A comparative study of the anticoagulant activities of eleven fucoidans

A modified uronic acid carbazole reaction

Bitter, T., & Muir, H. M. (1962) · Analytical Biochemistry · doi:10.1016/0003-2697(62)90095-7 · Cited by 6,239 · see citing works

A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds

Cumashi, A., Ushakova, N. A., Preobrazhenskaya, M. E., D'Incecco, A., Piccoli, A., Totani, L., Tinari, N., Morozevich, G. E., Berman, A. E., Bilan, M. I., et al. (2007) · Glycobiology · doi:10.1093/glycob/cwm014 · Cited by 1,026 · see citing works

Antioxidant activity of sulfated polysaccharide fractions extracted from Laminaria japonica

Wang, J., Zhang, Q., Zhang, Z., & Li, Z. (2007) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2007.10.003 · Cited by 745 · see citing works

A revised structure for fucoidan may explain some of its biological activities.

Patankar, M. S., Oehninger, S., Barnett, T., Williams, R. L., & Clark, G. F. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80609-7 · Cited by 531 · see citing works

Oversulfation of fucoidan enhances its anti-angiogenic and antitumor activities

Koyanagi, S., Tanigawa, N., Nakagawa, H., Soeda, S., & Shimeno, H. (2003) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)01478-8 · Cited by 479 · see citing works

Structure and antitumour activity of fucoidan isolated from sporophyll of Korean brown seaweed Undaria pinnatifida

Synytsya, A., Kim, W.-J., Kim, S.-M., Pohl, R., Synytsya, A., Kvasnička, F., Čopíková, J., & Il Park, Y. (2010) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2010.01.052 · Cited by 461 · see citing works

Potential antioxidant and anticoagulant capacity of low molecular weight fucoidan fractions extracted from Laminaria japonica

Wang, J., Zhang, Q., Zhang, Z., Song, H., & Li, P. (2010) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2009.10.015 · Cited by 456 · see citing works

Structure and Anticoagulant Activity of Sulfated Fucans

Pereira, M. S., Mulloy, B., & Mourão, P. A. S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.12.7656 · Cited by 377 · see citing works

A disaccharide repeat unit is the major structure in fucoidans from two species of brown algae

Chevolot, L., Mulloy, B., Ratiskol, J., Foucault, A. P., & Colliec‐Jouault, S. (2001) · Carbohydrate Research · doi:10.1016/s0008-6215(00)00314-1 · Cited by 304 · see citing works

Comparison of structures and anticoagulant activities of fucosylated chondroitin sulfates from different sea cucumbers

Chen, S., Xue, C., Yin, L., Tang, Q., Yu, G., & Chai, W. (2010) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2010.08.040 · Cited by 268 · see citing works

A highly regular fraction of a fucoidan from the brown seaweed Fucus distichus L.

Bilan, M. I., Grachev, A. A., Ustuzhanina, N. E., Shashkov, A. S., Nifantiev, N. E., & Usov, A. I. (2004) · Carbohydrate Research · doi:10.1016/j.carres.2003.10.028 · Cited by 255 · see citing works

Fucoidans from Brown Seaweeds Sargassum hornery, Eclonia cava, Costaria costata: Structural Characteristics and Anticancer Activity

Ermakova, S., Sokolova, R., Kim, S.-M., Um, B.-H., Isakov, V., & Zvyagintseva, T. (2011) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-011-9178-2 · Cited by 229 · see citing works

Structural characterization of laminaran and galactofucan extracted from the brown seaweed Saccharina longicruris

Rioux, L.-E., Turgeon, S. L., & Beaulieu, M. (2010) · Phytochemistry · doi:10.1016/j.phytochem.2010.05.021 · Cited by 216 · see citing works

Further studies on the composition and structure of a fucoidan preparation from the brown alga Saccharina latissima

Bilan, M. I., Grachev, A. A., Shashkov, A. S., Kelly, M. S., Sanderson, C. J., Nifantiev, N. E., & Usov, A. I. (2010) · Carbohydrate Research · doi:10.1016/j.carres.2010.07.009 · Cited by 215 · see citing works

Characterization of a fucoidan from Lessonia vadosa (Phaeophyta) and its anticoagulant and elicitor properties

Chandía, N. P., & Matsuhiro, B. (2008) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2007.10.023 · Cited by 201 · see citing works

Structural studies on a novel fucogalactan sulfate extracted from the brown seaweed Laminaria japonica

Wang, J., Zhang, Q., Zhang, Z., Zhang, H., & Niu, X. (2010) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2010.05.010 · Cited by 159 · see citing works

Relationship between oversulfation and conformation of low and high molecular weight fucoidans and evaluation of their in vitro anticancer activity

Cho, M. L., Lee, B.-Y., & You, S. G. (2010) · Molecules · doi:10.3390/molecules16010291 · Cited by 155 · see citing works

Fucans, but Not Fucomannoglucuronans, Determine the Biological Activities of Sulfated Polysaccharides from Laminaria saccharina Brown Seaweed

Croci, D. O., Cumashi, A., Ushakova, N. A., Preobrazhenskaya, M. E., Piccoli, A. L., Jr., Totani, L., Ustyuzhanina, N. E., Bilan, M. I., Usov, A. I., Grachev, A. A., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017283 · Cited by 151 · see citing works

