Age-dependent non-linear neuroplastic effects of cathodal tDCS in the elderly population: a titration study
Open accessAbstract
BACKGROUND: Neuromodulatory effects of transcranial direct current stimulation (tDCS) in older humans have shown heterogeneous results, possibly due to sub-optimal stimulation protocols associated with limited knowledge about optimized stimulation parameters in this age group. We systematically explored the association between the stimulation dosage of cathodal tDCS and induced after-effects on motor cortex excitability in the elderly. METHOD: Thirty-nine healthy volunteers in two age groups, namely Pre-Elderly (50-65 years) and Elderly (66-80 years), participated in the study. Ten sessions of cathodal tDCS, with a combination of four intensities (1, 2, 3 mA and sham) and three durations (15, 20, 30 min) were conducted over the M1 in each participant. Cortical excitability changes were monitored with TMS-induced motor evoked potentials (MEPs) for up to 2 h after stimulation. RESULTS: Motor cortex excitability was reduced by cathodal stimulation intensities of 1 and 3 mA in both age groups, in accordance with results observed in the younger age groups of previous studies. For the 2 mA stimulation condition, an age-dependent conversion of plasticity into a stimulation duration-dependent excitability enhancement was observed in the Pre-Elderly group, whereas in the Elderly group, LTD-like plasticity was preserved, or abolished, depending on stimulation duration. CONCLUSION: The LTD-like plasticity effects induced by cathodal tDCS originally described in young adults are also observable in older humans, but non-linearities of the resulting plasticity were partially preserved only in the Pre-Elderly, but not the Elderly group. These results aid in understanding age-dependent plasticity dynamics in humans, and to define more efficient tDCS protocols in the aging brain.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Adults ages 50-65 experience increased excitability underneath the cathode at 2mA/20min motor cortex parameters.
“Adults ages 50–65 also experience increased excitability underneath the cathode at these parameters, while older adults ages 66–80 demonstrate slight reductions in excitability [57].”
From Primary outcome from the augmenting cognitive training in older adults study (ACT): A tDCS and cognitive training randomized clinical trial (2023) · cites this paper as [57]
Older adults ages 66-80 demonstrate slight reductions in excitability at 2mA/20min motor cortex parameters.
“Adults ages 50–65 also experience increased excitability underneath the cathode at these parameters, while older adults ages 66–80 demonstrate slight reductions in excitability [57].”
From Primary outcome from the augmenting cognitive training in older adults study (ACT): A tDCS and cognitive training randomized clinical trial (2023) · cites this paper as [57]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The assessment and analysis of handedness: The Edinburgh inventory
Oldfield, R. C. (1971) · Neuropsychologia · doi:10.1016/0028-3932(71)90067-4 · Cited by 35,900 · see citing works
The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment
Nasreddine, Z. S., Phillips, N. A., Bédirian, V., Charbonneau, S., Whitehead, V., Collin, I., Cummings, J. L., & Chertkow, H. (2005) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2005.53221.x · Cited by 25,553 · see citing works
Nitsche, M. A., & Paulus, W. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.t01-1-00633.x · Cited by 5,656 · see citing works
Self-citationRossi, S., Hallett, M., Rossini, P. M., & Pascual-Leone, A. (2009) · Clinical Neurophysiology · doi:10.1016/j.clinph.2009.08.016 · Cited by 5,367 · see citing works
Transcranial direct current stimulation: State of the art 2008
