The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.
Circular RNA: A new star of noncoding RNAs
Abstract
Circular RNAs (circRNAs) are a novel type of RNA that, unlike linear RNAs, form a covalently closed continuous loop and are highly represented in the eukaryotic transcriptome. Recent studies have discovered thousands of endogenous circRNAs in mammalian cells. CircRNAs are largely generated from exonic or intronic sequences, and reverse complementary sequences or RNA-binding proteins (RBPs) are necessary for circRNA biogenesis. The majority of circRNAs are conserved across species, are stable and resistant to RNase R, and often exhibit tissue/developmental-stage-specific expression. Recent research has revealed that circRNAs can function as microRNA (miRNA) sponges, regulators of splicing and transcription, and modifiers of parental gene expression. Emerging evidence indicates that circRNAs might play important roles in atherosclerotic vascular disease risk, neurological disorders, prion diseases and cancer; exhibit aberrant expression in colorectal cancer (CRC) and pancreatic ductal adenocarcinoma (PDAC); and serve as diagnostic or predictive biomarkers of some diseases. Similar to miRNAs and long noncoding RNAs (lncRNAs), circRNAs are becoming a new research hotspot in the field of RNA and could be widely involved in the processes of life. Herein, we review the formation and properties of circRNAs, their functions, and their potential significance in disease.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Originating from various genomic regions, circRNAs are synthesized by the back-splicing of protein-coding precursor mRNAs (primarily in eukaryotes) [25,26].”
From Circular RNAs in depression: Biogenesis, function, expression, and therapeutic potential (2021) · cites this paper as [25]
Citations
Cites
Circular RNAs are a large class of animal RNAs with regulatory potency
Memczak, S., Jens, M., Elefsinioti, A., Torti, F., Krueger, J., Rybak, A., Maier, L., Mackowiak, S. D., Gregersen, L. H., Munschauer, M., et al. (2013) · Nature · doi:10.1038/nature11928 · Cited by 7,990
Natural RNA circles function as efficient microRNA sponges
Hansen, T. B., Jensen, T. I., Clausen, B. H., Bramsen, J. B., Finsen, B., Damgaard, C. K., & Kjems, J. (2013) · Nature · doi:10.1038/nature11993 · Cited by 7,985
Oncomirs—MicroRNAs with a role in cancer
Esquela-Kerscher, A., & Slack, F. J. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1840 · Cited by 5,884
Circular RNAs are abundant, conserved, and associated with ALU repeats
Jeck, W. R., Sorrentino, J. A., Wang, K., Slevin, M. K., Burd, C. E., Liu, J., Marzluff, W. F., & Sharpless, N. E. (2013) · RNA · doi:10.1261/rna.035667.112 · Cited by 4,388
circRNA biogenesis competes with pre-mRNA splicing
Ashwal-Fluss, R., Meyer, M., Pamudurti, N. R., Ivanov, A., Bartok, O., Hanan, M., Evantal, N., Memczak, S., Rajewsky, N., & Kadener, S. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.08.019 · Cited by 3,083
Exon-intron circular RNAs regulate transcription in the nucleus
Li, Z., Huang, C., Bao, C., Chen, L., Lin, M., Wang, X., Zhong, G., Yu, B., Hu, W., Dai, L., et al. (2015) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2959 · Cited by 2,905
Detecting and characterizing circular RNAs
Jeck, W. R., & Sharpless, N. E. (2014) · Nature Biotechnology · doi:10.1038/nbt.2890 · Cited by 2,710
Sanger, H. L., Klotz, G., Riesner, D., Gross, H. J., & Kleinschmidt, A. K. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.11.3852 · Cited by 2,296
Salzman, J., Gawad, C., Wang, P. L., Lacayo, N., & Brown, P. O. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030733 · Cited by 2,239
Circular intronic long noncoding RNAs
Zhang, Y., Zhang, X.-O., Chen, T., Xiang, J.-F., Yin, Q.-F., Xing, Y.-H., Zhu, S., Yang, L., & Chen, L.-L. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.08.017 · Cited by 2,221
Flagged first, then by citations
Cited by
Sorted by citations
Items 401–500 of 1,000
Down-regulation of circular RNAITCH and circHIPK3 in gastric cancer tissues
GHASEMI, S. (2019) · TURKISH JOURNAL OF MEDICAL SCIENCES · doi:10.3906/sag-1806-50 · Cited by 43
“Recent reports show that circRNAs can function as microRNA sponges, regulate gene expression, linear RNA transcription and protein production (7).”