Heterofucans from the Brown Seaweed Canistrocarpus cervicornis with Anticoagulant and Antioxidant Activities

Câmara, R. B. G., Costa, L. S., Fidelis, G. P., Nobre, L. T. D. B., Dantas-Santos, N., Cordeiro, S. L., Costa, M. S. S. P., Alves, L. G., & Rocha, H. A. O. (2011) · Marine Drugs · doi:10.3390/md9010124 · Cited by 137 · see citing works

Selective cleavage and anticoagulant activity of a sulfated fucan: Stereospecific removal of a 2-sulfate ester from the polysaccharide by mild acid hydrolysis, preparation of oligosaccharides, and heparin cofactor II-dependent anticoagulant activity

Pomin, V. H., Pereira, M. S., Valente, A.-P., Tollefsen, D. M., Pavão, M. S. G., & Mourão, P. A. S. (2005) · Glycobiology · doi:10.1093/glycob/cwi021 · Cited by 129 · see citing works

Analysis of the monosaccharide composition of fucoidan by precolumn derivation HPLC

Zhang, J., Zhang, Q., Wang, J., Shi, X., & Zhang, Z. (2009) · Chinese Journal of Oceanology and Limnology · doi:10.1007/s00343-009-9205-0 · Cited by 105 · see citing works

Effect of anticoagulative sulfated polysaccharide purified from enzyme-assistant extract of a brown seaweed Ecklonia cava on Wistar rats

Wijesinghe, W. A. J. P., Athukorala, Y., & Jeon, Y. (2011) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2011.05.047 · Cited by 101 · see citing works

Polysaccharides from Padina tetrastromatica: Structural features, chemical modification and antiviral activity

Karmakar, P., Pujol, C. A., Damonte, E. B., Ghosh, T., & Ray, B. (2009) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2009.12.014 · Cited by 95 · see citing works

Inactivation of Thrombin by a Fucosylated Chondroitin Sulfate from Echinoderm

Mourão, P. A. S., Boisson‐Vidal, C., Tapon‐Bretaudière, J., Drouet, B., Bros, A., & Fischer, A. (2001) · Thrombosis Research · doi:10.1016/s0049-3848(01)00230-4 · Cited by 77 · see citing works

Composition, structural characteristics, and antitumor properties of polysaccharides from the brown algae Dictyopteris polypodioides and Sargassum sp.

Sokolova, R., Ermakova, S. P., Awada, S., Николаевна, З. Т., & Kanaan, H. (2011) · Chemistry of Natural Compounds · doi:10.1007/s10600-011-9925-1 · Cited by 52 · see citing works

Influence of alginic acid and fucoidan on the immune responses of head kidney leukocytes in cod

Caipang, C. M. A., Lazado, C. C., Berg, I., Brinchmann, M. F., & Kiron, V. (2010) · Fish Physiology and Biochemistry · doi:10.1007/s10695-010-9462-z · Cited by 46 · see citing works

Biological Activities of Fucoidan and the Factors Mediating Its Therapeutic Effects: A Review of Recent Studies

Wang, Y., Xing, M., Cao, Q., Ji, A., Liang, H., & Song, S. (2019) · Marine Drugs · doi:10.3390/md17030183 · Cited by 516 · see citing works

Therapies from Fucoidan: An Update

Fitton, J., Stringer, D., & Karpiniec, S. (2015) · Marine Drugs · doi:10.3390/md13095920 · Cited by 418 · see citing works

Therapeutic Effects of Fucoidan: A Review on Recent Studies

Luthuli, S., Wu, S., Cheng, Y., Zheng, X., Wu, M., & Tong, H. (2019) · Marine Drugs · doi:10.3390/md17090487 · Cited by 395 · see citing works

Polysaccharides from macroalgae: Recent advances, innovative technologies and challenges in extraction and purification

Garcia-Vaquero, M., Rajauria, G., O'Doherty, J. V., & Sweeney, T. (2017) · Food Research International · doi:10.1016/j.foodres.2016.11.016 · Cited by 364 · see citing works

Dietary fucoidan modulates the gut microbiota in mice by increasing the abundance of Lactobacillus and Ruminococcaceae

Shang, Q., Shan, X., Cai, C., Hao, J., Li, G., & Yu, G. (2016) · Food & Function · doi:10.1039/c6fo00309e · Cited by 359 · see citing works

A review about brown algal cell walls and fucose-containing sulfated polysaccharides: Cell wall context, biomedical properties and key research challenges

Deniaud-Bouët, E., Hardouin, K., Potin, P., Kloareg, B., & Hervé, C. (2017) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2017.07.082 · Cited by 320 · see citing works

Edible Seaweeds: A Potential Novel Source of Bioactive Metabolites and Nutraceuticals With Human Health Benefits

Choudhary, B., Chauhan, O. P., & Mishra, A. (2021) · Frontiers in Marine Science · doi:10.3389/fmars.2021.740054 · Cited by 180 · see citing works

Exploring the partial degradation of polysaccharides: Structure, mechanism, bioactivities, and perspectives

Chen, S., Wang, X., Guo, Y., Song, X., Yin, J., & Nie, S. (2023) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.13244 · Cited by 166 · see citing works

Antithrombotic activity of oral administered low molecular weight fucoidan from Laminaria Japonica

