Cited by 1,808Circular RNAs in diseasesRNA Research and SplicingCancer-related molecular mechanisms research

The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.

Circular RNA: A new star of noncoding RNAs

Qu, Shibin, Yang, Xisheng, Li, Xiaolei, Wang, Jianlin, Gao, Yuan, Shang, Runze, Sun, Wei, Dou, Kefeng, Li, Haimin·2015·Cancer Letters

DOI 10.1016/j.canlet.2015.06.003

Open this paper in CoChat — free account

Abstract

Circular RNAs (circRNAs) are a novel type of RNA that, unlike linear RNAs, form a covalently closed continuous loop and are highly represented in the eukaryotic transcriptome. Recent studies have discovered thousands of endogenous circRNAs in mammalian cells. CircRNAs are largely generated from exonic or intronic sequences, and reverse complementary sequences or RNA-binding proteins (RBPs) are necessary for circRNA biogenesis. The majority of circRNAs are conserved across species, are stable and resistant to RNase R, and often exhibit tissue/developmental-stage-specific expression. Recent research has revealed that circRNAs can function as microRNA (miRNA) sponges, regulators of splicing and transcription, and modifiers of parental gene expression. Emerging evidence indicates that circRNAs might play important roles in atherosclerotic vascular disease risk, neurological disorders, prion diseases and cancer; exhibit aberrant expression in colorectal cancer (CRC) and pancreatic ductal adenocarcinoma (PDAC); and serve as diagnostic or predictive biomarkers of some diseases. Similar to miRNAs and long noncoding RNAs (lncRNAs), circRNAs are becoming a new research hotspot in the field of RNA and could be widely involved in the processes of life. Herein, we review the formation and properties of circRNAs, their functions, and their potential significance in disease.

Integrity signals

Registry

Crossref · 10.1016/j.canlet.2015.06.003

Cites

71 of 71 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Circular RNAs are a large class of animal RNAs with regulatory potency
Memczak, S., Jens, M., Elefsinioti, A., Torti, F., Krueger, J., Rybak, A., Maier, L., Mackowiak, S. D., Gregersen, L. H., Munschauer, M., et al. (2013) · Nature · doi:10.1038/nature11928 · Cited by 7,990
Natural RNA circles function as efficient microRNA sponges
Hansen, T. B., Jensen, T. I., Clausen, B. H., Bramsen, J. B., Finsen, B., Damgaard, C. K., & Kjems, J. (2013) · Nature · doi:10.1038/nature11993 · Cited by 7,985
Oncomirs—MicroRNAs with a role in cancer
Esquela-Kerscher, A., & Slack, F. J. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1840 · Cited by 5,884
Circular RNAs are abundant, conserved, and associated with ALU repeats
Jeck, W. R., Sorrentino, J. A., Wang, K., Slevin, M. K., Burd, C. E., Liu, J., Marzluff, W. F., & Sharpless, N. E. (2013) · RNA · doi:10.1261/rna.035667.112 · Cited by 4,388
circRNA biogenesis competes with pre-mRNA splicing
Ashwal-Fluss, R., Meyer, M., Pamudurti, N. R., Ivanov, A., Bartok, O., Hanan, M., Evantal, N., Memczak, S., Rajewsky, N., & Kadener, S. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.08.019 · Cited by 3,083
Exon-intron circular RNAs regulate transcription in the nucleus
Li, Z., Huang, C., Bao, C., Chen, L., Lin, M., Wang, X., Zhong, G., Yu, B., Hu, W., Dai, L., et al. (2015) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2959 · Cited by 2,905
Detecting and characterizing circular RNAs
Jeck, W. R., & Sharpless, N. E. (2014) · Nature Biotechnology · doi:10.1038/nbt.2890 · Cited by 2,710
Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures
Sanger, H. L., Klotz, G., Riesner, D., Gross, H. J., & Kleinschmidt, A. K. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.11.3852 · Cited by 2,296
Circular RNAs Are the Predominant Transcript Isoform from Hundreds of Human Genes in Diverse Cell Types
Salzman, J., Gawad, C., Wang, P. L., Lacayo, N., & Brown, P. O. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030733 · Cited by 2,239
Circular intronic long noncoding RNAs
Zhang, Y., Zhang, X.-O., Chen, T., Xiang, J.-F., Yin, Q.-F., Xing, Y.-H., Zhu, S., Yang, L., & Chen, L.-L. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.08.017 · Cited by 2,221

