chakrabarty, P., Golde, T. E., & Giasson, B. I. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.815357 · Cited by 144 · see citing works

Pathogenesis of FUS-associated ALS and FTD: insights from rodent models

Nolan, M., Talbot, K., & Ansorge, O. (2016) · Acta Neuropathologica Communications · doi:10.1186/s40478-016-0358-8 · Cited by 139 · see citing works

Tau: From research to clinical development

Holtzman, D. M., Carrillo, M. C., Hendrix, J. A., Bain, L. J., Catafau, A. M., Gault, L. M., Goedert, M., Mandelkow, E., Mandelkow, E., Miller, D. S., et al. (2016) · Alzheimer's &amp; Dementia · doi:10.1016/j.jalz.2016.03.018 · Cited by 139 · see citing works

Motor neuron intrinsic and extrinsic mechanisms contribute to the pathogenesis of FUS-associated amyotrophic lateral sclerosis

Scekic‐Zahirovic, J., Oussini, H. E., Mersmann, S., Drenner, K., Wagner, M., Sun, Y., Allmeroth, K., Dieterle, S., Sinniger, J., Dirrig‐Grosch, S., et al. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1687-9 · Cited by 135 · see citing works

The genetic landscape of Alzheimer disease

Carmona, S., Hardy, J., & Guerreiro, R. J. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64076-5.00026-0 · Cited by 133 · see citing works

Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss

Schludi, M. H., Becker, L., Garrett, L., Gendron, T. F., Zhou, Q., Schreiber, F., Popper, B., Dimou, L., Strom, T. M., Winkelmann, J., et al. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1711-0 · Cited by 131 · see citing works

Age-Dependent Dopaminergic Neurodegeneration and Impairment of the Autophagy-Lysosomal Pathway in LRRK-Deficient Mice

Giaime, E., Tong, Y., Wagner, L. K., Yang, Y. H., Huang, G., & Shen, J. (2017) · Neuron · doi:10.1016/j.neuron.2017.09.036 · Cited by 131 · see citing works

Animal Models of Parkinson's Disease: Vertebrate GeneticsPreprint

Lee, Y., Dawson, V. L., & Dawson, T. M. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a009324 · Cited by 129 · see citing works

The prion model for progression and diversity of neurodegenerative diseases

Stopschinski, B. E., & Diamond, M. I. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30037-6 · Cited by 125 · see citing works

Thinking laterally about neurodegenerative proteinopathies

Golde, T. E., Borchelt, D., Giasson, B. I., & Lewis, J. M. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66029 · Cited by 121 · see citing works

Four pioneers of L‐dopa treatment: Arvid Carlsson, Oleh Hornykiewicz, George Cotzias, and Melvin Yahr

Lees, A. J., TOLOSA, E. S., & Olanow, C. W. (2014) · Movement Disorders · doi:10.1002/mds.26120 · Cited by 119 · see citing works

Modeling neurodegenerative diseases in Caenorhabditis elegans

Li, J., & Le, W. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.09.024 · Cited by 118 · see citing works

Humanized mutant FUS drives progressive motor neuron degeneration without aggregation in ‘FUSDelta14’ knockin mice

Devoy, A., Kalmár, B., Stewart, M. E., Park, H., Burke, B., Noy, S., Redhead, Y. T., Humphrey, J., Lo, K., Jaeger, J., et al. (2017) · Brain · doi:10.1093/brain/awx248 · Cited by 117 · see citing works

Mouse models of ALS: Past, present and future

Lutz, C. M. (2018) · Brain Research · doi:10.1016/j.brainres.2018.03.024 · Cited by 117 · see citing works

Genetic risk for Alzheimer’s disease is concentrated in specific macrophage and microglial transcriptional networks

Tansey, K. E., Cameron, D., & Hill, M. J. (2018) · Genome Medicine · doi:10.1186/s13073-018-0523-8 · Cited by 115 · see citing works

Neuronal Structure is Altered by Amyloid Plaques

Spires‐Jones, T. L., & Hyman, B. T. (2004) · Reviews in the Neurosciences · doi:10.1515/revneuro.2004.15.4.267 · Cited by 107 · see citing works

Mutant PFN1 causes ALS phenotypes and progressive motor neuron degeneration in mice by a gain of toxicity

Yang, C., Danielson, E., Qiao, T., Metterville, J., Brown, R. H., Landers, J. E., & Xu, Z. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1605964113 · Cited by 107 · see citing works

Protein folding diseases and neurodegeneration: Lessons learned from yeast

Winderickx, J., Delay, C., Vos, A. D., Klinger, H., Pellens, K., Vanhelmont, T., LEUVEN, F. V., & Zabrocki, P. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.01.020 · Cited by 102 · see citing works

Invertebrate models of Alzheimer's disease

Link, C. D. (2004) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2004.00105.x · Cited by 97 · see citing works

Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice

Xiong, Y., Neifert, S., Karuppagounder, S. S., Liu, Q., Stankowski, J. N., Lee, B. D., Ko, H. S., Lee, Y., Grima, J. C., Mao, X., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1712648115 · Cited by 97 · see citing works