Zhao, X., Guo, F., Hu, J., Zhang, L., Xue, C., Zhang, Z., & Li, B. (2016) · Thrombosis Research · doi:10.1016/j.thromres.2016.03.008 · Cited by 149 · see citing works

An overview of extraction and purification techniques of seaweed dietary fibers for immunomodulation on gut microbiota

Praveen, M. A., Parvathy, K. R. K., Balasubramanian, P., & Jayabalan, R. (2019) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2019.08.011 · Cited by 140 · see citing works

Insights into the structure-bioactivity relationships of marine sulfated polysaccharides: A review

Kang, J., Jia, X., Wang, N., Xiao, M., Song, S., Wu, S., Li, Z., Wang, S., Cui, S. W., & Guo, Q. M. (2021) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2021.107049 · Cited by 134 · see citing works

Recent advances in industrial applications of seaweeds

Polat, S., Trif, M., Alexandru Vasile, R. U. S. U., Šimat, V., Čagalj, M., Alak, G., Meral, R., Özoğul, Y., Polat, A., & Özoğul, F. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.2010646 · Cited by 124 · see citing works

Hydrothermal degradation of seaweed polysaccharide: Characterization and biological activities

Saravana, P. S., Cho, Y.-N., Patil, M. P., Cho, Y., Kim, G., Park, Y. B., Woo, H.-C., & Chun, B.-S. (2018) · Food Chemistry · doi:10.1016/j.foodchem.2018.06.077 · Cited by 121 · see citing works

Fucoidan as bio-functional molecule: Insights into the anti-inflammatory potential and associated molecular mechanisms

Phull, A. R., & Kim, S. J. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.09.051 · Cited by 115 · see citing works

Anticoagulant Activity of Sulfated Ulvan Isolated from the Green Macroalga Ulva rigida

Adrien, A., Bonnet, A., Dufour, D., Baudouin, S., Maugard, T., & Bridiau, N. (2019) · Marine Drugs · doi:10.3390/md17050291 · Cited by 109 · see citing works

The Pharmacokinetics of Fucoidan after Topical Application to Rats

Pozharitskaya, O. N., Shikov, A. N., Obluchinskaya, E. D., & Vuorela, H. (2019) · Marine Drugs · doi:10.3390/md17120687 · Cited by 79 · see citing works

Fucoidan Extracted from the New Zealand Undaria pinnatifida—Physicochemical Comparison against Five Other Fucoidans: Unique Low Molecular Weight Fraction Bioactivity in Breast Cancer Cell Lines

Lu, J., Shi, K., Chen, S., Wang, J., Hassouna, A., White, L. N., Mérien, F., Xie, M., Kong, Q., Li, J., et al. (2018) · Marine Drugs · doi:10.3390/md16120461 · Cited by 79 · see citing works

Fucoidan for cardiovascular application and the factors mediating its activities

Yao, Y., & Yim, E. K. F. (2021) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2021.118347 · Cited by 80 · see citing works

Chain conformation and biological activities of hyperbranched fucoidan derived from brown algae and its desulfated derivative

Wei, X., Cai, L., Liu, H., Tu, H., Xu, X., Zhou, F., & Zhang, L. (2018) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2018.12.060 · Cited by 73 · see citing works

Therapeutic activity of fucoidan and carrageenan as marine algal polysaccharides against viruses

Oliyaei, N., Moosavi‐Nasab, M., & Mazloomi, S. M. (2022) · 3 Biotech · doi:10.1007/s13205-022-03210-6 · Cited by 72 · see citing works

Preparation of Low-Molecular-Weight Fucoidan with Anticoagulant Activity by Photocatalytic Degradation Method

Qi, Y., Wang, L., You, Y., Sun, X., Wen, C., Fu, Y., & Song, S. (2022) · Foods · doi:10.3390/foods11060822 · Cited by 71 · see citing works

Modification of native fucoidan from Fucus evanescens by recombinant fucoidanase from marine bacteria Formosa algae

Silchenko, A. S., Rasin, A. B., Игоревич, К. М., Malyarenko, O. S., Shevchenko, N. M., Zueva, A. O., Kalinovsky, A. I., Николаевна, З. Т., & Ermakova, S. P. (2018) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2018.03.094 · Cited by 68 · see citing works

Polysaccharides from Laminaria japonica: an insight into the current research on structural features and biological properties.

Luan, F., Zou, J.-B., Rao, Z., Ji, Y.-F., Lei, Z.-Q., Peng, L., Yang, Y., He, X.-R., & Zeng, N. (2021) · Food & Function · doi:10.1039/d1fo00311a · Cited by 56 · see citing works

Development of Injectable Fucoidan and Biological Macromolecules Hybrid Hydrogels for Intra-Articular Delivery of Platelet-Rich Plasma

Lu, H., Chang, W.-T., Tsai, M., Chen, C.-H., Chen, W., & Mi, F. (2019) · Marine Drugs · doi:10.3390/md17040236 · Cited by 64 · see citing works

The Structure-Activity Relationship between Marine Algae Polysaccharides and Anti-Complement Activity

Jin, W., Zhang, W., Liang, H., & Zhang, Q. (2015) · Marine Drugs · doi:10.3390/md14010003 · Cited by 62 · see citing works

