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Circular RNA: A new star of noncoding RNAs
Abstract
Circular RNAs (circRNAs) are a novel type of RNA that, unlike linear RNAs, form a covalently closed continuous loop and are highly represented in the eukaryotic transcriptome. Recent studies have discovered thousands of endogenous circRNAs in mammalian cells. CircRNAs are largely generated from exonic or intronic sequences, and reverse complementary sequences or RNA-binding proteins (RBPs) are necessary for circRNA biogenesis. The majority of circRNAs are conserved across species, are stable and resistant to RNase R, and often exhibit tissue/developmental-stage-specific expression. Recent research has revealed that circRNAs can function as microRNA (miRNA) sponges, regulators of splicing and transcription, and modifiers of parental gene expression. Emerging evidence indicates that circRNAs might play important roles in atherosclerotic vascular disease risk, neurological disorders, prion diseases and cancer; exhibit aberrant expression in colorectal cancer (CRC) and pancreatic ductal adenocarcinoma (PDAC); and serve as diagnostic or predictive biomarkers of some diseases. Similar to miRNAs and long noncoding RNAs (lncRNAs), circRNAs are becoming a new research hotspot in the field of RNA and could be widely involved in the processes of life. Herein, we review the formation and properties of circRNAs, their functions, and their potential significance in disease.
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“Originating from various genomic regions, circRNAs are synthesized by the back-splicing of protein-coding precursor mRNAs (primarily in eukaryotes) [25,26].”
From Circular RNAs in depression: Biogenesis, function, expression, and therapeutic potential (2021) · cites this paper as [25]
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Cao, Y., Wang, F., Chen, Y., Wang, Y., Song, H., & Long, J. (2021) · Journal of Molecular Neuroscience · doi:10.1007/s12031-021-01820-y · Cited by 17
Circ_0044516 Regulates miR-136/MAT2A Pathway to Facilitate Lung Cancer Development
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“or pseudogene transcripts that compete with their sequencecognate mRNAs for binding miRNAs and regulatory factors (Salmena et al., 2011; Bosson et al., 2014; Qu et al., 2015), an initially speculative hypothesis which has garnered progressively more extensive support (Vitiello et al.”
BackgroundLidocaine hampers colorectal cancer process via circITFG2/miR-1204/SOCS2 axis
Wang, H., Zhang, X., Li, Y., Li, Y., & Pang, T. (2022) · Anti-Cancer Drugs · doi:10.1097/cad.0000000000001091 · Cited by 17
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Identification of hsa_circ_0005654 as a new early biomarker of gastric cancer
Wang, Y., Xu, S., Chen, Y., Zheng, X., Li, T., & Guo, J. (2019) · Cancer Biomarkers · doi:10.3233/cbm-190561 · Cited by 17
“CircRNAs play a vital role in gene regulation, neural development and in the initiation and progression of numerous diseases such as atherosclerotic vascular diseases, neurological disorders, cardiovascular diseases and most heart diseases [9–13].”
Gong, Z., Chen, X., Zhang, Y., Liu, C., Wang, Z., Xu, X., Zhu, J., & Xue, T. (2020) · Cancer Management and Research · doi:10.2147/cmar.s254184 · Cited by 17
Vaccine formulation design: challenges and opportunities
Zafar, S., Akhtar, A., Sayed, E., Onaiwu, E., Arshad, M. S., & Ahmad, Z. (2025) · RSC Pharmaceutics · doi:10.1039/d5pm00017c · Cited by 17
Circ_0010729 knockdown protects cardiomyocytes against hypoxic dysfunction via miR-370-3p/TRAF6 axis
Zhang, J., Gao, C., Zhang, J., & Ye, F. (2020) · EXCLI journal · doi:10.17179/excli2020-2809 · Cited by 16
Sun, H., Sun, Y., Yu, X., Gao, X., Wang, H., Zhang, L., Shi, Y., & He, X. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.600632 · Cited by 16
“It has been recently revealed that circRNAs can function as microRNA (miRNA) sponges, regulators of splicing and transcription, and modifiers of parental gene expression (Qu et al., 2015).”