Analysis of tauopathies with transgenic mice

Hutton, M., Lewis, J., Dickson, D., Yen, S.-H., & McGowan, E. (2001) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(01)02123-2 · Cited by 91 · see citing works

Motor neuron disease, TDP-43 pathology, and memory deficits in mice expressing ALS–FTD-linked UBQLN2 mutations

Le, N. T. T., Chang, L., Kovlyagina, I., Georgiou, P., Safren, N., Braunstein, K. E., Kvarta, M. D., Dyke, A. M. V., LeGates, T. A., Philips, T., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1608432113 · Cited by 89 · see citing works

Mutant Profilin1 transgenic mice recapitulate cardinal features of motor neuron disease

Fil, D., DeLoach, A., Yadav, S., Alkam, D., MacNicol, M. C., Singh, A., Compadre, C. M., Goellner, J. J., O’Brien, C. A., Fahmi, T., et al. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw429 · Cited by 88 · see citing works

Normal cognition in transgenic BRI2-Aβ mice

Kim, J., Chakrabarty, P., Hanna, A., March, A., Dickson, D. W., Borchelt, D. R., Golde, T., & Janus, C. (2013) · Molecular Neurodegeneration · doi:10.1186/1750-1326-8-15 · Cited by 83 · see citing works

Models of LRRK2-Associated Parkinson’s Disease

Xiong, Y., Dawson, T. M., & Dawson, V. L. (2017) · Advances in neurobiology · doi:10.1007/978-3-319-49969-7_9 · Cited by 79 · see citing works

Challenges in detecting disease modification in Parkinson's disease clinical trials

Athauda, D. S., & Foltynie, T. (2016) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2016.07.019 · Cited by 73 · see citing works

FTD and ALS—translating mouse studies into clinical trials

Ittner, L. M., Halliday, G. M., Kril, J. J., Götz, J., Hodges, J. R., & Kiernan, M. C. (2015) · Nature Reviews Neurology · doi:10.1038/nrneurol.2015.65 · Cited by 69 · see citing works

Trumping neurodegeneration: Targeting common pathways regulated by autosomal recessive Parkinson’s disease genes

Scott, L., Dawson, V., & Dawson, T. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.04.008 · Cited by 67 · see citing works

LRRK2 mouse models: dissecting the behavior, striatal neurochemistry and neurophysiology of PD pathogenesis

Volta, M., & Melrose, H. L. (2017) · Biochemical Society Transactions · doi:10.1042/bst20160238 · Cited by 64 · see citing works

Viral Vector-Based Models of Parkinson’s Disease

der Perren, A. V., den Haute, C. V., & Baekelandt, V. (2014) · Current topics in behavioral neurosciences · doi:10.1007/7854_2014_310 · Cited by 61 · see citing works

Are rodent models of Parkinson’s disease behaving as they should?

Vingill, S., Connor‐Robson, N., & Wade‐Martins, R. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.10.021 · Cited by 60 · see citing works

Adenoviral-mediated expression of G2019S LRRK2 induces striatal pathology in a kinase-dependent manner in a rat model of Parkinson's disease

Tsika, E., Nguyen, A. P. T., Dusonchet, J., Colin, P., Schneider, B. L., & Moore, D. J. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.02.019 · Cited by 46 · see citing works

Pathogenic determinants and mechanisms of ALS/FTD linked to hexanucleotide repeat expansions in the C9orf72 gene

Wen, X., Westergard, T., Pasinelli, P., & Trotti, D. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.09.007 · Cited by 43 · see citing works

Transgenic Rodent Models to Study Alpha-Synuclein Pathogenesis, with a Focus on Cognitive Deficits

Hatami, A., & Chesselet, M. (2014) · Current topics in behavioral neurosciences · doi:10.1007/7854_2014_355 · Cited by 42 · see citing works

Of mice and CRISPR

Liu, E. T., Bolcun‐Filas, E., Grass, D., Lutz, C. M., Murray, S., Shultz, L., & Rosenthal, N. A. (2017) · EMBO Reports · doi:10.15252/embr.201643717 · Cited by 39 · see citing works

Simple, Efficient CRISPR-Cas9-Mediated Gene Editing in Mice: Strategies and Methods

Low, B. E., Kutny, P. M., & Wiles, M. V. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-3661-8_2 · Cited by 38 · see citing works

Clinical approaches to the development of a neuroprotective therapy for PD

Olanow, C. W., Kieburtz, K. D., & Katz, R. G. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.06.018 · Cited by 38 · see citing works

Clinical Trial Designs in Amyotrophic Lateral Sclerosis: Does One Design Fit All?

Nicholson, K. A., Cudkowicz, M., & Berry, J. D. (2015) · Neurotherapeutics · doi:10.1007/s13311-015-0341-2 · Cited by 36 · see citing works

Mouse models of frontotemporal dementia: A comparison of phenotypes with clinical symptomatology

Ahmed, R. M., Irish, M., van Eersel, J., Ittner, A., Ke, Y. D., Volkerling, A. M., van der Hoven, J., Tanaka, K., Karl, T., Kassiou, M., et al. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.01.004 · Cited by 33 · see citing works

Modeling LRRK2 Pathobiology in Parkinson's Disease: From Yeast to Rodents.