Flagged first, then by citations

Show all 71 references

Sorted by citations

Items 801–900 of 1,000

circRNA hsa_circ_0005909 Predicts Poor Prognosis and Promotes the Growth, Metastasis, and Drug Resistance of Non-Small-Cell Lung Cancer via the miRNA-338-3p/SOX4 Pathway
Song, H., Meng, D., Wang, J., & Zhang, X. (2021) · Disease Markers · doi:10.1155/2021/8388512 · Cited by 20
“circRNAs are derived mainly from introns or exons, while exonic circRNAs were mainly expressed in the cytoplasm and exhibit better stabilities than linearity RNAs [7].”
Background
RETRACTED ARTICLE: CircHAS2 promotes the proliferation, migration, and invasion of gastric cancer cells by regulating PPM1E mediated by hsa-miR-944
Ma, S., Gu, X., Shen, L., Chen, Y., Chen, Q., Shen, X., & Ju, S. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04158-w · Cited by 20
Retracted
Deregulation of hsa_circ_0001971/miR-186 and hsa_circ_0001874/miR-296 signaling pathways promotes the proliferation of oral squamous carcinoma cells by synergistically activating SHP2/PLK1 signals
Jun, W., Shaobo, O., Xianhua, Z., Zhao, S., Mingyang, C., Fan, X., Ying, C., & Liao, L. (2021) · Scientific Reports · doi:10.1038/s41598-021-99488-2 · Cited by 20
CircRNA hsa_circ_0071336 is associated with type 2 diabetes through targeting the miR‐93‐5p/GLUT4 axis
Yan, Y., Dong, J., Li, Y., Lu, Y., Yang, K., Wang, T., Zhang, X., & Xiao, H. (2022) · The FASEB Journal · doi:10.1096/fj.202200149rr · Cited by 21
RETRACTED: Non-coding RNA in SARS-CoV-2: Progress toward therapeutic significance
Shirvani, H., Jafari, H., Moravveji, S. S., Faranghizadeh, F. A., Talebi, M., Ghanavi, J., Esfandi, F., Najafi, S., Moghadam, M. N., Farnia, P., et al. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.09.105 · Cited by 20
Retracted
Computational model for ncRNA research
Chen, X., & Li, H. (2022) · Briefings in Bioinformatics · doi:10.1093/bib/bbac472 · Cited by 19
Non-coding RNA and their potential role in cardiovascular diseases
Samra, M., & Srivastava, K. (2022) · Gene · doi:10.1016/j.gene.2022.147011 · Cited by 20
Loss of circSRY reduces γH2AX level in germ cells and impairs mouse spermatogenesis
Song, Y., Chen, M., Zhang, Y., Li, J., Liu, B., Li, N., Chen, M., Qiao, M., Wang, N., Cao, Y., et al. (2022) · Life Science Alliance · doi:10.26508/lsa.202201617 · Cited by 21
“Circular RNA (circRNA) is a unique type of non-coding RNA generated through back-splicing to form a covalently linked loop (Memczak et al, 2013; Qu et al, 2015).”
Circular RNAs in ferroptosis: regulation mechanism and potential clinical application in disease
Li, F., Li, P., & Hao, X. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1173040 · Cited by 20
Exosomal circ_0008285 in follicle fluid regulates the lipid metabolism through the miR-4644/ LDLR axis in polycystic ovary syndrome
Yu, L., Wang, C., Zhang, D., Liu, M., Liu, T., Pan, B., Che, Q., Liu, S., Wang, B., Dong, X., et al. (2023) · Journal of Ovarian Research · doi:10.1186/s13048-023-01199-x · Cited by 20
“The bulk of circular RNAs (circRNAs), which are covalently closed continuous loops that are stable across species, are conserved [7].”
Background
RNA nanomedicine in liver diseases
Bakrania, A. K., Mo, Y., Zheng, G., & Bhat, M. (2023) · Hepatology · doi:10.1097/hep.0000000000000606 · Cited by 21
“258] Later, researchers discovered that circRNA can act as miRNA sponge, protein sponge, and scaffold for the formation of protein complexes, [259] enabling them as promising therapeutic targets.”
Exosomal noncoding RNA: A potential therapy for retinal vascular diseases
Heo, J.-I., & Ryu, J. (2024) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2024.102128 · Cited by 21
CircGLIS3 promotes gastric cancer progression by regulating the miR-1343-3p/PGK1 pathway and inhibiting vimentin phosphorylation
Zhang, Y., Wang, X., Liu, W., Lei, T., Qiao, T., Feng, W., & Song, W. C. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-023-04625-2 · Cited by 20
“Compared with their linear counterparts, circRNAs are highly stable due to their circular structure, which makes them potential diagnostic and prognostic biomarkers for various diseases, especially cancer [6].”
The microarray identification circular RNA hsa_circ_0105015 up‐regulated involving inflammation pathway in essential hypertension
He, X., Bao, X., Tao, Z., Sun, J., Zheng, S., Zhong, F., & Zhang, L. (2020) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.23603 · Cited by 20
MicroRNAs in Prion Diseases—From Molecular Mechanisms to Insights in Translational Medicine
Contiliani, D. F., Ribeiro, Y. D. A., de Moraes, V. N., & Pereira, T. C. (2021) · Cells · doi:10.3390/cells10071620 · Cited by 21
“Finally, due to the presence and abnormal expression of circRNAs throughout the development of prion disorder and other diseases, Qu and colleagues suggested the use of these molecules as diagnostic or predictive biomarkers [100].”
Background
Non-Coding RNAs Regulate Spontaneous Abortion: A Global Network and System Perspective
Gan, J., Gu, T., Yang, H., Ao, Z., Cai, G., Hong, L., & Wu, Z. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084214 · Cited by 20
CRBPSA: CircRNA-RBP interaction sites identification using sequence structural attention model
Cao, C., Wang, C., Dai, Q., Zou, Q., & Wang, T. (2024) · BMC Biology · doi:10.1186/s12915-024-02055-0 · Cited by 19
