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O2⋅− and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate
Open accessAbstract
Pharmacological ascorbate has been proposed as a potential anti-cancer agent when combined with radiation and chemotherapy. The anti-cancer effects of ascorbate are hypothesized to involve the autoxidation of ascorbate leading to increased steady-state levels of H 2 O 2; however, the mechanism(s) for cancer cell-selective toxicity remain unknown. The current study shows that alterations in cancer cell mitochondrial oxidative metabolism resulting in increased levels of O 2⋅- and H 2 O 2 are capable of disrupting intracellular iron metabolism, thereby selectively sensitizing non-small-cell lung cancer (NSCLC) and glioblastoma (GBM) cells to ascorbate through pro-oxidant chemistry involving redox-active labile iron and H 2 O 2. In addition, preclinical studies and clinical trials demonstrate the feasibility, selective toxicity, tolerability, and potential efficacy of pharmacological ascorbate in GBM and NSCLC therapy.
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“an increased level of mitochondrial ROS in lung and glioblastoma cancer cells led to increased levels of intracellular labile iron through the upregulation of the Tf receptor (TfR), thus increasing the sensitivity of these cancer cells to ascorbate43.”
From Targeting cancer vulnerabilities with high-dose vitamin C (2019) · cites this paper as [43]
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“Numerous preclinical and clinical studies indicate that parenteral injection of pharmacological ascorbate does not interfere with chemotherapy or radiotherapy and may even act synergistically43,104,105.”
From Targeting cancer vulnerabilities with high-dose vitamin C (2019) · cites this paper as [43]
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“Numerous preclinical and clinical studies indicate that parenteral injection of pharmacological ascorbate does not interfere with chemotherapy or radiotherapy and may even act synergistically43,104,105.”
From Targeting cancer vulnerabilities with high-dose vitamin C (2019) · cites this paper as [43]
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“This study shows that pharmacological ascorbate selectively sensitizes non-small-cell lung cancer (NSCLC) and glioblastoma (GBM) cells by generating redox-active labile iron and H2O2 using in vitro cell lines and mouse models.”
From Targeting cancer vulnerabilities with high-dose vitamin C (2019) · cites this paper as [43]
In the citing paper
“In addition, it shows the potential efficacy of ascorbate therapy combined with other chemotherapies in patients with GBM and NSCLC.”
From Targeting cancer vulnerabilities with high-dose vitamin C (2019) · cites this paper as [43]
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Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 316,394
New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)
Eisenhauer, E. A., Therasse, P., Bogaerts, J., Schwartz, L. H., Sargent, D., Ford, R., Dancey, J., Arbuck, S., Gwyther, S., Mooney, M., et al. (2009) · European Journal of Cancer · doi:10.1016/j.ejca.2008.10.026 · Cited by 29,534
Radiotherapy Plus Concomitant and Adjuvant Temozolomide for Glioblastoma
Stupp, R., Mason, W. P., van den Bent, M. J., Weller, M., Fisher, B., Taphoorn, M. J. B., Belanger, K., Brandes, A. A., Marosi, C., Bogdahn, U., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043330 · Cited by 21,807
MGMT Gene Silencing and Benefit from Temozolomide in Glioblastoma
Hegi, M. E., Diserens, A.-C., Gorlia, T., Hamou, M.-F., de Tribolet, N., Weller, M., Kros, J. M., Hainfellner, J. A., Mason, W., Mariani, L., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043331 · Cited by 7,405
Paclitaxel–Carboplatin Alone or with Bevacizumab for Non–Small-Cell Lung Cancer
Sandler, A., Gray, R., Perry, M. C., Brahmer, J., Schiller, J. H., Dowlati, A., Lilenbaum, R., & Johnson, D. H. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa061884 · Cited by 5,761
[1] Role of free radicals and catalytic metal ions in human disease: An overview
Halliwell, B., & Gutteridge, J. M. C. (1990) · Methods in Enzymology · doi:10.1016/0076-6879(90)86093-b · Cited by 4,994
Comparison of Four Chemotherapy Regimens for Advanced Non–Small-Cell Lung Cancer
Schiller, J. H., Harrington, D., Belani, C. P., Langer, C., Sandler, A., Krook, J., Zhu, J., & Johnson, D. H. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa011954 · Cited by 4,955
DISC ELECTROPHORESIS‐I BACKGROUND AND THEORY*
Ornstein, L. (1964) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1964.tb14207.x · Cited by 4,575
COMPARISON OF FOUR CHEMOTHERAPY REGIMENS FOR ADVANCED NON-SMALL-CELL LUNG CANCER
Chiller, J. O. H. S., Arrington, D. A. H., Elani, C. H. P. B., Anger, C., Andler, A. L. S., Rook, J. A. K., Hu, J., & Ohnson, D. A. H. J. (2002) · Cited by 3,730
Production of large amounts of hydrogen peroxide by human tumor cells.
