Immunomodulation and antitumor activity of κ-carrageenan oligosaccharides
Abstract
The modulation of carrageenan oligosaccharides from Kappaphycus striatum on the immune system in S180-bearing mice was investigated. The mice inoculated with S180 cell suspension were treated p.o. with carrageenan oligosaccharides (50, 100 and 200 microg/g) for 14 days. The effects of carrageenan oligosaccharides on transplantable tumors and macrophage phagocytosis, quantitative hemolysis of sheep red blood cells (QHS), lymphocyte proliferation, the activity of natural killer cells (NK), production of interleukin-2 (IL-2) and tumor necrosis factor-alpha (TNF-alpha) were studied. Carrageenan oligosaccharides could significantly inhibit the growth of transplantable sarcoma S180 and increase macrophage phagocytosis, the form of antibody secreted by spleen cells, spleen lymphocyte proliferation, NK cells activity, serumal IL-2 and TNF-alpha level in S180-bearing mice. Considering all these results, it is suggested that carrageenan oligosaccharides exert their antitumor effect by promoting the immune system.
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Low molecular λ-carrageenan from Chondrus ocellatus potentiated the antitumor effect of 5-FU.
“The latter also potentiated the antitumor effect of 5-FU [96,97].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [97]
In vivo antitumor activities for κ-carrageenan oligosaccharides and low molecular λ-carrageenan from Chondrus ocellatus have been established.
“In vivo antitumor activities for κ-carrageenan oligosachharides and low molecular λ-carrageenan from Chondrus ocellatus have been established.”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [97]
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- Authors
- YUAN, H., SONG, J., LI, X., LI, N., & DAI, J.
- Affiliations
- Chinese Academy of Sciences (CN)
- Corresponding author
- SONG, J
- Venue
- Cancer Letters
- Publisher
- Elsevier BV
- Published
- 2006-11-18
- Volume
- 243
- Issue
- 2
- Pages
- 228-234
- ISSN
- 0304-3835 (ISSN-L)
- OpenAlex
- W2112828382
- Cited by
- 324
- References
- 31
- Citations by year
- 2026: 17 · 2025: 12 · 2024: 11 · 2023: 22 · 2022: 17 · 2021: 25 · 2020: 25 · 2019: 16 · 2018: 22 · 2017: 25 · 2016: 19 · 2015: 21 · 2014: 22 · 2013: 15 · 2012: 17
- FWCI
- 7.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cancer Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Shandong University
- Chinese Academy of Sciences
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Health Sciences › Medicine › Pharmacology › Fungal Biology and Applications
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Keywords
- Kappaphycus striatum, immunomodulation, anticancer activity, sarcoma 180, macrophage phagocytosis, natural killer cells, lymphocyte proliferation, interleukin-2, TNF-α, hemolysis, marine polysaccharides
- MeSH terms
- Animals, Antibody Formation, Antineoplastic Agents, Carrageenan, Dose-Response Relationship, Drug, Tegafur, Immunity, Cellular, Immunologic Factors, Macrophages, Male, Mice, Inbred BALB C, Oligosaccharides, Organ Size, Phagocytosis, Sarcoma 180, Sheep, Spleen, Thymus Gland, Cytokines, Cell Line, Tumor, Mice
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