BackgroundFunctional Roles of Non-coding RNAs in the Interaction Between Host and Influenza A Virus
Sajjad, N., Wang, S., Liu, P., Chen, J., Chi, X., Liu, S., & Ma, S. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.742984 · Cited by 19
Zhang, Y., Dou, X., Kong, Q., Li, Y., & Zhou, X. (2021) · International Ophthalmology · doi:10.1007/s10792-021-02067-7 · Cited by 16
Yu, J., Zhang, H., Zhao, C., Li, G., Zhang, Y., & Sun, Y. (2021) · Thoracic Cancer · doi:10.1111/1759-7714.14235 · Cited by 16
“It has been reported that circRNAs can regulate gene expression via binging to microRNAs (miRs).(8) CircRNAs take part in a wide range of pathophysiological processes due to their specificity, abundance, and conservation.”
BackgroundCirc_0006006 facilitates non‐small cell lung cancer progression by modulating miR‐924/SRSF7 axis
Xu, Q.-F., Shi, J., Zhang, L., Sheng, Y., Zhang, Y., Chu, D., & Xu, A. (2022) · The Journal of Gene Medicine · doi:10.1002/jgm.3411 · Cited by 16
“More importantly, it was revealed that circRNAs acted as potent competing endogenous RNAs and efficiently sponged miRNAs to regulate gene transcription, which exerted regulatory action in human cancer progression.(6) For example, miR-767–3p, a target gene of circ_0018818, was downregulated in NSCLC tissues and played…”
BackgroundExpression and clinical value of circRNAs in serum extracellular vesicles for gastric cancer
Xiao, K., Li, S., Ding, J., Wang, Z., Wang, D., Cao, X., Zhang, Y., & Dong, Z. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.962831 · Cited by 16
“As circRNAs do not typically encode protein and its function is not clear, they are initially considered to be the by-products of post-transcriptional modification of mRNA (16).”
BackgroundHsa_Circ_0066351 Acts as a Prognostic and Immunotherapeutic Biomarker in Colorectal Cancer
Gao, Y., Zhou, Y., Le, W., Feng, Z., Chen, Y., Liu, P., Peng, Y., Huang, Q., Gao, L., Liu, Y., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.927811 · Cited by 16
Apoptosis and heart failure: The role of non-coding RNAs and exosomal non-coding RNAs
Li, K., Ma, L., Lü, Z., Yan, L., Chen, W., Wang, B., Xu, H., & Asemi, Z. (2023) · Pathology - Research and Practice · doi:10.1016/j.prp.2023.154669 · Cited by 16
Ma, S., Xu, Y., Qin, X., Tao, M., Gu, X., Shen, L., Chen, Y., Zheng, M., Qin, S., Wu, G., et al. (2024) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-024-00610-9 · Cited by 16
“These covalently closed, reversal-spliced loops are predominantly formed by the circularization of exons [9, 10].”
BackgroundA two‑circRNA signature predicts tumour recurrence in clinical non‑functioning pituitary adenoma
Guo, J., Wang, Z., Miao, Y., Shen, Y., Li, M., Gong, L., Wang, H., He, Y., Gao, H., Liu, Q., et al. (2018) · Oncology Reports · doi:10.3892/or.2018.6851 · Cited by 16
“However, current evidence demonstrates that circRNA may be involved in disease development and even in the development of a tumour (44).”
Diagnostic and prognostic roles of circ-SHPRH for solid cancers: a meta-analysis
Li, F., Huang, Q., Gong, Z., Wang, H., & Chen, J. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s200755 · Cited by 17
Hu, Y. X., Zhang, N., Zhang, S., Zhou, P., Lv, L., Richard, S. A., Ma, W., Chen, C., Wang, X., Huang, S., et al. (2019) · Medicine · doi:10.1097/md.0000000000016148 · Cited by 16
“Some circRNAs can function as miRNA decoys to sequester miRNAs from their target mRNAs, and a circRNA - miRNA - mRNA regulatory axis is increasingly recognized in tumor pathogenesis and progression.([11,12,17,18,28]) In the literature, we found some potential miRNA targets that have been reported to associate with the…”
BackgroundUpregulated Circular RNA hsa_circ_0008433 Regulates Pathogenesis in Endometriosis Via miRNA
Jiang, N., Pan, W., Li, J., Cao, T., & Shen, H. (2020) · Reproductive Sciences · doi:10.1007/s43032-020-00219-1 · Cited by 16
“circRNAs have several main features, such as covalently linked terminals, high circulating stability, and abundant expression, indicating that circRNAs may be ideal candidate biomarkers for disease diagnosis, prognosis, and therapeutic response prediction [8, 9].”