Fucoidanases

Игоревич, К. М., Silchenko, A. S., Zakharenko, A. M., & Николаевна, З. Т. (2015) · Glycobiology · doi:10.1093/glycob/cwv072 · Cited by 60 · see citing works

Advances in fucoidan and fucoidan oligosaccharides: Current status, future prospects, and biological applications

Hamouda, H. I., Li, T., Shabana, S., Hashem, A. H., & Yin, H. (2025) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2025.123559 · Cited by 61 · see citing works

Renoprotective effect of low-molecular-weight sulfated polysaccharide from the seaweed Laminaria japonica on glycerol-induced acute kidney injury in rats

Li, X., Wang, J., Zhang, H., & Zhang, Q. (2016) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2016.11.051 · Cited by 58 · see citing works

Characterization of laminaran and a highly sulfated polysaccharide from Sargassum fusiforme

Jin, W., Zhang, W., Wang, J., Ren, S., Song, N., Duan, D., & Zhang, Q. (2013) · Carbohydrate Research · doi:10.1016/j.carres.2013.12.009 · Cited by 54 · see citing works

Endo-1,4-fucoidanase from Vietnamese marine mollusk Lambis sp. which producing sulphated fucooligosaccharides

Silchenko, A. S., Игоревич, К. М., Zakharenko, A. M., Usoltseva, R. V., Khánh, H. H. N., Dmitrenok, P. S., Isakov, V. V., & Николаевна, З. Т. (2014) · Journal of Molecular Catalysis B Enzymatic · doi:10.1016/j.molcatb.2014.02.007 · Cited by 53 · see citing works

The neuroprotective activities of heteropolysaccharides extracted from Saccharina japonica

Jin, W., Wang, J., Jiang, H. F., Song, N., Zhang, W., & Zhang, Q. (2013) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2013.04.055 · Cited by 52 · see citing works

A Sulfated Polysaccharide from Saccharina japonica Suppresses LPS-Induced Inflammation Both in a Macrophage Cell Model via Blocking MAPK/NF-κB Signal Pathways In Vitro and a Zebrafish Model of Embryos and Larvae In Vivo

Wang, S.-N., Ni, L., Fu, X.-T., Duan, D., Xu, J.-C., & Gao, X. (2020) · Marine Drugs · doi:10.3390/md18120593 · Cited by 50 · see citing works

Low molecular weight fucoidan attenuating pulmonary fibrosis by relieving inflammatory reaction and progression of epithelial-mesenchymal transition

Wu, N., Li, Z., Wang, J., Geng, L., Yue, Y., Deng, Z., Wang, Q., & Zhang, Q. (2021) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2021.118567 · Cited by 51 · see citing works

Immunopotentiating Activity of Fucoidans and Relevance to Cancer Immunotherapy

Li, Y., McGowan, E. M., Chen, S., Santos, J., Yin, H., & Lin, Y. (2023) · Marine Drugs · doi:10.3390/md21020128 · Cited by 52 · see citing works

Seaweed and seaweed-derived metabolites as prebiotics

Charoensiddhi, S., Abraham, R. E., Su, P. H., & Zhang, W. Y. (2019) · Advances in food and nutrition research · doi:10.1016/bs.afnr.2019.10.001 · Cited by 48 · see citing works

Low-molecular-weight fucoidan: Chemical modification, synthesis of its oligomeric fragments and mimetics

Suprunchuk, V. E. (2019) · Carbohydrate Research · doi:10.1016/j.carres.2019.107806 · Cited by 47 · see citing works

Seaweed sulfated polysaccharides and their medicinal properties

Zaitseva, O. O., Sergushkina, M. I., Khudyakov, A. N., Polezhaeva, T. V., & Solomina, O. N. (2022) · Algal Research · doi:10.1016/j.algal.2022.102885 · Cited by 44 · see citing works

Fourier-transform infrared imaging and multivariate analysis for direct identification of principal polysaccharides in brown seaweeds

Beratto-Ramos, A., Agurto-Muñoz, C., Vargas-Montalba, J. P., & Castillo, R. D. P. (2019) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2019.115561 · Cited by 45 · see citing works

Functional Characterization of a New GH107 Endo-α-(1,4)-Fucoidanase from the Marine Bacterium Formosa haliotis

Vuillemin, M., Silchenko, A. S., Cao, H. T. T., Kokoulin, M. S., Trang, V. T. D., Holck, J., Ermakova, S. P., Meyer, A. S., & Mikkelsen, M. D. (2020) · Marine Drugs · doi:10.3390/md18110562 · Cited by 41 · see citing works

Fucoidan from brown seaweed Tubinaria decurrens: Structure and structure - anticancer activity relationship

Nguyen, A. N., Ngo, Q. V., Quach, T. T. M., Ueda, S., Yuguchi, Y., Matsumoto, Y., Kitamura, S., Ho, C. D., & Thanh, T. T. T. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.129326 · Cited by 38 · see citing works

Preparation of low molecular weight Sargassum fusiforme polysaccharide and its anticoagulant activity

Sun, Y., Chen, X., Liu, S., Yu, H., Li, R., Wang, X., Qin, Y., & Li, P. (2017) · Journal of Oceanology and Limnology · doi:10.1007/s00343-018-7089-6 · Cited by 38 · see citing works

