Executive "Brake Failure" following Deactivation of Human Frontal Lobe

Chambers, Christopher D.; Bellgrove, Mark A.; Stokes, Mark G.; Henderson, Tracy R.; Garavan, Hugh; Robertson, Ian H.; Morris, Adam P.; Mattingley, Jason B.

doi:10.1162/089892906775990606

Cited by 545Neural and Behavioral Psychology StudiesTranscranial Magnetic Stimulation StudiesFree Will and Agency

Executive "Brake Failure" following Deactivation of Human Frontal Lobe

Chambers, Christopher D., Bellgrove, Mark A., Stokes, Mark G., Henderson, Tracy R., Garavan, Hugh, Robertson, Ian H., Morris, Adam P., Mattingley, Jason B.·2006·Journal of Cognitive Neuroscience

DOI 10.1162/089892906775990606

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Abstract

In the course of daily living, humans frequently encounter situations in which a motor activity, once initiated, becomes unnecessary or inappropriate. Under such circumstances, the ability to inhibit motor responses can be of vital importance. Although the nature of response inhibition has been studied in psychology for several decades, its neural basis remains unclear. Using transcranial magnetic stimulation, we found that temporary deactivation of the pars opercularis in the right inferior frontal gyrus selectively impairs the ability to stop an initiated action. Critically, deactivation of the same region did not affect the ability to execute responses, nor did it influence physiological arousal. These findings confirm and extend recent reports that the inferior frontal gyrus is vital for mediating response inhibition.

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The right inferior frontal gyrus (IFG) and the right pre-supplementary motor area (pre-SMA) are involved in RI.
“Meanwhile, the right inferior frontal gyrus (IFG) and the right pre‐supplementary motor area (pre‐SMA) are involved in RI (Aron et al., 2003; Chambers et al., 2006).”
From Differences in response inhibition between medication-free patients with obsessive-compulsive disorder with and without sensory phenomena (2026) · cites this paper as Chambers et al., 2006
The inferior frontal gyrus (IFG) and pre-supplementary motor area (pre-SMA) are key components of the response inhibition network.
“The inferior frontal gyrus (IFG) and pre-supplementary motor area (pre-SMA) are key components (Aron et al., 2003b; Chambers et al., 2006; Floden and Stuss, 2006; Cai et al., 2012)”
From Response Inhibition and Interference Control in Obsessiveâ€“Compulsive Spectrum Disorders (2014) · cites this paper as Chambers et al., 2006