Szatrowski, T. P., & Nathan, C. (1991) · PubMed · Cited by 2,504
Flagged first, then by citations
Research works printed but not linked: 1
- Spitz, 2001, Measurement of MnSOD and CuZnSOD activity in mammalian tissue homogenates, Curr. Protoc. Toxicol., Chapter 7
Cited by
Sorted by citations
Items 101–200 of 442
Ren, X., Santhosh, S. M., Coppo, L., Ogata, F. T., Lu, J., & Holmgren, A. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.01.037 · Cited by 59
Wang, F., He, M.-M., Wang, Z., Su, L., Jin, Y., Ren, C., Shi, S., Bi, B., Chen, S.-Z., Lv, Z.-D., et al. (2019) · BMC Cancer · doi:10.1186/s12885-019-5696-z · Cited by 57
FLASH irradiation does not induce lipid peroxidation in lipids micelles and liposomes
Froidevaux, P., Grilj, V., Bailat, C. J., Geyer, W. R., Bochud, F. O., & Vozenin, M. (2022) · Radiation Physics and Chemistry · doi:10.1016/j.radphyschem.2022.110733 · Cited by 61
Ou, J., Zhu, X., Chen, P., Du, Y., Lu, Y., Peng, X., Bao, S., Wang, J., Zhang, X., Zhang, T., et al. (2020) · Journal of Advanced Research · doi:10.1016/j.jare.2020.03.004 · Cited by 54
Paradoxical roles of dual oxidases in cancer biology
Little, A. C., Sulovari, A., Danyal, K., Heppner, D. E., Seward, D. J., & van der Vliet, A. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.05.024 · Cited by 55
NADPH oxidase‐derived reactive oxygen species: Dosis facit venenum
Schröder, K. (2019) · Experimental Physiology · doi:10.1113/ep087125 · Cited by 52
Sishc, B. J., Ding, L., Nam, T.-K., Heer, C. D., Rodman, S. N., Schoenfeld, J. D., Fath, M. A., Saha, D., Pulliam, C. F., Langen, B., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abb3768 · Cited by 51
Self-citationFurqan, M., Hejleh, T. A., Stephens, L. M., Hartwig, S. M., Mott, S. L., Pulliam, C. F., Petronek, M. S., Henrich, J. B., Fath, M. A., Houtman, J. C. D., et al. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102318 · Cited by 55
Self-citationFLASH: New intersection of physics, chemistry, biology, and cancer medicine
Vozenin, M., Loo, B. W., Tantawi, S. G., Maxim, P. G., Spitz, D. R., Bailat, C. J., & Limoli, C. L. (2024) · Reviews of Modern Physics · doi:10.1103/revmodphys.96.035002 · Cited by 59
Self-citationVitamin C Controls Neuronal Necroptosis Under Oxidative Stress
Ferrada, L., Barahona, M. J., Salazar, K., Vandenabeele, P., & Nualart, F. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101408 · Cited by 51
Targeting of stress response pathways in the prevention and treatment of cancer
Zelenka, J., Koncošová, M., & Ruml, T. (2018) · Biotechnology Advances · doi:10.1016/j.biotechadv.2018.01.007 · Cited by 50
High-Dose Vitamin C: Preclinical Evidence for Tailoring Treatment in Cancer Patients
Giansanti, M., Karimi, T., Faraoni, I., & Graziani, G. (2021) · Cancers · doi:10.3390/cancers13061428 · Cited by 50
A novel red pigment from marine Arthrobacter sp. G20 with specific anticancer activity
Afra, S., Makhdoumi, A., Matin, M. M., & Feizy, J. (2017) · Journal of Applied Microbiology · doi:10.1111/jam.13576 · Cited by 49
Sciegienka, S. J., Solst, S. R., Falls, K. C., Schoenfeld, J. D., Klinger, A. R., Ross, N. L., Rodman, S. N., Spitz, D. R., & Fath, M. A. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.04.001 · Cited by 49
