Cited by 1,808Circular RNAs in diseasesRNA Research and SplicingCancer-related molecular mechanisms research

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Circular RNA: A new star of noncoding RNAs

Qu, Shibin, Yang, Xisheng, Li, Xiaolei, Wang, Jianlin, Gao, Yuan, Shang, Runze, Sun, Wei, Dou, Kefeng, Li, Haimin·2015·Cancer Letters

DOI 10.1016/j.canlet.2015.06.003

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Abstract

Circular RNAs (circRNAs) are a novel type of RNA that, unlike linear RNAs, form a covalently closed continuous loop and are highly represented in the eukaryotic transcriptome. Recent studies have discovered thousands of endogenous circRNAs in mammalian cells. CircRNAs are largely generated from exonic or intronic sequences, and reverse complementary sequences or RNA-binding proteins (RBPs) are necessary for circRNA biogenesis. The majority of circRNAs are conserved across species, are stable and resistant to RNase R, and often exhibit tissue/developmental-stage-specific expression. Recent research has revealed that circRNAs can function as microRNA (miRNA) sponges, regulators of splicing and transcription, and modifiers of parental gene expression. Emerging evidence indicates that circRNAs might play important roles in atherosclerotic vascular disease risk, neurological disorders, prion diseases and cancer; exhibit aberrant expression in colorectal cancer (CRC) and pancreatic ductal adenocarcinoma (PDAC); and serve as diagnostic or predictive biomarkers of some diseases. Similar to miRNAs and long noncoding RNAs (lncRNAs), circRNAs are becoming a new research hotspot in the field of RNA and could be widely involved in the processes of life. Herein, we review the formation and properties of circRNAs, their functions, and their potential significance in disease.

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Natural RNA circles function as efficient microRNA sponges
Hansen, T. B., Jensen, T. I., Clausen, B. H., Bramsen, J. B., Finsen, B., Damgaard, C. K., & Kjems, J. (2013) · Nature · doi:10.1038/nature11993 · Cited by 7,985
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Esquela-Kerscher, A., & Slack, F. J. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1840 · Cited by 5,884
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circRNA biogenesis competes with pre-mRNA splicing
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Li, Z., Huang, C., Bao, C., Chen, L., Lin, M., Wang, X., Zhong, G., Yu, B., Hu, W., Dai, L., et al. (2015) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2959 · Cited by 2,905
Detecting and characterizing circular RNAs
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Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures
Sanger, H. L., Klotz, G., Riesner, D., Gross, H. J., & Kleinschmidt, A. K. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.11.3852 · Cited by 2,296
Circular RNAs Are the Predominant Transcript Isoform from Hundreds of Human Genes in Diverse Cell Types
Salzman, J., Gawad, C., Wang, P. L., Lacayo, N., & Brown, P. O. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030733 · Cited by 2,239
Circular intronic long noncoding RNAs
Zhang, Y., Zhang, X.-O., Chen, T., Xiang, J.-F., Yin, Q.-F., Xing, Y.-H., Zhu, S., Yang, L., & Chen, L.-L. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.08.017 · Cited by 2,221

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“Recently, circular RNAs (circRNAs), a new type of non-coding RNAs derived from back-spliced exons and intron-derived RNAs forming a specific covalently closed loop structure have received extensive attention (Qu et al., 2015; Wang et al., 2019).”
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“Circular RNAs (circRNAs) are a class of noncoding RNAs molecules possessing ring structures which have no 5ʹ-3ʹ polarity and polyA tail; besides, circRNAs are highly represented in the eukaryotic transcriptome and often show specie-, tissue- and cell-specific expressed [7,8], which suggest important functions for thes…”
Background
Screening of cashmere fineness-related genes and their ceRNA network construction in cashmere goats
Hui, T., Zheng, Y., Chang, Y., Wang, Y., Bai, Z., Sun, J., Cai, W., Zhang, X., Bai, W., & Wang, Z. (2021) · Scientific Reports · doi:10.1038/s41598-021-01203-8 · Cited by 29
Exosomal circDNER enhances paclitaxel resistance and tumorigenicity of lung cancer via targeting miR ‐139‐5p/ ITGB8
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“To date, it has been proven that circRNAs play a vital role and participate in proliferation, invasion, and metastasis in various malignancies, including bladder, pancreatic, and esophageal cancers.(3) Previous studies have shown that circRNAs can regulate tumor pathological progression and may serve as potential diag…”
Background
The profiles and networks of miRNA, lncRNA, mRNA, and circRNA in benzo(a)pyrene-transformed bronchial epithelial cells
Jiang, X., Wu, X., Chen, F., He, W., Chen, X., Liu, L., & Tang, H. (2018) · The Journal of Toxicological Sciences · doi:10.2131/jts.43.281 · Cited by 28
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Zhou, L., Yang, L., Jiang, W., Zhang, H., Wen, Z., Su, Y., Wu, F., Zhi, Z., Shen, Q., Li, H., et al. (2018) · Cell Cycle · doi:10.1080/15384101.2018.1480210 · Cited by 27
“[23], we then forecasted the potential targets of circ-PRKCI (RegRNA, Circinteractome, miRDB), and miR-1324 might be the most potentially complementary miRNA to bind with circPRKCI.”