Daniel, G., & Moore, D. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2014_311 · Cited by 24 · see citing works

Non-prion-type transmission in A53T α-synuclein transgenic mice: a normal component of spinal homogenates from naïve non-transgenic mice induces robust α-synuclein pathology

Sacino, A. N., Ayers, J. I., Brooks, M., Chakrabarty, P., Hudson, V. J., Howard, J. K., Golde, T. E., Giasson, B. I., & Borchelt, D. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1505-1 · Cited by 23 · see citing works

Predicting success: Optimizing phase II ALS trials for the transition to phase III

Berry, J. D., Cudkowicz, M., & Shefner, J. M. (2014) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.3109/21678421.2013.838969 · Cited by 14 · see citing works

Insights into LRRK2 function and dysfunction from transgenic and knockout rodent models

Sloan, M., Alegre‐Abarrategui, J., & Wade‐Martins, R. (2012) · Biochemical Society Transactions · doi:10.1042/bst20120151 · Cited by 11 · see citing works

Alzheimer disease

Knopman, D. S., Amieva, H., Petersen, R. C., Chételat, G., Holtzman, D. M., Hyman, B. T., Nixon, R. A., & Jones, D. T. (2021) · Nature Reviews Disease Primers · doi:10.1038/s41572-021-00269-y · Cited by 2,606 · see citing works

The gut microbiota–brain axis in behaviour and brain disorders

Morais, L. H., Schreiber, H. L., & Mazmanian, S. K. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-020-00460-0 · Cited by 2,149 · see citing works

Development of a Chimeric Model to Study and Manipulate Human Microglia In Vivo

Hasselmann, J., Coburn, M. A., England, W., Figueroa Velez, D. X., Kiani Shabestari, S., Tu, C. H., McQuade, A., Kolahdouzan, M., Echeverria, K., Claes, C., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.07.002 · Cited by 380 · see citing works

Microglia: Agents of the CNS Pro-Inflammatory Response

Rodríguez-Gómez, J. A., Kavanagh, E., Engskog-Vlachos, P., Engskog, M. K. R., Herrera, A. J., Espinosa-Oliva, A. M., Joseph, B., Hajji, N., Venero, J. L., & Burguillos, M. A. (2020) · Cells · doi:10.3390/cells9071717 · Cited by 365 · see citing works

Immune Signaling in Neurodegeneration

Hammond, T. R., Marsh, S. E., & Stevens, B. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.016 · Cited by 336 · see citing works

The Impact of Systemic Inflammation on Alzheimer’s Disease Pathology

Xie, J., Van Hoecke, L., & Vandenbroucke, R. E. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.796867 · Cited by 324 · see citing works

Enhancing glycolysis attenuates Parkinson’s disease progression in models and clinical databases

Cai, R., Zhang, Y., Simmering, J. E., Schultz, J. L., Li, Y., Fernandez-Carasa, I., Consiglio, A., Raya, A., Polgreen, P. M., Narayanan, N. S., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci129987 · Cited by 286 · see citing works

The Potential Use of Plant Natural Products and Plant Extracts with Antioxidant Properties for the Prevention/Treatment of Neurodegenerative Diseases: In Vitro, In Vivo and Clinical Trials

Pohl, F., & Lin, P. K. T. (2018) · Molecules · doi:10.3390/molecules23123283 · Cited by 281 · see citing works

Neuroinflammation in frontotemporal dementia

Bright, F., Werry, E. L., Dobson-Stone, C., Piguet, O., Ittner, L. M., Halliday, G. M., Hodges, J. R., Kiernan, M. C., Loy, C. T., Kassiou, M., et al. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-019-0231-z · Cited by 280 · see citing works

Identification of neural oscillations and epileptiform changes in human brain organoids

Samarasinghe, R. A., Miranda, O. A., Buth, J. E., Mitchell, S. A., Ferando, I., Watanabe, M., Allison, T. F., Kurdian, A., Fotion, N. N., Gandal, M. J., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00906-5 · Cited by 278 · see citing works

Lysosomal dysfunction in neurodegeneration: emerging concepts and methods

Udayar, V., Chen, Y., Sidransky, E., & Jagasia, R. (2022) · Trends in Neurosciences · doi:10.1016/j.tins.2021.12.004 · Cited by 238 · see citing works

Protein neddylation and its role in health and diseases

Zhang, S., Yu, Q., Li, Z., Zhao, Y., & Sun, Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01800-9 · Cited by 171 · see citing works

Precision drug delivery to the central nervous system using engineered nanoparticles

Gao, J., Xia, Z. J., Gunasekar, S., Jiang, C., Karp, J. M., & Joshi, N. (2024) · Nature Reviews Materials · doi:10.1038/s41578-024-00695-w · Cited by 162 · see citing works

Implications of Gut Microbiota in Neurodegenerative Diseases

Zhang, H., Chen, Y., Wang, Z., Xie, G., Liu, M., Yuan, B., Chai, H., Wang, W., & Cheng, P. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.785644 · Cited by 157 · see citing works