Circular RNA Gprc5a Promotes HCC Progression by Activating YAP1/TEAD1 Signalling Pathway by Sponging miR-1283
Ye, L., Huang, G., Jin, H., & Jian, Z. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s240261 · Cited by 20
Retracted
The Emerging Role of Circ-SHPRH in Cancer
Ju, X., Tang, Y., Qu, R., & Hao, S. (2021) · OncoTargets and Therapy · doi:10.2147/ott.s317403 · Cited by 19
Roles of Non-Coding RNAs as Novel Diagnostic Biomarkers in Parkinson’s Disease
Manna, I., Quattrone, A., Benedittis, S. D., Iaccino, E., & Quattrone, A. (2021) · Journal of Parkinson s Disease · doi:10.3233/jpd-212726 · Cited by 19
“circRNAs, a new class of single-stranded regulatory RNAs, are involved in different mechanisms of action in both physiological and pathological conditions, and recent studies revealed that many circRNAs play important roles in the regulation of gene expression at both transcriptional and post-transcriptional levels, h…”
Background
Circular RNA Circ_0000677 promotes cell proliferation by regulating microRNA-106b-5p/CCND1 in non-small cell lung cancer
Hu, X. T., Wang, P., Qu, C., Zhang, H., & Li, L. (2021) · Bioengineered · doi:10.1080/21655979.2021.1965697 · Cited by 19
“Existing researches established that circRNAs exert a variety of modes of function, of which acting as ‘miRNA sponge’ accounts for a significant part [38].”
Background
Circ_0114427 promotes LPS-induced septic acute kidney injury by modulating miR-495-3p/TRAF6 through the NF-κB pathway
Xu, L., Cao, H., Xu, P., Nie, M., & Zhao, C. (2021) · Autoimmunity · doi:10.1080/08916934.2021.1995861 · Cited by 19
“RNAs (ncRNAs) with covalent closed loop structures [6,7].”
Background
Erotic Figurines : The Cairo Museum Material
Martín, G. (1987) · Göttinger Miszellen: Beiträge zur ägyptologischen Diskussion · Cited by 19
Hsa_circ_0001020 accelerates the lower extremity deep vein thrombosis via sponging miR-29c-3p to promote MDM2 expression
Lou, Z., Ma, H., Li, X., Zhang, F., Du, K., & Wang, B. (2022) · Thrombosis Research · doi:10.1016/j.thromres.2021.12.022 · Cited by 19
Circular RNAs: Novel Biomarkers in Spermatogenesis Defects and Male Infertility
Saberiyan, M., Karimi, E., Safi, A., Movahhed, P., Dehdehi, L., Haririan, N., & Mirfakhraie, R. (2022) · Reproductive Sciences · doi:10.1007/s43032-022-00885-3 · Cited by 19
“CircRNAs have different functions as protein decoys, microRNA sponges, splicing regulators, transcriptional regulators, and translation modifiers [19, 20].”
Background
PRP8-Induced CircMaml2 Facilitates the Healing of the Intestinal Mucosa via Recruiting PTBP1 and Regulating Sec62
Deng, Y., Xu, X., Meng, F., Lou, J., Liao, Y., Li, Q., Zhuang, M., & Sun, Y. J. (2022) · Cells · doi:10.3390/cells11213460 · Cited by 19
““back-to-back splicing” sites and has discovered thousands of circRNAs from transcripts of humans, mice, and other species [9,10].”
CircRNA hsa_circ_0001627 aggravates cervical cancer progression through upregulation of FNDC3B and activating PI3K/mTOR signaling pathway
Li, Y., Meng, F., Sui, C., Wang, Y., & Cheng, D. (2022) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-022-00696-w · Cited by 19
“CircRNAs are resistant to RNA exonuclease degradation, and thus are more stable than related linear mRNAs (Qu et al. 2015).”
Background
CircRNF111 Contributes to Adipocyte Differentiation by Elevating PPARγ Expression via miR-27a-3p
Shen, X., Tang, J., Huang, Y., Lan, X., Lei, C., & Chen, H. (2022) · Epigenetics · doi:10.1080/15592294.2022.2145058 · Cited by 19
“Existing reports indicate that circRNAs function mainly as a miRNA molecular sponge and contain numbers and types of miRNA response elements at varying degrees [49].”
Background
Multi-omics study and ncRNA regulation of anti-BmNPV in silkworms, Bombyx mori: an update
Fan, Y., Andoh, V., & Chen, L. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1123448 · Cited by 19
“With the development of technology, the functions of circRNA have been found not only to act as a miRNA sponge that regulates the transcriptional level but also to encode proteins and regulate protein binding at different levels (Qu et al., 2015; Kristensen et al., 2019).”
Background
Circular RNAs expressed in chorionic villi are probably involved in the occurrence of recurrent spontaneous abortion
Qian, Y., Wang, X., Ruan, H., Rui, C., Mao, P., Cheng, Q., & Jia, R. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.01.172 · Cited by 19
Altered expression patterns of circular RNAs between implantation sites and interimplantation sites in early pregnant mice
Zhang, S., Ding, Y., He, J., Zhang, J., Liu, X., Chen, X., Yan, S., Wang, Y., & Gao, R. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27675 · Cited by 19
“Unlike traditional linear RNAs, circRNAs do not have a free 3′‐ or 5′‐end and are structured as a covalently closed continuous loop, which prevents them from degradation by RNA exonucleases (Qu et al., 2015).”
Background
Cecal CircRNAs Are Associated With the Response to Salmonella Enterica Serovar Enteritidis Inoculation in the Chicken
Zheng, L., Liu, L., Lin, L., Tang, H., Fan, X., Lin, H., & Li, X. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01186 · Cited by 18
