Structure of a fucoidan from the brown seaweed Fucus evanescens C.Ag.
Abstract
A fucoidan consisting of L-fucose, sulfate and acetate in a molar proportion of 1:1.23:0.36 was isolated from the Pacific brown seaweed Fucus evanescens. The structures of its desulfated and de-O-acetylated derivatives were investigated by 1D and 2D (1)H and (13)C NMR spectroscopy, and the data obtained were confirmed by methylation analysis of the native and desulfated polysaccharides. The fucoidan was shown to contain a linear backbone of alternating 3- and 4-linked alpha-L-fucopyranose 2-sulfate residues: -->3)-alpha-L-Fucp(2SO(3)(-))-(1-->4)-alpha-L-Fucp(2SO(3)(-))-(1-->. Additional sulfate occupies position 4 in a part of 3-linked fucose residues, whereas a part of the remaining hydroxyl groups is randomly acetylated.
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Fucoidan from brown seaweed in the order of Fucales such as F. evanescens and F. serratus contain large proportions of both α(1→3) and α(1→4) glycosidic bonds.
“several studies—using highly advanced analytical methods—have documented that fucoidan from brown seaweed in the order of Fucales such as F. evanescens and F. serratus do indeed contain large proportions of both α(1→3) and α(1→4) glycosidic bonds [20–22]”
Fucoidans in the order Fucales, e.g. Fucus evanescens and Fucus serratus, possess a large proportion of both α(1→3)- and α(1→4)-linked L-fucopyranose residues, which may be substituted with sulfate on C-2 and C-4.
“The fucoidans in brown seaweeds in the order of Fucales, e.g.Fucus evanescens and Fucus serratus, represent the typical structures: They possess a large proportion of both a(1A3)and a(1A4)-linked L-fucopyranose residues, which may be substituted with sulfate (SO 3 2 ) on C-2 and C-4 (Table 1).6,7,10”
From Fucoidans from brown seaweeds: an update on structures, extraction techniques and use of enzymes as tools for structural elucidation (2013) · cites this paper as [10]
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Self-citation
- Authors
- Bilan, M. I., Grachev, A. A., Ustuzhanina, N. E., Shashkov, A. S., Nifantiev, N. E., & Usov, A. I.
- Affiliations
- Russian Academy of Sciences (RU)
- Corresponding author
- Usov, Anatolii I
- Venue
- Carbohydrate Research
- Publisher
- Elsevier BV
- Published
- 2002-04
- Volume
- 337
- Issue
- 8
- Pages
- 719-730
- ISSN
- 0008-6215 (ISSN-L)
- OpenAlex
- W2051771857
- Cited by
- 412
- References
- 36
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 14 · 2023: 24 · 2022: 25 · 2021: 20 · 2020: 28 · 2019: 24 · 2018: 25 · 2017: 27 · 2016: 23 · 2015: 36 · 2014: 28 · 2013: 25 · 2012: 14
- FWCI
- 9.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Carbohydrate Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Polysaccharides and Plant Cell Walls
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Keywords
- fucoidan, Fucus evanescens, brown seaweed polysaccharides, L-fucose, polysaccharide structure, O-acetylation, methylation analysis
- MeSH terms
- Acetates, Phaeophyceae, Carbohydrate Conformation, Carbohydrate Sequence, Fucose, Polysaccharides, Sulfates, Sequence Analysis, Nuclear Magnetic Resonance, Biomolecular
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