Nitsche, M. A., Cohen, L. G., Wassermann, E. M., Priori, A., Lang, N., Antal, A., Paulus, W., Hummel, F., Boggio, P. S., Fregni, F., et al. (2008) · Brain Stimulation · doi:10.1016/j.brs.2008.06.004 · Cited by 3,057 · see citing works
Self-citationSustained excitability elevations induced by transcranial DC motor cortex stimulation in humans
Nitsche, M. A., & Paulus, W. (2001) · Neurology · doi:10.1212/wnl.57.10.1899 · Cited by 2,617 · see citing works
Self-citationEvidence-based guidelines on the therapeutic use of transcranial direct current stimulation (tDCS)
Lefaucheur, J., Antal, A., Ayache, S. S., Benninger, D. H., Brunelin, J., Cogiamanian, F. M., Cotelli, M., Ridder, D. D., Ferrucci, R., Langguth, B., et al. (2016) · Clinical Neurophysiology · doi:10.1016/j.clinph.2016.10.087 · Cited by 1,872 · see citing works
Self-citationNeural plasticity in the ageing brain
Burke, S. N., & Barnes, C. A. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1809 · Cited by 1,600 · see citing works
Disruption of Large-Scale Brain Systems in Advanced Aging
Andrews-Hanna, J. R., Snyder, A. Z., Vincent, J. L., Lustig, C., Head, D., Raichle, M. E., & Buckner, R. L. (2007) · Neuron · doi:10.1016/j.neuron.2007.10.038 · Cited by 1,592 · see citing works
Nitsche, M. A., Fricke, K., Henschke, U., Schlitterlau, A., Liebetanz, D., Lang, N., Henning, S. J., Tergau, F., & Paulus, W. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.049916 · Cited by 1,514 · see citing works
Self-citationA technical guide to tDCS, and related non-invasive brain stimulation tools
Woods, A. J., Antal, A., Bikson, M., Boggio, P. S., Brunoni, A. R., Celnik, P. A., Cohen, L. G., Fregni, F., Herrmann, C. S., Kappenman, E. S., et al. (2015) · Clinical Neurophysiology · doi:10.1016/j.clinph.2015.11.012 · Cited by 1,450 · see citing works
Self-citationSafety of Transcranial Direct Current Stimulation: Evidence Based Update 2016
Bikson, M., Grossman, P., Thomas, C., Zannou, A. L., Jiang, J., Adnan, T., Mourdoukoutas, A. P., Kronberg, G., Truong, D. Q., Boggio, P. S., et al. (2016) · Brain stimulation · doi:10.1016/j.brs.2016.06.004 · Cited by 1,418 · see citing works
Self-citationLiebetanz, D. (2002) · Brain · doi:10.1093/brain/awf238 · Cited by 1,383 · see citing works
The cognitive neuroscience of ageing
Grady, C. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3256 · Cited by 1,286 · see citing works
Batsikadze, G., Moliadze, V., Paulus, W., Kuo, M. ‐., & Nitsche, M. A. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2012.249730 · Cited by 1,017 · see citing works
Self-citationPolarity-Sensitive Modulation of Cortical Neurotransmitters by Transcranial Stimulation
Stagg, C. J., Best, J. G., Stephenson, M. C., O’Shea, J., Wylezinska, M., Kincses, Z. T., Morris, P. G., Matthews, P. M., & Johansen‐Berg, H. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4432-08.2009 · Cited by 942 · see citing works
Ridding, M. C., & Ziemann, U. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.190314 · Cited by 787 · see citing works
Level of action of cathodal DC polarisation induced inhibition of the human motor cortex
Nitsche, M. A., Nitsche, M. S., Klein, C. C., Tergau, F., Rothwell, J. C., & Paulus, W. (2003) · Clinical Neurophysiology · doi:10.1016/s1388-2457(02)00412-1 · Cited by 751 · see citing works
Self-citationDeterminants of the electric field during transcranial direct current stimulation
Opitz, A., Paulus, W., Will, S., Antunes, A., & Thielscher, A. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.01.033 · Cited by 693 · see citing works
Resting state fMRI in Alzheimer's disease: beyond the default mode network
Agosta, F., Pievani, M., Geroldi, C., Copetti, M., Frisoni, G. B., & Filippi, M. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.06.007 · Cited by 572 · see citing works