Inhibition and the right inferior frontal cortex
Aron, A. R., Robbins, T. W., & Poldrack, R. A. (2004) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2004.02.010 · Cited by 3,197 · see citing works
Common regions of the human frontal lobe recruited by diverse cognitive demands
Duncan, J., & Owen, A. M. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01633-7 · Cited by 2,498 · see citing works
Attention and Performance IX
Bergum, B. O., Long, J. B., & Baddeley, A. (1982) · The American Journal of Psychology · doi:10.2307/1422199 · Cited by 2,240 · see citing works
Stop-signal inhibition disrupted by damage to right inferior frontal gyrus in humans
Aron, A. R., Fletcher, P. C., Bullmore, E. T., Sahakian, B. J., & Robbins, T. W. (2003) · Nature Neuroscience · doi:10.1038/nn1003 · Cited by 1,771 · see citing works
Right hemispheric dominance of inhibitory control: An event-related functional MRI study
Garavan, H., Ross, T. J., & Stein, E. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.14.8301 · Cited by 1,394 · see citing works
Self-citation
On the ability to inhibit thought and action: A users' guide to the stop signal paradigm
Logan, G. D. (1994) · UvA-DARE (University of Amsterdam) · Cited by 964 · see citing works
The Prefrontal Cortex: Response Selection or Maintenance Within Working Memory?
Rowe, J. B., Toni, I., Josephs, O., Frackowiak, R. S. J., & Passingham, R. E. (2000) · Science · doi:10.1126/science.288.5471.1656 · Cited by 856 · see citing works
Right inferior prefrontal cortex mediates response inhibition while mesial prefrontal cortex is responsible for error detection
Rubia, K., Smith, A. B., Brammer, M. J., & Taylor, E. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00275-1 · Cited by 852 · see citing works
Common inhibitory mechanism in human inferior prefrontal cortex revealed by event-related functional MRI
Konishi, S., Nakajima, K., Uchida, I., Kikyo, H., Kameyama, M., & Miyashita, Y. (1999) · Brain · doi:10.1093/brain/122.5.981 · Cited by 823 · see citing works
Transcranial magnetic stimulation and cognitive neuroscience
Walsh, V., & Cowey, A. (2000) · Nature Reviews Neuroscience · doi:10.1038/35036239 · Cited by 814 · see citing works
Transcranial magnetic stimulation: new insights into representational cortical plasticity
Siebner, H. R., & Rothwell, J. C. (2003) · Experimental Brain Research · doi:10.1007/s00221-002-1234-2 · Cited by 753 · see citing works
Using human brain lesions to infer function: a relic from a past era in the fMRI age?
Rorden, C., & Karnath, H. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1521 · Cited by 656 · see citing works
The cognitive-energetic model: an empirical approach to attention-deficit hyperactivity disorder
Sergeant, J. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(99)00060-3 · Cited by 645 · see citing works
Differential patterns of striatal activation in young children with and without ADHD
Durston, S., Tottenham, N. T., Thomas, K. M., Davidson, M. C., Eigsti, I.-M., Yang, Y., Ulug, A. M., & Casey, B. J. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01904-2 · Cited by 619 · see citing works
Modeling Attention-Deficit/Hyperactivity Disorder: A Critical Appraisal of the Cognitive-Energetic Model
Sergeant, J. A. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.09.010 · Cited by 589 · cited 1× · see citing works
“Even though deficits of arousal, such as in ADHD and schizophrenia, are commonly accompanied by inhibitory pathology (Sergeant, 2005; Granholm & Verney, 2004; Hermens et al., 2004; Aron, Dowson, et al., 2003; Badcock et al., 2002), the present findings indicate that impairments of inhibitory processing need not be ass…”
Background
Enhanced visual spatial attention ipsilateral to rTMS-induced 'virtual lesions' of human parietal cortex
Hilgetag, C. C., Théoret, H., & Pascual‐Leone, Á. (2001) · Nature Neuroscience · doi:10.1038/nn0901-953 · Cited by 583 · see citing works
Methylphenidate improves response inhibition in adults with attention-deficit/hyperactivity disorder
Aron, A. R., Dowson, J. H., Sahakian, B. J., & Robbins, T. W. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00609-7 · Cited by 392 · see citing works
Simple Metric For Scaling Motor Threshold Based on Scalp-Cortex Distance: Application to Studies Using Transcranial Magnetic Stimulation
Stokes, M. G., Chambers, C., Gould, I. C., Henderson, T. R., Janko, N. E., Allen, N. B., & Mattingley, J. B. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00067.2005 · Cited by 369 · see citing works
Self-citation
The Effect of Preceding Context on Inhibition: An Event-Related fMRI Study
Durston, S., Thomas, K. M., Worden, M. S., Yang, Y., & Casey, B. J. (2002) · NeuroImage · doi:10.1006/nimg.2002.1074 · Cited by 357 · see citing works
Studies in Cognition: The Problems Solved and Created by Transcranial Magnetic Stimulation
Robertson, E. M., Théoret, H., & Pascual‐Leone, Á. (2003) · Journal of Cognitive Neuroscience · doi:10.1162/089892903770007344 · Cited by 338 · see citing works
Functional anatomy of GO/NO-GO discrimination and response selection – a PET study in man
