Cited by 229Seaweed-derived Bioactive CompoundsMarine and coastal plant biologyPolysaccharides Composition and Applications

Fucoidans from Brown Seaweeds Sargassum hornery, Eclonia cava, Costaria costata: Structural Characteristics and Anticancer Activity

Ermakova, Svetlana, Sokolova, Roza, Kim, Sang-Min, Um, Byung-Hun, Isakov, Vladimir, Zvyagintseva, Tatyana·2011·Applied Biochemistry and Biotechnology

Abstract

Fucoidans were isolated by water extraction and ion-exchange chromatography from brown algae Eclonia cava, Sargassum hornery, and Costaria costata collected near of Korean coasts. The structures of fucoidans were investigated. Fucoidan from E. cava was mixture of sulfated rhamnogalactofucan and galactofucan. Fucoidan from C. costata was a sulfated galactofucan. Fucoidan isolated from S. hornery was separated into three fractions: a homofucan sulfate, a homofucan but without sulfate groups, and a sulfated rhamnofucan. The results clearly showed that fucoidans play an inhibitory role in colony formation in human melanoma and colon cancer cells and may be effective antitumor agents.

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Crossref · 10.1007/s12010-011-9178-2

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  • Anti-cancer activity of fucoidans is not a function of a single specific structural trait but a combination of many factors such as amount of sulfate groups, monosaccharide composition, and types of linkages of sugar residues.

    “Nevertheless, it appears that the anti-cancer activity of fucoidans is not a function of a single specific structural trait but a combination of many factors such as the amount of sulfate groups, the monosaccharide composition, and the types of linkages of the sugar residues.1,30”

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Authors
Ermakova, S., Sokolova, R., Kim, S.-M., Um, B.-H., Isakov, V., & Zvyagintseva, T.
Affiliations
  • Pacific Institute of Bioorganic Chemistry. GB Elyakova Far Eastern Branch of the Russian Academy of Sciences (RU)
  • Korea Institute of Science and Technology (KR)
Corresponding author
Ermakova, Svetlana
Venue
Applied Biochemistry and Biotechnology
Published
2011-02-08
Volume
164
Issue
6
Pages
841-850
ISSN
  • 0273-2289 (ISSN-L)
  • 1559-0291
OpenAlex
W2055508057
Cited by
229
References
18
Citations by year
2026: 8 · 2025: 8 · 2024: 21 · 2023: 19 · 2022: 15 · 2021: 24 · 2020: 23 · 2019: 16 · 2018: 17 · 2017: 13 · 2016: 11 · 2015: 16 · 2014: 12 · 2013: 14 · 2012: 10
FWCI
18.59
Type
journal article
Language
en
Open access
closed
Locations
  • Applied Biochemistry and Biotechnology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
  • Physical Sciences › Earth and Planetary Sciences › Oceanography › Marine and coastal plant biology
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
Keywords
fucoidan, brown algae, Costaria costata, anticancer activity, melanoma, colon cancer, colony formation inhibition, seaweed polysaccharides
MeSH terms
Phaeophyceae, Antineoplastic Agents, Humans, Neoplasms, Polysaccharides, Seaweed, Cell Line, Tumor, Cell Proliferation

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