Recent Advancements of Nanomedicine in Neurodegenerative Disorders Theranostics

Mukherjee, S., Madamsetty, V. S., Bhattacharya, D., Roy Chowdhury, S., Paul, M. K., & Mukherjee, A. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202003054 · Cited by 152 · see citing works

Human iPSC‐derived microglia: A growing toolset to study the brain's innate immune cells

Hasselmann, J., & Blurton‐Jones, M. (2020) · Glia · doi:10.1002/glia.23781 · Cited by 145 · see citing works

Stem Cells, Genome Editing, and the Path to Translational Medicine

Soldner, F., & Jaenisch, R. (2018) · Cell · doi:10.1016/j.cell.2018.09.010 · Cited by 139 · see citing works

Mechanobiology of the brain in ageing and Alzheimer's disease

Hall, C. M., Moeendarbary, E., & Sheridan, G. K. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14766 · Cited by 137 · see citing works

QUINT: Workflow for Quantification and Spatial Analysis of Features in Histological Images From Rodent Brain

Yates, S. C., Groeneboom, N. E., Coello, C. S., Lichtenthaler, S. F., Kuhn, P., Demuth, H.-U., Hartlage‐Rübsamen, M., Roßner, S., Leergaard, T. B., Kreshuk, A., et al. (2019) · Frontiers in Neuroinformatics · doi:10.3389/fninf.2019.00075 · Cited by 130 · see citing works

Transgenic Mouse Models of Alzheimer’s Disease: An Integrative Analysis

Sanchez-Varo, R. M., Mejias‐Ortega, M., Fernandez-Valenzuela, J. J., Nuñez‐Diaz, C., Cáceres-Palomo, L., Vegas‐Gomez, L., Sánchez‐Mejías, E., Trujillo‐Estrada, L., García‐León, J. A., Moreno‐González, I., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105404 · Cited by 130 · see citing works

Neuroinflammation in Neurodegenerative Disorders: Current Knowledge and Therapeutic Implications

Giri, P. M., Banerjee, A., Ghosal, A., & Layek, B. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25073995 · Cited by 123 · see citing works

Map kinase signaling as therapeutic target for neurodegeneration

Ahmed, T., Zulfiqar, A., Argüelles, S., Rasekhian, M., Nabavi, S. F., Sanches-Silva, A. T., & Nabavi, S. M. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105090 · Cited by 121 · see citing works

Disease-Modifying Therapies for Alzheimer’s Disease: More Questions than Answers

Golde, T. E. (2022) · Neurotherapeutics · doi:10.1007/s13311-022-01201-2 · Cited by 119 · see citing works

Behavioral Tests in Neurotoxin-Induced Animal Models of Parkinson’s Disease

Prasad, E. M., & Hung, S. (2020) · Antioxidants · doi:10.3390/antiox9101007 · Cited by 118 · see citing works

Contribution of astrocytes to neuropathology of neurodegenerative diseases

Acıoğlu, Ç., Li, L., & Elkabes, S. (2021) · Brain Research · doi:10.1016/j.brainres.2021.147291 · Cited by 115 · see citing works

Genome-scale metabolic network reconstruction of model animals as a platform for translational research

Wang, H., Robinson, J. L., Kocabaş, P., Gustafsson, J., Anton, M., Cholley, P., Huang, S., Gobom, J., Svensson, T., Uhlén, M., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2102344118 · Cited by 113 · see citing works

Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer’s disease-like pathology

Baglietto‐Vargas, D., Forner, S., Cai, L., Martini, A. C., Trujillo‐Estrada, L., Swarup, V., Nguyen, M. M. T., Huynh, K. D., Javonillo, D. I., Tran, K. M., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22624-z · Cited by 112 · see citing works

Organotypic brain slice cultures to model neurodegenerative proteinopathies

Croft, C. L., Futch, H. S., Moore, B. D., & Golde, T. E. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0346-0 · Cited by 109 · see citing works

Improved modeling of human AD with an automated culturing platform for iPSC neurons, astrocytes and microglia

Bassil, R., Shields, K., Granger, K., Zein, I., Ng, S., & Chih, B. (2021) · Nature Communications · doi:10.1038/s41467-021-25344-6 · Cited by 106 · see citing works

Miniaturized head-mounted microscope for whole-cortex mesoscale imaging in freely behaving mice

Rynes, M. L., Surinach, D. A., Linn, S., LaRoque, M. C., Rajendran, V., Dominguez, J., Hadjistamoulou, O., Navabi, Z. S., Ghanbari, L., Johnson, G. W., et al. (2021) · Nature Methods · doi:10.1038/s41592-021-01104-8 · Cited by 101 · see citing works

Antisense Oligonucleotides for the Study and Treatment of ALS

Boros, B. D., Schoch, K. M., Kreple, C. J., & Miller, T. M. (2022) · Neurotherapeutics · doi:10.1007/s13311-022-01247-2 · Cited by 100 · see citing works

The A1 astrocyte paradigm: New avenues for pharmacological intervention in neurodegeneration