Background
Profiling and bioinformatics analyses reveal differential expression of circular RNA in tongue cancer revealed by high‐throughput sequencing
Qiu, X., Xu, K., Ma, H., Han, L., Chen, Q., Zhang, S., Da, P., & Wu, H. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27695 · Cited by 28
“It was originally misclassified as a junk by product of selective splicing of pre‐messenger RNA (pre‐mRNA).(7,8) Currently, however, circRNA is considered to be similar to mRNA and an important product of pre‐mRNA processing.”
BackgroundMethod
Altered expression pattern of circular RNAs in metastatic oral mucosal melanoma.
Ju, H., Zhang, L., Mao, L., Liu, S., Xia, W., Hu, J., Ruan, M., & Ren, G. (2018) · Europe PMC (PubMed Central) · Cited by 28
Circular RNA MTO1 suppresses tumorigenesis of gastric carcinoma by sponging miR‐3200-5p and targeting PEBP1
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Circular RNA PVT1 promotes the invasion and epithelial–mesenchymal transition of breast cancer cells through serving as a competing endogenous RNA for miR-204-5p
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Retracted
Circular RNA circNHSL1 Contributes to Gastric Cancer Progression Through the miR-149-5p/YWHAZ Axis
Hui, C., Tian, L., & He, X. (2020) · Cancer Management and Research · doi:10.2147/cmar.s253152 · Cited by 28
“Currently, circular RNAs (circRNAs), covalently linked to form a closed loop without 5ʹ caps or 3ʹ poly (A) tails, can regulate gene expression at the transcriptional or posttranscriptional level.(4) It was previously reported that circRNAs were widely expressed in exosomes and plasma, tissues and spatiotemporal speci…”
Background
Biogenesis of circular RNAs and their role in cellular and molecular phenotypes of neurological disorders
Guerra, B., Lima, J. E., Araujo, B., Torres, L. A. G. M. M., Santos, J. X., Machado, D., Cunha, E., Serrato, J., de Souza, J., Martins, J., et al. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.08.003 · Cited by 28
Circ_0084927 Facilitates Cervical Cancer Development via Sponging miR-142-3p and Upregulating ARL2
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Retracted
The diverse roles of circular RNAs in pancreatic cancer
Chen, S., Chen, C., Hu, Y., Song, G., & Shen, X. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107869 · Cited by 29
Circular RNA circLMF1 regulates PDGF-BB-induced proliferation and migration of human aortic smooth muscle cells by regulating the miR-125a-3p/VEGFA or FGF1 axis
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“Up to now, an extensive body of recent research has focused on non-coding RNAs, particularly circular RNAs (circRNAs), which are formed by back-splicing covalently closed-loop structures [9, 10].”
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“CircRNAs are largely generated from exonic or intronic sequences, and reverse complementary sequences or RNA-binding proteins (RBPs) are necessary for circRNA biogenesis [77,78].”
Background
Exploring the physiological roles of circular RNAs in livestock animals
Raza, S. H. A., Wijayanti, D., Pant, S. D., Abdelnour, S. A., Hashem, N. M., Amin, A. A., Wani, A. K., Prakash, A., Dawood, M. A. O., & Zan, L. (2022) · Research in Veterinary Science · doi:10.1016/j.rvsc.2022.09.036 · Cited by 28
Construction of Genetically Encoded Light-Up RNA Aptamers for Label-free and Ultrasensitive Detection of CircRNAs in Cancer Cells and Tissues
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Identification of circular RNA in the Bombyx mori silk gland
Gan, H., Feng, T., Wu, Y., Liu, C., Xia, Q., & Cheng, T. (2017) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2017.09.003 · Cited by 28
YAP1 inhibits circRNA-000425 expression and thus promotes oncogenic activities of miR-17 and miR-106
Liu, Z., Huang, S., Cao, Y., Yao, Y., Li, J., Chen, J., Jiang, B., Yuan, X., Xiang, X., Xiong, J., et al. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.06.163 · Cited by 27
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Circular RNA circVAPA Promotes Cell Proliferation in Hepatocellular Carcinoma
Liu, C., Zhong, X., Li, J., & Xu, F. (2019) · Human Gene Therapy Clinical Development · doi:10.1089/humc.2019.079 · Cited by 27
Role of CircRNAs_100395 in Proliferation and Metastases of Liver Cancer
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“In addition, the multifunctionality of circRNAs has been gradually elaborated, including the splicing and transcriptional regulation of specific RNAs and the interaction with RNA-binding proteins [11,12].”