BackgroundEstrogen-decreased hsa_circ_0001649 promotes stromal cell invasion in endometriosis
Li, Q., Li, N., Liu, H., Du, Y., He, H., Zhang, L., & Liu, Y. (2020) · Reproduction · doi:10.1530/rep-19-0540 · Cited by 16
“In contrast to linear RNAs, circRNAs are characterized by covalently linked terminals, high stability in the circulation, and abundant expression, rendering them ideal biomarkers for diagnostic, prognostic, and therapeutic response predictions (Qu et al .”
Shao, F., Cai, M., Fan, F.-F., Huang, M., Tao, Y., Wang, C., Meng, F., & Huang, Q. (2020) · PubMed Central · Cited by 16
Wen, J., Liu, J., Wang, B., Jiang, H., Wan, L., Xin, L., Sun, Y., Sun, Y., Zhang, Y., Du, X., et al. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.00567 · Cited by 16
“Circular RNAs (circRNAs) and long non-coding RNA (lncRNA), a novel type of endogenous non-coding RNA recently rediscovered (12, 13), are known to modulate the activity of interacting proteins or act as miRNA sponges.”
BackgroundKong, Q., Fan, Q., Ma, X., Li, J., & Ma, R. (2020) · Cancer Management and Research · doi:10.2147/cmar.s263985 · Cited by 16
“Increasing researches have revealed that circRNAs are associated with the initiation and advancement of diverse tumors.(7) For instance, circRNA circBPTF accelerated bladder cancer recurrence and advancement through sponging miR-31-5p and regulating RAB27A expression.”
BackgroundHuang, B., Zhou, D., Huang, X., Xu, X., & Xu, Z. (2020) · Cancer Management and Research · doi:10.2147/cmar.s267927 · Cited by 16
“Circular RNAs (circRNAs) are one kind of endogenous non-coding RNAs that form covalently closed-loop structures through back-splicing pre-mRNA.(7) RNA deep sequencing technology and bioinformatics have revealed that circRNAs are highly conserved genes that are stably and abundantly expressed in mammalian cells.”
BackgroundJin, X., Yuan, L., Liu, B., Kuang, Y., Li, H., Li, L., Zhao, X., Li, F., Bing, Z., Chen, W., et al. (2020) · Annals of Translational Medicine · doi:10.21037/atm-20-2002 · Cited by 16
“CircRNA, unlike the well-known linear RNA, forms a ring structure through the linkage of the 3′ and 5′ ends with a covalent bond (12).”
BackgroundPromotive Role of CircATRNL1 on Chondrogenic Differentiation of BMSCs Mediated by miR-338-3p
Zheng, J., Lin, Y., Tang, F., Guo, H.-L., Yan, L.-P., Hu, S., & Wu, H. (2021) · Archives of Medical Research · doi:10.1016/j.arcmed.2021.02.003 · Cited by 16
Role of Circular RNA in Kidney-Related Diseases
Chen, X., Li, Z., Zhao, X., Li, M.-L., Hou, P., Chu, S., Zheng, J., & Bai, J. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.615882 · Cited by 17
Huang, C., Yue, W., Li, L., Li, S., Gao, C., Si, L., Qi, L., Cheng, C., Lü, M., Chen, G., et al. (2021) · Annals of Translational Medicine · doi:10.21037/atm-21-844 · Cited by 16
“Recently, some circRNAs have been proven to possess protein translation ability (13).”
Gao, Q., Liu, Q., & Chen, H. (2021) · Bioengineered · doi:10.1080/21655979.2021.1918992 · Cited by 16
Cao, J., Huang, Z., Ou, S., Wen, F., Yang, G., Miao, Q., Zhang, H., Wang, Y., He, X., Shan, Y., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.647352 · Cited by 16
“circRNAs are highly represented in the eukaryotic transcriptome which are ordinated from the back-spliced sequences of exonic or intronic pre-mRNAs (precursor mRNAs) sequences without an upstream head or a downstream tail (5).”
BackgroundDelpu, Y., Larrieu, D., Gayral, M., Arvanitis, D. N., Dufresne, M., Cordelier, P., & Torrisani, J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802208-5.00012-6 · Cited by 16
Circular RNAs and hereditary bone diseases
Zhai, N., Lu, Y., Wang, Y., Ren, X., & Han, J. (2018) · Intractable & Rare Diseases Research · doi:10.5582/irdr.2018.01013 · Cited by 16
“CircRNAs can be combined with proteins or used to influence RNA splicing, which indirectly affects protein function (29).”
