Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer

Integrated analysis of multimodal single-cell data

Hao, Y., Hao, S., Andersen-Nissen, E., Mauck, W. M., Zheng, S., Butler, A., Lee, M. J., Wilk, A. J., Darby, C., Zagar, M., et al. (2020) · doi:10.1101/2020.10.12.335331 · Cited by 15,508 · see citing works

Comprehensive Integration of Single-Cell Data

Stuart, T., Butler, A., Hoffman, P., Hafemeister, C., Papalexi, E., Mauck, W. M., Hao, Y., Stoeckius, M., Smibert, P., & Satija, R. (2019) · Cell · doi:10.1016/j.cell.2019.05.031 · Cited by 15,453 · see citing works

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

Zhou, Y., Zhou, B., Pache, L., Chang, M., Khodabakhshi, A. H., Tanaseichuk, O., Benner, C., & Chanda, S. K. (2019) · Nature Communications · doi:10.1038/s41467-019-09234-6 · Cited by 14,611 · see citing works

Integrating single-cell transcriptomic data across different conditions, technologies, and species

Butler, A., Hoffman, P., Smibert, P., Papalexi, E., & Satija, R. (2018) · Nature Biotechnology · doi:10.1038/nbt.4096 · Cited by 13,174 · see citing works

Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States

Rahib, L., Smith, B. D., Aizenberg, R., Rosenzweig, A. B., Fleshman, J. M., & Matrisian, L. M. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0155 · Cited by 7,094 · see citing works

Reversed graph embedding resolves complex single-cell trajectories

Qiu, X., Mao, Q., Tang, Y., Wang, L., Chawla, R., Pliner, H. A., & Trapnell, C. (2017) · Nature Methods · doi:10.1038/nmeth.4402 · Cited by 5,070 · see citing works

The biology and function of fibroblasts in cancer

Kalluri, R. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.73 · Cited by 4,366 · see citing works

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

Özdemir, B. C., Pentcheva-Hoang, T., Carstens, J. L., Zheng, X., Wu, C.-C., Simpson, T. R., Laklai, H., Sugimoto, H., Kahlert, C., Novitskiy, S. V., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.04.005 · Cited by 2,681 · see citing works

Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

Hingorani, S. R., Wang, L., Multani, A. S., Combs, C., Deramaudt, T. B., Hruban, R. H., Rustgi, A. K., Chang, S., & Tuveson, D. A. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.04.023 · Cited by 2,609 · see citing works

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

Öhlund, D., Handly-Santana, A., Biffi, G., Elyada, E., Almeida, A. S., Ponz-Sarvise, M., Corbo, V., Oni, T. E., Hearn, S. A., Lee, E. J., et al. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20162024 · Cited by 2,590 · see citing works

Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

Hingorani, S. R., Petricoin, E. F., Maitra, A., Rajapakse, V., King, C., Jacobetz, M. A., Ross, S., Conrads, T. P., Veenstra, T. D., Hitt, B. A., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00309-x · Cited by 2,471 · see citing works

Cross-species single-cell analysis of pancreatic ductal adenocarcinoma reveals antigen-presenting cancer-associated fibroblasts

Elyada, E., Bolisetty, M., Laise, P., Flynn, W. F., Courtois, E. T., Burkhart, R. A., Teinor, J. A., Belleau, P., Biffi, G., Lucito, M. S., et al. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0094 · Cited by 2,241 · see citing works

Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

Rhim, A. D., Oberstein, P. E., Thomas, D. H., Mirek, E. T., Palermo, C. F., Sastra, S. A., Dekleva, E. N., Saunders, T., Becerra, C. P., Tattersall, I. W., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.04.021 · Cited by 2,085 · see citing works

Turning foes to friends: targeting cancer-associated fibroblasts

Chen, X., & Song, E. (2018) · Nature Reviews Drug Discovery · doi:10.1038/s41573-018-0004-1 · Cited by 1,884 · see citing works

Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer

Costa, A., Kieffer, Y., Scholer-Dahirel, A., Pelon, F., Bourachot, B., Cardon, M., Sirven, P., Magagna, I., Fuhrmann, L., Bernard, C., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.01.011 · Cited by 1,705 · see citing works

Defective TCR expression in transgenic mice constructed using cDNA‐based α‐ and β‐chain genes under the control of heterologous regulatory elements

Barnden, M., Allison, J., Heath, W. R., & Carbone, F. (1998) · Immunology and Cell Biology · doi:10.1046/j.1440-1711.1998.00709.x · Cited by 1,491 · see citing works

A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade

Jerby-Arnon, L., Shah, P., Cuoco, M. S., Rodman, C., Su, M.-J., Melms, J. C., Leeson, R., Kanodia, A., Mei, S., Lin, J.-R., et al. (2018) · Cell · doi:10.1016/j.cell.2018.09.006 · Cited by 1,429 · see citing works