Self-citationTransferrin receptor-involved HIF-1 signaling pathway in cervical cancer
Xu, X., Liu, T., Wu, J., Wang, Y., Hong, Y., & Zhou, H. (2019) · Cancer Gene Therapy · doi:10.1038/s41417-019-0078-x · Cited by 49
Heer, C. D., Davis, A. B., Riffe, D., Wagner, B. A., Falls, K. C., Allen, B. G., Buettner, G. R., Beardsley, R., Riley, D. P., & Spitz, D. R. (2018) · Antioxidants · doi:10.3390/antiox7010018 · Cited by 48
Self-citationBodeker, K. L., Smith, B. J., Berg, D., Chandrasekharan, C., Sharif, S., Fei, N. H., Vollstedt, S., Brown, H., Chandler, M. L., Lorack, A. C., et al. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103375 · Cited by 50
Self-citationMetabolite regulation of epigenetics in cancer
Wang, P., Chen, L., Xiong, Y., & Ye, D. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114815 · Cited by 50
Huang, Y., Huang, J., Huang, Y. H., Gan, L., Long, L., Pu, A., & Xie, R. (2020) · PubMed Central · Cited by 47
Current views on mechanisms of the FLASH effect in cancer radiotherapy
Ma, Y., Zhang, W., Zhao, Z.-M., Lv, J., Chen, J., Yan, X., Lin, X., Zhang, J., Wang, B., Gao, S., et al. (2024) · National Science Review · doi:10.1093/nsr/nwae350 · Cited by 46
Self-citationBrandt, K. E., Falls, K. C., Schoenfeld, J. D., Rodman, S. N., Gu, Z., Zhan, F., Cullen, J. J., Wagner, B. A., Buettner, G. R., Allen, B. G., et al. (2017) · Redox Biology · doi:10.1016/j.redox.2017.08.017 · Cited by 50
Self-citationLiu, Y., Pang, Y. K., Zhu, B., Uher, O., Caisová, V., Huynh, T., Taïeb, D., Vanova, K. H., Ghayee, H. K., Neužil, J., et al. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-2335 · Cited by 46
Iron–Sulfur Cluster Biogenesis as a Critical Target in Cancer
Petronek, M. S., Spitz, D. R., & Allen, B. G. (2021) · Antioxidants · doi:10.3390/antiox10091458 · Cited by 46
Self-citationNavigating the redox landscape: reactive oxygen species in regulation of cell cycle
Mackova, V., Raudenská, M., Polanska, H. H., Jakubek, M., & Masařík, M. (2024) · Redox Report · doi:10.1080/13510002.2024.2371173 · Cited by 48
Banna, N. E., Hatem, E., Heneman-Masurel, A., Léger, T., Baïlle, D., Vernis, L., Garcia, C., Martineau, S., Dupuy, C., Vagner, S., et al. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101290 · Cited by 45
Harnessing altered oxidative metabolism in cancer by augmented prooxidant therapy
Firczuk, M., Bajor, M., Graczyk‐Jarzynka, A., Fidyt, K., Góral, A., & Zagożdżon, R. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.11.037 · Cited by 45
Kampa, J. M., Kellner, U., Marsching, C., Guevara, C. R., Knappe, U. J., Sahin, M., Giampà, M., Niehaus, K., & Bednarz, H. (2020) · Neuropathology · doi:10.1111/neup.12671 · Cited by 45
Bekhet, O. H., & Eid, M. E. (2021) · Translational Cancer Research · doi:10.21037/tcr-21-629 · Cited by 45
Artificial intelligence in radiotherapy: a technological review
Sheng, K. (2020) · Frontiers of Medicine · doi:10.1007/s11684-020-0761-1 · Cited by 44
Vaishampayan, P., & Lee, Y. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103288 · Cited by 43
Graczyk‐Jarzynka, A., Góral, A., Muchowicz, A., Zagożdżon, R., Winiarska, M., Bajor, M., Trzeciecka, A., Fidyt, K., Krupka, J. A., Cyran, J., et al. (2018) · Redox Biology · doi:10.1016/j.redox.2018.11.020 · Cited by 43