Transcranial direct current stimulation – update 2011
Nitsche, M. A., & Paulus, W. (2011) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-2011-0618 · Cited by 544 · see citing works
Self-citationSelective Induction of LTP and LTD by Postsynaptic [Ca<sup>2+</sup>]<sub>i</sub> Elevation
Yang, S.-N., Tang, Y.-G., & Zucker, R. S. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.81.2.781 · Cited by 534 · see citing works
Regulation of ion channel localization and phosphorylation by neuronal activity
Misonou, H., Mohapatra, D. P., Park, E. W., Leung, V. C. M., Zhen, D., Misonou, K., Anderson, A. E., & Trimmer, J. S. (2004) · Nature Neuroscience · doi:10.1038/nn1260 · Cited by 464 · see citing works
Glutamate: its role in learning, memory, and the aging brain
McEntee, W. J., & Crook, T. H. (1993) · Psychopharmacology · doi:10.1007/bf02253527 · Cited by 404 · see citing works
tDCS-enhanced motor and cognitive function in neurological diseases
Flöel, A. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.05.098 · Cited by 397 · see citing works
Calcium and the aging nervous system
Gibson, G. E., & Peterson, C. (1987) · Neurobiology of Aging · doi:10.1016/0197-4580(87)90072-8 · Cited by 386 · see citing works
Glutamatergic neurotransmission in aging: a critical perspective
Segovia, G., Porras, A., Arco, A. D., & Mora, F. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00225-6 · Cited by 375 · see citing works
GABAergic modulation of DC stimulation‐induced motor cortex excitability shifts in humans
Nitsche, M. A., Liebetanz, D., Schlitterlau, A., Henschke, U., Fricke, K., Frommann, K., Lang, N., Henning, S., Paulus, W., & Tergau, F. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2004.03398.x · Cited by 368 · see citing works
Self-citationJamil, A., Batsikadze, G., Kuo, H.-I., Labruna, L., Hasan, A., Paulus, W., & Nitsche, M. (2017) · Journal of Physiology · doi:10.1113/jp272738 · Cited by 366 · see citing works
Self-citationAge-related dopamine D2/D3 receptor loss in extrastriatal regions of the human brain
Kaasinen, V. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00149-4 · Cited by 355 · see citing works
Long-term depression: multiple forms and implications for brain function
Massey, P. V., & Bashir, Z. I. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.02.005 · Cited by 325 · see citing works
Involvement of hippocampal synaptic plasticity in age-related memory decline
Foster, T. C. (1999) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00017-x · Cited by 317 · see citing works
Patterns of cognitive decline in aged rhesus monkeys
Herndon, J. G., Moss, M. B., Rosene, D. L., & Killiany, R. (1997) · Behavioural Brain Research · doi:10.1016/s0166-4328(96)02256-5 · Cited by 290 · see citing works
Long-term depression: a cascade of induction and expression mechanisms.
Kemp, N., & Bashir, Z. (2001) · Progress in neurobiology · doi:10.1016/s0301-0082(01)00013-2 · Cited by 271 · see citing works
Henderson, G., Tomlinson, B. E., & Gibson, P. H. (1980) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(80)90048-9 · Cited by 264 · see citing works
Aged monkeys exhibit behavioral deficits indicative of widespread cerebral dysfunction
Bachevalier, J., Landis, L. S., Walker, L. C., Brickson, M., Mishkin, M., Price, D. L., & Cork, L. C. (1991) · Neurobiology of Aging · doi:10.1016/0197-4580(91)90048-o · Cited by 264 · see citing works
Three Ca2+ levels affect plasticity differently: the LTP zone, the LTD zone and no man's land
Lisman, J. E. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.0285f.x · Cited by 223 · see citing works
Basic and functional effects of transcranial Electrical Stimulation (tES)—An introduction