Hinkle, J. T., Dawson, V. L., & Dawson, T. M. (2019) · Movement Disorders · doi:10.1002/mds.27718 · Cited by 98 · see citing works

Group B Streptococcal Neonatal Meningitis

Tavares, T., Pinho, L., & Andrade, E. B. (2022) · Clinical Microbiology Reviews · doi:10.1128/cmr.00079-21 · Cited by 97 · see citing works

Gene therapy for CNS disorders: modalities, delivery and translational challenges

Gao, J., Gunasekar, S., Xia, Z. J., Shalin, K., Jiang, C., Chen, H., Lee, D., Lee, S., Pisal, N. D., Luo, J. N., et al. (2024) · Nature reviews. Neuroscience · doi:10.1038/s41583-024-00829-7 · Cited by 96 · see citing works

The Potential of Flavonoids and Flavonoid Metabolites in the Treatment of Neurodegenerative Pathology in Disorders of Cognitive Decline

Melrose, J. (2023) · Antioxidants · doi:10.3390/antiox12030663 · Cited by 95 · see citing works

Aβ plaques

Walker, L. C. (2020) · Free Neuropathology · doi:10.17879/freeneuropathology-2020-3025 · Cited by 95 · see citing works

Brain drug delivery and neurodegenerative diseases: Polymeric PLGA-based nanoparticles as a forefront platform

Pinto, M., Silva, V., Barreiro, S., Silva, R. V. D. S., Remião, F., Borges, F., & Fernandes, C. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101658 · Cited by 94 · see citing works

White matter microglia heterogeneity in the CNS

Amor, S., McNamara, N. B., Gerrits, E., Marzin, M. C., Kooistra, S. M., Miron, V. E., & Nutma, E. (2022) · Acta Neuropathologica · doi:10.1007/s00401-021-02389-x · Cited by 89 · see citing works

Multimodal mapping and analysis of the cyto- and receptorarchitecture of the human hippocampus

Palomero‐Gallagher, N., Kedo, O., Mohlberg, H., Zilles, K., & Amunts, K. (2020) · Brain Structure and Function · doi:10.1007/s00429-019-02022-4 · Cited by 90 · see citing works

Targeting Pathogenic Lafora Bodies in Lafora Disease Using an Antibody-Enzyme Fusion

Brewer, M. K., Uittenbogaard, A., Austin, G. L., Segvich, D. M., DePaoli-Roach, A. A., Roach, P. J., McCarthy, J. J., Simmons, Z. R., Brandon, J. A., Zhou, Z., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.07.002 · Cited by 89 · see citing works

Application of Human Brain Organoids—Opportunities and Challenges in Modeling Human Brain Development and Neurodevelopmental Diseases

Kim, S.-H., & Chang, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241512528 · Cited by 89 · see citing works

Integrating deep learning and unbiased automated high-content screening to identify complex disease signatures in human fibroblasts

Schiff, L., Migliori, B., Chen, Y., Carter, D., Bonilla, C., Hall, J., Fan, M., Tam, E., Ahadi, S., Fischbacher, B., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28423-4 · Cited by 86 · see citing works

Hyperphosphorylated tau (p-tau) and drug discovery in the context of Alzheimer's disease and related tauopathies

Moore, K. B. E., Hung, T.-J., & Fortin, J. S. (2023) · Drug Discovery Today · doi:10.1016/j.drudis.2023.103487 · Cited by 86 · see citing works

<i>Bifidobacterium breve</i> HNXY26M4 Attenuates Cognitive Deficits and Neuroinflammation by Regulating the Gut–Brain Axis in APP/PS1 Mice

Zhu, G., Zhao, J., Wang, G., & Chen, W. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c00652 · Cited by 84 · see citing works

Neuroinflammation: Mechanisms, Dual Roles, and Therapeutic Strategies in Neurological Disorders

García‐Domínguez, M. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47060417 · Cited by 85 · see citing works

Biomarkers and therapeutic strategies targeting microglia in neurodegenerative diseases: current status and future directions

Noh, M., Kwon, H. S., Kwon, M., Nahm, M., Jin, H. K., Bae, J., & Kim, S. H. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00867-4 · Cited by 85 · see citing works

The Convergence of Alpha-Synuclein, Mitochondrial, and Lysosomal Pathways in Vulnerability of Midbrain Dopaminergic Neurons in Parkinson’s Disease

Minakaki, G., Krainc, D., & Burbulla, L. F. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.580634 · Cited by 83 · see citing works

Bioprinting Neural Systems to Model Central Nervous System Diseases

Qiu, B., Bessler, N., Figler, K. P., Buchholz, M., Rios, A. C., Malda, J., Levato, R., & Caiazzo, M. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201910250 · Cited by 81 · see citing works

Re-thinking the Etiological Framework of Neurodegeneration

Castillo, X., Castro‐Obregón, S., Gutiérrez-Becker, B., Gutiérrez‐Ospina, G., Karalis, N., Khalil, A. A., López‐Noguerola, J. S., Rodríguez, L. L., Martínez‐Martínez, E., Perez‐Cruz, C., et al. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00728 · Cited by 80 · see citing works