The Endo-α(1,3)-Fucoidanase Mef2 Releases Uniquely Branched Oligosaccharides from Saccharina latissima Fucoidans

Tran, V. H. N., Nguyen, T. T., Meier, S., Holck, J., Cao, H. T. T., Van, T. T. T., Meyer, A. S., & Mikkelsen, M. D. (2022) · Marine Drugs · doi:10.3390/md20050305 · Cited by 37 · see citing works

Isolation and characterization of fucoidans from five brown algae and evaluation of their antioxidant activity

Qu, G., Liu, X., Wang, D., Yuan, Y., & Han, L. (2014) · Journal of Ocean University of China · doi:10.1007/s11802-014-2260-y · Cited by 35 · see citing works

Inhibitory Effects of Laminaria japonica Fucoidans Against Noroviruses

Kim, H., Lim, C. Y., Lee, D. B., Seok, J. H., Kim, K. H., & Chung, M. S. (2020) · Viruses · doi:10.3390/v12090997 · Cited by 34 · see citing works

Metabolic regulation mechanism of fucoidan via intestinal microecology in diseases

Sun, T., Xue, M., Yang, J., Pei, Z., Zhang, N., Qin, K., & Liang, H. W. (2021) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.11202 · Cited by 34 · see citing works

Rheological, Mechanical, and thermal properties of polylactide/cellulose nanofiber biocomposites

Safdari, F., Bagheriasl, D., Carreau, P. J., Heuzey, M. C., & Kamal, M. R. (2016) · Polymer Composites · doi:10.1002/pc.24127 · Cited by 33 · see citing works

Evaluation of the anticoagulant potential of polysaccharide-rich fractions extracted from macroalgae

Adrien, A., Dufour, D., Baudouin, S., Maugard, T., & Bridiau, N. (2017) · Natural Product Research · doi:10.1080/14786419.2017.1278595 · Cited by 33 · see citing works

Multipurpose Antifouling Coating of Solid Surfaces with the Marine‐Derived Polymer Fucoidan

Jeong, Y., Thủy, L. T., Ki, S. H., Ko, S., Kim, S., Cho, W. K., Choi, J. S., & Kang, S. M. (2018) · Macromolecular Bioscience · doi:10.1002/mabi.201800137 · Cited by 32 · see citing works

Degradation of Sargassum crassifolium Fucoidan by Ascorbic Acid and Hydrogen Peroxide, and Compositional, Structural, and In Vitro Anti-Lung Cancer Analyses of the Degradation Products

Wu, T.-C., Hong, Y., Tsai, Y., Hsieh, S., Huang, R.-H., Kuo, C., & Huang, C.-Y. (2020) · Marine Drugs · doi:10.3390/md18060334 · Cited by 32 · see citing works

Effect of Enzymatically Extracted Fucoidans on Angiogenesis and Osteogenesis in Primary Cell Culture Systems Mimicking Bone Tissue Environment

Ohmes, J., Xiao, Y., Wang, F., Mikkelsen, M. D., Nguyen, T. T., Schmidt, H., Seekamp, A., Meyer, A. S., & Fuchs, S. (2020) · Marine Drugs · doi:10.3390/md18090481 · Cited by 29 · see citing works

Anticoagulant Macromolecules

Wang, X., Hadi, M. K., Niu, J., Zhou, Q., & Ran, F. (2023) · Macromolecules · doi:10.1021/acs.macromol.2c02501 · Cited by 29 · see citing works

Nutritional and therapeutic potential of functional components of brown seaweed: A review

Alloyarova, Y., Kolotova, D. S., & Derkach, S. R. (2024) · Foods and raw materials · doi:10.21603/2308-4057-2024-2-616 · Cited by 29 · see citing works

Low molecular weight fucoidan alleviates cerebrovascular damage by promoting angiogenesis in type 2 diabetes mice

Li, Z., Wu, N., Wang, J., Yue, Y., Geng, L., & Zhang, Q. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.07.053 · Cited by 28 · see citing works

Screening of complex fucoidans from four brown algae species as procoagulant agents

Zhang, Z., Till, S., Knappe, S., Quinn, C., Catarello, J., Ray, G. J., Scheiflinger, F., Szabo, C. M., & Dockal, M. (2014) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2014.09.001 · Cited by 28 · see citing works

Degradation of different molecular weight fucoidans and their inhibition of TGF-β1 induced epithelial–mesenchymal transition in mouse renal tubular epithelial cells

Li, X., Wu, N., Chen, Y., Tan, J., Wang, J., Geng, L., Qin, Y., & Zhang, Q. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.02.068 · Cited by 28 · see citing works

Comparative study of the immunomodulatory effects of different fucoidans from Saccharina japonica mediated by scavenger receptors on RAW 264.7 macrophages

Cui, M., Li, X., Geng, L., Wu, N., Wang, J., Deng, Z., Li, Z., & Zhang, Q. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.06.111 · Cited by 27 · see citing works

Marine Biological Macromolecules and Chemically Modified Macromolecules; Potential Anticoagulants

Chandika, P., Tennakoon, P., Kim, T., Kim, S.-C., Je, J., Kim, J., Lee, B., Ryu, B., Kang, H. W., Kim, H., et al. (2022) · Marine Drugs · doi:10.3390/md20100654 · Cited by 27 · see citing works