BackgroundFlaming the fight against cancer cells: the role of microRNA-93
Ashrafizadeh, M., Najafi, M., Mohammadinejad, R., Farkhondeh, T., & Samarghandian, S. (2020) · Cancer Cell International · doi:10.1186/s12935-020-01349-x · Cited by 18
Zhao, Z., Wang, K., & Tan, S. (2020) · Cancer Gene Therapy · doi:10.1038/s41417-020-00237-w · Cited by 15
“An example of such case includes the association of epithelial–mesenchymal transition (EMT) with cancer stem-like cells CD44 in PCa metastasis [6].”
BackgroundRetractedYuan, X., Zhang, Y., Cai, C., Liu, C., Xie, J., & Yi, C. (2021) · Autoimmunity · doi:10.1080/08916934.2021.1951716 · Cited by 15
“transcriptional and/or translational levels [11].”
Lu, Q., Li, Y., Lou, J., Li, P., Gu, Y., & Wang, X. (2021) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-211288 · Cited by 15
“Circular RNAs (circRNAs), a novel subgroup of noncoding RNAs [7], have been implicated in the pathogenesis of numerous human diseases, including atherosclerosis [8].”
Wang, Y., Chen, X., Lu, Z., & Lai, C. (2022) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-221445 · Cited by 15
“CircRNAs are widespread in eukaryotic cells and participate in the regulation of biological and pathological processes of various diseases [27].”
RetractedRoles of circular RNAs in osteogenic differentiation of bone marrow mesenchymal stem cells (Review)
Wang, J., Wang, T., Zhang, F., Zhang, Y., Guo, Y., Jiang, X. P., & Yang, B. (2022) · Molecular Medicine Reports · doi:10.3892/mmr.2022.12743 · Cited by 15
“circRNAs are abundantly present in the nucleus and can bind to RBPs, especially transcription‐related factors, including RNA polymerase II and transcription factors, and recruit them to the parental gene, thereby affecting the expression of the parental gene and regulating the transcription process (37).”
BackgroundPeng, T., Yan, S., & Zhang, F. (2022) · Biochemical Genetics · doi:10.1007/s10528-022-10238-z · Cited by 15
CircRNA expression profiles of breast cancer and construction of a circRNA-miRNA-mRNA network
Xu, L., Lyu, M., Yang, S., Zhang, J., & Yu, D. (2022) · Scientific Reports · doi:10.1038/s41598-022-21877-y · Cited by 15
Noncoding RNA PVT1 in osteosarcoma: The roles of lncRNA PVT1 and circPVT1
Wu, T., Ji, Z., Lin, H., Wei, B., Xie, G., Ji, G., Fu, S., Huang, W., & Liu, H. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-01192-1 · Cited by 15
“These ncRNAs account for more than 98% of all human transcripts and are the main components of the transcriptome [7, 8].”
BackgroundHu, W., Wang, Q., Luo, Z., Shi, Y., Zhang, L., Zhang, Z., Liu, J., & Liu, K. (2023) · General Physiology and Biophysics · doi:10.4149/gpb_2022054 · Cited by 15
Circular RNA hsa_circ_0007444 inhibits ovarian cancer progression through miR-23a-3p/DICER1 axis
Zhang, M., Sun, Y., Xu, H., Shi, Y., Shen, R., Teng, F., Xu, J., & Jia, X. (2023) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2023052 · Cited by 15
“Accumulating evidence has revealed that circRNAs perform several biological functions, such as acting as miRNA sponges and regulation of RNA splicing, chromatin remodeling, mRNA translation, and so on [5,10,11].”
