Modeling transcranial electrical stimulation in the aging brain
Open accessAbstract
BACKGROUND: Varying treatment outcomes in transcranial electrical stimulation (tES) recipients may depend on the amount of current reaching the brain. Brain atrophy associated with normal aging may affect tES current delivery to the brain. Computational models have been employed to compute predicted tES current inside the brain. This study is the largest study that uses computational models to investigate tES field distribution in healthy older adults. METHODS: Individualized head models from 587 healthy older adults (mean = 73.9years, 51-95 years) were constructed to create field maps. Two electrode montages (F3-F4, M1-SO) with 2 mA input current were modeled using ROAST with modified codes. A customized template of healthy older adults, the UFAB-587, was created from the same dataset and used to warp individual brains into the same space. Warped models were analyzed to determine the relationship between computed field measures, brain atrophy and age. MAIN RESULTS: = 0.0829, p = 1.14e-12). Field pattern showed negative correlation with age in brain sub-regions including part of DLPFC and precentral gyrus. Mediation analysis revealed that the negative correlation between age and current density is partially mediated by brain-to-CSF ratio. CONCLUSIONS: Computed field measures showed decreasing amount of tES current reaching the brain with increasing atrophy. Therefore, adjusting current dose by modifying tES stimulation parameters in older adults based on degree of atrophy may be necessary to achieve desired stimulation benefits. Results from this study may inform future tES application in healthy older adults.
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Inter-individual anatomical differences can affect response to tDCS due to differing amounts of current reaching cortical tissue.
“Furthermore, increasing evidence to suggests that inter-individual anatomical differences can affect response to tDCS due to differing amounts of current reaching cortical tissue.”
From Primary outcome from the augmenting cognitive training in older adults study (ACT): A tDCS and cognitive training randomized clinical trial (2023) · cites this paper as [59]
Greater atrophy has been associated with less electrical current reaching the brain in older adults due to shunting.
“As such, greater atrophy has been associated with less electrical current reaching the brain in older adults due to shunting [59].”
From Primary outcome from the augmenting cognitive training in older adults study (ACT): A tDCS and cognitive training randomized clinical trial (2023) · cites this paper as [59]
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White matter hyperintensities affect transcranial electrical stimulation in the aging brain
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Self-citationThe impact of a tDCS and cognitive training intervention on task-based functional connectivity
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Self-citationApplications of open-source software ROAST in clinical studies: A review
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The Influence of White Matter Lesions on the Electric Field in Transcranial Electric Stimulation
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Self-citationPersonalized Dose Selection for Treatment of Patients with Neuropsychiatric Disorders Using tDCS
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Improving locomotor performance with motor imagery and tDCS in young adults
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Comparison of electric field modeling pipelines for transcranial direct current stimulation
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Self-citationImpact of electrode selection on modeling tDCS in the aging brain
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Self-citationThe Application of Transcranial Electrical Stimulation in Sports Psychology
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Clinical Research and Methodological Aspects for tDCS Research
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- Authors
- Indahlastari, A., Albizu, A., O’Shea, A., Forbes, M. A., Nissim, N. R., Kraft, J. N., Evangelista, N. D., Hausman, H. K., & Woods, A. J.
- Affiliations
- University of Florida Health (US)
- University of Pennsylvania (US)
- Corresponding author
- Indahlastari, Aprinda
- ORCID
- Venue
- Brain Stimulation
- Publisher
- Elsevier BV
- Published
- 2020-05
- Volume
- 13
- Issue
- 3
- Pages
- 664-674
- ISSN
- 1876-4754 (ISSN-L)
- 1935-861X
- PMC
- PMC7196025
- OpenAlex
- W3004493719
- Cited by
- 113
- References
- 47
- Citations by year
- 2026: 12 · 2025: 18 · 2024: 20 · 2023: 13 · 2022: 14 · 2021: 25 · 2020: 9 · 2012: 1
- FWCI
- 5.90
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Brain stimulation (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Janssen Research and Development
- University of Southern California
- GE Healthcare
- National Institutes of Health (K01AG050707, R01AG054077, U01 AG024904)
- Alzheimer's Disease Neuroimaging Initiative
- Merck
- National Institute of Biomedical Imaging and Bioengineering (1U54MH091657)
- Fujirebio US
- NIH Blueprint for Neuroscience Research
- H. Lundbeck A/S
- Genentech
- IXICO
- Johnson and Johnson
- McDonnell Center for Systems Neuroscience
- National Institute on Aging
- Northern California Institute for Research and Education
- U.S. Department of Defense (W81XWH-12-2-0012)
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › EEG and Brain-Computer Interfaces
- Keywords
- transcranial electrical stimulation, brain aging, brain atrophy, roast, healthy older adults, medial prefrontal cortex, precentral gyrus, mediation analysis
- MeSH terms
- Aged, Aged, 80 and over, Aging, Brain, Computer Simulation, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Finite Element Analysis, Imaging, Three-Dimensional, Transcranial Direct Current Stimulation
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