miRNAs in immune responses to Mycobacterium tuberculosis infection

Yang, Tianshu; Ge, Baoxue

doi:10.1016/j.canlet.2018.05.028

Cited by 78Tuberculosis Research and EpidemiologyMicroRNA in disease regulationInfectious Diseases and Tuberculosis

miRNAs in immune responses to Mycobacterium tuberculosis infection

Yang, Tianshu, Ge, Baoxue·2018·Cancer Letters

DOI 10.1016/j.canlet.2018.05.028

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Abstract

Tuberculosis (TB) is one of the most fatal infectious diseases, affecting one third of the world's population. The causative agent, Mycobacterium tuberculosis (Mtb), has a well-established ability to circumvent the host's immune system for its long-term intracellular survival. MicroRNAs (miRNAs) are crucial post-transcriptional regulators of immune response. They act by negatively regulating the expression levels of important genes in both innate and adaptive immunity. It has been established in recent studies that the host immune response against Mtb is regulated by many miRNAs, most of which are induced by Mtb infection. Moreover, differential expression of miRNA in tuberculosis (TB) patients may help distinguish between TB patients and healthy individuals or latent TB. In this review, we present the recent advancements on the miRNA regulation of the host responses against Mtb infection, as well as the potential of miRNAs to as biomarkers for TB diagnosis.

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During Mtb infection, miR-26a is downregulated, leading to upregulation of KLF4 and stimulation of the M2 phenotype.
“Interestingly, during Mtb infection, miR-26a is downregulated, leading to upregulation of KLF4 and stimulation of the M2 phenotype [198].”
From MicroRNAs as Regulators of Phagocytosis (2022) · cites this paper as [198]
A negative correlation between miR-142-3p activity and Mtb internalization is caused by targeting PKCα.
“A negative correlation of miR-142–3p activity and Mtb internalization was caused by targeting PKC alpha, a key regulator involved in phagocytosis [198].”
From MicroRNAs as Regulators of Phagocytosis (2022) · cites this paper as [198]
miR-142-3p targets N-wasp, an actin-binding protein regulating actin dynamics during bacterial uptake.
“miR-142–3p targets N-wasp, an actin-binding protein regulating actin dynamics during bacterial uptake [145,198].”
From MicroRNAs as Regulators of Phagocytosis (2022) · cites this paper as [198]
miR-106-5p is upregulated by Mtb infection in macrophages and targets cathepsin S mRNA, decreasing lysosomal activity.
“miR-106-5p, a microRNA upregulated by Mtb infection in macrophages and targets cathepsin S (CtsS) mRNA, thus decreasing lysosomal activity [136,198].”
From MicroRNAs as Regulators of Phagocytosis (2022) · cites this paper as [198]
miR-582-5p and miR-223 inhibit apoptosis by suppressing FOXO1 and FOXO3, and let-7b-5p targets the 3′-UTR of Fas.
“miR-582-5p and miR-223 inhibited apoptosis by suppression FOXO1 and FOXO3. In turn, let-7b-5p has been identified as a microRNA targeting the 3′-UTR of Fas, a protein with a central role in the regulation of apoptosis [198].”
From MicroRNAs as Regulators of Phagocytosis (2022) · cites this paper as [198]

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MiR-381-3p Regulates the Antigen-Presenting Capability of Dendritic Cells and Represses Antituberculosis Cellular Immune Responses by Targeting CD1c
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MicroRNA-34 family: a potential tumor suppressor and therapeutic candidate in cancer
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MicroRNA-27a controls the intracellular survival of Mycobacterium tuberculosis by regulating calcium-associated autophagy
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ESAT-6 modulates Calcimycin-induced autophagy through microRNA-30a in mycobacteria infected macrophages
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Down-Regulation of miR-378d Increased Rab10 Expression to Help Clearance of Mycobacterium tuberculosis in Macrophages
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Shedding Light on Autophagy During Human Tuberculosis. A Long Way to Go
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MicroRNAs as Regulators of Phagocytosis
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Chen, Y.-C., Lee, C. P., Hsiao, C.-C., Hsu, P.-Y., Wang, T.-Y., Wu, C.-C., Chao, T.-Y., Leung, S.-Y., Chang, Y.-P., & Lin, M.-C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228587 · Cited by 21 · see citing works
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ESAT-6 impedes IL-18 mediated phagosome lysosome fusion via microRNA-30a upon Calcimycin treatment in mycobacteria infected macrophages
Behura, A., Das, M., Kumar, A., Naik, L., Mishra, A., Manna, D., Patel, S., Mishra, A., Singh, R., & Dhiman, R. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.108319 · Cited by 20 · see citing works
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Identification of MicroRNAs as Potential Blood-Based Biomarkers for Diagnosis and Therapeutic Monitoring of Active Tuberculosis
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RNAi-based immunity in insects against baculoviruses and the strategies of baculoviruses involved in siRNA and miRNA pathways to weaken the defense
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Mycobacterium marinum down-regulates miR-148a in macrophages in an EsxA-dependent manner
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Identifying host microRNAs in bronchoalveolar lavage samples from lung transplant recipients infected with Aspergillus
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Mycobacterium tuberculosis ESAT6 modulates host innate immunity by downregulating miR-222-3p target PTEN
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Progressive Host-Directed Strategies to Potentiate BCG Vaccination Against Tuberculosis
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Comparative Profiling of Circulating Exosomal Small RNAs Derived From Peruvian Patients With Tuberculosis and Pulmonary Adenocarcinoma
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MicroRNA-495: a therapeutic and diagnostic tumor marker
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Role of non-coding RNAs in tuberculosis and their potential for clinical applications
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Novel Biomarker Panel of Let-7d-5p and MiR-140-5p Can Distinguish Latent Tuberculosis Infection from Active Tuberculosis Patients
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Authors: Yang, T., & Ge, B.
Affiliations: Tongji University (CN)
Corresponding author: Ge, Baoxue
ORCID: Yang, Tianshu
Ge, Baoxue
Venue: Cancer Letters
Publisher: Elsevier BV
Published: 2018-09
Volume: 431
Pages: 22-30
ISSN: 0304-3835 (ISSN-L)
DOI: 10.1016/j.canlet.2018.05.028
OpenAlex: W2803132334
Cited by: 78
References: 125
Citations by year: 2026: 4 · 2025: 11 · 2024: 7 · 2023: 11 · 2022: 13 · 2021: 14 · 2020: 10 · 2019: 5 · 2018: 3
FWCI: 1.17
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cancer Letters (publishedVersion)
PubMed (publishedVersion)
Funders: National Program on Key Basic Research Project (2017YFA0505900, 2015CB964601)
National Natural Science Foundation of China (91542111, 81330069, 31730025)
Topics: Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Health Sciences › Medicine › Surgery › Infectious Diseases and Tuberculosis
Keywords: microRNA, Mycobacterium tuberculosis, tuberculosis, host immune response, innate immunity, adaptive immunity, post-transcriptional regulation, microRNA biomarkers, tuberculosis diagnosis, latent tuberculosis infection, intracellular survival
MeSH terms: Autophagy, Dendritic Cells, Humans, Immune System, Immunity, Innate, Macrophages, Mycobacterium tuberculosis, Phagocytosis, Polymorphism, Genetic, Tuberculosis, Signal Transduction, Biomarkers, Gene Expression Regulation, Bacterial, Genetic Predisposition to Disease, MicroRNAs, Adaptive Immunity

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miRNAs in immune responses to Mycobacterium tuberculosis infection

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