Kawashima, R., Satoh, K., Itoh, H., Ono, S., Furumoto, S., Gotoh, R., Koyama, M., Yoshioka, S., Takahashi, T., Takahashi, K., et al. (1996) · Brain Research · doi:10.1016/s0006-8993(96)00389-7 · Cited by 275 · see citing works
Human brain plasticity: an emerging view of the multiple substrates and mechanisms that cause cortical changes and related sensory dysfunctions after injuries of sensory inputs from the body
Wall, J. T., Xu, J., & Wang, X. (2002) · Brain Research Reviews · doi:10.1016/s0165-0173(02)00192-3 · Cited by 266 · see citing works
Cortico-subcortical contributions to executive control
Heyder, K., Suchan, B., & Daum, I. (2004) · Acta Psychologica · doi:10.1016/j.actpsy.2003.12.010 · Cited by 263 · see citing works
Fast and slow parietal pathways mediate spatial attention
Chambers, C., Payne, J. M., Stokes, M. G., & Mattingley, J. B. (2004) · Nature Neuroscience · doi:10.1038/nn1203 · Cited by 246 · see citing works
Self-citation
Mindfulness training and neural integration: differentiation of distinct streams of awareness and the cultivation of well-being
Siegel, D. J. (2007) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsm034 · Cited by 245 · see citing works
Cognitive Control Mechanisms Revealed by ERP and fMRI: Evidence from Repeated Task-Switching
Swainson, R., Cunnington, R., Jackson, G. M., Rorden, C., Peters, A. M., Morris, P. G., & Jackson, S. R. (2003) · Journal of Cognitive Neuroscience · doi:10.1162/089892903322370717 · Cited by 204 · see citing works
Function of striatum beyond inhibition and execution of motor responses
Vink, M., Kahn, R. S., Raemaekers, M., van den Heuvel, M., Boersma, M., & Ramsey, N. F. (2005) · Human Brain Mapping · doi:10.1002/hbm.20111 · Cited by 202 · see citing works
Reduced cognitive inhibition in obsessive—compulsive disorder
Enright, S. J., & Beech, A. R. (1993) · British Journal of Clinical Psychology · doi:10.1111/j.2044-8260.1993.tb01028.x · Cited by 177 · see citing works
The interaction between stop signal inhibition and distractor interference in the flanker and Stroop task
Verbruggen, F., Liefooghe, B., & Vandierendonck, A. (2004) · Acta Psychologica · doi:10.1016/j.actpsy.2003.12.011 · Cited by 163 · see citing works
Acts of control in schizophrenia: dissociating the components of inhibition
Badcock, J. C., Michie, P. T., JOHNSON, L., & COMBRINCK, J. (2002) · Psychological Medicine · doi:10.1017/s0033291701005128 · Cited by 121 · see citing works
Modality-Specific Control of Strategic Spatial Attention in Parietal Cortex
Chambers, C., Stokes, M. G., & Mattingley, J. B. (2004) · Neuron · doi:10.1016/j.neuron.2004.12.009 · Cited by 120 · see citing works
Self-citation
Material-dependent and material-independent selection processes in the frontal and parietal lobes: an event-related fMRI investigation of response competition
Hazeltine, E., Bunge, S. A., Scanlon, M. D., & Gabrieli, J. D. E. (2003) · Neuropsychologia · doi:10.1016/s0028-3932(03)00040-x · Cited by 114 · see citing works
Development of attentional allocation in the dual task paradigm
Karatekin, C. (2004) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2003.12.002 · Cited by 109 · see citing works
A Code for Behavioral Inhibition on the Basis of Color, But Not Motion, in Ventrolateral Prefrontal Cortex of Macaque Monkey
Sakagami, M., Tsutsui, K., Lauwereyns, J., Koizumi, M., Kobayashi, S., & Hikosaka, O. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-13-04801.2001 · Cited by 108 · see citing works
Sex differences in adult ADHD: a double dissociation in brain activity and autonomic arousal
Hermens, D. F., Williams, L. M., Lazzaro, I., Whitmont, S., Melkonian, D. S., & Gordon, E. (2004) · Biological Psychology · doi:10.1016/j.biopsycho.2003.10.006 · Cited by 100 · see citing works
Prefrontal Neurons Coding Suppression of Specific Saccades
Hasegawa, R. P., Peterson, B. W., & Goldberg, M. E. (2004) · Neuron · doi:10.1016/j.neuron.2004.07.013 · Cited by 100 · see citing works
Magnetic stimulation of the dorsal premotor cortex modulates the Simon effect
Praamstra, P., Kleine, B. U., & Schnitzler, A. (1999) · Neuroreport · doi:10.1097/00001756-199911260-00038 · Cited by 94 · see citing works
Beyond common resources: the cortical basis for resolving task interference
Hester, R., Murphy, K., & Garavan, H. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.05.024 · Cited by 77 · see citing works
Self-citation
Modeling attention-deficit/hyperactivity disorder: A critical appraisal of the cognitive?energetic model
SERGEANT, J. (2004) · Biological Psychiatry · doi:10.1016/j.bps.2004.09.010 · Cited by 62 · see citing works
Pupillary responses and attentional allocation problems on the backward masking task in schizophrenia
Granholm, E. L., & Verney, S. P. (2004) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2003.12.004 · Cited by 59 · see citing works
Influence of transcranial magnetic stimulation on pupil size
Niehaus, L., Guldin, B., & Meyer, B.-U. (2001) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(00)00462-7 · Cited by 31 · see citing works
A rapid presentation event-related functional magnetic resonance imaging study of response inhibition in macaque monkeys
Morita, M., Nakahara, K., & Hayashi, T. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2003.11.066 · Cited by 22 · see citing works