BackgroundLv, X., Wang, M., Qiang, J., & Guo, S. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.172643 · Cited by 43
CircMYC Regulates Glycolysis and Cell Proliferation in Melanoma
Jin, C. S., Dong, D., Yang, Z., Xia, R., Tao, S., & Piao, M. (2019) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-019-00895-0 · Cited by 43
Circ-0001313/miRNA-510-5p/AKT2 axis promotes the development and progression of colon cancer.
Tu, F.-L., Guo, X.-Q., Wu, H., He, Z., Wang, F., Sun, A., & Dai, X. (2020) · PubMed Central · Cited by 43
Wang, M., Gu, B., Yao, G., Li, P., & Wang, K. (2020) · International Journal of Medical Sciences · doi:10.7150/ijms.45637 · Cited by 44
“CircRNAs shape into covalently closed loops which neither have 5’ to 3’ polarity nor a polyadenylated tail [3].”
BackgroundLi, S., Yan, G., Liu, W., Li, C., & Wang, X. (2020) · Molecular Carcinogenesis · doi:10.1002/mc.23259 · Cited by 43
“This closed, long noncoding RNAs has a conserved stable structure that can tolerate RNase R.(6,7) Although scholars were knowledgeable about the”
BackgroundWeng, H., Zeng, L., Cao, L., Chen, T., Li, Y., Xu, Y., Peng, Y., & Ye, Y. (2020) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2020.12.019 · Cited by 43
“Circular RNA (circRNA) is a novel non-coding RNA (ncRNA) with a highly conserved and stable covalently closed structure.(5) circRNAs”
BackgroundWen, J., Liu, J., Wan, L., Xin, L., Guo, J., Sun, Y., Wang, X., & Wang, J. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108616 · Cited by 43
Wu, G., Zhou, W., Lin, X., Sun, Y., Li, J., Xu, H., Shi, P., Gao, L., & Tian, X. (2020) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2019.11.037 · Cited by 42
RetractedGui, X., Li, Y., Zhang, X., Su, K., & Cao, W. (2020) · Cancer Cell International · doi:10.1186/s12935-020-01327-3 · Cited by 42
Wang, Y., Yang, T., Li, Q., Zheng, Z., Liao, L., Cen, J., Chen, W., Luo, J., Xu, Y., Zhou, M., et al. (2025) · Molecular Cancer · doi:10.1186/s12943-024-02122-8 · Cited by 44
Wang, Q., Jia, C., Wang, A., Sun, L., Li, Q., Zhou, X., Liu, Y., Tang, S., Chen, X., Cheng, Y., et al. (2018) · Oncology Reports · doi:10.3892/or.2018.6263 · Cited by 41
Shi, J., Hu, N., Mo, L., Zeng, Z., Sun, J., & Hu, Y. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000491471 · Cited by 42
Profiles of differentially expressed circRNAs in esophageal and breast cancer
Shi, P., Sun, J., He, B., Song, H., Li, Z., Kong, W., Wang, J., Wang, J., & Xue, H. (2018) · Cancer Management and Research · doi:10.2147/cmar.s167863 · Cited by 42
“CircRNAs are a class of noncoding RNA molecules that lack 5′3′ ends and a poly A tail, covalently forming closed continuous loops.(11,12) In general, circRNAs are stable molecules, and some have functioned as efficient miRNA sponges with gene-regulatory ability.”
