Cited by 156Seaweed-derived Bioactive CompoundsPolysaccharides Composition and ApplicationsPolysaccharides and Plant Cell Walls

Structural characterization and effect on anti-angiogenic activity of a fucoidan from Sargassum fusiforme

Cong, Qifei, Chen, Huanjun, Liao, Wenfeng, Xiao, Fei, Wang, Peipei, Qin, Yi, Dong, Qun, Ding, Kan·2016·Carbohydrate Polymers

Abstract

A fucoidan FP08S2 was isolated from the boiling-water extract of Sargassum fusiforme, purified by CaCl2 precipitation and chromatography on DEAE-cellulose and Sephacryl S-300. FP08S2 contained fucose, xylose, galactose, mannose, glucuronic acid, and 20.8% sulfate. The sulfate groups were attached to diverse positions of fucose, xylose, mannose, and galactose residues. The backbone of FP08S2 consisted of alternate 1,2-linked α-D-Manp and 1,4-linked β-D-GlcpA. Sugar composition analysis and ESI-MS revealed that the oligosaccharides from branches contained fucose, xylose, galactose, glucuronic acid and sulfate. FP08S2 could significantly inhibit tube formation and migration of human microvascular endothelial cells (HMEC-1) dose-dependently. These results suggested that the fucoidan FP08S2 from brown seaweeds S. fusiforme could be a potent anti-angiogenic agent.

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Crossref · 10.1016/j.carbpol.2015.09.087

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Authors
Cong, Q., Chen, H., Liao, W., Xiao, F., Wang, P., Qin, Y., Dong, Q., & Ding, K.
Affiliations
Chinese Academy of Sciences (CN)
Corresponding author
  • Dong, Qun
  • Ding, Kan
Venue
Carbohydrate Polymers
Publisher
Elsevier BV
Published
2016-01
Volume
136
Pages
899-907
ISSN
0144-8617 (ISSN-L)
OpenAlex
W1926086786
Cited by
156
References
39
Citations by year
2026: 7 · 2025: 14 · 2024: 18 · 2023: 16 · 2022: 11 · 2021: 28 · 2020: 20 · 2019: 20 · 2018: 7 · 2017: 9 · 2016: 6
FWCI
11.39
Type
journal article
Language
en
Open access
closed
Locations
  • Carbohydrate Polymers (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Science Fund for Distinguished Young Scholars (81125025)
  • National Natural Science Foundation of China (31230022)
  • National Key New Drug Creation and Manufacturing Program, Ministry of Science and Technology (2012ZX09301001-003)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Polysaccharides and Plant Cell Walls
Keywords
fucoidan, Sargassum fusiforme, antiangiogenic activity, sulfated polysaccharides, sulfation patterns, oligosaccharide structure, human microvascular endothelial cells, cell migration inhibition, brown seaweed polysaccharides
MeSH terms
Cell Line, Endothelium, Vascular, Humans, Monosaccharides, Polysaccharides, Wound Healing, Angiogenesis Inhibitors, Endothelial Cells, Sargassum

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