Physicochemical Properties and Anticoagulant Activity of Purified Heteropolysaccharides from Laminaria japonica

Li, T., Ma, H., Li, H., Tang, H., Huang, J., Wei, S., Yuan, Q., Shi, X., Gao, C., Mi, S., et al. (2022) · Molecules · doi:10.3390/molecules27093027 · Cited by 26 · see citing works

Swelling behavior and chemical stability of chitosan/nanocellulose biocomposites

Mohaiyiddin, M. S., Ong, H. L., Othman, M. B. H., Julkapli, N. M., Villagracia, A. R., & Akil, H. M. (2018) · Polymer Composites · doi:10.1002/pc.24712 · Cited by 26 · see citing works

A New Route of Fucoidan Immobilization on Low Density Polyethylene and Its Blood Compatibility and Anticoagulation Activity

Özaltın, K., Lehocký, M., Humpolíček, P., Pelková, J., & Sáha, P. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17060908 · Cited by 25 · see citing works

Current developments in the oral drug delivery of fucoidan

Tran, P. H. L., Lee, B., & Tran, T. T. D. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.120371 · Cited by 25 · see citing works

Investigation of Different Molecular Weight Fucoidan Fractions Derived from New Zealand Undaria pinnatifida in Combination with GroA Therapy in Prostate Cancer Cell Lines

Yang, X., Wang, S., Trangle, S. S., Li, Y., White, W. L., Li, J., Ying, T., Kong, Q., Zhao, Y., & Lu, J. (2018) · Marine Drugs · doi:10.3390/md16110454 · Cited by 24 · see citing works

Physicochemical Characterization of Fucoidans from Sargassum henslowianum C.Agardh and Their Antithrombotic Activity In Vitro

Lin, P., Chen, S., Liao, M., & Wang, W. (2022) · Marine Drugs · doi:10.3390/md20050300 · Cited by 22 · see citing works

The Discovery of the Fucoidan-Active Endo-1→4-α-L-Fucanase of the GH168 Family, Which Produces Fucoidan Derivatives with Regular Sulfation and Anticoagulant Activity

Silchenko, A. S., Taran, I. V., Usoltseva, R. V., Zvyagintsev, N. V., Zueva, A. O., Rubtsov, N. K., Lembikova, D. E., Nedashkovskaya, O. I., Игоревич, К. М., Isaeva, M. P., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010218 · Cited by 22 · see citing works

Primary structural features, physicochemical and biological properties of two water-soluble polysaccharides extracted from the brown Tunisian seaweed Halopteris scoparia

Hadjkacem, F., Elleuch, J., Aitouguinane, M., Chakou, F. Z., Ursu, A.-V., Dubessay, P., Bourgougnon, N., Traı̈kia, M., Cerf, D. L., Alaoui-Talibi, Z. E., et al. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.126757 · Cited by 21 · see citing works

Structural analysis of heteropolysaccharide from Saccharina japonica and its derived oligosaccharides

Jin, W., Zhang, W., Wang, J., Ren, S., Song, N., & Zhang, Q. (2013) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2013.10.017 · Cited by 21 · see citing works

Fucoidans inhibit the formation of post-operative abdominal adhesions in a rat model

Charboneau, A. J., Delaney, J., & Beilman, G. (2018) · PLoS ONE · doi:10.1371/journal.pone.0207797 · Cited by 15 · see citing works

A versatile modification strategy for functional non-glutaraldehyde cross-linked bioprosthetic heart valves with enhanced anticoagulant, anticalcification and endothelialization properties

Yu, T., Pu, H., Chen, X., Kong, Q., Chen, C., Li, G., Jiang, Q. Y., & Wang, Y. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.02.002 · Cited by 19 · see citing works

Cystoseira myrica: from beach-cast seaweed to fucoidan with antioxidant and anticoagulant capacity

Dhahri, M. (2023) · Frontiers in Marine Science · doi:10.3389/fmars.2023.1327408 · Cited by 19 · see citing works

Synthesis of biologically-active reduced graphene oxide by using fucoidan as a multifunctional agent for combination cancer therapy

Kang, S., Hong, Y., Ku, B., Lee, S., Ryu, S., Min, D., Jang, H., & Kim, Y. (2018) · Nanotechnology · doi:10.1088/1361-6528/aadfa5 · Cited by 19 · see citing works

The neuroprotective activities and antioxidant activities of the polysaccharides from Saccharina japonica

Jin, W., Zhang, W., Wang, J., & Zhang, Q. (2013) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2013.04.009 · Cited by 18 · see citing works

Sulfated polysaccharides with antioxidant and anticoagulant activity from the sea cucumber Holothuria fuscogliva

Li, R., Yu, H., Yue, Y., Liu, S., Xing, R., Chen, X., & Li, P. (2016) · Chinese Journal of Oceanology and Limnology · doi:10.1007/s00343-017-5339-7 · Cited by 18 · see citing works

The preparation and anti-atherosclerotic effects of different low-molecular weights fucoidan

Lu, C. D., Gu, Q., & Yu, X. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.103755 · Cited by 17 · see citing works

Polysaccharides and their depolymerized fragments from Costaria costata: Molecular weight and sulfation-dependent anticoagulant and FGF/FGFR signal activating activities