Background
Circular RNA expression profiles in extracellular vesicles from the plasma of patients with pancreatic ductal adenocarcinoma
Li, Q., Geng, S., Yuan, H., Li, Y., Zhang, S., Pu, L., Ge, J., Niu, X., Li, Y., & Jiang, H. (2019) · FEBS Open Bio · doi:10.1002/2211-5463.12741 · Cited by 27
Circular RNAs and cancer: Opportunities and challenges
Solé, C., & Lawrie, C. H. (2020) · Advances in clinical chemistry · doi:10.1016/bs.acc.2020.02.008 · Cited by 27
Epigenetic Regulation of Differentially Expressed Drug-Metabolizing Enzymes in Cancer
Wang, J., Yu, L., Jiang, H., Zheng, X., & Zeng, S. (2020) · Drug Metabolism and Disposition · doi:10.1124/dmd.120.000008 · Cited by 27
“They have a closed-loop structure and exist in a lot of eukaryotic transcriptomes (Qu et al., 2015).”
Background
Circular RNA MTO1 Inhibits the Proliferation and Invasion of Ovarian Cancer Cells Through the miR-182-5p/KLF15 Axis
Wang, N., Cao, Q., Tian, J., Ren, L., Cheng, H., & Yang, S.-Q. (2020) · Cell Transplantation · doi:10.1177/0963689720943613 · Cited by 27
“3 Circular RNAs (circRNAs) are a novel class of endogenous noncoding RNAs and characterized by covalently closed loop structures [10, 11].”
Background
Circular RNA has_circ_0000034 accelerates retinoblastoma advancement through the miR-361-3p/ADAM19 axis
Jiang, Y., Xiao, F. R., Wang, L., Wang, T., & Chen, L. (2020) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-020-03886-5 · Cited by 27
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Circ0120816 acts as an oncogene of esophageal squamous cell carcinoma by inhibiting miR-1305 and releasing TXNRD1
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PCirc: random forest-based plant circRNA identification software
Yin, S., Tian, X., Zhang, J., Sun, P., & Li, G. (2021) · BMC Bioinformatics · doi:10.1186/s12859-020-03944-1 · Cited by 27
Regulating effect of Circ_ATRNL1 on the promotion of SOX9 expression to promote chondrogenic differentiation of hAMSCs mediated by MiR‐145‐5p
Zhu, J., Fu, Q., Shao, J., Peng, J., Qian, Q., Zhou, Y., & Chen, Y. (2021) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.3189 · Cited by 27
“CircRNAs differ from linear RNAs as they form cova- lently closed continuous rings and are highly expressed in eukaryotic transcriptomes (Qu et al., 2015).”
Background
iCircDA-LTR: identification of circRNA–disease associations based on Learning to Rank
Wei, H., Xu, Y. D., & Liu, B. (2021) · Bioinformatics · doi:10.1093/bioinformatics/btab334 · Cited by 27
Circular RNA circPVT1 Contributes to Doxorubicin (DXR) Resistance of Osteosarcoma Cells by Regulating TRIAP1 via miR‐137
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Circular RNA circ_0001588 sponges miR‐211‐5p to facilitate the progression of glioblastoma via up‐regulating YY1 expression
Wang, Q., Zheng, D., Li, Y., Zhang, Y., Sui, R., Chen, Y., Liang, H., Shi, J., Pan, R., Xu, X., et al. (2021) · The Journal of Gene Medicine · doi:10.1002/jgm.3371 · Cited by 27
“Circular RNAs (circRNAs) are a type of endogenous RNA molecules with covalently end-to-end connection.(7,8) Numerous have shown that circRNAs are dysregulated in various tumors, which sug-”
Background
circRNA-DURSA regulates trophoblast apoptosis via miR-760-HIST1H2BE axis in unexplained recurrent spontaneous abortion
Tang, M., Bai, L., Wan, Z., Wan, S., Xiang, Y., Qian, Y., Cui, L., You, J., Hu, X., Qu, F., et al. (2021) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2021.06.012 · Cited by 27
“in URSA and normal pregnancy With the advances in microarray and sequencing technologies, circRNAs have been identified in many tissues across different species, prompting research into new circRNA-based diagnostic and therapeutic tools.(11,24) To assess circRNA expression and distinct competing endogenous (ceRNA) net…”
Method
Identifying a novel biological mechanism for alcohol addiction associated with circRNA networks acting as potential miRNA sponges
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“CircRNAs are abundantly and dynamically expressed throughout the mammalian central nervous system (CNS).(12,13) They primarily arise from pre-mRNA splicing events in which the 50 and 30 ends of introns or alternatively spliced exons are covalently linked to form closed-loop structures.”