Towards Visual Proteomics at High Resolution

Bäuerlein, F. J. B., & Baumeister, W. P. (2021) · Journal of Molecular Biology · doi:10.1016/j.jmb.2021.167187 · Cited by 79 · see citing works

New pathogenic insights from large animal models of neurodegenerative diseases

Yin, P., Li, S., Li, X., & Yang, W. (2022) · Protein & Cell · doi:10.1007/s13238-022-00912-8 · Cited by 79 · see citing works

Modeling late-onset Alzheimer’s disease neuropathology via direct neuronal reprogramming

Sun, Z., Kwon, J.-S., Ren, Y., Chen, S., Walker, C. K., Lu, X., Cates, K., Karahan, H., Sviben, S., Fitzpatrick, J. A. J., et al. (2024) · Science · doi:10.1126/science.adl2992 · Cited by 77 · see citing works

"Lipopolysaccharide-induced animal models for neuroinflammation – An overview."

Silva, A., Fiadeiro, M. B., Bernardino, L. I., Fonseca, C. P., Baltazar, G., & Cristóvão, A. C. (2023) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2023.578273 · Cited by 76 · see citing works

Animal Models for the Study of Human Disease

Morgan, S. J., Hutt, J. A., & Sura, R. (2023) · Springer eBooks · doi:10.1007/978-981-99-1284-1_15 · Cited by 74 · see citing works

Non-coding RNAs in Nervous System Development and Disease

Salvatori, B., Biscarini, S., & Morlando, M. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00273 · Cited by 73 · see citing works

Animal Models of Neurodegenerative Disease: Recent Advances in Fly Highlight Innovative Approaches to Drug Discovery

Tello, J. A., Williams, H., Eppler, R., Steinhilb, M. L., & Khanna, M. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.883358 · Cited by 73 · see citing works

The use of fibroblasts as a valuable strategy for studying mitochondrial impairment in neurological disorders

Olesen, M. A., Villavicencio-Tejo, F., & Quintanilla, R. (2022) · Translational Neurodegeneration · doi:10.1186/s40035-022-00308-y · Cited by 63 · see citing works

Insights into Computational Drug Repurposing for Neurodegenerative Disease

Paranjpe, M. D., Taubes, A. L., & Sirota, M. (2019) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2019.06.003 · Cited by 71 · see citing works

Neuroinflammation in Huntington’s disease: From animal models to clinical therapeutics

Jia, Q., Li, S., Li, X.-J., & Yin, P. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1088124 · Cited by 70 · see citing works

Dedifferentiation and neuronal repression define familial Alzheimer’s disease

Caldwell, A. B., Liu, Q., Schroth, G. P., Galasko, D. R., Yuan, S. H., Wagner, S. L., & Subramaniam, S. (2020) · Science Advances · doi:10.1126/sciadv.aba5933 · Cited by 69 · see citing works

High-Density Electrical Recording and Impedance Imaging With a Multi-Modal CMOS Multi-Electrode Array Chip

Miccoli, B., López, C. M., Goikoetxea, E., Putzeys, J., Sekeri, M., Krylychkina, O., Chang, S.-W., Firrincieli, A., Andrei, A., Reumers, V., et al. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00641 · Cited by 69 · see citing works

The Gypsy Endogenous Retrovirus Drives Non-Cell-Autonomous Propagation in a Drosophila TDP-43 Model of Neurodegeneration

Chang, Y.-H., & Dubnau, J. (2019) · Current Biology · doi:10.1016/j.cub.2019.07.071 · Cited by 68 · see citing works

Transposable elements as new players in neurodegenerative diseases

Ravel‐Godreuil, C., Znaidi, R., Bonnifet, T., Joshi, R. L., & Fuchs, J. (2021) · FEBS Letters · doi:10.1002/1873-3468.14205 · Cited by 67 · see citing works

Self-triggered click reaction in an Alzheimer's disease model: in situ bifunctional drug synthesis catalyzed by neurotoxic copper accumulated in amyloid-β plaques

Du, Z., Yu, D., Du, X., Scott, P., Ren, J., & Qu, X. (2019) · Chemical Science · doi:10.1039/c9sc04387j · Cited by 67 · see citing works

Alzheimer’s disease patient brain extracts induce multiple pathologies in novel vascularized neuroimmune organoids for disease modeling and drug discovery

Ji, Y., Chen, X., Wang, Z., Meek, C. J., McLean, J. L., Yang, Y., Yuan, C., Rochet, J., Liu, F., & Xu, R. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03041-w · Cited by 65 · see citing works

Region-specific glial homeostatic signature in prion diseases is replaced by a uniform neuroinflammation signature, common for brain regions and prion strains with different cell tropism

Makarava, N., Chang, J. C.-Y., Molesworth, K., & Baskakov, I. V. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104783 · Cited by 64 · see citing works

Organs to Cells and Cells to Organoids: The Evolution of in vitro Central Nervous System Modelling

Pacitti, D., Privolizzi, R., & Bax, B. E. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00129 · Cited by 64 · see citing works

CRISPR System: A High-throughput Toolbox for Research and Treatment of Parkinson’s Disease

