Both early and late changes in psychological variables relate to treatment outcome for musculoskeletal pain patients at risk for disability
Abstract
We know little about why some people get better after psychological treatments for pain disability, whereas other people do not. In order to understand differences in treatment response, we need to explore processes of change during treatment. It has been suggested that people with pain complaints who change early in treatment have better outcomes. Therefore, we aimed to investigate whether changes in psychological variables at different time points are related to outcome, and whether early or late changes are better predictors of outcome. We used the fear avoidance model as a theoretical framework. We followed 64 patients weekly over 6-7 weeks and then determined outcome. Our findings indicate that people who decrease in catastrophizing and function early in treatment as well as in depressive symptoms, worry, fear avoidance beliefs and function late in treatment have better outcomes. Early decreases in function, and late decreases in depressive symptoms and worry uniquely predict improvements in disability. While early and late changes covaried concurrently, there were no significant sequential relationships between early and late changes. Changes in the proposed process variables in the fear avoidance model, early as well as late in treatment, thus add valuable information to the explanation of outcome.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A second category of mechanistic study delivers a pain-related intervention intended to change a psychological factor, with the expectation that changing that psychosocial factor will be associated with later change in pain-related outcomes.
“The second category of mechanistic study involves delivery of some type of pain-related intervention that is hypothesized to directly affect a psychological factor, presuming that changing that psychosocial factor (e.g., reducing distress, improving pain-coping, etc) will be associated with a subsequent change in one or more pain-related outcomes.”
From Evaluating psychosocial contributions to chronic pain outcomes (2018) · cites this paper as [31]
In such intervention studies, the psychological factor acts as a mediator, not necessarily a causal mechanism, through which treatment benefits occur.
“That is, the psychological factor acts as a mediator (though not necessarily a causal mechanism) through which a treatment confers its benefits 30, 31.”
From Evaluating psychosocial contributions to chronic pain outcomes (2018) · cites this paper as [31]
Early-treatment changes in catastrophizing account for substantial portions of variability in end-of-treatment outcomes.
“There is also evidence suggesting that substantial portions of the variability in end-of-treatment outcomes can be accounted for by early-treatment changes in catastrophizing 30, 31.”
From Evaluating psychosocial contributions to chronic pain outcomes (2018) · cites this paper as [31]
Cites
The Hospital Anxiety and Depression Scale
Zigmond, A. S., & Snaith, R. P. (1983) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1983.tb09716.x · Cited by 47,139 · see citing works
EuroQol: a new facility for the measurement of health-related quality of life
(1990) · Health Policy · doi:10.1016/0168-8510(90)90421-9 · Cited by 15,736 · see citing works
The validity of the Hospital Anxiety and Depression Scale
Bjelland, I., Dahl, A. A., Haug, T. T., & Neckelmann, D. (2002) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(01)00296-3 · Cited by 9,779 · see citing works
The Pain Catastrophizing Scale: Development and validation.
Sullivan, M. J. L., Bishop, S. R., & Pivik, J. (1995) · Psychological Assessment · doi:10.1037//1040-3590.7.4.524 · Cited by 8,227 · see citing works
Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art.
Vlaeyen, J. W. S., & Linton, S. J. (2000) · Pain · doi:10.1016/s0304-3959(99)00242-0 · Cited by 4,931 · see citing works
Self-citationHow we should measure "change": Or should we?