Background
High-throughput sequencing identified circular RNA circUBE2K mediating RhoA associated bladder cancer phenotype via regulation of miR-516b-5p/ARHGAP5 axis
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Integrated reporting, audit quality: presence of environmental auditing in an international context
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Extracellular vesicles in gastric cancer: role of exosomal lncRNA and microRNA as diagnostic and therapeutic targets
Jiang, C., Zhang, J., Wang, W., Shan, Z., Sun, F., Tan, Y., Tong, Y., & Qiu, Y. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1158839 · Cited by 26
“Compared to linear RNAs, circular RNAs (circRNAs) have a distinct structure in which the 5′ and 3′ends are directly covalently joined to form a loop structure devoid of a 3′ tail or 5′cap structure (Qu et al., 2015; Salzman, 2016).”
Background
Role of a novel circRNA-CGNL1 in regulating pancreatic cancer progression via NUDT4–HDAC4–RUNX2–GAMT-mediated apoptosis
Yuan, H., Chen, C., Li, H., Qu, G., Chen, L., Liu, Y., Zhang, Y., Zhao, Q., Lian, C., Ji, A., et al. (2024) · Molecular Cancer · doi:10.1186/s12943-023-01923-7 · Cited by 28
“CircRNA dysregulation has been identified in assorted cancers, but the associated roles and mechanisms remain unclear in most cases [33, 34].”
Background
Circular RNA alterations in the Bombyx mori midgut following B. mori nucleopolyhedrovirus infection
Hu, X., Zhu, M., Liu, B., Liang, Z., Huang, L., Xu, J. C., Yu, L., Li, K., Jiang, M., Xue, R., et al. (2018) · Molecular Immunology · doi:10.1016/j.molimm.2018.08.008 · Cited by 27
Possible epigenetic regulatory effect of dysregulated circular RNAs in epilepsy
Lee, W.-J., Moon, J., Jeon, D., Kim, T., Yoo, J.-S., Park, D.-K., Lee, S., Jung, K., Park, K., Jung, K., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0209829 · Cited by 27
circNFATC3 sponges miR‐548I acts as a ceRNA to protect NFATC3 itself and suppressed hepatocellular carcinoma progression
Jia, C., Yao, Z., Lin, Z., Zhao, L., Cai, X., Chen, S., Deng, M., & Zhang, Q. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29931 · Cited by 27
CircZNF609 regulates pulmonary fibrosis via miR-145-5p/KLF4 axis and its translation function
Sun, W., Zhou, S., Lan, P., Liu, Y., Cheng, D., Wang, Y., & Ni, C. (2023) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-023-00518-w · Cited by 26
“These RNAs were first found in viruses in 1976 and have recently been reported to be abundant in mammalian cells [8].”
Background
CircBIRC6 facilitates the malignant progression via miR-488/GRIN2D-mediated CAV1-autophagy signal axis in gastric cancer
Tang, Z., Li, J., Lu, B., Zhang, X., Yang, L., Yue, Q., Jiang, S., Wu, Q., Wang, Y., Cheng, T., et al. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107127 · Cited by 27
Genome-wide analysis of circular RNAs in goat skin fibroblast cells in response to Orf virus infection
Pang, F., Zhang, M., Yang, X., Li, G., Zhu, S., Nie, X., Cao, R., Yang, X., Zhang, Z., Huang, H., et al. (2019) · PeerJ · doi:10.7717/peerj.6267 · Cited by 26
“Increasing evidence suggests that circRNAs can function as competing endogenous RNAs (ceRNAs) or miRNA sponges, thereby acting as post-transcriptional regulatory elements (Hansen et al., 2013;Qu et al., 2015; Zhang et al., 2016).”