IL1-Induced JAK/STAT Signaling Is Antagonized by TGFβ to Shape CAF Heterogeneity in Pancreatic Ductal Adenocarcinoma

Biffi, G., Oni, T. E., Spielman, B., Hao, Y., Elyada, E., Park, Y., Preall, J., & Tuveson, D. A. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-0710 · Cited by 1,360 · see citing works

Pancreatic cancer stroma: an update on therapeutic targeting strategies

Hosein, A. N., Brekken, R. A., & Maitra, A. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0300-1 · Cited by 950 · see citing works

TGFβ biology in cancer progression and immunotherapy

Derynck, R., Turley, S. J., & Akhurst, R. J. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0403-1 · Cited by 944 · see citing works

Single-cell analysis reveals fibroblast clusters linked to immunotherapy resistance in cancer.

Kieffer, Y., Hocine, H. R., Gentric, G., Pelon, F., Bernard, C., Bourachot, B., Lameiras, S., Albergante, L., Bonneau, C., Guyard, A., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-1384 · Cited by 910 · see citing works

Single-cell RNA sequencing reveals stromal evolution into LRRC15(+) myofibroblasts as a determinant of patient response to cancer immunotherapy

Dominguez, C. X., Müller, S., Keerthivasan, S., Koeppen, H., Hung, J., Gierke, S., Breart, B., Foreman, O., Bainbridge, T. W., Castiglioni, A., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0644 · Cited by 857 · see citing works

Prevalence of FOXP3+ Regulatory T Cells Increases During the Progression of Pancreatic Ductal Adenocarcinoma and Its Premalignant Lesions

Hiraoka, N., Onozato, K., Kosuge, T., & Hirohashi, S. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-0369 · Cited by 831 · see citing works

Direct derivation of conditionally immortal cell lines from an H-2Kb-tsA58 transgenic mouse.

Jat, P., Noble, M., Ataliotis, P., Tanaka, Y., Yannoutsos, N., Larsen, L., & Kioussis, D. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.12.5096 · Cited by 744 · see citing works

Tumor Cell-Intrinsic Factors Underlie Heterogeneity of Immune Cell Infiltration and Response to Immunotherapy

Li, J., Byrne, K. T., Yan, F., Yamazoe, T., Chen, Z., Baslan, T., Richman, L. P., Lin, J., Sun, Y. H., Rech, A. J., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.06.006 · Cited by 738 · see citing works

Human FOXP3+ Regulatory T Cell Heterogeneity and Function in Autoimmunity and Cancer

Wing, J. B., Tanaka, A., & Sakaguchi, S. (2019) · Immunity · doi:10.1016/j.immuni.2019.01.020 · Cited by 726 · see citing works

A peek into cancer-associated fibroblasts: origins, functions and translational impact

LeBleu, V. S., & Kalluri, R. (2018) · Disease Models & Mechanisms · doi:10.1242/dmm.029447 · Cited by 539 · see citing works

Visceral and subcutaneous fat have different origins and evidence supports a mesothelial source

Chau, Y.-Y., Bandiera, R., Serrels, A., Martínez-Estrada, O. M., Qing, W., Lee, M., Slight, J., Thornburn, A., Berry, R., McHaffie, S., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb2922 · Cited by 518 · see citing works

Fluorescent dyes for lymphocyte migration and proliferation studies

Parish, C. R. (1999) · Immunology and Cell Biology · doi:10.1046/j.1440-1711.1999.00877.x · Cited by 473 · see citing works

Mesothelial cells: Their structure, function and role in serosal repair

Mutsaers, S. E. (2002) · Respirology · doi:10.1046/j.1440-1843.2002.00404.x · Cited by 436 · see citing works

Single-cell dissection of cellular components and interactions shaping the tumor immune phenotypes in ovarian cancer

Hornburg, M., Desbois, M., Lu, S., Guan, Y., Lo, A. A., Kaufman, S., Elrod, A. K., Lotstein, A., DesRochers, T. M., Muñoz-Rodríguez, J. L., et al. (2021) · Cancer Cell · doi:10.1016/j.ccell.2021.04.004 · Cited by 391 · see citing works

Regulatory T-cell Depletion Alters the Tumor Microenvironment and Accelerates Pancreatic Carcinogenesis

Zhang, Y., Lazarus, J., Steele, N. G., Yan, W., Lee, H.-J., Nwosu, Z. C., Halbrook, C. J., Menjivar, R. E., Kemp, S. B., Sirihorachai, V. R., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0958 · Cited by 385 · see citing works

<scp>IL</scp>‐1 and <scp>IL</scp>‐1 regulatory pathways in cancer progression and therapy

Mantovani, A., Barajon, I., & Garlanda, C. (2018) · Immunological Reviews · doi:10.1111/imr.12614 · Cited by 376 · see citing works

Cancer-associated fibroblast compositions change with breast cancer progression linking the ratio of S100A4+ and PDPN+ CAFs to clinical outcome