“Circular RNAs (CircRNAs), a novel type of noncoding RNAs, compose a class of RNA developing covalently closed loop structures without 5-3 polarities (7) but with widespread,”
Background
Molecular Network-Based Identification of Circular RNA-Associated ceRNA Network in Papillary Thyroid Cancer
Liu, Q., Pan, L.-Z., Hu, M., & Ma, J.-Y. (2019) · Pathology & Oncology Research · doi:10.1007/s12253-019-00697-y · Cited by 19
“Like long non-coding RNA (lncRNAs), circRNA could decrease the cytoplasmic levels of target microRNAs (miRNAs) by absorbing the miRNAs, thus liberating mRNA transcripts targeted by aforementioned miRNAs [6, 7].”
Background
High-throughput sequencing of circRNAs reveals novel insights into mechanisms of nigericin in pancreatic cancer
Xu, Z., Shen, J., Hua, S., Wan, D., Chen, Q., Han, Y., Ren, R., Liu, F., Du, Z., Guo, X., et al. (2019) · BMC Genomics · doi:10.1186/s12864-019-6032-3 · Cited by 19
Circular RNAs regulate its parental genes transcription in the AD mouse model using two methods of library construction
Ma, N., Tie, C., Yu, B., Zhang, W., & Wan, J. (2020) · The FASEB Journal · doi:10.1096/fj.201903157r · Cited by 19
Puerarin Inhibits the Progression of Bladder Cancer by Regulating circ_0020394/miR-328-3p/NRBP1 Axis
Du, L., Zhang, L., & Sun, F. (2020) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1089/cbr.2019.3382 · Cited by 19
“24,25 Thus, we searched the possible miRNAs that could bind to circ_0020394 in the database of StarBase.”
CircRNAs and LncRNAs in Osteoporosis
He, T., Liu, W., Cao, L., Liu, Y., Zi, Z., Zhong, Y., Wang, H., Mo, Y., Peng, S., & Shuai, C. (2020) · Differentiation · doi:10.1016/j.diff.2020.10.002 · Cited by 18
CircSAMD4A contributes to cell doxorubicin resistance in osteosarcoma by regulating the miR-218-5p/KLF8 axis
Wei, W., Ji, L., Duan, W., & Zhu, J. (2020) · Open Life Sciences · doi:10.1515/biol-2020-0079 · Cited by 19
Circ_0035483 Functions as a Tumor Promoter in Renal Cell Carcinoma via the miR-31-5p-Mediated HMGA1 Upregulation
Liu, Z., Wang, R., & Zhu, G. (2021) · Cancer Management and Research · doi:10.2147/cmar.s282806 · Cited by 19
“miRNAs to play their regulatory roles in various kinds of cancers.(8) For example, Mao et al have reported that”
Background
CircSEC24A promotes IL‐1β‐induced apoptosis and inflammation in chondrocytes by regulating miR‐142‐5p/SOX5 axis
Shi, L., Zhang, H., Sun, J., Gao, X., & Liu, C. (2021) · Biotechnology and Applied Biochemistry · doi:10.1002/bab.2145 · Cited by 19
circSLC8A1 Acts as a Tumor Suppressor in Prostate Cancer via Sponging miR‐21
Wang, D., Yan, S., Wang, L., Li, Y., & Qiao, B. (2021) · BioMed Research International · doi:10.1155/2021/6614591 · Cited by 19
“The reverse complementary sequence, containing the inverted repeat Alu pair and exon skipping, is essential for the formation of circRNA [5, 6].”
Background
CircPTK2 (hsa_circ_0003221) Contributes to Laryngeal Squamous Cell Carcinoma by the miR-1278/YAP1 Axis
Yang, Z., Jin, J., & Chang, T. (2021) · Journal of Oncology · doi:10.1155/2021/2408384 · Cited by 19
“Circular RNAs (circRNAs) are endogenous noncoding transcripts generated by pre-mRNA back splicing and are characterized by a covalently closed loop without 5′ caps and 3′ tails [8, 9].”
Background
Exosomes: Potential Biomarkers and Functions in Head and Neck Squamous Cell Carcinoma
Li, T., Li, J., Wang, H., Zhao, J., Yan, M., He, H., & Yu, S. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.881794 · Cited by 18
Macrophages enhance cisplatin resistance in gastric cancer through the transfer of circTEX2
Qu, B., Liu, J., Peng, Z., Xiao, Z., Li, S., Wu, J., Li, S., & Luo, J. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18070 · Cited by 18
“17,18 Their unique structure renders them highly stable and they are widely present in various cell types.”
Background
Computational approaches for circRNA-disease association prediction: a review
Niu, M., Chen, Y., Wang, C., Zou, Q., & Xu, L. (2024) · Frontiers of Computer Science · doi:10.1007/s11704-024-40060-2 · Cited by 18
Overcoming therapy resistance in pancreatic cancer: challenges and emerging strategies
du Toit‐Thompson, T., Leck, L. Y. W., Gillson, J., Pavlakis, N., Gill, A. J., Samra, J. S., Mittal, A., & Sahni, S. (2025) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2025.115647 · Cited by 20
Involvement of Non-coding RNAs in the Signaling Pathways of Colorectal Cancer
Yang, Y., Du, Y., Liu, X., & Cho, W. C. S. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-42059-2_2 · Cited by 19
Identification of differentially expressed circular RNAs in HeLa cells infected with Chlamydia trachomatis
Liu, Y., Hu, C., Sun, Y., Wu, H.-Q., Chen, X., & Liu, Q. (2019) · Pathogens and Disease · doi:10.1093/femspd/ftz062 · Cited by 18
“With the technological breakthroughs of high-throughput sequencing and bioinformatics, circRNAs have been revealed as a class of abundant, stable, conserved and tissue-specific endogenous non-coding RNAs in eukaryotic cells (Qu et al. 2015).”
Background
RETRACTED ARTICLE: Circ-TFCP2L1 Promotes the Proliferation and Migration of Triple Negative Breast Cancer through Sponging miR-7 by Inhibiting PAK1
Wang, Q., Li, Z., Hu, Y., Zheng, W., Tang, W., Zhai, C., Gu, Z., Tao, J., & Wang, H. (2019) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-019-09440-4 · Cited by 18
Retracted