Background
Circ_0005075 promotes hepatocellular carcinoma progression by suppression of microRNA‐335
Yang, X., Song, H., Zi, Z., Kou, J., Chen, S., Dai, Y., Wang, J., Yuan, L., & Gao, K. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28757 · Cited by 26
“Circular RNAs (circRNAs) are a class of newly defined endogenous noncoding RNAs which may play a key role in gene expression regulation in mammals (Lasda & Parker, 2014; Qu et al., 2015).”
Background
Microarray Profiling of Circular RNA Identifies hsa_circ_0126991 as a Potential Risk Factor for Essential Hypertension
Liu, L., Gu, T., Bao, X., Zheng, S., Zhao, J., & Zhang, L. (2019) · Cytogenetic and Genome Research · doi:10.1159/000500063 · Cited by 26
“The most significant properties of circRNAs are that they are highly stable, tissue/development-stage-specific, and conserved [Jeck et al., 2013; Li et al., 2015a; Qu et al., 2015].”
Background
Altered expression of circular RNA in primary Sjögren’s syndrome
Su, L., Xu, W., Liu, X.-Y., Fu, L., & Huang, A. (2019) · Clinical Rheumatology · doi:10.1007/s10067-019-04728-6 · Cited by 26
Circ_0006332 promotes growth and progression of bladder cancer by modulating MYBL2 expression via miR-143
Ming-shan, L., Liu, Y., Liu, J., Li, W., Li, N., Xue, D., Zhang, X., & Wang, P. (2019) · Aging · doi:10.18632/aging.102481 · Cited by 26
“Sanger forward sequencing and FISH analysis [13] shows that circ_0006332 has a special ring structure and is generated from the sequence of the splice junction between exons 8 and 9 of the MYBL2 transcript.”
Background
RETRACTED: Circular RNA circ-FoxO3 Inhibits Myoblast Cells Differentiation
Li, X., Li, C., Liu, Z., Ni, W., Yao, R., Xu, Y., Quan, R., Zhang, M., Li, H., Liu, L., et al. (2019) · Cells · doi:10.3390/cells8060616 · Cited by 27
“Studies have shown that circRNA molecules contain an miRNA response element (MRE), which can act as competitive endogenous RNAs (ceRNAs) and bind with miRNAs to play the role of the miRNA sponge in the cell, in order to release the inhibitory effect of miRNA on target genes and regulate the expression level of target…”
Background
Retracted
High Throughput Sequencing of circRNAs in Tomato Leaves Responding to Multiple Stresses of Drought and Heat
Zhou, R., Yu, X., Ottosen, C., & Zhao, T. (2019) · Horticultural Plant Journal · doi:10.1016/j.hpj.2019.12.004 · Cited by 26
Circular RNA expression profiling in the fetal side of placenta from maternal polycystic ovary syndrome and circ_0023942 inhibits the proliferation of human ovarian granulosa cell
Zhao, C., Zhou, Y., Shen, X., Gong, M., Lu, Y., Fang, C., Chen, J., & Ju, R. (2020) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-020-05495-5 · Cited by 26
Screening Circular RNAs Related to Acquired Gefitinib Resistance in Non-small Cell Lung Cancer Cell Lines
Wen, C., Xu, G., He, S., Huang, Y., Shi, J., Wu, L., & Zhou, H. (2020) · Journal of Cancer · doi:10.7150/jca.39783 · Cited by 26
Cell proliferation and invasion is promoted by circSERPINA3 in nasopharyngeal carcinoma by regulating miR-944/MDM2 axis
Liu, R., Zhou, M., Zhang, P., Zhao, Y., & Zhang, Y. (2020) · Journal of Cancer · doi:10.7150/jca.42799 · Cited by 26
“Unlike linear RNAs, circular RNAs (circRNAs) have a characteristic covalent closed loop structure, with a lack of 5' 3' polarity or a polyadenylation tail [5, 6].”
Background
CircAPLP2 regulates the proliferation and metastasis of colorectal cancer by targeting miR-101-3p to activate the Notch signalling pathway.
Wu, H., Huang, S., Lu, C.-G., Shao-dong, T., & Chen, M. (2020) · PubMed Central · Cited by 26
Circular RNA circ_0091579 Promotes Hepatocellular Carcinoma Proliferation, Migration, Invasion, and Glycolysis Through miR-490-5p/CASC3 Axis
Liu, W., Yin, C., & Liu, Y. (2020) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1089/cbr.2019.3472 · Cited by 26
“7 Usually, circRNAs regulated transcription and translation by acting as microRNA (miRNA) and RNA binding protein sponges or directly binding to the mRNA translation start site.”