Circular RNA: A new expectation for cardiovascular diseases
Xie, Q., Ma, Y., Ren, Z., Gu, T., & Jiang, Z. (2023) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30512 · Cited by 15
Bioorthogonal labeling and profiling of N6-isopentenyladenosine (i6A) modified RNA
Li, Y., Zhou, H., Chen, S., Li, Y., Guo, Y., Chen, X., Wang, S., Wang, L., Gan, Y., Zhang, S., et al. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae150 · Cited by 15
“…and revealed their additional functions and potential therapeutic applications ( 2 ), including modulating signaling pathways by circular RNAs ( 3 ), RNA epitranscriptomics ( 4 ), and RNA nanobiology ( 5 ), etc. Advances in technology and the desire to elucidate the high complexity of RNA…”
BackgroundHu, Y., Zhu, H., Bu, L., & He, D. (2019) · PubMed Central · Cited by 15
Fang, J., Chen, W., & Meng, X.-L. (2020) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-020-04834-w · Cited by 15
Jiang, B., Zhu, S., Zeng, J.-Y., & Mao, Z. (2020) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-020-02129-z · Cited by 15
Circ0083429 Regulates Osteoarthritis Progression via the Mir-346/SMAD3 Axis
Teng, Y., Yang, Y., Xie, Z., Xu, Y., Huang, Y., Gao, J., Shen, S., Ye, H., Iranmanesh, Y., Fan, S., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.579945 · Cited by 15
“CircRNAs have functions mainly through the following three mechanisms: (1) as microRNA (miRNA) sponges, the circRNAs competitively bind to miRNAs to regulate downstream gene expression; (2) circRNAs bind with RNA binding proteins to regulate the transcription of the linear parent genes or to regulate protein functions…”
BackgroundLiu, X., Zhong, L., Jiang, W., & Wen, D. (2021) · Pancreatology · doi:10.1016/j.pan.2020.12.023 · Cited by 15
Circ_0005927 Inhibits the Progression of Colorectal Cancer by Regulating miR-942-5p/BATF2 Axis
Yu, C., Li, D., Yan, Q., Wang, Y.-G., Yang, X., Zhang, S., Zhang, Y., & Zhang, Z. (2021) · Cancer Management and Research · doi:10.2147/cmar.s281377 · Cited by 15
“Circular RNA (circRNA) is a non-coding RNA with closed loop structure.(7,8) CircRNA is more stable than linear RNA and constantly acts as a sponge of microRNA (miRNA).”
BackgroundTeng, X., Liao, J., Zhao, L., Dong, W., Xue, H., Bai, L., & Xu, S. (2021) · PLoS ONE · doi:10.1371/journal.pone.0251359 · Cited by 15
CircRNAs as promising biomarker in diagnosis of breast cancer: An updated meta‐analysis
Chu, M., Fang, Y., & Jin, Y. (2021) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.23934 · Cited by 14
Cheng, C., Zhang, H., Dai, Z., & Zheng, J. (2021) · Bioengineered · doi:10.1080/21655979.2021.1965695 · Cited by 15
“CircRNAs have been considered as a by-product of molecular splicing since they were observed in eukaryotic cells 40 years ago [15,41].”
BackgroundZhao, L., Zhou, L., Hao, X., Wang, L., Han, F., Liu, L., Duan, X., Guo, F., He, J., & Liu, N. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.759747 · Cited by 15
“, 2019), which makes them more stable (Qu et al., 2015) and resistant to digestion by RNase R (Jeck and Sharpless, 2014; Xiao and Wilusz.”
BackgroundcircITGA7 Acts as a miR-370-3p Sponge to Suppress the Proliferation of Prostate Cancer
Luo, G., Li, G.-H., Wan, Z., Zhang, Y., Liu, D., & Guo, Y. (2021) · Journal of Oncology · doi:10.1155/2021/8060389 · Cited by 15
“It forms a closed circular structure by backsplicing mechanism and is more stable than linear noncoding RNA [3, 4].”
BackgroundHou, D., Wang, Z., Li, H., Liu, J., Liu, Y., Jiang, Y., & Lou, M. (2022) · Journal of Cancer · doi:10.7150/jca.57691 · Cited by 15
Liu, W., An, S., Cheng, P., Zhang, K., Gong, M., Zhong, Z., & Zhang, R. (2023) · Parasites & Vectors · doi:10.1186/s13071-022-05648-2 · Cited by 15
Annalora, A. J., Jozic, M., Marcus, C. B., & Iversen, P. L. (2018) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2018.12.009 · Cited by 15
CircRNA as CeRNA mediated by microRNA may be involved in goat lactation
Ma, D., Zhao, Y. M., Yu, S., Zhang, H., Cheng, M. Y., Cao, H., Li, Q., & Min, L. (2019) · Small Ruminant Research · doi:10.1016/j.smallrumres.2018.12.009 · Cited by 15
Transcriptomics Analysis of Circular RNAs Differentially Expressed in Apoptotic HeLa Cells
Yaylak, B., Erdoğan, İ., & Akgül, B. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00176 · Cited by 15
“The majority of circular RNAs are conserved across species, and generally reveal tissue/developmental-stagespecific expression (Qu et al., 2015).”