Ovarian Circular RNAs Associated with High and Low Fertility in Large White Sows during the Follicular and Luteal Phases of the Estrous Cycle
Hu, H., Xi, J., Zhou, B., Zhang, J., Li, Z., Liu, Z., & Jia, Q. (2020) · Animals · doi:10.3390/ani10040696 · Cited by 18
“As their 3′- and 5′-termini are joined together [1], circRNAs are resistant to digestion by RNase R and are exceptionally stable in vivo, compared with their linear counterparts [2].”
Background
Hsa_circ_0003732 promotes osteosarcoma cells proliferation via miR-545/CCNA2 axis
Li, L., Kong, X., Zang, M., Dong, J., Feng, Y., Gui, B., & Hu, Y. (2020) · Bioscience Reports · doi:10.1042/bsr20191552 · Cited by 18
The circular RNA circEIF3M promotes breast cancer progression by promoting cyclin D1 expression
Li, X., Ren, Z.-J., Yao, Y., Bao, J., & Yu, Q. (2020) · Aging · doi:10.18632/aging.103539 · Cited by 18
“The R software was used to identify differentially expressed circRNAs [22].”
Method
circAkap17b acts as a miR-7 family molecular sponge to regulate FSH secretion in rat pituitary cells
Wang, C., Gao, F., Huang, Y., Han, D., Zheng, Y., Wang, W., Jiang, H., Gao, Y., Yuan, B., & Zhang, J. (2020) · Journal of Molecular Endocrinology · doi:10.1530/jme-20-0036 · Cited by 18
Nuclear and Mitochondrial Genome, Epigenome and Gut Microbiome: Emerging Molecular Biomarkers for Parkinson’s Disease
Cabral, G. F., Schaan, A. P., Cavalcante, G. C., Sena-dos-Santos, C., de Souza, T. P., Port’s, N. M. D. S., Pinheiro, J. A. D. S., Ribeiro‐dos‐Santos, Â., & Vidal, A. F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189839 · Cited by 18
Oestrogen-induced epithelial-mesenchymal transition (EMT) in endometriosis: Aetiology of vaginal agenesis in Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome
Yuan, T. L., Sulaiman, N. S., Azurah, A. G. N., Maarof, M., Razali, R. A., & Yazid, M. D. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.937988 · Cited by 18
Construction of ceRNA Networks at Different Stages of Somatic Embryogenesis in Garlic
Bai, Y., Liu, M., Zhou, R., Jiang, F., Li, P., Li, M., Zhang, M., Wei, H., & Wu, Z. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065311 · Cited by 18
Circ_0114581 promotes osteogenic differentiation of BMSCs via the MiR-155-5p/HNRNPA3 axis
Li, H., Wang, C., Yao, J., Jin, Y., Song, X., Meng, Q., Wu, J., Liu, Q., Liu, M., & Sun, H. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.122127 · Cited by 18
Non-coding RNAs in gynecologic cancer
Solati, A., Taghvimi, S., Khatami, S. H., Shabaninejad, Z., Malekzadegan, Y., Alizadeh, M., Mousavi, P., Taheri‐Anganeh, M., Razmjoue, D., Bahmyari, S., et al. (2023) · Clinica Chimica Acta · doi:10.1016/j.cca.2023.117618 · Cited by 18
Bridging the gaps in understanding POD and POCD: A thorough examination of genetic and clinical biomarkers
Figueiredo, S., & Devezas, M. (2024) · Perioperative Care and Operating Room Management · doi:10.1016/j.pcorm.2024.100401 · Cited by 19
Analysis of differentially expressed circular RNAs for the identification of a coexpression RNA network and signature in colorectal cancer
Zhang, Z., Song, N., Wang, Y., Zhong, J., Gu, T., Yang, L., Shen, X., Li, Y., Yang, X., Liu, X., et al. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27928 · Cited by 18
“The cyclized exons that retain introns are referred to as exon‐intron circRNAs or EIciRNAs.(12) Different types of circRNAs have different locations within cells, as well as different functions.”
BackgroundInfluential
Mitochondrial mRNA fragments are circularized in a human HEK cell line
Mance, L. G., Mawla, I., Shell, S. M., & Cahoon, A. B. (2019) · Mitochondrion · doi:10.1016/j.mito.2019.11.002 · Cited by 18
Neisseria gonorrhoeae-induced salpingitis is targeted by circular RNA EIF3K via miR-139-5p and regulating MAPK/NF-κB signaling pathway to promotes apoptosis and autophagy bacterial cells
Li, Y., Xu, B., & Li, X. (2020) · Microbial Pathogenesis · doi:10.1016/j.micpath.2020.104051 · Cited by 18
Genome-wide identification and analysis of circular RNAs differentially expressed in the longissimus dorsi between Kazakh cattle and Xinjiang brown cattle.
Yan, X.-M., Zhang, Z., Meng, Y., Li, H., Gao, L., Luo, D., Jiang, H., Gao, Y., Yuan, B., & Zhang, J. (2020) · PubMed Central · doi:10.7717/peerj.8646 · Cited by 18
“CircRNAs, which area newly discovered type of RNA, form covalently closed continuous rings and are expressed at high levels in eukaryotic transcriptomes (Qu et al., 2015).”
Background
circRNA MYLK Accelerates Cervical Cancer via Up-Regulation of RHEB and Activation of mTOR Signaling
Chen, R., Mao, L., Shi, R., Wang, W., & Cheng, J. (2020) · Cancer Management and Research · doi:10.2147/cmar.s238172 · Cited by 18
Role of Circular Ribonucleic Acids in the Treatment of Traumatic Brain and Spinal Cord Injury
Yuan, J., Botchway, B. O. A., Zhang, Y., Wang, X., & Liu, X. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02027-9 · Cited by 18
“Circular RNAs were initially regarded as splicing error or aberrant molecular product; however, its regulating functions have been presently substantiated [35, 36].”
Background
FOXA1-induced circOSBPL10 potentiates cervical cancer cell proliferation and migration through miR-1179/UBE2Q1 axis
Yang, S., Jiang, Y., Ren, X., Feng, D., Zhang, L., He, D., Hong, S., Jin, L., Zhang, F., & Lu, S. (2020) · Cancer Cell International · doi:10.1186/s12935-020-01360-2 · Cited by 18