CircRNA-1926 Promotes the Differentiation of Goat SHF Stem Cells into Hair Follicle Lineage by miR-148a/b-3p/CDK19 Axis
Yin, R. H., Zhao, S. J., Jiao, Q., Wang, Z. Y., Bai, M., Fan, Y. X., Zhu, Y. B., & Bai, W. L. (2020) · Animals · doi:10.3390/ani10091552 · Cited by 26
CircTBL1XR1/miR-424 axis regulates Smad7 to promote the proliferation and metastasis of colorectal cancer
Li, N. (2020) · Journal of Gastrointestinal Oncology · doi:10.21037/jgo-20-395 · Cited by 26
“found that hsa_circ_001569 can sponge miR-145 to regulate the E2F5, BAG4, and FMNL2 genes, thereby promoting the proliferation and invasion of colorectal cancer (11).”
Background
CircZKSCAN1 Suppresses Hepatocellular Carcinoma Tumorigenesis by Regulating miR-873-5p/Downregulation of Deleted in Liver Cancer 1
Li, J., Bao, S.-Y., Wang, L., & Wang, R. (2021) · Digestive Diseases and Sciences · doi:10.1007/s10620-020-06789-z · Cited by 26
Circ_RPL23A acts as a miR-1233 sponge to suppress the progression of clear cell renal cell carcinoma by promoting ACAT2
Cheng, L., Cao, H., Xu, J., Xu, M., He, W., Zhang, W., Dong, L., & Chen, D. (2021) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-021-09901-8 · Cited by 26
A survey of circular RNAs in complex diseases: databases, tools and computational methods
Xiao, Q., Dai, J., & Luo, J. (2021) · Briefings in Bioinformatics · doi:10.1093/bib/bbab444 · Cited by 26
Epigenetic modifications in acute myeloid leukemia: The emerging role of circular RNAs (Review)
Issah, M. A., Wu, D., Zhang, F., Zheng, W., Liu, Y., Fu, H., Zhou, H., Chen, R., & Shen, J. (2021) · International Journal of Oncology · doi:10.3892/ijo.2021.5287 · Cited by 26
Circ_0091579 exerts an oncogenic role in hepatocellular carcinoma via mediating miR-136-5p/TRIM27
Mao, Y., Ding, Z., Jiang, M., Yuan, B., Zhang, Y., & Zhang, X. (2021) · Biomedical Journal · doi:10.1016/j.bj.2021.12.009 · Cited by 26
“[6] Qu S, YangX, Li X,Wang J, Gao Y, Shang R, et al.”
Circ-Ntrk2 acts as a miR-296-5p sponge to activate the TGF-β1/p38 MAPK pathway and promote pulmonary hypertension and vascular remodelling
Su, L., Li, X., Mao, X., Xu, T., Zhang, Y., Li, S., Zhu, X., Wang, L., Yao, D., Wang, J., et al. (2023) · Respiratory Research · doi:10.1186/s12931-023-02385-7 · Cited by 26
“Circular RNAs (circRNAs), as a class of highly conserved regulatory ncRNAs, are derived from exons, introns, or intergenic regions through back-splicing [6, 7].”
Background
Tying malaria and microRNAs: from the biology to future diagnostic perspectives
Rubio, M., Bassat, Q., Estivill, X., & Mayor, A. G. (2016) · Malaria Journal · doi:10.1186/s12936-016-1222-9 · Cited by 29
“Other small regulatory RNAs recently found in malaria parasites, such as circular RNAs (circRNAs) [135], which have been suggested to act as miRNA sponges [136], may also be involved in the regulation against the defences of the host.”
Background
RNAs as Candidate Diagnostic and Prognostic Markers of Prostate Cancer—From Cell Line Models to Liquid Biopsies
Lim, M. C. J., Baird, A., Aird, J. J., Greene, J. P., Kapoor, D., Gray, S. G., McDermott, R., & Finn, S. P. (2018) · Diagnostics · doi:10.3390/diagnostics8030060 · Cited by 26
“This is also reflected by the findings of circRNAs dysregulation across different types of malignancy [174].”
Background
Possible epigenetic regulatory effect of dysregulated circular RNAs in Alzheimer’s disease model
Lee, W. J., Moon, J., Jeon, D., Shin, Y., Yoo, J.-S., Park, D.-K., Lee, S., Jung, K., Park, K., Jung, K., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-48471-z · Cited by 26
Circular RNA cVIM promotes hepatic stellate cell activation in liver fibrosis via miR-122-5p/miR-9-5p-mediated TGF-β signaling cascade
Zhou, Z., Zhang, R., Li, X., Zhang, W., Zhan, Y., Lang, Z., Tao, Q., Yu, J., Yu, S., Yu, Z., et al. (2024) · Communications Biology · doi:10.1038/s42003-024-05797-3 · Cited by 25
“Circular RNAs (circRNAs), a novel class of RNAs generated from protein-coding genes via back splicing, are characterized by covalently closed loop structures without free 3 ′ or 5 ′ ends 12 – 14 .”
