Executive “Brake Failure” following Deactivation of Human Frontal Lobe
Abstract
In the course of daily living, humans frequently encounter situations in which a motor activity, once initiated, becomes unnecessary or inappropriate. Under such circumstances, the ability to inhibit motor responses can be of vital importance. Although the nature of response inhibition has been studied in psychology for several decades, its neural basis remains unclear. Using transcranial magnetic stimulation, we found that temporary deactivation of the pars opercularis in the right inferior frontal gyrus selectively impairs the ability to stop an initiated action. Critically, deactivation of the same region did not affect the ability to execute responses, nor did it influence physiological arousal. These findings confirm and extend recent reports that the inferior frontal gyrus is vital for mediating response inhibition.
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Anterior insular cortex activation precedes and directly influences prefrontal activation during response inhibition and striatal activation during reward anticipation.
“The notion that the AIC may govern the engagement of specialized brain networks to which it is connected finds support in evidence that activation of the AIC precedes, and directly influences, activation of prefrontal regions during response inhibition [44] and activation of the striatum during reward anticipation [27].”
From The role of the anterior insula in adolescent decision making (2014) · cites this paper as [44]
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Executive function in early-treated phenylketonuria: Profile and underlying mechanisms☆☆☆
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The Common Neural Basis of Exerting Self-Control in Multiple Domains
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A Neurogenetic Approach to Impulsivity
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Self-citation
- Authors
- Chambers, C. D., Bellgrove, M. A., Stokes, M. G., Henderson, T. R., Garavan, H., Robertson, I. H., Morris, A. P., & Mattingley, J. B.
- Affiliations
- 1University of Melbourne
- The University of Melbourne (AU)
- Trinity College Dublin (IE)
- ORCID
- Venue
- Journal of Cognitive Neuroscience
- Publisher
- MIT Press
- Published
- 2006-03-01
- Volume
- 18
- Issue
- 3
- Pages
- 444-455
- ISSN
- 0898-929X (ISSN-L)
- 1530-8898
- OpenAlex
- W2152343703
- Cited by
- 544
- References
- 42
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 8 · 2023: 12 · 2022: 20 · 2021: 21 · 2020: 62 · 2019: 17 · 2018: 33 · 2017: 26 · 2016: 25 · 2015: 31 · 2014: 43 · 2013: 38 · 2012: 32
- FWCI
- 14.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cognitive Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- University College London
- Medical Research Council
- National Health and Medical Research Council
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Free Will and Agency
- Keywords
- response inhibition, executive function, inferior frontal gyrus, pars opercularis, transcranial magnetic stimulation, physiological arousal
- MeSH terms
- Adolescent, Adult, Arousal, Automobile Driving, Female, Fixation, Ocular, Frontal Lobe, Humans, Male, Motor Activity, Neuropsychological Tests, Psychomotor Performance, Reaction Time, Task Performance and Analysis
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