BackgroundLuo, L., Gao, Y., & Sun, X. (2018) · Cancer Biomarkers · doi:10.3233/cbm-181609 · Cited by 42
CircNUP214 sponges miR-145 to promote the expression of ZEB2 in thyroid cancer cells
Li, X., Tian, Y., Hu, Y., Yang, Z., Zhang, L., & Luo, J. P. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.10.200 · Cited by 42
Matboli, M., Shafei, A., ALI, M. A. M., Ashry, A. M., Kamal, K. M., Agag, M. A., Reda, I., Tash, E. F., & Ali, M. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28045 · Cited by 42
“Most circRNAs are known for their abundance and stability and often exhibit tissue/developmental‐stage‐specific expression.(11) Because of the rapid advances in the development of combined high‐throughput sequencing and bioinformatics analysis tools, many circRNAs have recently been discovered, revealing an expansive…”
BackgroundResearch progress on circularRNAs in pancreatic cancer: emerging but promising
Wang, Y., An, Y., Li, B., Lü, J., & Guo, J. (2019) · Cancer Biology & Therapy · doi:10.1080/15384047.2019.1617563 · Cited by 42
“ribonucleases so circRNAs can maintain stable intracellular expression.(5) In 1976, Sanger et al.”
BackgroundThe emerging roles of circular RNAs in ovarian cancer
Yang, X., Mei, J., Wang, H., Gu, D., Ding, J., & Liu, C. (2020) · Cancer Cell International · doi:10.1186/s12935-020-01367-9 · Cited by 43
“CircRNAs regulate gene transcription In addition to acting as sponges for miRNAs, a portion of circRNAs can cis- or trans-regulate gene transcription, thus impacting gene expression [35] (Fig.”
Cheng, C., Shen, H. M., Huang, Q., & Li, Q. (2020) · Genetic Testing and Molecular Biomarkers · doi:10.1089/gtmb.2020.0034 · Cited by 42
“Growing evidence indicates that circRNA can affect gene expression through different pathways, thereby regulating the occurrence and development of diseases (Qu et al. , 2015; Salzman, 2016; Ebbesen et al. , 2017).”
Li, Y., Bian, M., Zhou, Z., Xiao, W., Ge, X., Tong, X., & Yu, J. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01970-7 · Cited by 41
Li, H., Li, Q., & He, S. (2021) · World Journal of Surgical Oncology · doi:10.1186/s12957-021-02149-x · Cited by 43
Ding, T., Zhu, Y., Jin, H., Zhang, P., Guo, J., & Zheng, J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.644397 · Cited by 41
“circ_0057558 Sponged miR-206 Lately, accumulated evidence has indicated that circRNAs could absorb miRNAs, thereby reducing the regulation of miRNAs on their target genes (Qu et al., 2015).”
BackgroundNon-Coding RNAs in Colorectal Cancer: Their Functions and Mechanisms
Jia, Z., An, J., Liu, Z., & Zhang, F. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.783079 · Cited by 43
“Most recently, an increasing number of circRNAs have been observed to be aberrantly expressed in CRC (85).”
BackgroundCircular RNAs in depression: Biogenesis, function, expression, and therapeutic potential
Gan, H., Lei, Y., Yuan, N., Tang, K., Hao, W., Ma, Q., Wu, M., Zhou, X., Li, X., Huang, J., et al. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111244 · Cited by 41
Ren, G.-J., Fan, X.-C., Liu, T.-L., Wang, S., & Zhao, G. (2018) · BMC Genomics · doi:10.1186/s12864-018-4754-2 · Cited by 41
“Generally, the functions of both lncRNAs and circRNAs were performed by inter-acting with their targets [27, 28].”
BackgroundHsa_circ_0061140 promotes endometrial carcinoma progression via regulating miR-149-5p/STAT3
Liu, Y., Chang, Y., & Cai, Y. (2020) · Gene · doi:10.1016/j.gene.2020.144625 · Cited by 41
Zang, H.-L., Li, Y., Zhang, X., & Huang, G. (2020) · Cancer Management and Research · doi:10.2147/cmar.s243300 · Cited by 41
RetractedcircRNA: A Promising All-Around Star in the Future
Li, H. (2023) · Epigenomics · doi:10.2217/epi-2023-0141 · Cited by 42
The miRNA biogenesis in marine bivalves
Rosani, U., Pallavicini, A., & Venier, P. (2016) · PeerJ · doi:10.7717/peerj.1763 · Cited by 43
Circular RNAs as a New Field in Gene Regulation and their Implications in Translational Research
Vidal, A. F., Sandoval, G. T., de Magalhães, L. L., Santos, S. E., & Ribeiro‐dos‐Santos, Â. (2016) · Epigenomics · doi:10.2217/epi.16.3 · Cited by 41
Hsa_circ_0079530 promotes cell proliferation and invasion in non-small cell lung cancer
Li, J., Wang, J., Chen, Z., Chen, Y., & Jin, M. (2018) · Gene · doi:10.1016/j.gene.2018.04.059 · Cited by 41
Wang, J., Yin, J., Wang, X., Liu, H., Hu, Y., Yan, X., Zhuang, B., Yu, Z., & Han, S. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28212 · Cited by 41
Song, Y., Zhang, L., Liu, X., Niu, M., Cui, J., Che, S., Liu, Y., An, X., & Cao, B. (2019) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-019-0339-4 · Cited by 42
The Roles of Circular RNAs in Osteosarcoma
Zhang, Y., Li, J., Wang, Y., Jing, J., & Li, J. (2019) · Medical Science Monitor · doi:10.12659/msm.915559 · Cited by 42
“Therefore, circRNA is more conservative and stable than the corresponding linear RNA [10].”