Wu, T.-M., Liu, S., Chen, S.-Y., Chen, G., Wu, C., & Huang, S. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01483 · Cited by 44
Tóth, S. Z., Lőrincz, T., & Szarka, A. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7125 · Cited by 43
Reactive oxygen species: Janus-faced molecules in the era of modern cancer therapy
O’Reilly, A., Zhao, W., Wickström, S. L., Arnér, E. S. J., & Kiessling, R. W. (2024) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-009409 · Cited by 42
Falls-Hubert, K. C., Butler, A. L., Gui, K., Anderson, M., Li, M., Stolwijk, J. M., Rodman, S. N., Solst, S. R., Tomanek‐Chalkley, A., Searby, C. C., et al. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.01.186 · Cited by 42
Self-citationNanoparticles weaponized with built‐in functions for imaging‐guided cancer therapy
Jing, L., Yang, C., Zhang, P., Zeng, J., Li, Z., & Gao, M. (2020) · Open Research (University of Surrey) · doi:10.1002/viw2.19 · Cited by 42
O’Leary, B. R., Houwen, F. K., Johnson, C. L., Allen, B. G., Mezhir, J. J., Berg, D., Cullen, J. J., & Spitz, D. R. (2018) · Radiation Research · doi:10.1667/rr14978.1 · Cited by 42
Self-citationGupta, K., Vučković, I., Zhang, S., Xiong, Y., Carlson, B. L., Jacobs, J., Olson, I., Petterson, X.-M. T., Macura, S. I., Sarkaria, J. N., et al. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00535 · Cited by 40
Ascorbate Is a Primary Antioxidant in Mammals
Fujii, J., Osaki, T., & Bo, T. (2022) · Molecules · doi:10.3390/molecules27196187 · Cited by 44
Enterobactin, an iron chelating bacterial siderophore, arrests cancer cell proliferation
Saha, P., Yeoh, B. S., Xiao, X., Golonka, R. M., Kumarasamy, S., & Vijay–Kumar, M. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.06.017 · Cited by 39
Ascorbate kills breast cancer cells by rewiring metabolism via redox imbalance and energy crisis
Ghanem, A., Melzer, A. M., Zaal, E. A., Neises, L., Baltissen, D., Matar, O., Glennemeier-Marke, H., Almouhanna, F., Theobald, J., el Maaty, M. A. A., et al. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.12.012 · Cited by 38
Petronek, M. S., Stolwijk, J. M., Murray, S., Steinbach, E. J., Zakharia, Y., Buettner, G. R., Spitz, D. R., & Allen, B. G. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101864 · Cited by 41
Self-citationBuranasudja, V., Doskey, C. M., Gibson, A. R., Wagner, B. A., Du, J., Gordon, D. J., Koppenhafer, S. L., Cullen, J. J., & Buettner, G. R. (2019) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-19-0381 · Cited by 40
Self-citationFerrada, L., Barahona, M. J., Vera, M., Stockwell, B. R., & Nualart, F. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06153-9 · Cited by 36
Gerecke, C., Schumacher, F., Berndzen, A., Homann, T., & Kleuser, B. (2019) · Epigenetics · doi:10.1080/15592294.2019.1666652 · Cited by 36
Ma, D. C., Anderson, C. M., Rodman, S. N., Buranasudja, V., McCormick, M. L., Davis, A. B., Loth, E., Bodeker, K. L., Ahmann, L., Parkhurst, J. R., et al. (2021) · Radiation Research · doi:10.1667/rade-20-00150.1 · Cited by 36
Self-citationSelenium Modulates Cancer Cell Response to Pharmacologic Ascorbate
Jankowski, C. S. R., & Rabinowitz, J. D. (2022) · Cancer Research · doi:10.1158/0008-5472.can-22-0408 · Cited by 36
Zheng, Z., Luo, G., Shi, X., Long, Y., Shen, W., Li, Z., & Zhang, X. (2019) · Cellular Oncology · doi:10.1007/s13402-019-00474-8 · Cited by 36
Gibson, A. R., O’Leary, B. R., Du, J., Sarsour, E. H., Kalen, A. L., Wagner, B. A., Stolwijk, J. M., Falls-Hubert, K. C., Alexander, M. S., Carroll, R. S., et al. (2020) · Cancer Research · doi:10.1158/0008-5472.can-19-3094 · Cited by 35
Self-citationBakalova, R., Semkova, S., Ivanova, D., Zhelev, Z., Miller, T. J., Takeshima, T., Shibata, S., Lazarova, D., Aoki, I., & Higashi, T. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/6212935 · Cited by 35
Darwiche, W., Gomila, C., Ouled‐Haddou, H., Naudot, M., Doualle, C., Morel, P., Nguyen‐Khac, F., Garçon, L., Marolleau, J., & Ghamlouch, H. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01738-0 · Cited by 35
Wang, S.-F., Liu, X., Ding, M., Ma, S., Zhao, J., Wang, Y., & Li, S. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101173 · Cited by 35
Xie, Q., Li, S., Feng, X., Shi, J., Li, Y., Yuan, G., Yang, C., Shen, Y., Kong, L., & Zhang, Z. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01416-7 · Cited by 34
The Interrelationship of Pharmacologic Ascorbate Induced Cell Death and Ferroptosis
Lőrincz, T., Holczer, M., Kapuy, O., & Szarka, A. (2018) · Pathology & Oncology Research · doi:10.1007/s12253-018-0539-9 · Cited by 34
Yue, S., Zhang, P., Qin, M., Zhu, L., Qiao, Y., Li, Q., Lu, Y., Wu, H., Jiang, N., Liu, C., et al. (2022) · Advanced Functional Materials · doi:10.1002/adfm.202202848 · Cited by 34
Zhang, M., Ran, S., Yin, X., Zhang, J., Sun, X. J., Sun, W., & Zhu, Z. (2023) · BMEMat · doi:10.1002/bmm2.12041 · Cited by 34
Self-citationNanomedicine targeting ferroptosis to overcome anticancer therapeutic resistance
Cai, J., Xu, X., & Saw, P. E. (2023) · Science China Life Sciences · doi:10.1007/s11427-022-2340-4 · Cited by 34
Two Distinct Faces of Vitamin C: AA vs. DHA
Ferrada, L., Magdalena, R., Barahona, M. J., Ramírez, E., Sanzana, C., Gutiérrez, J. L., & Nualart, F. (2021) · Antioxidants · doi:10.3390/antiox10020215 · Cited by 33
Zhang, K., Wu, Y., Chen, G., Wang, H., Liu, Y., & Zhou, Y. (2023) · Cancer Cell International · doi:10.1186/s12935-023-02848-3 · Cited by 33
Wang, L., Fu, H., Song, L., Wu, Z., Yu, J., Guo, Q., Chen, C., Yang, X., Zhang, J., Wang, Q., et al. (2022) · Small · doi:10.1002/smll.202204133 · Cited by 32
Self-citationBitonto, V., Alberti, D., Ruiu, R., Aime, S., Crich, S. G., & Cutrìn, J. C. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.12.051 · Cited by 32
Diverse antitumor effects of ascorbic acid on cancer cells and the tumor microenvironment
Maekawa, T., Miyake, T., Tani, M., & Üemoto, S. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.981547 · Cited by 36
Vitamin C and Helicobacter pylori Infection: Current Knowledge and Future Prospects
Mei, H., & Tu, H. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01103 · Cited by 33
Unveiling ferroptosis as a promising therapeutic avenue for colorectal cancer and colitis treatment
Kao, A. T., Cabanlong, C. V., Padilla, K., & Xue, X. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.05.025 · Cited by 30
Rong, X., Xiao, S., Geng, W., Zhu, B., Mou, P., Ding, Z., Zhang, B., Fan, Y., Qiu, L., & Cheng, C. (2025) · Nature Communications · doi:10.1038/s41467-025-61377-x · Cited by 32
Guram, K., Smith, M. C., Ginader, T., Bodeker, K. L., Pelland, D., Pennington, E. C., & Buatti, J. M. (2018) · Practical Radiation Oncology · doi:10.1016/j.prro.2018.06.001 · Cited by 30
Self-citationVitamin C, From Supplement to Treatment: A Re-Emerging Adjunct for Cancer Immunotherapy?
Kouakanou, L., Peters, C., Brown, C. E., Kabelitz, D., & Wang, L. D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.765906 · Cited by 31
Zhou, Y., Zhang, W., Wang, X., Li, P., & Tang, B. (2022) · Chemistry - An Asian Journal · doi:10.1002/asia.202200155 · Cited by 30
Reactive Oxygen Species and Oncoprotein Signaling-A Dangerous Liaison
Chong, S. J. F., Lai, J. X. H., Eu, J. Q., Bellot, G. L., & Pervaiz, S. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7441 · Cited by 30
Petronek, M. S., Monga, V., Bodeker, K. L., Kwofie, M. A., Lee, C., Mapuskar, K. A., Stolwijk, J. M., Zaher, A., Wagner, B. A., Smith, M. C., et al. (2023) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-22-3952 · Cited by 29
Self-citationYan, Y., Huang, Z., Zhu, Z. Y., Cui, Y., Li, M., Huang, R., Yan, J., & Shen, B. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00667 · Cited by 29
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Zhang, M., Liu, Z., Le, Y., Gu, Z., & Zhao, H. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/7449941 · Cited by 32
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Lee, J., & Roh, J. (2023) · Cancers · doi:10.3390/cancers15102694 · Cited by 29
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Baillie, N., Carr, A. C., & Peng, S. (2018) · Antioxidants · doi:10.3390/antiox7090115 · Cited by 28
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Hunyady, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084380 · Cited by 29
Superoxide Dismutases in Pancreatic Cancer
Wilkes, J. G., Alexander, M. S., & Cullen, J. J. (2017) · Antioxidants · doi:10.3390/antiox6030066 · Cited by 27
Self-citationHexose Transporters in Cancer: From Multifunctionality to Diagnosis and Therapy
Echeverría, C. E., Nualart, F., Ferrada, L., Smith, G. J., & Godoy, A. (2021) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2020.12.006 · Cited by 27
Ascorbate as a Bioactive Compound in Cancer Therapy: The Old Classic Strikes Back
González‐Montero, J., Chichiarelli, S., Eufemi, M., Fabio Altieri, F., Saso, L., & Rodrigo, R. (2022) · Molecules · doi:10.3390/molecules27123818 · Cited by 28
Sharma, A., Özayral, S., Caserto, J. S., ten Cate, R., Anders, N. M., Barnett, J. D., Kandala, S. K., Henderson, E., Stewart, J., Liapi, E. A., et al. (2019) · International Journal of Hyperthermia · doi:10.1080/02656736.2019.1631494 · Cited by 27
Chen, Q., Lin, R., Wang, W., Zuo, Y., Zhuo, Y., Yu, Y., Chen, S., & Gu, H. C. (2024) · Analytical Chemistry · doi:10.1021/acs.analchem.4c00076 · Cited by 26
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Codini, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218397 · Cited by 27
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Jensen, I. J., McGonagill, P. W., Berton, R. R., Wagner, B. A., Silva, E. E., Buettner, G. R., Griffith, T. S., & Badovinac, V. P. (2021) · ImmunoHorizons · doi:10.4049/immunohorizons.2100027 · Cited by 25
Self-citationFalls, K. C., Sharma, R. A., Lawrence, Y. R., Amos, R. A., Advani, S. J., Ahmed, M. M., Vikram, B., Coleman, C. N., & Prasanna, P. G. S. (2018) · Radiation Research · doi:10.1667/rr15121.1 · Cited by 27
Semkova, S., Zhelev, Z., Miller, T. J., SUGAYA, K., Aoki, I., Higashi, T., & Bakalova, R. (2020) · Anticancer Research · doi:10.21873/anticanres.14151 · Cited by 25
Cruz‐Gregorio, A. (2026) · Metabolites · doi:10.3390/metabo16010060 · Cited by 24
Crake, R., Burgess, E. R., Royds, J. A., Phillips, E., Vissers, M. C. M., & Dachs, G. U. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.619300 · Cited by 24
Xu, Y., Guo, X., Wang, G., & Zhou, C. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00645 · Cited by 23
Pharmacological ascorbate as a novel therapeutic strategy to enhance cancer immunotherapy
Zaher, A., Stephens, L. M., Miller, A. M., Hartwig, S. M., Stolwijk, J. M., Petronek, M. S., Zacharias, Z. R., Wadas, T. J., Monga, V., Cullen, J. J., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.989000 · Cited by 25
Self-citationBalanced Duality: H2O2-Based Therapy in Cancer and Its Protective Effects on Non-Malignant Tissues
Zaher, A., Petronek, M. S., Allen, B. G., & Mapuskar, K. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168885 · Cited by 23
Self-citationRole of amino acids in regulation of ROS balance in cancer
Jaune, E., & Vasseur, S. (2020) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2020.108438 · Cited by 23
Iron metabolism: an emerging therapeutic target underlying the anti-cancer effect of quercetin
Yin, M., Liu, Y., & Chen, Y. (2021) · Free Radical Research · doi:10.1080/10715762.2021.1898604 · Cited by 23
AQP3‐mediated H2O2 uptake inhibits LUAD autophagy by inactivating PTEN
Wang, Y., Chen, D., Liu, Y., Zhang, Y., Duan, C., Otkur, W., Chen, H., Liu, X., Xia, T., Qi, H., et al. (2021) · Cancer Science · doi:10.1111/cas.15008 · Cited by 23
Insight into the roles of vitamins C and D against cancer: Myth or truth?
Zhao, C., Li, Y., Meng, X., Li, S., Liu, Q., Tang, G., Gan, R., & Li, H. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.05.039 · Cited by 23
Dietary Modulation of Bacteriophages as an Additional Player in Inflammation and Cancer
Marongiu, L., Burkard, M., Venturelli, S., & Allgayer, H. (2021) · Cancers · doi:10.3390/cancers13092036 · Cited by 23
Research progress on the occurrence and therapeutic mechanism of ferroptosis in NSCLC
Zhang, Y., Guo, R., Li, J., & Zhu, L. (2021) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-021-02178-z · Cited by 21
Epigenetic Regulators of DNA Cytosine Modification: Promising Targets for Cancer Therapy
Jung, I., An, J., & Ko, M. (2023) · Biomedicines · doi:10.3390/biomedicines11030654 · Cited by 22
Ma, Y., Chen, P., Drisko, J., Khabele, D., Godwin, A. K., & Chen, Q. (2020) · Oncology Letters · doi:10.3892/ol.2020.11364 · Cited by 22
Parenteral high‑dose ascorbate - A possible approach for the treatment of glioblastoma (Review)
Renner, O., Burkard, M., Michels, H., Vollbracht, C., Sinnberg, T. W., & Venturelli, S. (2021) · International Journal of Oncology · doi:10.3892/ijo.2021.5215 · Cited by 24
Paller, C. J., ZAHURAK, M. L., Mandl, A., Metri, N. A., Lalji, A., Heath, E. I., Kelly, W. K., Hoimes, C. J., Barata, P. C., Taksey, J. D., et al. (2024) · Cancer Research Communications · doi:10.1158/2767-9764.crc-24-0225 · Cited by 21
Coppock, D., Violet, P.-C., Vásquez, G., Belden, K. A., Foster, M. W., Mullin, B., Magee, D., Mikell, I., Shah, L., Powers, V., et al. (2022) · Life · doi:10.3390/life12030453 · Cited by 21
Metadata
- Authors
- Schoenfeld, J. D., Sibenaller, Z. A., Mapuskar, K. A., Wagner, B. A., Cramer-Morales, K. L., Furqan, M., Sandhu, S., Carlisle, T. L., Smith, M. C., Abu Hejleh, T., Berg, D. J., Zhang, J., Keech, J., Parekh, K. R., Bhatia, S., Monga, V., Bodeker, K. L., Ahmann, L., Vollstedt, S., Brown, H., Shanahan Kauffman, E. P., Schall, M. E., Hohl, R. J., Clamon, G. H., Greenlee, J. D., Howard, M. A., Schultz, M. K., Smith, B. J., Riley, D. P., Domann, F. E., Cullen, J. J., Buettner, G. R., Buatti, J. M., Spitz, D. R., & Allen, B. G.
- Affiliations
- University of Iowa (US)
- Galera Therapeutics, Inc. (United States) (US)
- Corresponding author
- Spitz, Douglas R.
- Allen, Bryan G.
- ORCID
- Schoenfeld, Joshua D.
- Sibenaller, Zita A.
- Mapuskar, Kranti A.
- Wagner, Brett A.
- Furqan, Muhammad
- Sandhu, Sonia
- Smith, Mark C.
- Berg, Daniel J.
- Zhang, Jun
- Keech, John
- Parekh, Kalpaj R.
- Monga, Varun
- Bodeker, Kellie L.
- Vollstedt, Sandy
- Brown, Heather
- Greenlee, Jeremy D.
- Howard, Matthew A.
- Schultz, Michael K.
- Riley, Dennis P.
- Domann, Frederick E.
- Cullen, Joseph J.
- Buettner, Garry R.
- Buatti, John M.
- Spitz, Douglas R.
- Allen, Bryan G.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2017-04
- Volume
- 31
- Issue
- 4
- Pages
- 487-500.e8
- ISSN
- 1535-6108 (ISSN-L)
- PMC
- PMC5497844
- OpenAlex
- W2597494578
- Cited by
- 443
- References
- 74
- Citations by year
- 2026: 27 · 2025: 34 · 2024: 44 · 2023: 52 · 2022: 59 · 2021: 56 · 2020: 61 · 2019: 45 · 2018: 45 · 2017: 20
- FWCI
- 38.88
- Type
- journal article
- Language
- en
- Update notices
- erratum (2017-08-14)
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cancer Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- American Society for Radiation Oncology (JF2014-1)
- Carver Research Program of Excellence in Redox Biology
- US NIH (R01-CA182804, R01-CA184051, R01-CA169046, U01-CA166800)
- IBM
- CCSG (P30-CA086862)
- University of Iowa Medical Scientist Training Program (T32-GM007337, T32-CA078586)
- Galera Therapeutics
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Keywords
- pharmacological ascorbate, reactive oxygen species, superoxide, hydrogen peroxide, mitochondrial oxidative metabolism, non-small cell lung cancer, glioblastoma
- MeSH terms
- Animals, Antineoplastic Combined Chemotherapy Protocols, Ascorbic Acid, Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Female, Glioblastoma, Humans, Hydrogen Peroxide, Iron, Lung Neoplasms, Male, Mice, Nude, Oxygen, Radiation-Sensitizing Agents, Xenograft Model Antitumor Assays, Cell Line, Tumor, Chemoradiotherapy
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