Cronbach, L. J., & Furby, L. (1970) · Psychological Bulletin · doi:10.1037/h0029382 · Cited by 2,456 · see citing works
The fear-avoidance model of musculoskeletal pain: Current state of scientific evidence
Leeuw, M., Goossens, M. E. J. B., Linton, S. J., Crombez, G., Boersma, K., & Vlaeyen, J. W. S. (2007) · Journal of Behavioral Medicine · doi:10.1007/s10865-006-9085-0 · Cited by 2,261 · see citing works
Self-citationRichardson, H. A., Simmering, M. J., & Sturman, M. C. (2009) · Organizational Research Methods · doi:10.1177/1094428109332834 · Cited by 1,721 · see citing works
Psychological therapies for the management of chronic pain (excluding headache) in adults
Williams, A. C. D. C., Eccleston, C., & Morley, S. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007407.pub3 · Cited by 1,634 · see citing works
Morley, S., Eccleston, C., & Williams, A. (1999) · Pain · doi:10.1016/s0304-3959(98)00255-3 · Cited by 1,597 · see citing works
Outcome Measures for Low Back Pain Research: A Proposal for Standardized Use
Deyo, R. A., Battie, M., Beurskens, A. J. H. M., Bombardier, C., Croft, P., Koes, B., Malmivaara, A., Roland, M., Von Korff, M., & Waddell, G. (1998) · Spine · doi:10.1097/00007632-199809150-00018 · Cited by 1,229 · see citing works
Kinesiophobia : a new view of chronic pain behavior
Kori, S. (1990) · Medical Entomology and Zoology · Cited by 1,040 · see citing works
A Comparison of Five Low Back Disability Questionnaires: Reliability and Responsiveness
Davidson, M., & Keating, J. L. (2002) · Physical Therapy · doi:10.1093/ptj/82.1.8 · Cited by 756 · see citing works
Hospital anxiety and depression scale (had): Some psychometric data for a swedish sample
Lisspers, J., Nygren, A., & Söderman, E. (1997) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1997.tb10164.x · Cited by 706 · see citing works
Nicholas, M. K., Linton, S. J., Watson, P. J., & Main, C. J. (2011) · Physical Therapy · doi:10.2522/ptj.20100224 · Cited by 690 · see citing works
Self-citationThe Quebec Back Pain Disability Scale
Kopec, J. A., Esdaile, J. M., Abrahamowicz, M., Abenhaim, L., Wood-Dauphinée, S., Lamping, D. L., & Williams, J. I. (1995) · Spine · doi:10.1097/00007632-199502000-00016 · Cited by 660 · see citing works
Smeets, R. J. E. M., Vlaeyen, J. W. S., Kester, A. D. M., & Knottnerus, J. A. (2006) · The Journal of Pain · doi:10.1016/j.jpain.2005.10.011 · Cited by 629 · see citing works
Linton, S. J., & Boersma, K. (2003) · The Clinical Journal of Pain · doi:10.1097/00002508-200303000-00002 · Cited by 523 · see citing works
Self-citationThe role of nonspecific factors in cognitive-behavior therapy for depression.
Ilardi, S. S., & Craighead, W. E. (1994) · Clinical Psychology: Science and Practice · doi:10.1111/j.1468-2850.1994.tb00016.x · Cited by 501 · see citing works
Jensen, M. P., Turner, J. A., & Romano, J. M. (2001) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.69.4.655 · Cited by 473 · see citing works
Jensen, M. P., Turner, J. A., & Romano, J. M. (2001) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.69.4.655 · Cited by 473 · see citing works
Cognitive-Behavioral Treatments for Chronic Pain: What Works for Whom?
Vlaeyen, J. W. S., & Morley, S. (2005) · The Clinical Journal of Pain · doi:10.1097/00002508-200501000-00001 · Cited by 350 · see citing works
Test-retest reliability of health state valuations collected with the EuroQol questionnaire
van Agt, H. M. E., Essink‐Bot, M., Krabbe, P. F. M., & Bonsel, G. J. (1994) · Social Science & Medicine · doi:10.1016/0277-9536(94)90005-1 · Cited by 343 · see citing works
Correlates of improvement in multidisciplinary treatment of chronic pain.