BackgroundShao, S., Wang, C., Wang, S., Zhang, H., & Zhang, Y. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109582 · Cited by 42
Zhao, M., Dong, G., Meng, Q., Lin, S., & Li, X. (2020) · Journal of Cellular Biochemistry · doi:10.1002/jcb.29672 · Cited by 41
Circ‐PRMT5 promotes breast cancer by the miR‐509‐3p/TCF7L2 axis activating the PI3K/AKT pathway
Wu, D., Jia, H., Zhang, Z., & Li, S. (2020) · The Journal of Gene Medicine · doi:10.1002/jgm.3300 · Cited by 41
“Unlike linear RNAs, circRNAs have more stable structures because of their closed loops without 3' and 5' ends.(8,9) Accumulating evidence suggests that circRNAs participate in many biological processes, including the tumorigenesis of human cancers.”
BackgroundCircular RNAs: Promising biomarkers for cancer diagnosis and prognosis
Wei, G., Zhu, J., Hu, H., & Liu, J. (2020) · Gene · doi:10.1016/j.gene.2020.145365 · Cited by 43
CircCAMSAP1 promotes hepatocellular carcinoma progression through miR‐1294/GRAMD1A pathway
Luo, Z., Lu, L., Tang, Q., Wang, W., Chen, P., Chen, Y., Pu, J., & Wang, J. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16254 · Cited by 40
Research Progress on the Functions and Mechanism of circRNA in Cisplatin Resistance in Tumors
Mu, Q., Lv, Y., Luo, C., Liu, X., Huang, C., Xiu, Y., & Tang, L. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.709324 · Cited by 41
Jiang, W., & Ye, Z. (2019) · Bioscience Reports · doi:10.1042/bsr20190996 · Cited by 40
LncRNAs and CircRNAs from the same gene: Masterpieces of RNA splicing
Huang, M., Zhu, T., Li, L., Xie, P., Li, X., Zhou, H., & Liu, Z. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.11.034 · Cited by 40
Expression Profiling Identifies Circular RNA Signature in Hepatoblastoma
Liu, B.-H., Zhang, B., Liu, X., Zheng, S., Dong, K., & Dong, R. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000487163 · Cited by 40
Wang, G., Xue, W., Jian, W., Liu, P., Wang, Z., Wang, C., Li, H., Yu, Y., Zhang, D., & Zhang, C. L. (2018) · Journal of Cancer · doi:10.7150/jca.25902 · Cited by 40
“By interacting with miRNA, circRNA plays an important regulatory role in disease, especially in cancer [30].”
BackgroundWang, W., Su, Y., Tang, S., Li, H., Xie, W., Chen, J., Shen, L., Pan, X., & Ning, B. (2019) · Aging · doi:10.18632/aging.101919 · Cited by 40
Duan, X., Shen, N., Chen, J., Wang, J., Zhu, Q., & Zhai, Z. (2019) · Bioscience Reports · doi:10.1042/bsr20190227 · Cited by 40
Chen, H., Gu, B., Zhao, X., Zhao, Y., Huo, S., Liu, X., & Lu, H. (2020) · Bioengineered · doi:10.1080/21655979.2020.1832343 · Cited by 41
“Circular RNA (circRNA) has attracted immense attention recently, particularly regarding their role in cancer development [5,6].”