BackgroundGe, S., Sun, C., Hu, Q., Guo, Y., Xia, G., Mi, Y., & Zhu, L. (2020) · PubMed Central · Cited by 15
Shan, L., & Hou, X. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.12438 · Cited by 15
“CircRNAs constitute a significant part of the mammalian transcriptome and can regulate the expression of specific genes through transcriptional and post‐transcriptional modulation and post‐translational mechanisms, broadly altering the expression and func‐ tion of proteins and thus being involved in several cellular m…”
Su, X., Zhao, Q., Ke, J.-M., Wu, D., Zhu, X. J., Lin, J., & Deng, Z.-Q. (2020) · Cancer Management and Research · doi:10.2147/cmar.s278499 · Cited by 14
Chen, R., Liang, F., Yan, J., & Wang, Y. (2022) · Journal of Ovarian Research · doi:10.1186/s13048-022-00952-y · Cited by 14
“Circular RNA (circRNA) is a noncoding RNA and is more stable than its matched linear RNA based on its closed loop structure [6].”
BackgroundCircular RNAs in Pregnancy and the Placenta
Arthurs, A. L., Jankovic‐Karasoulos, T., Smith, M., & Roberts, C. T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094551 · Cited by 15
“tate the circularisation of this intron [28,29] (Figure 2C) and the 3′ ‘tail’ downstream from”
BackgroundLiu, X., Wu, J., Nie, H., Zhu, X., Song, G., Han, L., & Qin, W. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.858641 · Cited by 14
Unique regulatory roles of ncRNAs changed by PM2.5 in human diseases
He, B., Xu, H.-M., Liu, H.-W., & Zhang, Y. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.114812 · Cited by 15
Dou, X.-L., Xia, F., & Li, X.-Y. (2023) · Epigenetics · doi:10.1080/15592294.2023.2210339 · Cited by 14
“Existing reports have suggested that circRNAs served mainly as an miRNA molecular sponge and contained numbers and types of miRNA response elements at varying degrees [37].”
BackgroundCirc-Slain2 Alleviates Cartilage Degradation and Inflammation of TMJOA
Pan, X., Zhao, Z., Huang, X., & Cen, X. B. (2023) · Journal of Dental Research · doi:10.1177/00220345231198448 · Cited by 14
“…experiments confirmed that circ-slain2 could suppress ER stress in OA mCCs. Mechanistically, circRNAs can regulate parental gene expression and splicing, and they can also function as protein scaffolds and miRNA sponges to perform biological functions (Conn et al. 2015; Qu et al. 2015; Panda 2018).”
BackgroundUnderstanding Circular RNAs in Health, Welfare, and Productive Traits of Cattle, Goats, and Sheep
Kirgiafini, D., Kyrgiafini, M.-A., Gournaris, T., & Mamuris, Z. (2024) · Animals · doi:10.3390/ani14050733 · Cited by 14
Role of circular RNA as competing endogenous RNA in ovarian cancer (Review)
Ye, W., Xiang, N., Wang, Q., & Lü, Y. (2024) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2024.5365 · Cited by 14
“There are four main mechanisms of circRNAs: i) Sponging miRNA (19); ii) binding to diverse RNA binding proteins (20) or acting as a protein sponge; iii) regulating transcription (21); and iv) participating in the translation progress (22).”
BackgroundEpigenetic control of dental stem cells: progress and prospects in multidirectional differentiation
Li, Y., Guo, X., Yao, H., Zhang, Z., & Zhao, H. (2024) · Epigenetics & Chromatin · doi:10.1186/s13072-024-00563-5 · Cited by 14
“They are highly conserved across species and exhibit tissue-specific expression profiles [159].”
An Overview of the Biological Complexity of Vitiligo
Matarrese, P., Puglisi, R., Mattia, G., Samela, T., ABENI, D. D., & Malorni, W. (2024) · Oxidative Medicine and Cellular Longevity · doi:10.1155/omcl/3193670 · Cited by 16
“Several studies have demonstrated abnormal expression of lncRNAs and circRNAs in various human diseases, indicating that they may become new markers for disease detection [117].”
Li, W., Zhou, X. P., Wu, X., Wei, J., & Huang, Z. (2019) · Cancer Management and Research · doi:10.2147/cmar.s211020 · Cited by 14
“Previous studies have shown that circRNAs exhibit cell-type- and developmental-stage-specific expression.(5) CircRNAs might act as miRNA sponges and mature miRNAs, which have important regulatory functions in cell proliferation, differentiation and apoptosis.”
