Structural characterization and effect on anti-angiogenic activity of a fucoidan from Sargassum fusiforme
Abstract
A fucoidan FP08S2 was isolated from the boiling-water extract of Sargassum fusiforme, purified by CaCl2 precipitation and chromatography on DEAE-cellulose and Sephacryl S-300. FP08S2 contained fucose, xylose, galactose, mannose, glucuronic acid, and 20.8% sulfate. The sulfate groups were attached to diverse positions of fucose, xylose, mannose, and galactose residues. The backbone of FP08S2 consisted of alternate 1,2-linked α-D-Manp and 1,4-linked β-D-GlcpA. Sugar composition analysis and ESI-MS revealed that the oligosaccharides from branches contained fucose, xylose, galactose, glucuronic acid and sulfate. FP08S2 could significantly inhibit tube formation and migration of human microvascular endothelial cells (HMEC-1) dose-dependently. These results suggested that the fucoidan FP08S2 from brown seaweeds S. fusiforme could be a potent anti-angiogenic agent.
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Laminarin and fucoidan are further purified using membrane filtration or chromatographic procedures.
“Laminarin and fucoidan were further purified from the extract using different techniques such as membrane filtration or chromatographic procedures”
From Polysaccharides from macroalgae: Recent advances, innovative technologies and challenges in extraction and purification (2017) · cites this paper as Cong et al., 2016
Macroalgal polysaccharides, especially fucoidan and laminarin, exhibit a broad range of biological activities in in vitro and in vivo models.
“These macroalgal polysaccharides, particularly fucoidan and laminarin, show a wide range of biological activities such as antiinflammatory, antimicrobial, anticoagulant, antiadhesive, antioxidant, antiviral, antipeptic, antitumour, antiapoptosis, antiproliferative and immunostimulatory in in vitro and in vivo model systems”
From Polysaccharides from macroalgae: Recent advances, innovative technologies and challenges in extraction and purification (2017) · cites this paper as Cong et al., 2016
Fucoidan fractions from Sargassum fusiforme show potent antiangiogenic activities that could be useful in cancer therapy.
“Also, fucoidan fractions from Sargassum fusiforme showed potent antiangiogenic activities that could be useful in cancer therapy”
From Polysaccharides from macroalgae: Recent advances, innovative technologies and challenges in extraction and purification (2017) · cites this paper as Cong et al., 2016
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- Authors
- Cong, Q., Chen, H., Liao, W., Xiao, F., Wang, P., Qin, Y., Dong, Q., & Ding, K.
- Affiliations
- Chinese Academy of Sciences (CN)
- Corresponding author
- Dong, Qun
- Ding, Kan
- Venue
- Carbohydrate Polymers
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 136
- Pages
- 899-907
- ISSN
- 0144-8617 (ISSN-L)
- OpenAlex
- W1926086786
- Semantic Scholar
- 522fcd1f5c52af9241c7af14d5dac90a0f5363d8
- Cited by
- 156
- References
- 39
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 18 · 2023: 16 · 2022: 11 · 2021: 28 · 2020: 20 · 2019: 20 · 2018: 7 · 2017: 9 · 2016: 6
- FWCI
- 11.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Carbohydrate Polymers (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Fund for Distinguished Young Scholars (81125025)
- National Natural Science Foundation of China (31230022)
- National Key New Drug Creation and Manufacturing Program, Ministry of Science and Technology (2012ZX09301001-003)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Polysaccharides and Plant Cell Walls
- Keywords
- fucoidan, Sargassum fusiforme, antiangiogenic activity, sulfated polysaccharides, sulfation patterns, oligosaccharide structure, human microvascular endothelial cells, cell migration inhibition, brown seaweed polysaccharides
- MeSH terms
- Cell Line, Endothelium, Vascular, Humans, Monosaccharides, Polysaccharides, Wound Healing, Angiogenesis Inhibitors, Endothelial Cells, Sargassum
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