BackgroundWang, X., Ren, Y., Ma, S., & Wang, S. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s240642 · Cited by 39
Qi, K., Liu, Y., Li, C., Li, X., Li, X., Wang, K., Qiao, R., & Han, X. (2021) · Molecular Genetics and Genomics · doi:10.1007/s00438-021-01836-4 · Cited by 39
Recent advances of exosomal circRNAs in cancer and their potential clinical applications
Yi, Q., Yue, J., Liu, Y., Shi, H., Sun, W., Feng, J., & Sun, W. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04348-4 · Cited by 41
“Furthermore, circRNAs were found to be dysregulated under pathological conditions and enriched in exosomes, which could be detected in body fluids such as blood, serum, urine, saliva, and cerebrospinal fluid [14, 15].”
BackgroundGenome-wide analysis of circular RNAs in prenatal and postnatal muscle of sheep
Li, C., Li, X., Yao, Y., Ma, Q., Ni, W., Zhang, X., Cao, Y., Hazi, W., Wang, D., Quan, R., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.21835 · Cited by 39
“The biological functions of circRNAs are still being indicated, but they are shown to sponge miRNAs [15], regulate gene transcription [16], translate into proteins [14], interact with RNA binding proteins [17] and modulate the stability of mRNAs [16].”
BackgroundDifferential circular RNAs expression in ovary during oviposition in honey bees
Chen, X., Shi, W., & Chen, C. (2018) · Genomics · doi:10.1016/j.ygeno.2018.03.015 · Cited by 39
Wang, S., Cui, S., Zhao, W., Qian, Z., Liu, H., Chen, Y., Lv, F., & Ding, H.-G. (2018) · Cancer Biomarkers · doi:10.3233/cbm-170910 · Cited by 39
“Increasing experments suggests that cir-cRNAs are involved in many disease, including can-638 cer [14].”
Wang, L., Ma, H., Kong, W., Liu, B., & Zhang, X. (2019) · Bioscience Reports · doi:10.1042/bsr20182433 · Cited by 39
RetractedCircular RNA CCDC66 facilitates abdominal aortic aneurysm through the overexpression of CCDC66
Yang, R., Wang, Z., Meng, G., & Li, H. (2020) · Cell Biochemistry and Function · doi:10.1002/cbf.3494 · Cited by 39
Sun, X., Luo, L., & Gao, Y. (2020) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.14190 · Cited by 39
“cycle progression, invasion, metastasis and senescence.(6) With advancement of circRNA research, it”
BackgroundWei, J., Xu, H., Wei, W., Wang, Z., Zhang, Q., De, W., & Shu, Y. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s226300 · Cited by 39
RetractedLong, N., Chu, L., Jia, J., Peng, S., Gao, Y., Yang, H., Yang, Y., Zhao, Y., & Liu, J. (2020) · Cancer Cell International · doi:10.1186/s12935-020-01454-x · Cited by 40
Feng, Z., Zheng, L., Teng, Y., Tao, S., Wei, X.-A., Zheng, Z., Zheng, B., Zhang, X., Huang, B. H., Liu, J., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04339-7 · Cited by 39
Ma, X., Liu, C., Gao, C., Li, J., Zhuang, J., Liu, L., Li, H., Wang, X., Zhang, X., Dong, S., et al. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29291 · Cited by 38
“The circRNAs are key regulators of several biological processes and are involved in the occurrence and development of many diseases, including cancer (Qu et al., 2015).”
BackgroundEngineering circular RNA medicines
Cao, X., Cai, Z., Zhang, J., & Zhao, F. (2024) · Nature Reviews Bioengineering · doi:10.1038/s44222-024-00259-1 · Cited by 45
Lan, X., Xu, J., Chen, C., Zheng, C., Wang, J., Cao, J., Zhu, X., & Ge, M. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000490188 · Cited by 38
Genome-Wide Identification of Circular RNAs in Fungal Parasite Nosema ceranae
Guo, R., Chen, D., Chen, H., Xiong, C., Zheng, Y., Hou, C., Du, Y., Geng, S., Wang, H., Dingding, Z., et al. (2018) · Current Microbiology · doi:10.1007/s00284-018-1576-z · Cited by 38
Circular RNA Expression in Oral Squamous Cell Carcinoma
Wang, Y., Li, B., Sun, S., Li, X., Su, W., Wang, Z., Wang, F., Zhang, W., & Yang, H. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00398 · Cited by 38
“It is a form of RNA whose head 3 and tail 5 ends covalently bond together to result in a circular form (16).”