Safari, F., Hatam, G., Behzad‐Behbahani, A., Tabar, V. R., Barekati‐Mowahed, M., Petramfar, P., & Khademi, F. (2019) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-019-00761-w · Cited by 64 · see citing works

A novel glaucoma approach: Stem cell regeneration of the trabecular meshwork

Coulon, S. J., Schuman, J. S., Du, Y., Fard, M. R. B., Ethier, C. R., & Stamer, W. D. (2022) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2022.101063 · Cited by 62 · see citing works

Chronic corticosterone aggravates behavioral and neuronal symptomatology in a mouse model of alpha-synuclein pathology

Burtscher, J., Copin, J., Rodrigues, J., Kumar, S. T., Chiki, A., de Suduiraut, I. G., Sandi, C., & Lashuel, H. A. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.08.007 · Cited by 60 · see citing works

Chronotherapies for Parkinson’s disease

Fifel, K., & Videnović, A. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.01.002 · Cited by 58 · see citing works

Age-related changes in social behaviours in the 5xFAD mouse model of Alzheimer’s disease

Kosel, F., Muñoz, P., Yang, J., Wong, A. A., & Franklin, T. B. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.01.029 · Cited by 57 · see citing works

Oxidative Stress in Tauopathies: From Cause to Therapy

Bartolomé, F. B., Carro, E., & Alquézar, C. (2022) · Antioxidants · doi:10.3390/antiox11081421 · Cited by 57 · see citing works

Heavy Metal Mediated Progressive Degeneration and Its Noxious Effects on Brain Microenvironment

Murumulla, L., Bandaru, L. J. M., & Challa, S. (2023) · Biological Trace Element Research · doi:10.1007/s12011-023-03778-x · Cited by 57 · see citing works

Integrative proteomics identifies a conserved Aβ amyloid responsome, novel plaque proteins, and pathology modifiers in Alzheimer’s disease

Levites, Y., Dammer, E. B., Ran, Y., Tsering, W., Duong, D. M., Abreha, M. H., Gadhavi, J. D., Lolo, K., Trejo‐Lopez, J. A., Phillips, J., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101669 · Cited by 57 · see citing works

Are some animal models more equal than others? A case study on the translational value of animal models of efficacy for Alzheimer''s disease.

Veening-Griffioen, D., Ferreira, G. S., van Meer, P. V., Boon, W., Wied, C. G. G.-D., Moors, E., & Schellekens, H. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.172524 · Cited by 49 · see citing works

Blood-brain barrier-on-a-chip for brain disease modeling and drug testing

Cui, B., & Cho, S. (2022) · BMB Reports · doi:10.5483/bmbrep.2022.55.5.043 · Cited by 56 · see citing works

Impact of Aging on the 6-OHDA-Induced Rat Model of Parkinson’s Disease

Barata‐Antunes, S., Teixeira, F. G., Mendes-Pinheiro, B., Domingues, A. V., Vilaça-Faria, H., Marote, A., Silva, D., Sousa, R. A., & Salgado, A. J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103459 · Cited by 56 · see citing works

Single-cell mapping of lipid metabolites using an infrared probe in human-derived model systems

Bai, Y., Camargo, C. M., Glasauer, S. M. K., Gifford, R., Tian, X., Longhini, A. P., & Kosik, K. S. (2024) · Nature Communications · doi:10.1038/s41467-023-44675-0 · Cited by 55 · see citing works

Modeling neurodegenerative diseases with cerebral organoids and other three-dimensional culture systems: focus on Alzheimer’s disease

Venkataraman, L., Fair, S. R., McElroy, C. A., Hester, M. E., & Fu, H. (2020) · Stem Cell Reviews and Reports · doi:10.1007/s12015-020-10068-9 · Cited by 54 · see citing works

Classic and evolving animal models in Parkinson's disease

Pingale, T. D., & Gupta, G. L. (2020) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2020.173060 · Cited by 54 · see citing works

Mice in translational neuroscience: What R we doing?

Azkona, G., & Sánchez‐Pernaute, R. (2022) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2022.102330 · Cited by 53 · see citing works

The role of glia in protein aggregation

Li, Q., & Haney, M. S. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105015 · Cited by 51 · see citing works

Heterocellular spheroids of the neurovascular blood-brain barrier as a platform for personalized nanoneuromedicine

Kumarasamy, M., & Sosnik, A. (2021) · iScience · doi:10.1016/j.isci.2021.102183 · Cited by 51 · see citing works

Induced pluripotent stem cell-based organ-on-a-chip as personalized drug screening tools: A focus on neurodegenerative disorders

Fanizza, F., Campanile, M., Forloni, G., Giordano, C., & Albani, D. (2022) · Journal of Tissue Engineering · doi:10.1177/20417314221095339 · Cited by 51 · see citing works

The Disease Modification Conundrum in Parkinson’s Disease: Failures and Hopes

Mari, Z. K., & Mestre, T. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.810860 · Cited by 50 · see citing works

CRISPR and iPSCs: Recent Developments and Future Perspectives in Neurodegenerative Disease Modelling, Research, and Therapeutics