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Inhibition and the right inferior frontal cortex: one decade on
Aron, A. R., Robbins, T. W., & Poldrack, R. A. (2014) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2013.12.003 · Cited by 2,166 · see citing works
Claude Bernard and the heart-brain connection: further elaboration of a model of neurovisceral integration
Thayer, J. F., & Lane, R. D. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.08.004 · Cited by 2,040 · see citing works
Inhibition and impulsivity: behavioral and neural basis of response control
Bari, A., & Robbins, T. W. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.06.005 · Cited by 1,921 · see citing works
Heart rate variability, prefrontal neural function, and cognitive performance: the neurovisceral integration perspective on self-regulation, adaptation, and health
Thayer, J. F., Hansen, A. L., Saus-Rose, E., & Johnsen, B. H. (2009) · Annals of Behavioral Medicine · doi:10.1007/s12160-009-9101-z · Cited by 1,872 · see citing works
Cortical and subcortical contributions to stop signal response inhibition: Role of the subthalamic nucleus
Aron, A. R., & Poldrack, R. A. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4682-05.2006 · Cited by 1,630 · see citing works
Response inhibition in the stop-signal paradigm
Verbruggen, F., & Logan, G. D. (2008) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2008.07.005 · Cited by 1,373 · see citing works
From Reactive to Proactive and Selective Control: Developing a Richer Model for Stopping Inappropriate Responses
Aron, A. R. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.07.024 · Cited by 1,236 · see citing works
The Neural Basis of Inhibition in Cognitive Control
Aron, A. R. (2007) · The Neuroscientist · doi:10.1177/1073858407299288 · Cited by 1,098 · see citing works
Meta-analysis of Go/No-go tasks demonstrating that fMRI activation associated with response inhibition is task-dependent
Simmonds, D. J., Pekar, J. J., & Mostofsky, S. H. (2008) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2007.07.015 · Cited by 1,015 · see citing works
Triangulating a cognitive control network using diffusion-weighted magnetic resonance imaging (MRI) and functional MRI
Aron, A. R., Behrens, T. E., Smith, S., Frank, M. J., & Poldrack, R. A. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.0519-07.2007 · Cited by 982 · see citing works
Insights into the neural basis of response inhibition from cognitive and clinical neuroscience
Chambers, C. D., Garavan, H., & Bellgrove, M. A. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.08.016 · Cited by 938 · see citing works
Self-citation
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Huster, R. J., Enriquez‐Geppert, S., Lavallee, C. F., Falkenstein, M., & Herrmann, C. S. (2012) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2012.08.001 · Cited by 744 · see citing works
Models of response inhibition in the stop-signal and stop-change paradigms
Verbruggen, F., & Logan, G. D. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.08.014 · Cited by 710 · see citing works
A unified framework for inhibitory control
Munakata, Y., Herd, S. A., Chatham, C. H., Depue, B. E., Banich, M. T., & O’Reilly, R. C. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.07.011 · Cited by 699 · see citing works
Physiology of repetitive transcranial magnetic stimulation of the human brain
Hoogendam, J. M., Ramakers, G. M. J., & Di Lazzaro, V. (2010) · Brain Stimulation · doi:10.1016/j.brs.2009.10.005 · Cited by 669 · see citing works
Cognitive control and right ventrolateral prefrontal cortex: Reflexive reorienting, motor inhibition, and action updating
Levy, B. J., & Wagner, A. D. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.05958.x · Cited by 625 · see citing works
Converging Evidence for a Fronto-Basal-Ganglia Network for Inhibitory Control of Action and Cognition: Figure 1.
Aron, A. R., Durston, S., Eagle, D. M., Logan, G. D., Stinear, C. M., & Stuphorn, V. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3644-07.2007 · Cited by 539 · see citing works
Response Inhibition and Response Selection: Two Sides of the Same Coin
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The neurocognitive consequences of sleep restriction: A meta-analytic review
Lowe, C. J., Safati, A., & Hall, P. A. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.07.010 · Cited by 520 · see citing works
Intracranial EEG reveals a time- and frequency-specific role for the right inferior frontal gyrus and primary motor cortex in stopping initiated responses
Swann, N., Tandon, N., Canolty, R., Ellmore, T. M., McEvoy, L. K., Dreyer, S., DiSano, M., & Aron, A. R. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3359-09.2009 · Cited by 474 · see citing works
Roles for the pre-supplementary motor area and the right inferior frontal gyrus in stopping action: Electrophysiological responses and functional and structural connectivity
Swann, N. C., Cai, W., Conner, C. R., Pieters, T. A., Claffey, M. P., George, J. S., Aron, A. R., & Tandon, N. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.09.049 · Cited by 459 · see citing works
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Shifting and stopping: fronto-striatal substrates, neurochemical modulation and clinical implications
Robbins, T. W. (2007) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2007.2097 · Cited by 413 · see citing works
Linear age‐correlated functional development of right inferior fronto‐striato‐cerebellar networks during response inhibition and anterior cingulate during error‐related processes
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Effects of focal frontal lesions on response inhibition
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Dissociable Roles of Right Inferior Frontal Cortex and Anterior Insula in Inhibitory Control: Evidence from Intrinsic and Task-Related Functional Parcellation, Connectivity, and Response Profile Analyses across Multiple Datasets
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Toward a New Understanding of Attention-Deficit Hyperactivity Disorder Pathophysiology: An Important Role for Prefrontal Cortex Dysfunction
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The Mindful Brain and Emotion Regulation in Mood Disorders
Farb, N. A. S., Anderson, A. K., & Segal, Z. V. (2012) · The Canadian Journal of Psychiatry · doi:10.1177/070674371205700203 · Cited by 366 · see citing works
Preparation to Inhibit a Response Complements Response Inhibition during Performance of a Stop-Signal Task
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Resting-state functional connectivity of subgenual anterior cingulate cortex in depressed adolescents
Connolly, C. G., Wu, J., Ho, T. C., Hoeft, F., Wolkowitz, O., Eisendrath, S., Frank, G., Hendren, R., Max, J. E., Paulus, M. P., et al. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.05.036 · Cited by 356 · see citing works
Impulsivity and response inhibition in alcohol dependence and problem gambling
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The Role of Cognitive Control in Cocaine Dependence