Knockdown of hsa_circ_0059955 Induces Apoptosis and Cell Cycle Arrest in Nucleus Pulposus Cells via Inhibiting Itchy E3 Ubiquitin Protein Ligase
Kong, D., Gu, R., Zhang, C.-T., & Yin, R. (2020) · Drug Design Development and Therapy · doi:10.2147/dddt.s253293 · Cited by 18
Comprehensive Assessment of Plasma Circ_0004771 as a Novel Diagnostic and Dynamic Monitoring Biomarker in Gastric Cancer
Xu, Y., Kong, S., Qin, X., & Ju, S. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s263536 · Cited by 18
Genome-wide analysis of differentially expressed mRNAs, lncRNAs, and circRNAs in chicken bursae of Fabricius during infection with very virulent infectious bursal disease virus
Huang, X., Zhang, J., Liu, Z., Wang, M., Fan, X., Wang, L., Zhou, H., Jiang, Y., Cui, W., Qiao, X., et al. (2020) · BMC Genomics · doi:10.1186/s12864-020-07129-1 · Cited by 18
Circular RNA circ_0000039 enhances gastric cancer progression through miR-1292-5p/DEK axis
Fan, D., Wang, C., Wang, D., Zhang, N., & Yi, T. (2020) · Cancer Biomarkers · doi:10.3233/cbm-201754 · Cited by 18
“It is formed by back-splicing from immature RNA, lacking 5’ caps and 3’ poly (A) tail [8].”
CircTP53 promotes colorectal cancer by acting as a miR-876-3p sponge to increase cyclin-dependent kinase-like 3 expression
Yan, S., Wei, H., Li, Q., Si, M., Feng, W., & Chen, Z. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109845 · Cited by 18
Silencing of circular RNA_0000326 inhibits cervical cancer cell proliferation, migration and invasion by boosting microRNA-338-3p-dependent down-regulation of CDK4
Wang, Z., Ren, C., Yang, L., Zhang, X., Liu, J., Zhu, Y., & Jiang, D. (2021) · Aging · doi:10.18632/aging.103711 · Cited by 18
Retracted
Genome-Wide Identification of Circular RNAs as a Novel Class of Putative Biomarkers for an Ocular Surface Disease
Li, X., Ge, H., Yao, J., Zhou, Y., Yao, M., Liu, C., Hu, H., Zhu, Y., Shan, K. Y., Yan, B., et al. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000490982 · Cited by 18
The promoting effects of hsa_circ_0050102 in pancreatic cancer and the molecular mechanism by targeting miR-1182/NPSR1
Hua, S., Gao, J., Li, T., Wang, M., You, L., Chen, G., Han, X., & Liao, Q. (2020) · Carcinogenesis · doi:10.1093/carcin/bgaa130 · Cited by 18
Unraveling the advances of non-coding RNAs on the tumor microenvironment: innovative strategies for cancer therapies
Mu, D., Han, B., Huang, H., Zheng, Y., Zhang, J., & Shi, Y. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06629-6 · Cited by 17
“Dysfunction of circRNAs is widely reported in cancer and plays a significant role in the development of various malignant tumors [76].”
Long non‐coding RNA EWSAT1 promoted metastasis and actin cytoskeleton changes via miR‐24‐3p sponging in osteosarcoma
Shen, D., Liu, Y., Liu, Y., Wang, T., Yuan, L., Huang, X., & Wang, Y. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16121 · Cited by 17
Peripheral blood hsa-circRNA5333-4: A novel biomarker for myasthenia gravis
Lv, J., Ren, L., Han, S., Zhang, J., Zhao, X., Zhang, Y., Hua, F., Zhang, L., Yang, H., Wang, S., et al. (2021) · Clinical Immunology · doi:10.1016/j.clim.2021.108676 · Cited by 17
Circular RNA circDNA2 upregulates CCDC6 expression to promote the progression of gastric cancer via miR-149-5p suppression
Jin, D., Huang, K., Peng, L., Xu, P., Dang, Y., Yang, J., Chen, M., Zhu, X., Wei, S., Jin, Y., et al. (2021) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2021.05.021 · Cited by 17
Hsa_circ_0006232 promotes laryngeal squamous cell cancer progression through FUS-mediated EZH2 stabilization
Wu, T., Wang, G., Zeng, X., Sun, Z., Li, S., Wang, W., & Yu, B. (2021) · Cell Cycle · doi:10.1080/15384101.2021.1959973 · Cited by 17
“Circular RNA (circRNA) is a kind of endogenous non-coding RNA with extensiveness and diversity [3].”
Background
Evaluation of methods to detect circular RNAs from single-end RNA-sequencing data
Nguyen, M. H., Nguyen, H.-N., & Vu, T. N. (2022) · BMC Genomics · doi:10.1186/s12864-022-08329-7 · Cited by 18
“CircRNA has also been known to have other diverse functions, including microRNA sponge [3, 4], RNA-binding protein (RBP) sponge [5, 6], gene regulation by competing with pre-mRNA splicing [7], and the parental gene modulation of exon-intron circular RNAs [8, 9].”
Background
circEPSTI1 promotes tumor progression and cisplatin resistance via upregulating MSH2 in cervical cancer
Wu, P., Qin, J., Liu, L., Tan, W., Lei, L., & Zhu, J. (2022) · Aging · doi:10.18632/aging.204152 · Cited by 17
Circ_0004712 Silencing Suppresses the Aggressive Changes of Rheumatoid Arthritis Fibroblast-Like Synoviocytes by Targeting miR-633/TRAF6 Axis
Zhang, S., Shen, Z., Gao, C., Du, X., Zhang, W., Jin, D., & Liu, Y. (2022) · Biochemical Genetics · doi:10.1007/s10528-022-10265-w · Cited by 17
“Circular RNAs (circRNAs) are a unique group of RNAs with continuous loop architecture without free ends (Qu et al. 2015).”
Background
Role of hsa_circ_0000280 in regulating vascular smooth muscle cell function and attenuating neointimal hyperplasia via ELAVL1
Wang, Z., Wang, H., Guo, C., Yu, F., Zhang, Y., Qiao, L., Zhang, H., & Zhang, C. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04602-w · Cited by 17
