Cited by 89Seaweed-derived Bioactive CompoundsSkin Protection and AgingMarine and coastal plant biology

Structural properties and protective effect of Sargassum fusiforme polysaccharides against ultraviolet B radiation in hairless Kun Ming mice

Open access
Ye, Yuhui, Ji, Desheng, You, Lijun, Zhou, Lin, Zhao, Zhengang, Brennan, Charles·2018·Journal of Functional Foods

Abstract

Sargassum fusiforme polysaccharide (SFP) was extracted from Sargassum fusiforme by hot water boiling, concentration and ethanol precipitation. The composition was determined as 58.10 ± 2.12% carbohydrate, 1.01 ± 0.15% protein, 9.85 ± 0.96% sulfate group and 17.66 ± 0.54% glucuronic acid. The average molecular weight of SFP was 224 kDa. The monosaccharide composition of SFP was 43.2% L-fucose, 3.5% rhamnose, 18.4% galactose, 1.5% glucose, 18.5% fructose, 5.9% xylose and 9.0% mannose respectively. SFP showed significant protective effect against ultraviolet B (UVB) radiation in hairless Kun Ming (KM) mice by manipulating the skin water content and thymus and spleen indexes. SFP could also alleviate UVB-induced oxidative stress by enhancing the activities of superoxide dismutase (SOD) and catalase (CAT) and reducing the levels of reactive oxygen species (ROS) and malondialdehyde (MDA) equivalents. The levels of matrix metalloproteinase (MMP)-1 and 9 were also suppressed in SFP treatments. These findings suggest that SFP could be used as a potential functional food supplement for skin protection.

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Crossref · 10.1016/j.jff.2018.01.025

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  • Both Tremella fuciformis and Sargassum fusiforme polysaccharides enhance activity of antioxidant enzymes, reduce oxidative stress, and ultimately improve skin damage.

    “For example, both Tremella fuciformis and Sargassum fusiforme polysaccharides enhance the activity of antioxidant enzymes, such as superoxide dismutase and catalase, reduce oxidative stress, and ultimately improve skin damage.”
  • Sargassum fusiforme polysaccharide enhanced superoxide dismutase and catalase activities, and decreased ROS and malondialdehyde levels, in mouse dorsal skin, resulting in reduction of UVB-induced oxidative stress.

    “Moreover, Sargassum fusiforme polysaccharide enhanced superoxide dismutase and catalase activities, and decreased ROS and malondialdehyde levels, in mouse dorsal skin, resulting in the reduction of UVB-induced oxidative stress [12].”
  • Oral administration of Sargassum fusiforme polysaccharide protected hairless Kunming mice from UVB radiation by inhibiting MMP-1 and MMP-9 in skin.

    “Oral administration of Sargassum fusiforme polysaccharide protected hairless Kunming mice from UVB radiation by inhibiting MMP-1 and MMP-9 in skin.”

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Authors
Ye, Y., Ji, D., You, L., Zhou, L., Zhao, Z., & Brennan, C.
Affiliations
  • South China University of Technology (CN)
  • Guangdong Pharmaceutical University (CN)
  • Lincoln University (NZ)
Corresponding author
You, Lijun
Venue
Journal of Functional Foods
Publisher
Elsevier BV
Published
2018-04
Volume
43
Pages
8-16
ISSN
1756-4646 (ISSN-L)
OpenAlex
W2793113470
Cited by
89
References
58
Citations by year
2026: 1 · 2025: 7 · 2024: 4 · 2023: 11 · 2022: 19 · 2021: 16 · 2020: 12 · 2019: 16 · 2018: 3
FWCI
11.79
Type
journal article
Language
en
Open access
Locations
  • Journal of Functional Foods (publishedVersion)
  • RMIT Research Repository (RMIT University Library) (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Figshare (submittedVersion)
  • Lincoln University Research Archive (Lincoln University) (submittedVersion)
Funders
  • Guangdong Special Support Program (2015TQ01N670)
  • Pearl River S&T Nova Program of Guangzhou (201610010096)
  • Fundamental Research Funds for the Central Universities (2015ZZ110)
  • Group Program of Natural Science Foundation of Guangdong Province (2016A030312001)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Physical Sciences › Earth and Planetary Sciences › Oceanography › Marine and coastal plant biology
Keywords
Sargassum fusiforme, seaweed polysaccharides, UV-B radiation, photoprotection, oxidative stress, superoxide dismutase, catalase, reactive oxygen species, malondialdehyde, MMP-1, MMP-9, skin hydration, spleen and thymus index, monosaccharide composition, functional food supplement

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