BackgroundLeng, X., Huang, G., Ding, J., & Fu-cheng, M. (2020) · Biochemistry and Cell Biology · doi:10.1139/bcb-2020-0219 · Cited by 14
Ai, Y., Tang, Z., Zou, C., Wei, H., Wu, S., & Huang, D. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15943 · Cited by 13
Xin, R., Qu, D., Xu, H., & Chen, D. (2020) · Cancer Gene Therapy · doi:10.1038/s41417-020-00247-8 · Cited by 14
RetractedZhao, Q., Lu, Y., Wang, X., & Zhang, X.-J. (2020) · Europe PMC (PubMed Central) · Cited by 14
Identification of circ_0089153/miR‐608/EGFR p53 axis in ameloblastoma via MAPK signaling pathway
Liu, J., Qiao, X., Liu, J., & Zhong, M. (2021) · Oral Diseases · doi:10.1111/odi.13788 · Cited by 14
Chen, F., He, L., Qiu, L., Zhou, Y., Li, Z., Chen, G., Xin, F., Dong, X., Xu, H., Wang, G., et al. (2021) · Cancer Management and Research · doi:10.2147/cmar.s291682 · Cited by 14
“For a long time, circRNAs were regarded as a byproduct of splicing without biological functions.(8) However, with the development of bioinformatics technologies, the functional importance of circRNAs in cancer has been gradually recognized.”
BackgroundGao, Y., Yao, F., Rao, J., Zhang, L., Guo, Y., Huang, Z., Huang, Q., Li, J., & Luo, Q. (2021) · Autoimmunity · doi:10.1080/08916934.2021.1922891 · Cited by 15
Hsa_Circ_0001860 Promotes Smad7 to Enhance MPA Resistance in Endometrial Cancer via miR-520h
Yuan, S., Zheng, P., Sun, X., Zeng, J., Cao, W., Gao, W., Wang, Y., & Wang, L. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.738189 · Cited by 15
“It is reported that circRNA is divided into exotic circular RNA (ecircRNA), circular intronic RNA (ciRNAs), and exonic-intron circular RNA (EiciRNA) (Qu et al., 2015).”
Li, Z., Xu, J., Guan, H., Lai, J., Yang, X., & Ma, J. (2021) · Journal of Endocrinological Investigation · doi:10.1007/s40618-021-01713-2 · Cited by 14
“CircRNAs are associated with multiple biological processes in human cancers [6, 7].”
BackgroundShen, X., Zhu, X., Hu, P., Ji, T., Qin, Y., & Zhu, J. (2022) · Biochemical Genetics · doi:10.1007/s10528-021-10165-5 · Cited by 14
“Circular RNAs (circRNAs) are a novel class of RNA transcripts with covalent closed-loop structures, and they can regulate post-transcriptional gene expression, thus, to drive tumor progression via exerting sponge effects on microRNAs (miRNAs) in cancer cells (Han et al. 2018; Hsiao et al. 2017; Qu et al. 2015).”
BackgroundLiu, Y., & Zhou, Y. (2022) · Regenerative Therapy · doi:10.1016/j.reth.2022.01.003 · Cited by 14
Ren, Y., Li, L., Wang, M., Yang, Z., Sun, Z., Zhang, W., Cao, L., & Nie, S. (2022) · Immunological Investigations · doi:10.1080/08820139.2022.2027961 · Cited by 14
“CircRNA is a non-coding RNA that is relatively stable, evolutionally conserved, and highly specific in different types of cells (Qu et al. 2015).”
BackgroundMa, Z., Liu, C., Zhang, L., Xiang, N., Zhang, Y., & Chu, L. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.806200 · Cited by 15
“CircRNA-regulated ceRNA is a circRNA-miRNA-mRNA regulatory network constructed based on the regulatory and regulated relationship between different RNAs (Qu et al., 2015), and its possible mechanism is that there are a variety of miRNA response elements (MREs).”
BackgroundNovel Insight of CircRNAs in Cervical Cancer: Potential Biomarkers and Therapeutic Target
Wu, M., Han, Y., Gong, X., Wan, K. M., Liu, Y., Zhou, Y., Zhang, L., Tang, G., Fang, H., Chen, B., et al. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.759928 · Cited by 14
“Amounting studies digging deeper into the mechanisms demonstrated that circRNAs can function as microRNA (miRNA) sponges, regulators of splicing and transcription, and modifiers of parental gene expression (32).”