BackgroundWang, Y., Zhang, J., Li, J., Gui, R., Nie, X., & Huang, R. (2019) · Bosnian Journal of Basic Medical Sciences · doi:10.17305/bjbms.2019.3935 · Cited by 38
Lin, G., Sheng, H., Xie, H., Zheng, Q., Shen, Y., Shi, G., & Ye, D. (2019) · Oncology Letters · doi:10.3892/ol.2019.9970 · Cited by 39
Luo, Q., Zhang, L., Fang, L., Fu, B., Guo, Y., Huang, Z., & Li, J. (2020) · Autoimmunity · doi:10.1080/08916934.2020.1728529 · Cited by 38
Trend analysis of the role of circular RNA in goat skeletal muscle development
Ling, Y., Zheng, Q., Zhu, L., Xu, L., Sui, M., Zhang, Y., Liu, Y., Fang, F., Chu, M., Ma, Y., et al. (2020) · BMC Genomics · doi:10.1186/s12864-020-6649-2 · Cited by 38
“They could display as sponge miRNAs [7], regulate gene transcription [8], interact with RNA-binding proteins [9], regulate mRNA stability [8], and even in some cases are translated into polypeptides [10].”
BackgroundPan, J., Xu, Z., Guo, G., Xu, C., Song, Z., Li, K., Zhong, K. L., & Wang, D. (2021) · Bioengineered · doi:10.1080/21655979.2021.1960462 · Cited by 38
“They also serve a vital role in the initiation and progression of cardiovascular disease [22,24,25].”
BackgroundChen, L., Rong, D., Hui, B., He, X., Jiang, W., Xu, Y., Cao, H., Xu, Z., & Tang, W. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00710-x · Cited by 38
The Dual Role of Circular RNAs as miRNA Sponges in Breast Cancer and Colon Cancer
Huang, J., Yu, S., Ding, L., Ma, L., Chen, H., Zhou, H., Zou, Y., Yu, M., Lin, J., & Cui, Q. (2021) · Biomedicines · doi:10.3390/biomedicines9111590 · Cited by 40
Zhao, Y., & Wang, H. (2025) · Briefings in Bioinformatics · doi:10.1093/bib/bbaf263 · Cited by 40
“As a more stable alternative, circular RNA (circRNA) exhibits a 10-fold increase in nuclease resistance compared to linear mRNA, largely due to its topologically closed structure [25, 26].”
Cao, S., Wei, D., Xu, L., Zhou, J., Li, W., Qian, Y., Wang, Z., Li, G., Pan, X., & Lei, D. (2017) · Oncotarget · doi:10.18632/oncotarget.17488 · Cited by 37
“A new type of endogenous noncoding RNA, circular RNA (circRNA), is joining microRNA (miRNA) and long noncoding RNA (lncRNA) as an area of great interest in the field of RNA research [3].”
Zeng, Y., Xu, Y., Shu, R., Sun, L. D., Tian, Y., Shi, C., Zheng, Z., Wang, K., & Luo, H. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.3189 · Cited by 37
“Given that circRNA interact with miRNA to regulate their target genes, circRNA may be involved in diseases correlated with miRNA (24).”
Regulation of long non-coding RNAs and circular RNAs in spermatogonial stem cells
Zhou, F., Chen, W., Jiang, Y., & He, Z. (2019) · Reproduction · doi:10.1530/rep-18-0517 · Cited by 37
Su, W., Sun, S., Wang, F., Shen, Y., & Yang, H. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-019-1830-6 · Cited by 37
RetractedLong noncoding RNA PVT1: A highly dysregulated gene in malignancy
Ghafouri‐Fard, S., Omrani, M. D., & Taheri, M. N. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29060 · Cited by 37
“They differ with linear transcripts in their special feature of constructing a covalently closed uninterrupted loop without 5′ caps and 3′ poly (A) tails (Qu et al., 2015).”