Yavari, F., Jamil, A., Mosayebi-Samani, M., Vidor, L. P., & Nitsche, M. A. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.06.015 · Cited by 219 · see citing works
Self-citationCa2+ regulation and gene expression in normal brain aging
Toescu, E. C., Verkhratsky, A., & Landfield, P. W. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.07.010 · Cited by 218 · see citing works
Summers, J. J., Kang, N., & Cauraugh, J. H. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.11.004 · Cited by 183 · see citing works
Executive system dysfunction in the aged monkey: Spatial and object reversal learning
Lai, Z. C., Moss, M. B., Killiany, R., Rosene, D. L., & Herndon, J. G. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)02014-4 · Cited by 178 · see citing works
Mosayebi Samani, M., Agboada, D., Jamil, A., Kuo, M.-F., & Nitsche, M. A. (2019) · Cortex · doi:10.1016/j.cortex.2019.04.016 · Cited by 175 · see citing works
Self-citationRossini, P. M., Desiato, M. T., & Caramia, M. D. (1992) · Brain Research · doi:10.1016/0006-8993(92)91256-e · Cited by 160 · see citing works
Foster, T. C. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.01.007 · Cited by 159 · see citing works
Heise, K.-F., Zimerman, M., Hoppe, J., Gerloff, C. P., Wegscheider, K., & Hummel, F. C. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.4094-12.2013 · Cited by 149 · see citing works
Agboada, D., Mosayebi-Samani, M., Jamil, A., Kuo, M., & Nitsche, M. A. (2019) · Scientific Reports · doi:10.1038/s41598-019-54621-0 · Cited by 133 · see citing works
Self-citationCharacterizing cognitive aging in humans with links to animal models
Alexander, G. E., Ryan, L., Bowers, D., Foster, T. C., Bizon, J. L., Geldmacher, D., & Glisky, E. L. (2012) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2012.00021 · Cited by 132 · see citing works
The application of transcranial magnetic stimulation in psychiatry and neurosciences research
Fitzgerald, P. B., Brown, T. L., & Daskalakis, Z. J. (2002) · Acta Psychiatrica Scandinavica · doi:10.1034/j.1600-0447.2002.1r179.x · Cited by 128 · see citing works
Effects of age and sex on brain glutamate and other metabolites
Chang, L., Jiang, C. S., & Ernst, T. (2008) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2008.06.002 · Cited by 123 · see citing works
Modeling transcranial electrical stimulation in the aging brain
Indahlastari, A., Albizu, A., O’Shea, A., Forbes, M. A., Nissim, N. R., Kraft, J. N., Evangelista, N. D., Hausman, H. K., & Woods, A. J. (2020) · Brain Stimulation · doi:10.1016/j.brs.2020.02.007 · Cited by 113 · see citing works
Freitas, C., Farzan, F., & Pascual‐Leone, Á. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00042 · Cited by 109 · see citing works
Rehman, H. U. (2001) · Age and Ageing · doi:10.1093/ageing/30.4.279 · Cited by 104 · see citing works
Paulus, W., & Rothwell, J. C. (2016) · The Journal of Physiology · doi:10.1113/jp271452 · Cited by 100 · see citing works
Kabaso, D., Coskren, P. J., Henry, B. I., Hof, P. R., & Wearne, S. L. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhn242 · Cited by 98 · see citing works
Potentials and limits to enhance cognitive functions in healthy and pathological aging by tDCS
Prehn, K., & Flöel, A. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00355 · Cited by 97 · see citing works
Age reduces cortical reciprocal inhibition in humans
Hortobágyi, T., Fernández‐del‐Olmo, M., & Rothwell, J. C. (2005) · Experimental Brain Research · doi:10.1007/s00221-005-0274-9 · Cited by 97 · see citing works
Kossev, A. R., Schrader, C., Däuper, J., Dengler, R., & Rollnik, J. D. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00986-2 · Cited by 97 · see citing works
Mosayebi-Samani, M., Jamil, A., Salvador, R., Ruffini, G., Haueisen, J., & Nitsche, M. A. (2021) · Brain stimulation · doi:10.1016/j.brs.2021.01.016 · Cited by 95 · see citing works
Self-citationGhasemian-Shirvan, E., Farnad, L., Mosayebi-Samani, M., Verstraelen, S., Meesen, R., Kuo, M., & Nitsche, M. A. (2020) · Brain stimulation · doi:10.1016/j.brs.2020.09.004 · Cited by 86 · see citing works
Self-citationLarge-scale analysis of interindividual variability in single and paired-pulse TMS data
Bereznicki, H. G. K., Clark, G. M., Youssef, G. J., Fried, P. J., Jannati, A., Davies, C. B., Gomes‐Osman, J., Kirkovski, M., Albein‐Urios, N., Fitzgerald, P. B., et al. (2021) · Clinical Neurophysiology · doi:10.1016/j.clinph.2021.06.014 · Cited by 86 · see citing works
Circadian Modulation of GABA-Mediated Cortical Inhibition
Lang, N., Rothkegel, H., Reiber, H., Hasan, A., Sueske, E., Tergau, F., Ehrenreich, H., Wuttke, W., & Paulus, W. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr003 · Cited by 84 · see citing works
Motor Slowing and Parkinsonian Signs in Aging Rhesus Monkeys Mirror Human Aging
Zhang, Z., Andersen, A. H., Smith, C., Grondin, R., Gerhardt, G. A., & Gash, D. M. (2000) · The Journals of Gerontology Series A · doi:10.1093/gerona/55.10.b473 · Cited by 81 · see citing works
Muller, P. A., Dhamne, S. C., Vahabzadeh‐Hagh, A. M., Pascual‐Leone, Á., Jensen, F. E., & Rotenberg, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091065 · Cited by 80 · see citing works
Gomes‐Osman, J., Indahlastari, A., Fried, P. J., Cabral, D. F., Rice, J., Nissim, N. R., Aksu, S., McLaren, M. E., & Woods, A. J. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00177 · Cited by 79 · see citing works
Synapses, spines and kinases in mammalian learning and memory, and the impact of aging
van der Zee, E. A. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.06.012 · Cited by 77 · see citing works
Adams, I. (1987) · Neurobiology of Aging · doi:10.1016/0197-4580(87)90003-0 · Cited by 71 · see citing works
Bachtiar, V., Johnstone, A., Berrington, A., Lemke, C., Johansen‐Berg, H., Emir, U. E., & Stagg, C. J. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.2853-17.2018 · Cited by 70 · see citing works
Seizure suppression by EEG-guided repetitive transcranial magnetic stimulation in the rat
Rotenberg, A., Muller, P., Birnbaum, D., Harrington, M. G., Riviello, J. J., Pascual‐Leone, Á., & Jensen, F. E. (2008) · Clinical Neurophysiology · doi:10.1016/j.clinph.2008.09.003 · Cited by 63 · see citing works
A quantitative meta-analysis of brain glutamate metabolites in aging
Roalf, D. R., Sydnor, V. J., Woods, M. M., Wolk, D. A., Scott, J. C., Reddy, R. D., & Moberg, P. J. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.07.015 · Cited by 60 · see citing works
Age-related decline of functional inhibition in rat cortex
Schmidt, S., Redecker, C., Bruehl, C., & Witte, O. W. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.04.006 · Cited by 58 · see citing works
Age‐dependent effects of brain stimulation on network centrality
Antonenko, D., Nierhaus, T., Meinzer, M., Prehn, K., Thielscher, A., Ittermann, B., & Flöel, A. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.04.038 · Cited by 55 · see citing works
Age-related Differences in Short- and Long-interval Intracortical Inhibition in a Human Hand Muscle
Opie, G. M., & Semmler, J. G. (2014) · Brain stimulation · doi:10.1016/j.brs.2014.06.014 · Cited by 54 · see citing works
Farnad, L., Ghasemian-Shirvan, E., Mosayebi-Samani, M., Kuo, M., & Nitsche, M. (2021) · Brain Stimulation · doi:10.1016/j.brs.2021.03.013 · Cited by 42 · see citing works
Self-citationFoerster, Á., Yavari, F., Farnad, L., Jamil, A., Paulus, W., Nitsche, M. A., & Kuo, M. (2018) · Brain stimulation · doi:10.1016/j.brs.2018.10.014 · Cited by 37 · see citing works
Self-citationStimulating aged brains with transcranial direct current stimulation: Opportunities and challenges.
Habich, A., Fehér, K., Antonenko, D., Boraxbekk, C., Flöel, A., Nissen, C., Siebner, H., Thielscher, A., & Klöppel, S. (2020) · Psychiatry research. Neuroimaging · doi:10.1016/j.pscychresns.2020.111179 · Cited by 32 · see citing works
Mosayebi-Samani, M., Melo, L., Agboada, D., Nitsche, M. A., & Kuo, M. (2020) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2020.07.011 · Cited by 32 · see citing works
Self-citationNeuroplasticity and Successful Cognitive Aging
Vance, D. E., Kaur, J., Fazeli, P. L., Talley, M. H., Yuen, H. K., Kitchin, B., & Lin, F. V. (2012) · Journal of Neuroscience Nursing · doi:10.1097/jnn.0b013e3182527571 · Cited by 27 · see citing works
Melo, L., Mosayebi-Samani, M., Ghanavati, E., Nitsche, M. A., & Kuo, M. (2021) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyab035 · Cited by 23 · see citing works
Self-citationLoss of motor coordination in an aging mouse model
Allen, E. N., & Cavanaugh, J. E. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.03.032 · Cited by 13 · see citing works
A Developmental Framework of Brain and Cognition from Infancy to Old Age
Pascual‐Leone, Á., & Taylor, M. J. (2011) · Brain Topography · doi:10.1007/s10548-011-0197-7 · Cited by 11 · see citing works
Flagged first, then by citations
1 of the 81 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- Nitsche MA, Paulus W. Transcranial direct current stimulationeupdate 2011. Restor Neurol Neurosci 2011;29(6):463e92.
- Hoeltke V, Jakob E. Lüdenscheider aktivitatsfragebogen zum risikofaktor bewegungsmangel. Zugriff am 2002;24:2011.
- Yang S-N, Tang Y-G, Zucker RS. Selective induction of LTP and LTD by post- synaptic [Ca2þ]i elevation. J Neurophysiol 1999;81(2):781e7.
Cited by
Sorted by citations
Non-invasive brain stimulation and neuroenhancement
Antal, A., Luber, B. M., Brem, A., Bikson, M., Brunoni, A. R., Kadosh, R. C., Dubljević, V., Fecteau, S., Ferreri, F., Flöel, A., et al. (2022) · Clinical Neurophysiology Practice · doi:10.1016/j.cnp.2022.05.002 · Cited by 229 · see citing works
Self-citationHoornweder, S. V., Nuyts, M., Frieske, J., Verstraelen, S., Meesen, R., & Caulfield, K. A. (2023) · NeuroImage · doi:10.1016/j.neuroimage.2023.120379 · Cited by 37 · see citing works
Self-citationPersonalizing transcranial electrical stimulation
Hoornweder, S. V., Stagg, C. J., & Wischnewski, M. (2025) · Trends in Neurosciences · doi:10.1016/j.tins.2025.07.007 · Cited by 37 · see citing works
Pezzetta, R., Gambarota, F., Tarantino, V., Devita, M., Cattaneo, Z., Arcara, G., Mapelli, D., & Masina, F. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105509 · Cited by 35 · see citing works
Meinzer, M., Shahbabaie, A., Antonenko, D., Blankenburg, F., Fischer, R., Hartwigsen, G., Nitsche, M. A., Li, S., Thielscher, A., Timmann, D., et al. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1389651 · Cited by 33 · see citing works
Self-citationMosayebi-Samani, M., Agboada, D., Mutanen, T. P., Haueisen, J., Kuo, M., & Nitsche, M. A. (2023) · Brain stimulation · doi:10.1016/j.brs.2023.02.010 · Cited by 29 · see citing works
Self-citationHoornweder, S. V., Caulfield, K. A., Nitsche, M. A., Thielscher, A., & Meesen, R. (2022) · Journal of Neural Engineering · doi:10.1088/1741-2552/ac9a78 · Cited by 26 · see citing works
Self-citationHoornweder, S. V., Geraerts, M., Verstraelen, S., Nuyts, M., Caulfield, K. A., & Meesen, R. (2024) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2024.02.011 · Cited by 21 · see citing works
Self-citationtDCS augments decision-making efficiency in an intensity dependent manner: A training study