Jensen, M. P., Turner, J. A., & Romano, J. M. (1994) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.62.1.172 · Cited by 280 · see citing works
Spinhoven, P., ter Kuile, M., Kole‐Snijders, A. M. J., Mansfeld, M. H., den Ouden, D., & Vlaeyen, J. W. S. (2004) · European Journal of Pain · doi:10.1016/j.ejpain.2003.08.003 · Cited by 274 · see citing works
Von Korff, M., Moore, J. E., Lorig, K., Cherkin, D. C., Saunders, K., González, V. M., Laurent, D., Rutter, C., & Comite, F. (1998) · Spine · doi:10.1097/00007632-199812010-00016 · Cited by 257 · see citing works
Burns, J. W., Kubilus, A., Bruehl, S., Harden, R. N., & Lofland, K. (2003) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.71.1.81 · Cited by 256 · see citing works
Psychological therapies for the management of chronic pain (excluding headache) in adults
Eccleston, C., Williams, A. C. D. C., & Morley, S. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007407.pub2 · Cited by 247 · see citing works
The Quebec Back Pain Disability Scale: Conceptualization and development
Kopec, J. A., Esdaile, J. M., Abrahamowicz, M., Abenhaim, L., Wood-Dauphinee, S., Lamping, D. L., & Williams, J. I. (1996) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(96)00526-4 · Cited by 242 · see citing works
Cognitive therapy for depression: Individual differences and the process of change
Fennell, M. J. V., & Teasdale, J. D. (1987) · Cognitive Therapy and Research · doi:10.1007/bf01183269 · Cited by 228 · see citing works
Smeets, R., Vlaeyen, J. W. S., Hidding, A., Kester, A. D. M., van der Heijden, G. J. M. G., van Geel, A. C., & Knottnerus, J. A. (2006) · BMC Musculoskeletal Disorders · doi:10.1186/1471-2474-7-5 · Cited by 227 · see citing works
Do early responders to psychotherapy maintain treatment gains?
Haas, E., Hill, R., Lambert, M., & Morrell, B. (2002) · Journal of Clinical Psychology · doi:10.1002/jclp.10044 · Cited by 220 · see citing works
Burns, J. W., Glenn, B., Bruehl, S., Harden, R. N., & Lofland, K. (2003) · Behaviour Research and Therapy · doi:10.1016/s0005-7967(03)00029-9 · Cited by 174 · see citing works
A prospective sequential analysis of the fear-avoidance model of pain
Wideman, T. H., Adams, H., & Sullivan, M. J. L. (2009) · Pain · doi:10.1016/j.pain.2009.04.022 · Cited by 162 · see citing works
Sullivan, M., Adams, H., Thibault, P., Corbière, M., & Stanish, W. (2006) · Journal of occupational rehabilitation · doi:10.1007/s10926-005-9013-0 · Cited by 100 · see citing works
Fear-Avoidance Beliefs, Catastrophizing, and Distress
Westman, A., Boersma, K., Leppert, J., & Linton, S. J. (2011) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e318219ab6c · Cited by 94 · see citing works
Self-citationThe Role of Family Environment and Changes in Cognitive Processes
Tota-Faucette, M., Gil, K. M., Williams, D. A., Keefe, F. J., & Goli, V. (1993) · Clinical Journal of Pain · doi:10.1097/00002508-199306000-00006 · Cited by 86 · see citing works
Lackner, J. M., Gudleski, G. D., Keefer, L., Krasner, S. S., Powell, C., & Katz, L. A. (2010) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2010.02.007 · Cited by 76 · see citing works
Gladwell, P. (2010) · Dialnet (Universidad de la Rioja) · Cited by 73 · see citing works
Getting a handle on process and change in CBT for chronic pain
Morley, S., & Keefe, F. J. (2006) · Pain · doi:10.1016/j.pain.2006.10.025 · Cited by 37 · see citing works
Activities of Daily Living Scale for Patients with Chronic Pain
LINTON, S. J. (1990) · Perceptual and Motor Skills · doi:10.2466/pms.1990.71.3.722 · Cited by 26 · see citing works
Self-citationJensen, M. P. (2009) · Pain · doi:10.1016/j.pain.2009.07.036 · Cited by 16 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The role of psychosocial processes in the development and maintenance of chronic pain
Edwards, R. R., Dworkin, R. H., Sullivan, M. D., Turk, D. C., & Wasan, A. D. (2016) · The Journal of Pain · doi:10.1016/j.jpain.2016.01.001 · Cited by 954 · see citing works
Evaluating psychosocial contributions to chronic pain outcomes
Meints, S. M., & Edwards, R. R. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.01.017 · Cited by 719 · see citing works
Lee, H., Hübscher, M., Moseley, G. L., Kamper, S. J., Traeger, A. C., Mansell, G., & McAuley, J. H. (2015) · Pain · doi:10.1097/j.pain.0000000000000146 · Cited by 526 · see citing works
Marshall, P. W., Schabrun, S. M., & Knox, M. F. (2017) · PLoS ONE · doi:10.1371/journal.pone.0180788 · Cited by 231 · see citing works
Rethinking the fear avoidance model: toward a multidimensional framework of pain-related disability
Wideman, T. H., Asmundson, G. G. J., Smeets, R. J. E. M., Zautra, A. J., Simmonds, M. J., Sullivan, M. J. L., Haythornthwaite, J. A., & Edwards, R. R. (2013) · Pain · doi:10.1016/j.pain.2013.06.005 · Cited by 210 · see citing works
Wong, W. S., Lam, J., Chen, P. P., Chow, Y. F., Wong, S., Lim, H. S., Jensen, M. P., & Fielding, R. (2014) · International Journal of Behavioral Medicine · doi:10.1007/s12529-014-9413-7 · Cited by 83 · see citing works
Larsson, C., Hansson, E. E., Sundquist, K., & Jakobsson, U. (2014) · Physiotherapy Theory and Practice · doi:10.3109/09593985.2013.877546 · Cited by 60 · see citing works
Simons, L. E., Vlaeyen, J. W. S., Declercq, L., Smith, A. M., Beebe, J., Hogan, M., Li, E., Kronman, C. A., Mahmud, F., Corey, J. R., et al. (2020) · Pain · doi:10.1097/j.pain.0000000000001735 · Cited by 56 · see citing works
Marchand, G. H., Myhre, K., Leivseth, G., Sandvik, L., Lau, B., Bautz-Holter, E., & Røe, C. (2015) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-015-0553-y · Cited by 41 · see citing works
Work Outcomes in Patients Who Stay at Work Despite Musculoskeletal Pain
Cochrane, A., Higgins, N. M., Rothwell, C., Ashton, J., Breen, R., Corcoran, O., FitzGerald, O., Gallagher, P., & Desmond, D. M. (2017) · Journal of Occupational Rehabilitation · doi:10.1007/s10926-017-9748-4 · Cited by 33 · see citing works
Coronado, R. A., Ehde, D. M., Pennings, J. S., Vanston, S. W., Koyama, T., Phillips, S. E., Mathis, S. L., McGirt, M. J., Spengler, D. M., Aaronson, O. S., et al. (2020) · Physical Therapy · doi:10.1093/ptj/pzaa112 · Cited by 25 · see citing works
Esteve, R., Bendayan, R., López-Martínez, A. E., & Ramírez‐Maestre, C. (2017) · Pain Medicine · doi:10.1093/pm/pnx053 · Cited by 21 · see citing works
Kalakoti, P., Sciubba, D. M., Pugely, A. J., McGirt, M. J., Sharma, K., Patra, D. P., Phan, K. H., Madhavan, K., Menger, R., Notarianni, C., et al. (2018) · Spine · doi:10.1097/brs.0000000000002616 · Cited by 20 · see citing works
Predictors of response to foot orthoses and corticosteroid injection for plantar heel pain
Whittaker, G. A., Landorf, K. B., Munteanu, S. E., & Menz, H. B. (2020) · Journal of Foot and Ankle Research · doi:10.1186/s13047-020-00428-6 · Cited by 19 · see citing works
Jöud, A., Björk, J., Gerdle, B. U. C., Grimby‐Ekman, A., & Larsson, B. K. (2017) · Scandinavian Journal of Pain · doi:10.1016/j.sjpain.2017.04.071 · Cited by 17 · see citing works
Probst, T., Jank, R., Dreyer, N., Seel, S., Wagner, R., Hanshans, K., Reyersbach, R., Mühlberger, A., Lahmann, C., & Pieh, C. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8091373 · Cited by 15 · see citing works
Investigating the Fear Avoidance Model in People With Whiplash
Pedler, A. R., Kamper, S. J., Maujean, A., & Sterling, M. M. (2017) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000524 · Cited by 14 · see citing works