Garavan, H., & Hester, R. (2007) · Neuropsychology Review · doi:10.1007/s11065-007-9034-x · Cited by 327 · see citing works
Self-citation
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Theta burst stimulation dissociates attention and action updating in human inferior frontal cortex
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Self-citation
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Schachar, R., Logan, G. D., Robaey, P., Chen, S., Ickowicz, A., & Barr, C. (2007) · Journal of Abnormal Child Psychology · doi:10.1007/s10802-006-9075-2 · Cited by 293 · see citing works
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Xue, G., Aron, A. R., & Poldrack, R. A. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhm220 · Cited by 280 · see citing works
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Self-citation
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Neubert, F.-X., Mars, R. B., Buch, E. R., Olivier, E., & Rushworth, M. F. S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000674107 · Cited by 253 · see citing works
Dissociable mechanisms of cognitive control in prefrontal and premotor cortex
Chambers, C. D., Bellgrove, M. A., Gould, I. C., English, T., Garavan, H., McNaught, E., Kamke, M., & Mattingley, J. B. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00685.2007 · Cited by 239 · see citing works
Self-citation
Mindfulness training and neural integration: differentiation of distinct streams of awareness and the cultivation of well-being
Siegel, D. J. (2007) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsm034 · Cited by 245 · see citing works
Functional neural networks underlying response inhibition in adolescents and adults
Stevens, M. C., Kiehl, K. A., Pearlson, G. D., & Calhoun, V. D. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.03.023 · Cited by 241 · see citing works
Motor inhibition in hysterical conversion paralysis
Cojan, Y., Waber, L., Carruzzo, A., & Vuilleumier, P. O. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.05.023 · Cited by 234 · see citing works
Modulating inhibitory control with direct current stimulation of the superior medial frontal cortex
Hsu, T., Tseng, L.-Y., Yu, J., Kuo, W., Hung, D. L., Tzeng, O. J. L., Walsh, V., Muggleton, N. G., & Juan, C.-H. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.03.059 · Cited by 230 · see citing works
Activation of Inhibition: Diminishing Impulsive Behavior by Direct Current Stimulation over the Inferior Frontal Gyrus
Jacobson, L., Javitt, D. C., & Michal Lavidor, B. (2011) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00020 · Cited by 224 · see citing works
Distance-adjusted motor threshold for transcranial magnetic stimulation
Stokes, M. G., Chambers, C., Gould, I. C., English, T., McNaught, E., McDonald, O., & Mattingley, J. B. (2007) · Clinical Neurophysiology · doi:10.1016/j.clinph.2007.04.004 · Cited by 222 · see citing works
Self-citation
Neurocognitive mechanisms of action control: resisting the call of the Sirens.
Richard Ridderinkhof, K., Forstmann, B. U., Wylie, S. A., Burle, B., & van den Wildenberg, W. P. M. (2011) · WIREs Cognitive Science · doi:10.1002/wcs.99 · Cited by 215 · see citing works
ADHD and the Prefrontal Cortex
Arnsten, A. F. T. (2009) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2009.01.018 · Cited by 220 · see citing works
Common and unique components of inhibition and working memory: An fMRI, within-subjects investigation
McNab, F., Leroux, G., Strand, F., Thorell, L., Bergman, S., & Klingberg, T. (2008) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2008.04.023 · Cited by 209 · see citing works
Localizing performance of go/no-go tasks to prefrontal cortical subregions
Chikazoe, J. (2010) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e3283387a9f · Cited by 212 · see citing works
Inhibition of Action, Thought, and Emotion: A Selective Neurobiological Review.
Dillon, D., & Pizzagalli, D. (2007) · Applied & Preventive Psychology · doi:10.1016/j.appsy.2007.09.004 · Cited by 208 · see citing works
In the Trenches of Real-World Self-Control
Berkman, E. T., Falk, E. B., & Lieberman, M. D. (2011) · Psychological Science · doi:10.1177/0956797611400918 · Cited by 209 · see citing works
Role of Corticospinal Suppression during Motor Preparation
Duqué, J., & Ivry, R. B. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhn230 · Cited by 200 · see citing works
Disentangling common and specific neural subprocesses of response inhibition
Sebastian, A., Pohl, M. F., Klöppel, S., Feige, B., Lange, T., Stahl, C., Voss, A., Klauer, K. C., Lieb, K., & Tüscher, O. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2012.09.020 · Cited by 193 · see citing works
A causal role of the right inferior frontal cortex in implementing strategies for multi-component behaviour
Dippel, G., & Beste, C. (2015) · Nature Communications · doi:10.1038/ncomms7587 · Cited by 195 · see citing works
Overcoming status quo bias in the human brain
Fleming, S. M., Thomas, C. L., & Dolan, R. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910380107 · Cited by 191 · see citing works
Cognitive control reflects context monitoring, not motoric stopping, in response inhibition
Chatham, C. H., Claus, E. D., Kim, A., Curran, T., Banich, M. T., & Munakata, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031546 · Cited by 182 · see citing works
Association Between Response Inhibition and Working Memory in Adult ADHD: A Link to Right Frontal Cortex Pathology?
Clark, L., Blackwell, A. D., Aron, A. R., Turner, D. C., Dowson, J. H., Robbins, T. W., & Sahakian, B. J. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.020 · Cited by 188 · see citing works
Control of prepotent responses by the superior medial frontal cortex
CHEN, C., Muggleton, N. G., Tzeng, O. J. L., Hung, D. L., & Juan, C.-H. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.09.005 · Cited by 191 · see citing works
Common and differential ventrolateral prefrontal activity during inhibition of hand and eye movements
Leung, H.-C., & Cai, W. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2837-07.2007 · Cited by 185 · see citing works
Prefrontal and monoaminergic contributions to stop-signal task performance in rats
Bari, A., Mar, A. C., Theobald, D. E., Elands, S. A., Oganya, K. C. N. A., Eagle, D. M., & Robbins, T. W. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1543-11.2011 · Cited by 188 · see citing works
Neural correlates of cognitive control of reaching movements in the dorsal premotor cortex of rhesus monkeys
Mirabella, G., Pani, P., & Ferraina, S. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00995.2010 · Cited by 185 · see citing works
Primary motor cortex and movement prevention: Where Stop meets Go
Stinear, C. M., Coxon, J. P., & Byblow, W. D. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.08.013 · Cited by 182 · see citing works
Executive function in early-treated phenylketonuria: Profile and underlying mechanisms☆☆☆
Christ, S. E., Huijbregts, S. C. J., de Sonneville, L. M. J., & White, D. A. (2009) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2009.10.007 · Cited by 183 · see citing works
Engagement of large-scale networks is related to individual differences in inhibitory control