Circ_0000479 promotes proliferation, invasion, migration and inflammation and inhibits apoptosis of rheumatoid arthritis fibroblast-like synoviocytes via miR-766/FKBP5 axis
Zhao, P., Ma, G., & Ma, L. (2023) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-023-03700-0 · Cited by 17
Noncoding RNAs as an emerging resistance mechanism to immunotherapies in cancer: basic evidence and therapeutic implications
Wang, M., Yu, F., & Li, P. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1268745 · Cited by 17
From molecular pathogenesis to therapy: Unraveling non-coding RNAs/DNMT3A axis in human cancers
Huang, C., & Zarch, S. M. A. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116107 · Cited by 18
Competing endogenous RNA analysis reveals the regulatory potency of circRNA_036186 in HNSCC
Wang, W., Yang, Z. H., Zhang, Y.-J., Lu, P., Ni, Y., Sun, C., & Liu, F. (2018) · International Journal of Oncology · doi:10.3892/ijo.2018.4499 · Cited by 17
“Circular RNAs (circRNAs) are widespread and diverse endogenous ncRNAs with covalently closed circular structures (11,12).”
Salivary Biomarkers in Oral Cancer
Panta, P., & Wong, D. T. (2019) · Springer eBooks · doi:10.1007/978-3-319-61255-3_14 · Cited by 17
Role of circular RNAs in cardiovascular diseases
Gong, X., Wu, G., & Zeng, C. (2019) · Experimental Biology and Medicine · doi:10.1177/1535370218822988 · Cited by 17
“Exon-derived circRNA constitutes the most discovered or studied type yet but mostly for its conduction of post-transcriptional regulation in the cytoplasm.(27) In contrast, intronic circRNAs (ciRNAs) are a niche group, retained in the nucleus and affect gene transcription.”
Background
Identification of circular RNA‐associated competing endogenous RNA network in the development of cleft palate
Shu, X., Cheng, L., Dong, Z., & Shu, S. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28888 · Cited by 17
Circular RNAs in β-cell function and type 2 diabetes-related complications: a potential diagnostic and therapeutic approach
Ghasemi, H., Sabati, Z., Ghaedi, H., Salehi, Z., & Alipoor, B. (2019) · Molecular Biology Reports · doi:10.1007/s11033-019-04937-x · Cited by 16
Downregulated Circular RNA hsa_circ_0000291 Suppresses Migration And Proliferation Of Gastric Cancer Via Targeting The miR-183/ITGB1 Axis
Cao, C., Han, S., Yuan, Y., Wu, Y., Lian, W., Zhang, X., Pan, L., & Li, M. (2019) · Cancer Management and Research · doi:10.2147/cmar.s213830 · Cited by 17
“Several circRNAs appear to regulate gene function in tumorigenesis via sponge miRNA mechanisms.(10,11)”
Background
Changes in the circRNA expression profile of PC12 cells induced by TDCIPP exposure may regulate the downstream NF-κB pathway via the Traf2 gene
Li, Z., Sun, J., Liu, W., Wu, J., Peng, H., Zhao, Y., Qiao, H., & Fang, Y. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.126834 · Cited by 17
Circular RNA MYLK Promotes Hepatocellular Carcinoma Progression Through the miR29a/KMT5C Signaling Pathway
Gao, J., Li, E., Liu, W., Yang, Q., Xie, C., Ai, J., Zhou, F., Liao, W., & Wu, L. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s258715 · Cited by 17
“Recent studies have shown that circRNAs can regulate gene expression by acting as microRNA (miRNA) sponges, transcription regulators, and even RNA-binding protein sequestering agents.(9) However, it is well known that the ceRNA system represents the main means through which circRNAs achieve their biological functions.”
Background
Construction of circRNA-Associated ceRNA Network Reveals Novel Biomarkers for Esophageal Cancer
Sun, Y., Qiu, L., Chen, J., Wang, Y., Qian, J., Huang, L., & Ma, H. (2020) · Computational and Mathematical Methods in Medicine · doi:10.1155/2020/7958362 · Cited by 17
“[39, 40] found that circEIF3J and circPAIP2 with higher expression levels can complement U1 and interact with U1 small ribonucleoprotein to promote the transcription of EIF3J and PAIP2 genes in cis.”
Background
Circular RNA Signature in Lung Adenocarcinoma: A MiOncoCirc Database-Based Study and Literature Review
Zhao, S., Li, S., Liu, W., Wang, Y., Li, X., Zhu, S., Xi, L., & Xu, S. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.523342 · Cited by 17
“After being reported in atherosclerotic vascular disease risk, neurological disorders, and prion diseases (6), circRNAs are also detected to play important roles in the progression of cancer (7).”
Background
Identification, biogenesis and function prediction of novel circRNA during the chicken ALV-J infection
Yang, T., Qiu, L., Bai, M., Wang, L., Hu, X., Huang, L., Chen, G., & Chang, G. (2020) · Animal Biotechnology · doi:10.1080/10495398.2020.1856125 · Cited by 17
hsa_circRNA_000166 Facilitated Cell Growth and Limited Apoptosis through Targeting miR-326/LASP1 Axis in Colorectal Cancer
Hao, Q., & Zhang, Z. (2020) · Gastroenterology Research and Practice · doi:10.1155/2020/8834359 · Cited by 17
Circular RNA AKT3 governs malignant behaviors of esophageal cancer cells by sponging miR-17-5p
Zang, H.-L., Ji, F., Ju, H., & Tian, X. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i3.240 · Cited by 17
Inhibition of intervertebral disc disease progression via the circPKNOX1–miR-370-3p–KIAA0355 axis
Huang, Y., Gao, J., Wang, J., Ye, H., Teng, Y., Xu, Y., Chen, Z., Shen, S., & Ma, J. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00420-4 · Cited by 17