Sen, T., & Thummer, R. P. (2022) · Neurotoxicity Research · doi:10.1007/s12640-022-00564-w · Cited by 50 · see citing works

A Mouse Model to Test Novel Therapeutics for Parkinson's Disease: an Update on the Thy1-aSyn (“line 61”) Mice

Richter, F., Stanojlović, M., Käufer, C., Gericke, B., & Feja, M. (2023) · Neurotherapeutics · doi:10.1007/s13311-022-01338-0 · Cited by 50 · see citing works

Single-Cell RNA Sequencing in Parkinson’s Disease

Ma, S., & Lim, S. B. (2021) · Biomedicines · doi:10.3390/biomedicines9040368 · Cited by 49 · see citing works

SRT1720 as an SIRT1 activator for alleviating paraquat-induced models of Parkinson's disease

Chao, C.-C., Huang, C., Cheng, J., Chiou, C., Lee, I., Yang, Y.-C., Hsu, T.-H., Yei, C.-E., Lin, P.-Y., Chen, J., et al. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102534 · Cited by 49 · see citing works

Development and Application of Brain Region–Specific Organoids for Investigating Psychiatric Disorders

Zhang, Z., Wang, X., Park, S. S., Song, H., & Ming, G. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.12.015 · Cited by 49 · see citing works

Lymphocyte Activation Gene 3 (Lag3) Contributes to α-Synucleinopathy in α-Synuclein Transgenic Mice

Gu, H., Yang, X., Mao, X., Xu, E., Qi, C., Wang, H., Brahmachari, S., York, B., Sriparna, M., Li, A., et al. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.656426 · Cited by 49 · see citing works

Quantification of Dendritic Spines Remodeling under Physiological Stimuli and in Pathological Conditions

Bączyńska, E., Pels, K. K., Basu, S., Włodarczyk, J., & Ruszczycki, B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084053 · Cited by 47 · see citing works

Insulin-like growth factor II prevents oxidative and neuronal damage in cellular and mice models of Parkinson's disease

Martín‐Montañez, E., Valverde, N., de Guevara‐Miranda, D. L., Lara, E., Romero‐Zerbo, S., Millón, C., Boraldi, F., Ávila‐Gámiz, F., Pérez-Cano, A. M., Garrido‐Gil, P., et al. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102095 · Cited by 47 · see citing works

Engineered 3D immuno-glial-neurovascular human miBrain model

Stanton, A. E., Bubnys, A., Agbas, E., James, B. T., Park, D. S., Jiang, A. Y. L., Pinals, R. L., Liu, L., Truong, N., Loon, A. R., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2511596122 · Cited by 46 · see citing works

Alzheimer’s Disease: From Immune Homeostasis to Neuroinflammatory Condition

Cariddi, L. P., Mauri, M. F., Cosentino, M., Versino, M., & Marino, F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113008 · Cited by 45 · see citing works

Assessing Drug Administration Techniques in Zebrafish Models of Neurological Disease

Chaoul, V., Dib, E., Bedran, J., Khoury, C., Shmoury, O., Harb, F., & Soueid, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914898 · Cited by 45 · see citing works

An acetylcholinesterase inhibitor, donepezil, increases anxiety and cortisol levels in adult zebrafish

Giacomini, A. C. V. V., Bueno, B. W., Marcon, L., Scolari, N., Genário, R., Demin, K. A., Kolesnikova, T. O., Kalueff, A. V., & de Abreu, M. S. (2020) · Journal of Psychopharmacology · doi:10.1177/0269881120944155 · Cited by 45 · see citing works

Utilization of 3D bioprinting technology in creating human tissue and organoid models for preclinical drug research – State-of-the-art

Frankowski, J., Kurzątkowska, M., Sobczak, M., & Piotrowska, U. (2023) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2023.123313 · Cited by 44 · see citing works

Gut microbiome and amyotrophic lateral sclerosis: a systematic review of current evidence

Sun, J., Huang, T., Debelius, J. W., & Fang, F. (2021) · Journal of Internal Medicine · doi:10.1111/joim.13336 · Cited by 43 · see citing works

Advancement in the animal model-based therapeutics in neurodegenerative diseases

Pal, D., Das, P., Ghosh, P., Gupta, S., Basak, P., & Nandi, S. K. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-33877-9.00007-0 · Cited by 1 · see citing works

Transgenic animal models of neurodegeneration based on human genetic studies

Harvey, B. K., Richie, C. T., Hoffer, B. J., & Airavaara, M. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0476-6 · Cited by 38 · see citing works

Animal and Cell Models in Alzheimer’s and Parkinson’s Disease: Current Innovations Reviewed

Rejitha, C., & Babu, L. (2026) · Current Aging Science · doi:10.2174/0118746098403535251203121022

Progress in the modeling of neurodegenerative diseases in transgenic mice

Duff, K., & Rao, M. V. (2001) · Current Opinion in Neurology · doi:10.1097/00019052-200108000-00003 · Cited by 22 · see citing works

Animal models of Alzheimer's Parkinson's and Huntington's disease. A minireview.

Antal, A., & Bodis-Wollner, I. G. (1993) · PubMed