Congdon, E. L., Mumford, J. A., Cohen, J. R., Galván, A., Aron, A. R., Xue, G., Miller, E. N., & Poldrack, R. A. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.06.062 · Cited by 167 · see citing works
Cognitive control in alcohol use disorder: deficits and clinical relevance
Wilcox, C. E., Dekonenko, C. J., Mayer, A. R., Bogenschutz, M. P., & Turner, J. A. (2013) · Reviews in the Neurosciences · doi:10.1515/revneuro-2013-0054 · Cited by 162 · see citing works
The Molecular Genetics of Executive Function: Role of Monoamine System Genes
Barnes, J. J. M., Dean, A. J., Nandam, L. S., O’Connell, R. G., & Bellgrove, M. A. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.12.040 · Cited by 163 · see citing works
Self-citation
Interactions between cognition and motivation during response inhibition
Padmala, S., & Pessoa, L. (2010) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2009.10.017 · Cited by 162 · see citing works
Cortical Gray Matter in Attention-Deficit/Hyperactivity Disorder
Batty, M. J., Liddle, E. B., Pitiot, A., Toro, R., Groom, M. J., Scerif, G., Mario Liotti, A., Liddle, P. F., Paus, T., & Hollis, C. P. (2010) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2009.11.008 · Cited by 166 · see citing works
Response Inhibition and Interference Control in Obsessiveâ€“Compulsive Spectrum Disorders
van Velzen, L. S., Vriend, C., de Wit, S. J., & van den Heuvel, O. A. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00419 · Cited by 159 · see citing works
Functional Segregation of the Right Inferior Frontal Gyrus: Evidence From Coactivation-Based Parcellation
Hartwigsen, G., Neef, N. E., Camilleri, J. A., Margulies, D. S., & Eickhoff, S. B. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy049 · Cited by 152 · see citing works
Boosting brain functions: Improving executive functions with behavioral training, neurostimulation, and neurofeedback
Enriquez‐Geppert, S., Huster, R. J., & Herrmann, C. S. (2013) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2013.02.001 · Cited by 152 · see citing works
Fear bradycardia and activation of the human periaqueductal grey
Hermans, E. J., Henckens, M. J. A. G., Roelofs, K., & Fernández, G. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2012.10.063 · Cited by 151 · see citing works
Inhibitory spillover: Intentional motor inhibition produces incidental limbic inhibition via right inferior frontal cortex.
Berkman, E. T., Burklund, L., & Lieberman, M. D. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.04.084 · Cited by 146 · see citing works
Acute effects of cocaine on the neurobiology of cognitive control
Garavan, H., Kaufman, J. N., & Hester, R. (2008) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2008.0106 · Cited by 148 · see citing works
Self-citation
Stop-signal response inhibition in schizophrenia: Behavioural, event-related potential and functional neuroimaging data
Hughes, M. E., Fulham, W. R., Johnston, P., & Michie, P. T. (2011) · Biological Psychology · doi:10.1016/j.biopsycho.2011.10.013 · Cited by 147 · see citing works
The Common Neural Basis of Exerting Self-Control in Multiple Domains
Cohen, J. R., & Lieberman, M. D. (2010) · Self Control in Society, Mind, and Brain · doi:10.1093/acprof:oso/9780195391381.003.0008 · Cited by 147 · see citing works
Response inhibition and impulsivity in schizophrenia
Enticott, P. G., Ogloff, J. R. P., & Bradshaw, J. L. (2008) · Psychiatry Research · doi:10.1016/j.psychres.2007.04.007 · Cited by 144 · see citing works
A Neurogenetic Approach to Impulsivity
Congdon, E. L., & Canli, T. (2008) · Journal of Personality · doi:10.1111/j.1467-6494.2008.00528.x · Cited by 144 · see citing works
The spatial and temporal dynamics of anticipatory preparation and response inhibition in task-switching
Jamadar, S. D., Hughes, M. E., Fulham, W. R., Michie, P. T., & Karayanidis, F. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.01.090 · Cited by 138 · see citing works
Common and unique neural networks for proactive and reactive response inhibition revealed by independent component analysis of functional MRI data
van Belle, J., Vink, M., Durston, S., & Zandbelt, B. B. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.09.014 · Cited by 141 · see citing works
Brain Stimulation in Alzheimer's Disease
Chang, C.-H., Lane, H., & Lin, C. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00201 · Cited by 142 · see citing works
Effects of age and gender on neural networks of motor response inhibition: From adolescence to mid-adulthood
Rubia, K., Lim, L., Ecker, C., Halari, R., Giampietro, V., Simmons, A., Brammer, M., & Smith, A. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.06.078 · Cited by 133 · see citing works
Towards real-world generalizability of a circuit for action-stopping
Hannah, R., & Aron, A. R. (2021) · Nature reviews. Neuroscience · doi:10.1038/s41583-021-00485-1 · Cited by 130 · see citing works
Should I stay or should I go? Conceptual underpinnings of goal-directed actions
Mirabella, G. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00206 · Cited by 137 · see citing works
Dorsolateral Prefrontal γ-Aminobutyric Acid in Men Predicts Individual Differences in Rash Impulsivity
Boy, F., Evans, J., Edden, R. A. E., Lawrence, A. D., Singh, K. D., Husain, M., & Sumner, P. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.05.030 · Cited by 132 · see citing works
Pattern classification of response inhibition in ADHD: Toward the development of neurobiological markers for ADHD
Hart, H. C., Chantiluke, K. C., Cubillo, A., Smith, A. B., Simmons, A., Brammer, M. J., Marquand, A. F., & Rubia, K. (2013) · Human Brain Mapping · doi:10.1002/hbm.22386 · Cited by 135 · see citing works
Inhibition, conflict and the Nogo-N2
Falkenstein, M. (2006) · Clinical Neurophysiology · doi:10.1016/j.clinph.2006.05.002 · Cited by 132 · see citing works
Mechanisms and Dynamics of Cortical Motor Inhibition in the Stop-signal Paradigm: A TMS Study
van den Wildenberg, W. P. M., Burle, B., Vidal, F., van der Molen, M. W., Ridderinkhof, K. R., & Hasbroucq, T. (2009) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2009.21248 · Cited by 132 · see citing works
A meta-analysis of response inhibition and Stroop interference control deficits in adults with traumatic brain injury (TBI)
Marco, A. D.-D., McDonald, S., Kelly, M., Tate, R. L., & Johnstone, S. J. (2011) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2010.533158 · Cited by 132 · see citing works
Two Types of Action Error: Electrophysiological Evidence for Separable Inhibitory and Sustained Attention Neural Mechanisms Producing Error on Go/No-go Tasks
O’Connell, R. G., Dockree, P. M., Bellgrove, M. A., Turin, A., Ward, S., Foxe, J. J., & Robertson, I. H. (2008) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2009.21008 · Cited by 132 · see citing works
Self-citation
Deep Brain Stimulation of Subthalamic Nuclei Affects Arm Response Inhibition In Parkinson's Patients
Mirabella, G., Iaconelli, S., Romanelli, P., Modugno, N., Lena, F., Manfredi, M., & Cantore, G. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr187 · Cited by 129 · see citing works