Authors: Qu, S., Yang, X., Li, X., Wang, J., Gao, Y., Shang, R., Sun, W., Dou, K., & Li, H.
Affiliations: Xijing Hospital (CN)
Corresponding author: Li, Haimin
ORCID: Qu, Shibin
Li, Xiaolei
Wang, Jianlin
Gao, Yuan
Shang, Runze
Sun, Wei
Dou, Kefeng
Li, Haimin
Venue: Cancer Letters
Publisher: Elsevier BV
Published: 2015-09
Volume: 365
Issue: 2
Pages: 141-148
ISSN: 0304-3835 (ISSN-L)
DOI: 10.1016/j.canlet.2015.06.003
OpenAlex: W1866220599
Cited by: 1,808
References: 71
Citations by year: 2026: 30 · 2025: 71 · 2024: 142 · 2023: 176 · 2022: 236 · 2021: 328 · 2020: 326 · 2019: 205 · 2018: 154 · 2017: 75 · 2016: 52 · 2015: 7
FWCI: 9.30
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cancer Letters (publishedVersion)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (81772061)
Health Public Welfare Industry Special Scientific Research Projects of China (201202007)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Circular RNAs in diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Keywords: circular RNA, circRNA biogenesis, RNA-binding proteins, microRNA sponge, RNA splicing regulation, transcriptional regulation, circRNA stability, disease biomarkers, colorectal cancer, pancreatic ductal adenocarcinoma, atherosclerosis, neurological disorders, prion disease, long non-coding RNA
MeSH terms: RNA, Circular, Exoribonucleases, Gene Expression Regulation, Humans, Neoplasms, RNA, RNA Splicing, Transcription, Genetic, RNA, Untranslated

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Circular RNA: A new star of noncoding RNAs

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks