Effects of High-Definition and Conventional tDCS on Response Inhibition
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Background Response inhibition is a critical executive function, enabling the adaptive control of behavior in a changing environment. The inferior frontal cortex (IFC) is considered to be critical for response inhibition, leading researchers to develop transcranial direct current stimulation (tDCS) montages attempting to target the IFC and improve inhibitory performance. However, conventional tDCS montages produce diffuse current through the brain, making it difficult to establish causality between stimulation of any one given brain region and resulting behavioral changes. Recently, high-definition tDCS (HD-tDCS) methods have been developed to target brain regions with increased focality relative to conventional tDCS. Objective Remarkably few studies have utilized HD-tDCS to improve cognitive task performance, however, and no study has directly compared the behavioral effects of HD-tDCS to conventional tDCS. Methods In the present study, participants received either HD-tDCS or conventional tDCS to the IFC during performance of a response inhibition task (stop-signal task, SST) or a control task (choice reaction time task, CRT). A third group of participants completed the same behavioral protocols, but received tDCS to a control site (mid-occipital cortex). Post-stimulation improvement in SST performance was analyzed as a function of tDCS group and the task performed during stimulation using both conventional and Bayesian parameter estimation analyses. Results Bayesian estimat…
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When high-definition and conventional tDCS were directly compared, no significant effects emerged between them and both were effective in modulating performance on a behavioral paradigm.
“when these two approaches were directly compared, no significant effects emerged between them and both were effective in modulating the performance on a behavioral paradigm43”
From Ventrolateral but not Dorsolateral Prefrontal Cortex tDCS effectively impact emotion reappraisal – effects on Emotional Experience and Interbeat Interval (2018) · cites this paper as [43]
Cites
Nitsche, M. A., & Paulus, W. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.t01-1-00633.x · Cited by 5,656 · see citing works
Leys, C., Ley, C., Klein, O., Bernard, P., & Licata, L. (2013) · Journal of Experimental Social Psychology · doi:10.1016/j.jesp.2013.03.013 · Cited by 4,147 · see citing works
Transcranial direct current stimulation: State of the art 2008
Nitsche, M. A., Cohen, L. G., Wassermann, E. M., Priori, A., Lang, N., Antal, A., Paulus, W., Hummel, F., Boggio, P. S., Fregni, F., et al. (2008) · Brain Stimulation · doi:10.1016/j.brs.2008.06.004 · Cited by 3,057 · see citing works
On the ability to inhibit thought and action: a theory of an act of control
Logan, G. D., & Cowan, W. B. (1984) · Psychological Review · doi:10.1037/0033-295x.91.3.295 · Cited by 2,590 · see citing works
Response inhibition in the stop-signal paradigm
Verbruggen, F., & Logan, G. D. (2008) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2008.07.005 · Cited by 1,373 · see citing works
Anodal transcranial direct current stimulation of prefrontal cortex enhances working memory
Fregni, F., Boggio, P. S., Nitsche, M., Bermpohl, F., Antal, A., Feredoes, E., Marcolin, M. A., Rigonatti, S. P., Silva, M. T. A., Paulus, W., et al. (2005) · Experimental Brain Research · doi:10.1007/s00221-005-2334-6 · Cited by 1,159 · see citing works
Simmonds, D. J., Pekar, J. J., & Mostofsky, S. H. (2008) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2007.07.015 · Cited by 1,015 · see citing works
Left inferior frontal gyrus is critical for response inhibition
Swick, D., Ashley, V., & Turken, A. U. (2008) · BMC Neuroscience · doi:10.1186/1471-2202-9-102 · Cited by 745 · see citing works
Executive "Brake Failure" following Deactivation of Human Frontal Lobe
Chambers, C. D., Bellgrove, M. A., Stokes, M. G., Henderson, T. R., Garavan, H., Robertson, I. H., Morris, A. P., & Mattingley, J. B. (2006) · Journal of Cognitive Neuroscience · doi:10.1162/089892906775990606 · Cited by 544 · see citing works
Executive “Brake Failure” following Deactivation of Human Frontal Lobe
Chambers, C. D., Bellgrove, M. A., Stokes, M. G., Henderson, T. R., Garavan, H., Robertson, I. H., Morris, A. P., & Mattingley, J. B. (2006) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2006.18.3.444 · Cited by 544 · see citing works
Enhancement of Planning Ability by Transcranial Direct Current Stimulation
Dockery, C. A., Hueckel-Weng, R., Birbaumer, N., & Plewnia, C. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.0065-09.2009 · Cited by 380 · see citing works
Knoch, D., Nitsche, M. A., Fischbacher, U., Eisenegger, C., Pascual-Leone, A., & Fehr, E. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhm237 · Cited by 229 · see citing works
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Marques, L. M., Morello, L. Y. N., & Boggio, P. S. (2018) · Scientific Reports · doi:10.1038/s41598-018-33711-5 · Cited by 59 · see citing works
- Authors
- Hogeveen, J., Grafman, J., Aboseria, M., David, A., Bikson, M., & Hauner, K. K.
- Affiliations
- Northwestern University (US)
- City College of New York (US)
- Corresponding author
- Hogeveen, J.
- Venue
- Brain Stimulation
- Publisher
- Elsevier BV
- Published
- 2016-09
- Volume
- 9
- Issue
- 5
- Pages
- 720-729
- ISSN
- 1876-4754 (ISSN-L)
- 1935-861X
- OpenAlex
- W2335916142
- Cited by
- 95
- References
- 12
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 8 · 2023: 9 · 2022: 13 · 2021: 12 · 2020: 10 · 2019: 14 · 2018: 6 · 2017: 8 · 2016: 5
- FWCI
- 6.02
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Brain stimulation (acceptedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Agency for Healthcare Research and Quality (K12 HS023011)
- Julius N. Frankel Foundation
- NIH
- NSF
- DoD
- Epilepsy Foundation
- Coulter Foundation
- Soterix Medical Inc
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Keywords
- high-definition tDCS, transcranial direct current stimulation, response inhibition, inferior frontal cortex, stop-signal task, executive function, Bayesian parameter estimation, choice reaction time task, neuromodulation
- MeSH terms
- Bayes Theorem, Female, Frontal Lobe, Humans, Inhibition, Psychological, Male, Neuropsychological Tests, Reaction Time, Executive Function, Transcranial Direct Current Stimulation
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