BackgroundLin, G. R., Chen, W. R., Zheng, P., Chen, W. S., & Cai, G. (2022) · Journal of Digestive Diseases · doi:10.1111/1751-2980.13116 · Cited by 14
“In recent years, circRNAs have attracted much attention in cancer research due to their involvement in various cellular physiobiological processes.(27) Nevertheless, the exact roles and regulatory mechanisms of circRNAs have not been comprehensively explored in GC.”
BackgroundZhang, J., Jiang, J., Huang, R., Wang, Y., Nie, X., & Gui, R. (2018) · Leukemia Research · doi:10.1016/j.leukres.2018.05.010 · Cited by 14
Changing expression profiles of lncRNAs, circRNAs and mRNAs in esophageal squamous carcinoma
Song, J. T., Lu, Y., Sun, W., Han, M., Zhang, Y., & Zhang, J. (2019) · Oncology Letters · doi:10.3892/ol.2019.10880 · Cited by 14
“The characteristics of circRNA include the following: Exists in nearly all types of species, is expressed in a tissue- and disease-dependent manner; and is more stable in tissue and circulation compared with linear RNA, since it resists RNase (15).”
BackgroundInfluentialNon-coding RNAs and Pathological Cardiac Hypertrophy
He, J., Luo, Y., Song, J., Tan, T., & Zhu, H. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-1671-9_13 · Cited by 13
Differential CircRNA Expression Profiles in PK-15 Cells Infected with Pseudorabies Virus Type II
Li, H., Tang, W., Jin, Y., Dong, W.-R., Yan, Y., & Zhou, J. (2020) · Virologica Sinica · doi:10.1007/s12250-020-00255-w · Cited by 14
Role of RING-Type E3 Ubiquitin Ligases in Inflammatory Signalling and Inflammatory Bowel Disease
Zhu, L., Li, Y., Zhou, L., Yang, G., Wang, Y., Han, J., Li, L., & Zhang, S. (2020) · Mediators of Inflammation · doi:10.1155/2020/5310180 · Cited by 14
“, competing endogenous RNA [ceRNA], transcription regulation, and RNA-binding protein sponges) [72, 73], to what extent they modulate RING-type ligases awaits further analysis.”
BackgroundThe Roles of circMTO1 in Cancer
Liu, W., Xiong, Y., Wan, R., Shan, R., Li, J., & Wen, W. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.656258 · Cited by 14
“Moreover, Rao et al. (2018) also found that circMTO1 could attenuate the resistance of glioblastoma cells to TMZ, but its downstream genes have not been further studied.”
BackgroundInfluentialCircular RNAs in the regulation of cardiac hypertrophy
Wu, S., Chen, L., & Zhou, X. (2021) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2021.12.025 · Cited by 15
“Unlike traditional linear RNA molecules, circRNA molecules are covalently closed and do not have free termini.(7) Endogenous circRNAs are abundant and highly conserved and, in eukaryotic cells, display expression patterns that are specific to cell type, tissue type, and developmental stage.”
Background
Metadata
- Authors
- Qu, S., Yang, X., Li, X., Wang, J., Gao, Y., Shang, R., Sun, W., Dou, K., & Li, H.
- Affiliations
- Xijing Hospital (CN)
- Corresponding author
- Li, Haimin
- Venue
- Cancer Letters
- Publisher
- Elsevier BV
- Published
- 2015-09
- Volume
- 365
- Issue
- 2
- Pages
- 141-148
- ISSN
- 0304-3835 (ISSN-L)
- OpenAlex
- W1866220599
- Cited by
- 1,808
- References
- 71
- Citations by year
- 2026: 30 · 2025: 71 · 2024: 142 · 2023: 176 · 2022: 236 · 2021: 328 · 2020: 326 · 2019: 205 · 2018: 154 · 2017: 75 · 2016: 52 · 2015: 7
- FWCI
- 9.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cancer Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81772061)
- Health Public Welfare Industry Special Scientific Research Projects of China (201202007)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Circular RNAs in diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Keywords
- circular RNA, circRNA biogenesis, RNA-binding proteins, microRNA sponge, RNA splicing regulation, transcriptional regulation, circRNA stability, disease biomarkers, colorectal cancer, pancreatic ductal adenocarcinoma, atherosclerosis, neurological disorders, prion disease, long non-coding RNA
- MeSH terms
- RNA, Circular, Exoribonucleases, Gene Expression Regulation, Humans, Neoplasms, RNA, RNA Splicing, Transcription, Genetic, RNA, Untranslated
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