Background
CircRNA CDR1as affects functional repair after spinal cord injury and regulates fibrosis through the SMAD pathway
Wang, W., Liu, C., He, D., Shi, G., Song, P., Zhang, B., Tian, L., Wei, J., Jiang, Y., & Ma, L. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107189 · Cited by 28
Circ_0001947 encapsulated by small extracellular vesicles promotes gastric cancer progression and anti-PD-1 resistance by modulating CD8+ T cell exhaustion
Wang, B., Liu, W., Zhang, M., Li, Y., Tang, H., Wang, Y., Song, C., Song, B., & Tan, B. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02826-5 · Cited by 26
“Cir-cRNAs are a type of non-coding RNAs that are highly stable due to their covalent loop structures without 5’ caps, 3’ tails [13].”
Background
Circular RNA hsa_circ_0014243 may serve as a diagnostic biomarker for essential hypertension
Zheng, S., Gu, T., Bao, X., Sun, J., Zhao, J., Zhang, T., & Zhang, L. (2018) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2018.7107 · Cited by 25
“Certain circRNAs are important genetic material of polygenic inheritance and have the ability to inhibit the degradation by RNase R or RNA exonuclease (10).”
Background
Novel circular RNA expression profile of uveal melanoma revealed by microarray
Yang, X., Li, Y., Liu, Y., Xu, X., Wang, Y., Yan, Y., Zhou, W., Yang, J., & Wei, W. (2018) · Chinese Journal of Cancer Research · doi:10.21147/j.issn.1000-9604.2018.06.10 · Cited by 26
Decreased expression of hsa_circ_0072387 as a valuable predictor for oral squamous cell carcinoma
Dou, Z., Li, S., Ren, W., Wang, Q., Liu, J., Kong, X., Gao, L., & Zhi, K. (2019) · Oral Diseases · doi:10.1111/odi.13094 · Cited by 25
Identification of internal control genes for circular RNAs
Zhong, S., Zhou, S., Yang, S., Yu, X., Xu, H., Wang, J., Zhang, Q., Lv, M., & Feng, J. (2019) · Biotechnology Letters · doi:10.1007/s10529-019-02723-0 · Cited by 26
CircPOMT1 and circMCM3AP inhibit osteogenic differentiation of human adipose-derived stem cells by targeting miR-6881-3p.
Huang, X., Cen, X. B., Sun, W., Xia, K., Yu, L.-Y., Liu, J., & Zhao, Z. (2019) · Europe PMC (PubMed Central) · Cited by 25
Systematic identification of circular RNAs and corresponding regulatory networks unveil their potential roles in the midguts of eastern honeybee workers
Chen, D., Chen, H., Du, Y., Zhu, Z., Wang, J., Geng, S., Xiong, C., Zheng, Y., Hou, C., Diao, Q., et al. (2019) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-019-10159-9 · Cited by 25
Overview of noncoding RNAs involved in the osteogenic differentiation of periodontal ligament stem cells
Qiu, W., Wu, B., & Fang, F. (2020) · World Journal of Stem Cells · doi:10.4252/wjsc.v12.i4.251 · Cited by 25
Oestrogen induces epithelial‐mesenchymal transition in endometriosis via circ_0004712/miR‐148a‐3p sponge function
He, X., Liu, N., Mu, T., Lu, D., Jia, C., Wang, S., Yin, C., Liu, L., Zhou, L., Huang, X., et al. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15495 · Cited by 25
Emerging role of non-coding RNAs in response of cancer cells to radiotherapy
Ebahimzadeh, K., Shoorei, H., Mousavinejad, S. A., Anamag, F. T., Dinger, M. E., Taheri, M. N., & Ghafouri‐Fard, S. (2020) · Pathology - Research and Practice · doi:10.1016/j.prp.2020.153327 · Cited by 25
Research Progress of circRNAs in Head and Neck Cancers
Li, P., Zhu, K., Mo, Y., Deng, X., Jiang, X., Shi, L., Guo, C., Zhang, W., Zeng, Z., Li, G., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.616202 · Cited by 25
CircLphn3 protects the blood-brain barrier in traumatic brain injury
Liao, Z.-B., Cheng, Y., Wu, C., Du, M.-R., Zhou, Q., Wu, B., Fu, J., Balawi, E., & Tan, W.-L. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.322467 · Cited by 25
“Circular RNAs (circRNAs) are a new type of RNA molecules with a closed loop structure, which is different from linear RNAs (Qu et al., 2015).”