BackgroundLiu, G., Wan, Q., Li, J., Hu, X., Gu, X., & Xu, S. (2020) · Thoracic Cancer · doi:10.1111/1759-7714.13397 · Cited by 37
Lv, M., Zhou, L., Ge, P., Li, Y., Zhang, J., & Zhou, D. (2020) · Andrology · doi:10.1111/andr.12874 · Cited by 37
Li, X., Feng, Y., Yang, B., Xiao, T., Ren, H., Yu, X. Y., Li, L., Li, M., & Zhang, W. (2020) · Molecular Oncology · doi:10.1002/1878-0261.12852 · Cited by 37
Circular RNA circ_0000467 regulates colorectal cancer development via miR-382-5p/EN2 axis
Xie, L., & Pan, Z. (2021) · Bioengineered · doi:10.1080/21655979.2021.1889130 · Cited by 40
“CircRNAs are stable and conserved, and they are usually expressed at specific developmental stages or in specific tissues [6].”
BackgroundSong, T., Xu, A., Chen, X., Gao, J., Gao, F., & Kong, X. (2021) · The Kaohsiung Journal of Medical Sciences · doi:10.1002/kjm2.12378 · Cited by 37
“Characterized as a covalently closed continuous loop, circRNAs have no 50 to 30 polarity and polyadenylation tails.(7) With the progress of high-throughput sequence, increasing circRNAs have been identified.”
BackgroundZhang, Z., Yang, B., Huang, J., Li, W., Yi, P., Yi, M., & Peng, W. (2021) · Pharmaceutical Biology · doi:10.1080/13880209.2021.1893347 · Cited by 37
“Circular RNAs (circRNAs) are an emerging class of ncRNA and represent a class of closed circRNA molecules that are enriched in neural tissues and exert a range of neural functions (Qu et al. 2015).”
BackgroundCDR1as regulated by hnRNPM maintains stemness of periodontal ligament stem cells via miR‐7/KLF4
Gu, X., Li, X., Jin, Y., Zhang, Z., Li, M., Liu, D., & Wei, F. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16541 · Cited by 37
Circular RNA circ_RANBP9 exacerbates polycystic ovary syndrome via microRNA-136-5p/ XIAP axis
Lu, X., Gao, H., Zhu, B., & Lin, G. (2021) · Bioengineered · doi:10.1080/21655979.2021.1964157 · Cited by 37
“Circular RNAs (circRNAs) are covalently closed continuous loops, the majority of which are conserved and stable in different species [6].”
BackgroundCircular RNAs in pulmonary hypertension: Emerging biological concepts and potential mechanism
Wang, Q., Sun, Y., Zhao, Q., Wu, W., Wang, L., Miao, Y., & Yuan, P. (2022) · Animal Models and Experimental Medicine · doi:10.1002/ame2.12208 · Cited by 36
Role of circular RNA in myocardial ischemia and ageing-related diseases
Gao, X., Tian, X., Huang, Y., Fang, R., Wang, G., Li, D., Zhang, J., Li, T., & Yuan, R. (2022) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2022.04.005 · Cited by 37
Transcriptomic analysis of the role of RasGEF1B circular RNA in the TLR4/LPS pathway
Ng, W. L., Marinov, G. K., Chin, Y., Lim, Y., & Ea, C.-K. (2017) · Scientific Reports · doi:10.1038/s41598-017-12550-w · Cited by 36
MiR‐145 affected the circular RNA expression in prostate cancer LNCaP cells
He, J., Han, Z., Zhou, J., Chen, W., Lv, Y., He, M. L., & Li, Y. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27181 · Cited by 36
“Therefore, it has the potential to be used as a tumor biomarker.(6,7) A recent study has demonstrated that circRNA could function as a microRNA (miRNA) sponge and participate in the regulation of gene transcription.”
BackgroundAntitumor effects of circ‐EPHB4 in hepatocellular carcinoma via inhibition of HIF‐1α
Tan, Y.-H., Du, B., Zhan, Y., Wang, K., Wang, X., Chen, B., Wei, X., & Xiao, J. (2019) · Molecular Carcinogenesis · doi:10.1002/mc.22976 · Cited by 36
“loops.(9,10) Based on the development and extensive use of sequencing and bioinformatics techniques, several circRNAs have been identified”
BackgroundA novel strategy of identifying circRNA biomarkers in cardiovascular disease by meta‐analysis
Li, J., Wang, W., Wang, X., He, Y., Wang, S., & Yan, Y. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28817 · Cited by 36
“The advance in RNA sequencing and microarray technology has boosted extensive research of circRNAs among many species such as human, rat, mice, plant, and drosophila (Ashwal‐Fluss et al., 2014; Guo, Agarwal, Guo, & Bartel, 2014; Memczak et al., 2013; Qu et al., 2015).”