Linton, S. J., & Kienbacher, T. (2019) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000787 · Cited by 13 · see citing works
Self-citationMarshall, P. W., Morrison, N. M. V., Gibbs, M. T., & Schabrun, S. M. (2022) · Behaviour Research and Therapy · doi:10.1016/j.brat.2022.104205 · Cited by 10 · see citing works
The role of dispositional mindfulness in the fear-avoidance model of pain
Wilson, J. M., Haliwa, I., Lee, J., & Shook, N. J. (2023) · PLoS ONE · doi:10.1371/journal.pone.0280740 · Cited by 10 · see citing works
When Matching Fails: Understanding the Process of Matching Pain-Disability Treatment to Risk Profile
Bergbom, S., Boersma, K., & Linton, S. J. (2014) · Journal of Occupational Rehabilitation · doi:10.1007/s10926-014-9558-x · Cited by 10 · see citing works
Self-citationCognitive Behavioral Therapy for Chronic Pain
Thorn, B. E. (2018) · Journal of Health Service Psychology · doi:10.1007/bf03544660 · Cited by 10 · see citing works
Boersma, K., Carstens-Söderstrand, J., & Linton, S. J. (2014) · Handbooks in health, work, and disability · doi:10.1007/978-1-4939-0612-3_11 · Cited by 8 · see citing works
Self-citationMoraís, C. A., Newman, A. K., Dyke, B. P. V., & Thorn, B. E. (2021) · Journal of Pain · doi:10.1016/j.jpain.2021.04.005 · Cited by 5 · see citing works
Ross, M. H., Smith, M. D., & Vicenzino, B. (2023) · Brazilian Journal of Physical Therapy · doi:10.1016/j.bjpt.2023.100498 · Cited by 3 · see citing works
Longitudinal relationship between onset of physical symptoms and functional impairment
McAndrew, L. M., Helmer, D. A., Lu, S., Chandler, H. K., Slotkin, S., & Quigley, K. S. (2018) · Journal of Behavioral Medicine · doi:10.1007/s10865-018-9937-4 · Cited by 2 · see citing works
Bernier, L., Murray, G. E., Kratzer, M. P. L., & Palfai, T. P. (2026) · Journal of Clinical Psychology in Medical Settings · doi:10.1007/s10880-026-10127-2 · Cited by 1 · see citing works
Modelo de Miedo-Evitación del Dolor: evolución y nuevas propuestas
Esteve, R. (2013) · Revista de PSICOLOGÍA DE LA SALUD · doi:10.21134/pssa.v1i1.886 · Cited by 1 · see citing works
The impact of obesity on treatment outcomes in a multidisciplinary chronic pain management program
Pilchik, D. M. (2013) · CommonKnowledge Research Repository (Pacific University Oregon)
Exploring the clinical presentation of tibialis posterior tendinopathy
Ross, M. H. (2020) · The University of Queensland · doi:10.14264/uql.2020.227
- Authors
- Bergbom, S., Boersma, K., & Linton, S. J.
- Affiliations
- Örebro University (SE)
- Corresponding author
- Bergbom, Sofia
- Venue
- Behaviour Research and Therapy
- Publisher
- Elsevier BV
- Published
- 2012-11
- Volume
- 50
- Issue
- 11
- Pages
- 726-734
- ISSN
- 0005-7967 (ISSN-L)
- OpenAlex
- W2059475286
- Cited by
- 31
- References
- 41
- Citations by year
- 2026: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 6 · 2016: 1 · 2015: 2 · 2014: 4 · 2013: 3
- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behaviour Research and Therapy (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Forskningsrådet för Arbetsliv och Socialvetenskap
- Topics
- Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Keywords
- musculoskeletal pain, pain-related disability, treatment outcome prediction, fear-avoidance beliefs, pain catastrophizing, depressive symptoms, worry, functions, change processes
- MeSH terms
- Anxiety, Avoidance Learning, Conditioning, Operant, Depression, Disability Evaluation, Fear, Female, Humans, Implosive Therapy, Male, Middle Aged, Models, Psychological, Surveys and Questionnaires, Severity of Illness Index, Time Factors, Cognitive Behavioral Therapy, Treatment Outcome, Catastrophization, Musculoskeletal Pain
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review