Background
Circ-RPPH1 knockdown retards breast cancer progression via miR-328-3p-mediated suppression of HMGA2
Li, J., Li, Y., & Cheng, H. (2021) · Clinical Breast Cancer · doi:10.1016/j.clbc.2021.08.009 · Cited by 25
The Potential Role of Genetics, Environmental Factors, and Gut Dysbiosis in the Aberrant Non-Coding RNA Expression to Mediate Inflammation and Osteoclastogenic/Osteogenic Differentiation in Ankylosing Spondylitis
Liao, H., Tsai, C., Lai, C., Hsieh, S., Sun, Y.-S., Li, K., Shen, C., Wu, C.-H., Lu, C., Kuo, Y., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.748063 · Cited by 29
Role of circular RNA cdr1as in modulation of macrophage phenotype
González, C., Cimini, M., Cheng, Z. A., Benedict, C., Wang, C., Trungcao, M., Mallaredy, V., Rajan, S., Garikipati, V. N. S., & Kishore, R. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.121003 · Cited by 24
“Several studies have implicated circRNAs to regulate physiological conditions and disease progression [37].”
Background
N6-Methyladenosine Modification of CIRCKRT17 Initiated by METTL3 Promotes Osimertinib Resistance of Lung Adenocarcinoma by EIF4A3 to Enhance YAP1 Stability
Ji, Y., Zhao, Q., Feng, W., Peng, Y., Hu, B., & Chen, Q. (2022) · Cancers · doi:10.3390/cancers14225582 · Cited by 29
Hsa_circ_0002348 regulates trophoblast proliferation and apoptosis through miR-126-3p/BAK1 axis in preeclampsia
Zhou, J., Zhao, Y., An, P., Zhao, H., Li, X., & Xiong, Y. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04240-1 · Cited by 26
“A growing body of studies has reported that circRNAs involve in various pathobiological process, serving as disease biomarkers, competing endogenous RNA (ceRNA) [8], interacting with RNA binding proteins (RBPs) [9], and being translated into peptide [10].”
Background
Circular RNAs play an important role in late-stage gastric cancer: Circular RNA expression profiles and bioinformatics analyses
Fang, Y., Ma, M., Wang, J., Liu, X., & Wang, Y. (2017) · Tumor Biology · doi:10.1177/1010428317705850 · Cited by 25
Comprehensive circRNA expression profile during ischemic postconditioning attenuating hepatic ischemia/reperfusion injury
Zhang, P., Ming, Y., Ye, Q., & Niu, Y. (2019) · Scientific Reports · doi:10.1038/s41598-018-36443-8 · Cited by 25

Authors: Qu, S., Yang, X., Li, X., Wang, J., Gao, Y., Shang, R., Sun, W., Dou, K., & Li, H.
Affiliations: Xijing Hospital (CN)
Corresponding author: Li, Haimin
ORCID: Qu, Shibin
Li, Xiaolei
Wang, Jianlin
Gao, Yuan
Shang, Runze
Sun, Wei
Dou, Kefeng
Li, Haimin
Venue: Cancer Letters
Publisher: Elsevier BV
Published: 2015-09
Volume: 365
Issue: 2
Pages: 141-148
ISSN: 0304-3835 (ISSN-L)
DOI: 10.1016/j.canlet.2015.06.003
OpenAlex: W1866220599
Cited by: 1,808
References: 71
Citations by year: 2026: 30 · 2025: 71 · 2024: 142 · 2023: 176 · 2022: 236 · 2021: 328 · 2020: 326 · 2019: 205 · 2018: 154 · 2017: 75 · 2016: 52 · 2015: 7
FWCI: 9.30
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cancer Letters (publishedVersion)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (81772061)
Health Public Welfare Industry Special Scientific Research Projects of China (201202007)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Circular RNAs in diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Keywords: circular RNA, circRNA biogenesis, RNA-binding proteins, microRNA sponge, RNA splicing regulation, transcriptional regulation, circRNA stability, disease biomarkers, colorectal cancer, pancreatic ductal adenocarcinoma, atherosclerosis, neurological disorders, prion disease, long non-coding RNA
MeSH terms: RNA, Circular, Exoribonucleases, Gene Expression Regulation, Humans, Neoplasms, RNA, RNA Splicing, Transcription, Genetic, RNA, Untranslated

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Circular RNA: A new star of noncoding RNAs

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