Hou, N., Zhang, M., Xu, Y., Sun, Z., Wang, J., Zhang, L., & Zhang, Q. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.06.042 · Cited by 17 · see citing works

Sulfated Polysaccharides Isolated from ClonedGrateloupia filicinaand Their Anticoagulant Activity

Chen, X., Yang, S., Wang, J., Song, L., Xing, R., Liu, S., Yu, H., & Li, P. (2015) · BioMed Research International · doi:10.1155/2015/612352 · Cited by 17 · see citing works

Cell response to PLA scaffolds functionalized with various seaweed polysaccharides

Özaltın, K., Vargün, E., Martino, A. D., Capáková, Z., Lehocký, M., Humpolíček, P., Kazantseva, N. E., & Sáha, P. (2020) · International Journal of Polymeric Materials · doi:10.1080/00914037.2020.1798443 · Cited by 16 · see citing works

Coordination-driven antifouling spray coating using a sulfated polysaccharide Fucoidan

Cho, S., Thủy, L. T., Ko, S., Jeong, Y., Kang, S. M., Choi, J. S., & Cho, W. K. (2022) · Progress in Organic Coatings · doi:10.1016/j.porgcoat.2022.106916 · Cited by 15 · see citing works

The effect of polydisperse fucoidans from Fucus vesiculosus on Hep G2 and Chang liver cells

Zhurishkina, E. V., Stepanov, S. I., Ayrapetyan, O. N., Skorik, Y. А., Vlasova, E. N., Kruchina-Bogdanov, I. V., Лебедев, Д. В., Kulminskaya, A. A., & Lapina, I. M. (2019) · Bioactive Carbohydrates and Dietary Fibre · doi:10.1016/j.bcdf.2019.100209 · Cited by 13 · see citing works

Influence of alkali treatment and ultrasonication on the bioactivities and rheological properties of sulfated polysaccharides

Darko, C. N. S., Arthur, B., Saluri, K., Lepik, H., Punak, L., Robal, M., Martma, K., & Tuvikene, R. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.144122 · Cited by 11 · see citing works

A comparison of the effect of fucoidan from alga Fucus vesiculosus and its fractions obtained by anion-exchange chromatography on HeLa G-63, Hep G2, and Chang liver cells

Zhurishkina, E. V., Stepanov, S. I., Shvetsova, S. V., Kulminskaya, A. A., & Lapina, I. M. (2017) · Cell and Tissue Biology · doi:10.1134/s1990519x17030117 · Cited by 11 · see citing works

Branched architecture of fucoidan characterized by dynamic and static light scattering

Gasilova, E. R., Lapina, I. M., Kulminskaya, A. A., & Skorik, Y. А. (2020) · Colloid & Polymer Science · doi:10.1007/s00396-020-04706-4 · Cited by 11 · see citing works

Incorporation of fucoidan into zein-based electrospun fibers: A promising material for biotechnological applications

Leitzke, A. F., Bueno, D. T., Jansen-Alves, C., Trindade, T. M. L. S., Pedra, N. S., Santana, L. R., Stefanello, F. M., Zavareze, E. D. R., Borsuk, S., Carreño, N. L. V., et al. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.141788 · Cited by 10 · see citing works

Medicinal and Pharmaceutical Applications of Seaweeds

El-Sheekh, M. M., Fathy, A. A., Saber, H., & Saber, A. A. (2022) · Egyptian Journal of Botany · doi:10.21608/ejbo.2022.145631.2022 · Cited by 13 · see citing works

Evaluation of the anticoagulant potential of polysaccharide-rich fractions extracted from macroalgae

Adrien, A., Dufour, D., Baudouin, S., Maugard, T., & Bridiau, N. (2017) · PubMed · doi:10.6084/m9.figshare.4609186 · Cited by 10 · see citing works

The Effects of Fucoidan Derived from Sargassum filipendula and Fucus vesiculosus on the Survival and Mineralisation of Osteogenic Progenitors

Gupta, D., Martinez, D. C., Puertas-Mejía, M. A., Hearnden, V. L., & Reilly, G. C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042085 · Cited by 9 · see citing works

Prolonged administration of Ascophyllum nodosum to healthy human volunteers and cardiovascular risk

Iacoviello, L., Zito, F., Rago, L., Castelnuovo, A. F. D., Curtis, A. D., Zappacosta, B., de Gaetano, G., Donati, M. B., & Cerletti, C. (2013) · Nutrafoods · doi:10.1007/s13749-013-0059-x · Cited by 9 · see citing works

Bioassay-guided extraction of crude fucose-containing sulphated polysaccharides from Sargassum fusiforme with response surface methodology

Fu, Z., Li, H., Liu, H., Hu, S., Li, Y., Wang, M., & Guan, H. (2016) · Journal of Ocean University of China · doi:10.1007/s11802-016-2897-9 · Cited by 9 · see citing works

Marine‐origin Polysaccharides for Tissue Engineering and Regenerative Medicine

Reys, L. L., Silva, S. S., Oliveira, C., López‐Cebral, R., Neves, N. M., Martins, A. M., Oliveira, J. M., Silva, T. H., & Reis, R. L. (2020) · Encyclopedia of Marine Biotechnology · doi:10.1002/9781119143802.ch118 · Cited by 9 · see citing works

