Cited by 324Seaweed-derived Bioactive CompoundsFungal Biology and ApplicationsPolysaccharides Composition and Applications

Immunomodulation and antitumor activity of κ-carrageenan oligosaccharides

YUAN, H, SONG, J, LI, X, LI, N, DAI, J·2006·Cancer Letters

Abstract

The modulation of carrageenan oligosaccharides from Kappaphycus striatum on the immune system in S180-bearing mice was investigated. The mice inoculated with S180 cell suspension were treated p.o. with carrageenan oligosaccharides (50, 100 and 200 microg/g) for 14 days. The effects of carrageenan oligosaccharides on transplantable tumors and macrophage phagocytosis, quantitative hemolysis of sheep red blood cells (QHS), lymphocyte proliferation, the activity of natural killer cells (NK), production of interleukin-2 (IL-2) and tumor necrosis factor-alpha (TNF-alpha) were studied. Carrageenan oligosaccharides could significantly inhibit the growth of transplantable sarcoma S180 and increase macrophage phagocytosis, the form of antibody secreted by spleen cells, spleen lymphocyte proliferation, NK cells activity, serumal IL-2 and TNF-alpha level in S180-bearing mice. Considering all these results, it is suggested that carrageenan oligosaccharides exert their antitumor effect by promoting the immune system.

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Crossref · 10.1016/j.canlet.2005.11.032

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Authors
YUAN, H., SONG, J., LI, X., LI, N., & DAI, J.
Affiliations
Chinese Academy of Sciences (CN)
Corresponding author
SONG, J
Venue
Cancer Letters
Publisher
Elsevier BV
Published
2006-11-18
Volume
243
Issue
2
Pages
228-234
ISSN
0304-3835 (ISSN-L)
OpenAlex
W2112828382
Cited by
324
References
31
Citations by year
2026: 17 · 2025: 12 · 2024: 11 · 2023: 22 · 2022: 17 · 2021: 25 · 2020: 25 · 2019: 16 · 2018: 22 · 2017: 25 · 2016: 19 · 2015: 21 · 2014: 22 · 2013: 15 · 2012: 17
FWCI
7.15
Type
journal article
Language
en
Open access
closed
Locations
  • Cancer Letters (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Shandong University
  • Chinese Academy of Sciences
Topics
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
  • Health Sciences › Medicine › Pharmacology › Fungal Biology and Applications
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
Keywords
Kappaphycus striatum, immunomodulation, anticancer activity, sarcoma 180, macrophage phagocytosis, natural killer cells, lymphocyte proliferation, interleukin-2, TNF-α, hemolysis, marine polysaccharides
MeSH terms
Animals, Antibody Formation, Antineoplastic Agents, Carrageenan, Dose-Response Relationship, Drug, Tegafur, Immunity, Cellular, Immunologic Factors, Macrophages, Male, Mice, Inbred BALB C, Oligosaccharides, Organ Size, Phagocytosis, Sarcoma 180, Sheep, Spleen, Thymus Gland, Cytokines, Cell Line, Tumor, Mice

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