The Role of Right Prefrontal and Medial Cortex in Response Inhibition: Interfering with Action Restraint and Action Cancellation Using Transcranial Magnetic Brain Stimulation
Dambacher, F., Sack, A. T., Lobbestael, J., Arntz, A. R., Brugman, S., & Schuhmann, T. (2014) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00595 · Cited by 77 · see citing works
Imaging Response Inhibition in a Stop-Signal Task: Neural Correlates Independent of Signal Monitoring and Post-Response Processing
Ray Li, C.-S., Huang, C., Constable, R. T., & Sinha, R. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3741-05.2006 · Cited by 600 · see citing works
When response inhibition is followed by response reengagement: an event-related fMRI study
Boecker, M., Drueke, B., Vorhold, V., Knops, A., Philippen, B., & Gauggel, S. (2011) · Human Brain Mapping · doi:10.1002/hbm.21001 · Cited by 42 · see citing works
Differentiating functions of the lateral and medial prefrontal cortex in motor response inhibition
Rodrigo, A. H., Domenico, S. I. D., Ayaz, H., Gulrajani, S., Lam, J., & Ruocco, A. C. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.01.059 · Cited by 71 · see citing works
Effect of an electrical stimulation session on the right inferior frontal gyrus on the response inhibition
Abdorahimi, A., & Sohrabi, A. (2019) · Brain stimulation · doi:10.1016/j.brs.2018.12.838