Anti-Colorectal Cancer Effects of Fucoidan Complex-Based Functional Beverage Through Retarding Proliferation, Cell Cycle and Epithelial–Mesenchymal Transition Signaling Pathways

Chan, C.-H., Deng, Y.-H., Peng, B., Chiang, P.-C., Wu, L., Lee, Y.-Y., Tsao, W., Mao, H.-H., Wu, C.-Y., & Deng, W. (2023) · Integrative Cancer Therapies · doi:10.1177/15347354231213613 · Cited by 8 · see citing works

Anticoagulant Activity of Mangrove (Avicennia alba) Leaves Extract in Vitro

Rusyiana, R., Lestarini, I. A., Hamdin, C. D., & Muliasari, H. (2021) · ILMU KELAUTAN Indonesian Journal of Marine Sciences · doi:10.14710/ik.ijms.26.2.110-116 · Cited by 8 · see citing works

Nutritional Benefits of Fucoidan and Its Applications (A Review)

Bulya, E. T., Alqubelat, R. S., & Rao, A. R. (2024) · Russian Journal of Bioorganic Chemistry · doi:10.1134/s1068162024060335 · Cited by 8 · see citing works

Algal Polysaccharides and Their Biological Properties

Cheong, K., Jesumani, V., Khan, B. M., Liu, Y., & Du, H. (2021) · Wiley eBooks · doi:10.1002/9781119542650.ch10 · Cited by 8 · see citing works

Polysaccharide-Based Drug Carriers—A Patent Analysis

Ilić-Stojanović, S. S., Damiri, F., Musuc, A. M., & Berrada, M. (2024) · Gels · doi:10.3390/gels10120801 · Cited by 6 · see citing works

Fucoidan: A nutraceutical for metabolic and regulatory systems homeostasis maintenance

Mukhamejanov, E., & Kurilenko, V. M. (2020) · World Journal of Advanced Research and Reviews · doi:10.30574/wjarr.2020.6.1.0106 · Cited by 6 · see citing works

Extraction, optimization, and characterization of fucoidan from Polycladia myrica with the evaluation of its anticancer, antioxidant, and antiviral activities

El-Sheekh, M. M., Abu-Resha, A. M., Morsi, H. H., Abou-El-Souod, G. W., & Makhlof, M. E. M. (2025) · South African Journal of Botany · doi:10.1016/j.sajb.2025.07.004 · Cited by 5 · see citing works

Advances in degradation strategies and bioactivities of low-molecular-weight fucoidan: A review

Dong, C., Gong, P.-X., Wu, Y., & Li, H. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.149512 · Cited by 5 · see citing works

Polyvinylpyrrolidone-stabilised gold nanoparticle coatings inhibit blood protein adsorption

Tiyyagura, H. R., Rudolf, R., & Bračič, M. (2024) · Nanotechnology Reviews · doi:10.1515/ntrev-2023-0176 · Cited by 5 · see citing works

Isolation, Characterization, and Anti-Idiopathic Pulmonary Fibrosis Activity of a Fucoidan from Costaria costata

Wei, S., Geng, L., Yu, H., Wang, J., Yue, Y., Zhang, Q., & Wu, N. (2023) · Molecules · doi:10.3390/molecules28114343 · Cited by 5 · see citing works

Polyaniline Modified with Cobalt-Hexacyanoferrate (PmCH) as an Adsorbent for Removal of Heavy Metals from Aqueous Solutions

Moazezi, N., & Moosavian, M. A. (2018) · E3S Web of Conferences · doi:10.1051/e3sconf/20185103004 · Cited by 5 · see citing works

Enzymatic and chemical depolymerization of Fucus evanescens fucoidan: Impact on structure and hemostatic activity

Silchenko, A. S., Taran, I. V., Zueva, A. O., Zvyagintsev, N. V., Игоревич, К. М., & Ermakova, S. P. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.149773 · Cited by 4 · see citing works

The Relationship Between the Molecular Weight and the Anticoagulant Activity of Two Types of Fucan Sulfates from the Brown SeaweedEcklonia kurome

Nishino, T., Aizu, Y., & Nagumo, T. (1991) · Agricultural and Biological Chemistry · doi:10.1080/00021369.1991.10870645 · Cited by 33 · see citing works

In-vitro anticoagulant activity of fucoidan derivatives from brown seaweed Laminaria japonica

Wang, J., Zhang, Q., Zhang, Z., Hou, Y., & Zhang, H. (2011) · Chinese Journal of Oceanology and Limnology · doi:10.1007/s00343-011-0181-9 · Cited by 46 · see citing works

Anticoagulant activity of fucoidans from Laminaria japonica by free radical oxygen degradation

Fu, X. (2007) · Journal of Fishery Sciences of China

Effects of the structural characteristics of fucoidans from brown seaweeds on anticoagulant activity and the electrophoretic mobility of complexes with protamine sulfate

Drozd, N. N., Шевченко, Н. М., Ermakova, S. P., Лапикова, Е. С., Va, M., & Николаевна, З. Т. (2011) · Pharmaceutical Chemistry Journal · doi:10.1007/s11094-011-0560-8 · Cited by 14 · see citing works

A Comparative Study of Antithrombotic Activities of Fucoidan with Different Molecular Weight and Its Mechanism

Chen, A. (2012) · Zhōnghuá yàoxué zázhì · Cited by 1 · see citing works