Ehrhardt, S. E., Ballard, T., Wards, Y., Mattingley, J. B., Dux, P. E., & Filmer, H. L. (2022) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2022.108397 · Cited by 16 · see citing works
Pilloni, G., Charvet, L. E., Bikson, M., Palekar, N., & Kim, M.-J. (2022) · Journal of Clinical Neurology · doi:10.3988/jcn.2022.18.4.391 · Cited by 15 · see citing works
Gomez-Tames, J. D., & Fernández-Corazza, M. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13113084 · Cited by 15 · see citing works
Vestring, S., Wolf, E., Dinkelacker, J., Frase, S., Hessling-Zeinen, C., Insan, S., Kumlehn, M. M., Feige, B., Domschke, K., Normann, C., et al. (2024) · Journal of NeuroEngineering and Rehabilitation · doi:10.1186/s12984-024-01459-x · Cited by 15 · see citing works
Hausman, H. K., Alexander, G. E., Cohen, R., Marsiske, M., DeKosky, S. T., Hishaw, G. A., O'Shea, A., Kraft, J. N., Dai, Y., Wu, S., et al. (2023) · Brain Stimulation · doi:10.1016/j.brs.2023.05.021 · Cited by 13 · see citing works
Vimolratana, O., Lackmy‐Vallée, A., Aneksan, B., Hiengkaew, V., & Klomjai, W. (2023) · BMC Sports Science Medicine and Rehabilitation · doi:10.1186/s13102-023-00621-7 · Cited by 14 · see citing works
No robust online effects of transcranial direct current stimulation on corticospinal excitability
Pillen, S. D., Knodel, N., Hermle, D., Hanke, M., Ziemann, U., & Bergmann, T. O. (2022) · Brain stimulation · doi:10.1016/j.brs.2022.08.024 · Cited by 13 · see citing works
Carlson, H. L., Giuffre, A., Ciechanski, P., & Kirton, A. (2023) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2023.1075741 · Cited by 9 · see citing works
Shah, M., Suresh, S., Paddick, J., Mellow, M. L., Rees, A., Berryman, C. F., Stanton, T. R., & Smith, A. E. (2024) · Clinical Neurophysiology · doi:10.1016/j.clinph.2024.03.002 · Cited by 10 · see citing works
A Scalable Framework for Closed-Loop Neuromodulation with Deep LearningPreprint
Gebodh, N., Miskovic, V., Laszlo, S., Datta, A., & Bikson, M. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.18.524615 · Cited by 5 · see citing works
Abedi, R., Talimkhani, A., Mohammadzadeh, Z., Daryabor, A., & Naimi, S. S. (2022) · International Journal of Therapy and Rehabilitation · doi:10.12968/ijtr.2021.0158 · Cited by 3 · see citing works
Schroeder, P. A., Nuerk, H., & Svaldi, J. (2024) · European Journal of Neuroscience · doi:10.1111/ejn.16321 · Cited by 2 · see citing works
Song, J., Torres‐Carmona, E., Abdolizadeh, A., Kambari, Y., Amaev, A., Ueno, F., Koizumi, T., Remington, G. J., Luca, V. D., Graff‐Guerrero, A., et al. (2025) · Brain Topography · doi:10.1007/s10548-025-01140-z · Cited by 1 · see citing works
de Almeida, C. C. S., Valênça, M. M., Rosas, E. P., Montenegro, E. J. N., Alves, L. I. D. N., Wanderley, D., Tenório, A. D. S., & de Oliveira, D. A. (2022) · Research Society and Development · doi:10.33448/rsd-v11i8.30794 · Cited by 1 · see citing works
Acute effect of transcranial direct current stimulation on photoparoxysmal response
Erol, T. Y., Ilgezdi, İ., Özçeli̇k, E. U., Aksu, S., Şi̇ri̇n, N. G., Bebek, N., Kurt, A., Karamürsel, S., & Baykan, B. B. (2024) · Epilepsy Research · doi:10.1016/j.eplepsyres.2024.107320 · Cited by 1 · see citing works
Pereira, E. N., Arêas, F. Z. D. S., Kuster, E., Maia, M. D. L. S., da Silva, J. O., Norbim, L. R., Henriques, J. M. O., & Arêas, G. P. T. (2024) · MethodsX · doi:10.1016/j.mex.2024.102939 · Cited by 1 · see citing works
Dual-site theta stimulation modulates connectivity, but not sequence memory in older adults
Ehrhardt, N. M., (23277852), D. Y. L., Fleischmann, R., Grittner, U., Hayek, D., Hanna, J., Malinowski, R., Li, S.-C., Thielscher, A., Flöel, A., et al. (2026) · Brain Communications · doi:10.1093/braincomms/fcag153 · Cited by 1 · see citing works
Harmonizing the stimulation dose of focal tDCS across target sitesPreprint
Thielscher, A., Hayek, D., Puonti, O., Grittner, U., Blankenburg, F., Fischer, R., Hartwigsen, G., Li, S.-C., Meinzer, M., Nitsche, M. A., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.09.698549 · Cited by 1 · see citing works
Self-citationMosayebi-Samani, M., Agboada, D., Mutanen, T. P., Haueisen, J., Kuo, M., & Nitsche, M. A. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4173661
Self-citationVestring, S., Wolf, E., Dinkelacker, J., Frase, S., Hessling-Zeinen, C., Insan, S., Kumlehn, M. M., Feige, B., Domschke, K., Normann, C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.27049064
Vimolratana, O., Lackmy‐Vallée, A., Aneksan, B., Hiengkaew, V., & Klomjai, W. (2024) · Figshare · doi:10.6084/m9.figshare.26565048
Vestring, S., Wolf, E., Dinkelacker, J., Frase, S., Hessling-Zeinen, C., Insan, S., Kumlehn, M. M., Feige, B., Domschke, K., Normann, C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.27049061
Prathum, T., Dauguet, J., Apiworajirawit, I., Aneksan, B., Hoisan, S., Tragangoon, A., Siripornpanich, V., & Klomjai, W. (2025) · Scientific Reports · doi:10.1038/s41598-025-33298-8
Age-related differences in how tDCS priming modulates cortical inhibition during fatigue recovery
Moore, E. K., Otieno, L. A., Semmler, J. G., Smith, A. E., & Sidhu, S. K. (2026) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2026.06.001
Optogenetic insights into short- and long-duration random noise electrical stimulation
Gutiérrez, J. A., Requejo-Mendoza, N., Gutiérrez, R., Zamora-Ursulo, M. A., & Manjarrez, E. (2026) · Journal of Neurophysiology · doi:10.1152/jn.00049.2026
Frau, L., Bruno, D., & Cazzato, V. (2026) · Brain Research · doi:10.1016/j.brainres.2026.150546
- Authors
- Ghasemian-Shirvan, E., Mosayebi-Samani, M., Farnad, L., Kuo, M.-F., Meesen, R. L. J., & Nitsche, M. A.
- Affiliations
- Leibniz Research Centre for Working Environment and Human Factors (DE)
- Hasselt University (BE)
- BG University Hospital Bergmannsheil Bochum (DE)
- Corresponding author
- Nitsche, Michael A.
- Venue
- Brain Stimulation
- Publisher
- Elsevier BV
- Published
- 2022-03
- Volume
- 15
- Issue
- 2
- Pages
- 296-305
- ISSN
- 1876-4754 (ISSN-L)
- 1935-861X
- OpenAlex
- W4206968992
- Cited by
- 34
- References
- 81
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 11 · 2023: 7 · 2022: 8
- FWCI
- 2.55
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Brain stimulation (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Lirias (KU Leuven) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Document Server@UHasselt (UHasselt) (submittedVersion, cc-by)
- Informationszentrum Lebenswissenschaften (ZB MED) (submittedVersion, cc-by)
- Funders
- Bundesministerium für Bildung und Forschung (01EE1501, 01GQ1424E)
- Universiteit Hasselt (BOF17BL03)
- Bijzonder Onderzoeksfonds UGent
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- cathodal transcranial direct current stimulation, neuroplasticity, aging, older adults, motor cortex excitability, long-term potentiation, long-term depression, stimulation intensity, stimulation duration, age-dependent plasticity, motor evoked potentials
- MeSH terms
- Cortical Excitability, Aged, Humans, Middle Aged, Motor Cortex, Neuronal Plasticity, Evoked Potentials, Motor, Transcranial Magnetic Stimulation, Young Adult, Transcranial Direct Current Stimulation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