BackgroundRole of Long Noncoding RNAs and Circular RNAs in Nerve Regeneration
Yao, C., & Yu, B. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00165 · Cited by 36
“In addition to circRNAs formed from exon back-splicing circularization, there are various types of circRNAs existed according to different biogenesis mechanisms, such as circular viral RNA genomes, circRNA intermediates, spliced introns and exons production (Qu et al., 2015; Chen, 2016).”
BackgroundLuo, Q., Zeng, L., Zeng, L., Rao, J., Zhang, L., Guo, Y., Huang, Z., & Li, J. (2020) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2020.4498 · Cited by 36
Guo, M., Qiu, J., Shen, F., Wang, S., Yu, J., Zuo, H., Yao, J., Xu, S., Hu, T., Wang, D., et al. (2020) · Aging · doi:10.18632/aging.102932 · Cited by 36
“CircRNAs classically function as miRNA sponges to exert their regulatory effects on gene expression [26].”
BackgroundResultRen, T., Liu, C., Hou, J., & Shan, F. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s235231 · Cited by 36
Zhang, Y., Gao, T., Li, X., Wen, C., Yan, X., Peng, C., & Yun, X. (2020) · Gene · doi:10.1016/j.gene.2020.145079 · Cited by 36
circRNA circ-MYBL2 is a novel tumor suppressor and potential biomarker in multiple myeloma
Yu, S., Ai, L., Wei, W., & Pan, J. (2020) · Human Cell · doi:10.1007/s13577-020-00441-8 · Cited by 35
Circ_0001421 facilitates glycolysis and lung cancer development by regulating miR-4677-3p/CDCA3
Zhang, K., Hu, H., Xu, J., Qiu, L., Chen, H., Jiang, X., & Jiang, Y. (2020) · Diagnostic Pathology · doi:10.1186/s13000-020-01048-1 · Cited by 36
Circular RNAs: Their Role in the Pathogenesis and Orchestration of Breast Cancer
He, X., Xu, T., Hu, W., Tan, Y., Wang, D., Wang, Y., Zhao, C., Yi, Y., Xiong, M., Lv, W., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.647736 · Cited by 36
“With the advancement of high-throughput sequencing technology, emerging evidence indicates that circRNAs are widespread in mammals and their functions have been further explored (Qu et al., 2015).”
Background
Metadata
- Authors
- Qu, S., Yang, X., Li, X., Wang, J., Gao, Y., Shang, R., Sun, W., Dou, K., & Li, H.
- Affiliations
- Xijing Hospital (CN)
- Corresponding author
- Li, Haimin
- Venue
- Cancer Letters
- Publisher
- Elsevier BV
- Published
- 2015-09
- Volume
- 365
- Issue
- 2
- Pages
- 141-148
- ISSN
- 0304-3835 (ISSN-L)
- OpenAlex
- W1866220599
- Cited by
- 1,808
- References
- 71
- Citations by year
- 2026: 30 · 2025: 71 · 2024: 142 · 2023: 176 · 2022: 236 · 2021: 328 · 2020: 326 · 2019: 205 · 2018: 154 · 2017: 75 · 2016: 52 · 2015: 7
- FWCI
- 9.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cancer Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81772061)
- Health Public Welfare Industry Special Scientific Research Projects of China (201202007)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Circular RNAs in diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Keywords
- circular RNA, circRNA biogenesis, RNA-binding proteins, microRNA sponge, RNA splicing regulation, transcriptional regulation, circRNA stability, disease biomarkers, colorectal cancer, pancreatic ductal adenocarcinoma, atherosclerosis, neurological disorders, prion disease, long non-coding RNA
- MeSH terms
- RNA, Circular, Exoribonucleases, Gene Expression Regulation, Humans, Neoplasms, RNA, RNA Splicing, Transcription, Genetic, RNA, Untranslated
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