Authors: Chambers, C. D., Bellgrove, M. A., Stokes, M. G., Henderson, T. R., Garavan, H., Robertson, I. H., Morris, A. P., & Mattingley, J. B.
Affiliations: The University of Melbourne (AU)
Trinity College Dublin (IE)
ORCID: Bellgrove, Mark A.
Stokes, Mark G.
Garavan, Hugh
Robertson, Ian H.
Morris, Adam P.
Mattingley, Jason B.
Venue: Journal of Cognitive Neuroscience
Publisher: MIT Press - Journals
Published: 2006-03-01
Volume: 18
Issue: 3
Pages: 444-455
ISSN: 0898-929X (ISSN-L)
1530-8898
DOI: 10.1162/089892906775990606
OpenAlex: W2152343703
Cited by: 544
References: 42
Citations by year: 2026: 3 · 2025: 6 · 2024: 8 · 2023: 12 · 2022: 20 · 2021: 21 · 2020: 62 · 2019: 17 · 2018: 33 · 2017: 26 · 2016: 25 · 2015: 31 · 2014: 43 · 2013: 38 · 2012: 32
FWCI: 14.18
Type: journal article
Language: en
Open access: closed
Locations: Journal of Cognitive Neuroscience (publishedVersion)
PubMed (publishedVersion)
ORCA Online Research @Cardiff (Cardiff University) (acceptedVersion)
UCL Discovery (University College London) (submittedVersion)
Funders: University College London
Medical Research Council
National Health and Medical Research Council
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
Life Sciences › Neuroscience › Cognitive Neuroscience › Free Will and Agency
Keywords: response inhibition, executive function, inferior frontal gyrus, pars opercularis, transcranial magnetic stimulation, physiological arousal
MeSH terms: Adolescent, Adult, Arousal, Automobile Driving, Female, Fixation, Ocular, Frontal Lobe, Humans, Male, Motor Activity, Neuropsychological Tests, Psychomotor Performance, Reaction Time, Task Performance and Analysis

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Executive "Brake Failure" following Deactivation of Human Frontal Lobe

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