Friedman, G., Levi-Galibov, O., David, E., Bornstein, C., Giladi, A., Dadiani, M., Mayo, A., Halperin, C., Pevsner‐Fischer, M., Lavon, H., et al. (2020) · Nature Cancer · doi:10.1038/s43018-020-0082-y · Cited by 344 · see citing works

Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity

Hutton, C., Heider, F., Blanco-Gomez, A., Banyard, A., Kononov, A., Zhang, X., Karim, S., Paulus-Hock, V., Watt, D., Steele, N., et al. (2021) · Cancer Cell · doi:10.1016/j.ccell.2021.06.017 · Cited by 337 · see citing works

Cellular heterogeneity during mouse pancreatic ductal adenocarcinoma progression at single-cell resolution

Hosein, A. N., Huang, H., Wang, Z., Parmar, K., Du, W., Huang, J., Maitra, A., Olson, E., Verma, U., & Brekken, R. A. (2019) · JCI Insight · doi:10.1172/jci.insight.129212 · Cited by 302 · see citing works

Mesothelin Immunotherapy for Cancer: Ready for Prime Time?

Hassan, R., Thomas, A., Alewine, C., Le, D., Jaffee, E., & Pastan, I. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2016.68.3672 · Cited by 301 · see citing works

The epicardium as a hub for heart regeneration

Cao, J., & Poss, K. D. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0046-4 · Cited by 236 · see citing works

An Increased Abundance of Tumor-Infiltrating Regulatory T Cells Is Correlated with the Progression and Prognosis of Pancreatic Ductal Adenocarcinoma

Tang, Y., Xu, X., Guo, S., Zhang, C., Tang, Y., Tian, Y., Ni, B., Lu, B., & Wang, H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091551 · Cited by 229 · see citing works

Regulating the regulators: costimulatory signals control the homeostasis and function of regulatory T cells

Bour‐Jordan, H., & Bluestone, J. A. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00775.x · Cited by 223 · see citing works

Mesothelial cells in tissue repair and fibrosis

Mutsaers, S. E., Birnie, K. A., Lansley, S. M., Herrick, S. E., Lim, C.-B., & PrÃale, C. M. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00113 · Cited by 213 · see citing works

Mesothelial cells give rise to hepatic stellate cells and myofibroblasts via mesothelial–mesenchymal transition in liver injury

Li, Y., Wang, J., & Asahina, K. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1214136110 · Cited by 211 · see citing works

Lung tumor MHCII immunity depends on in situ antigen presentation by fibroblasts

Kerdidani, D., Aerakis, E., Verrou, K., Angelidis, I., Douka, K., Maniou, M.-A., Stamoulis, P., Goudevenou, K., Prados, A., Tzaferis, C., et al. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20210815 · Cited by 205 · see citing works

Identification and prospective isolation of a mesothelial precursor lineage giving rise to smooth muscle cells and fibroblasts for mammalian internal organs, and their vasculature

Rinkevich, Y., Mori, T., Sahoo, D., Xu, P., Bermingham, J. R., & Weissman, I. L. (2012) · Nature Cell Biology · doi:10.1038/ncb2610 · Cited by 187 · see citing works

Lineage dynamics of murine pancreatic development at single-cell resolution

Byrnes, L. E., Wong, D. M., Subramaniam, M., Meyer, N. P., Gilchrist, C. L., Knox, S. M., Tward, A. D., Ye, C., & Sneddon, J. B. (2018) · Nature Communications · doi:10.1038/s41467-018-06176-3 · Cited by 185 · see citing works

A Stromal Niche Defined by Expression of the Transcription Factor WT1 Mediates Programming and Homeostasis of Cavity-Resident Macrophages

Buechler, M. B., Kim, K.-W., Onufer, E. J., Williams, J. W., Little, C. C., Dominguez, C. X., Li, Q., Sandoval, W. N., Cooper, J. E., Harris, C. A., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.05.010 · Cited by 161 · see citing works

Small-Molecule Inhibition of Axl Targets Tumor Immune Suppression and Enhances Chemotherapy in Pancreatic Cancer

Ludwig, K. F., Du, W., Sorrelle, N. B., Wnuk-Lipińska, K., Topalovski, M., Toombs, J. E., Cruz, V. H., Yabuuchi, S., Rajeshkumar, N. V., Maitra, A., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-1973 · Cited by 159 · see citing works

Inhibition of hyperglycolysis in mesothelial cells prevents peritoneal fibrosis

Si, M., Wang, Q., Li, Y., Lin, H., Luo, D., Zhao, W., Dou, X., Liu, J., Zhang, H., Huang, Y. L., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aav5341 · Cited by 130 · see citing works

Elucidation of tumor-stromal heterogeneity and the ligand-receptor interactome by single-cell transcriptomics in Real-world pancreatic cancer biopsies

Lee, J. J., Bernard, V., Semaan, A., Monberg, M. E., Huang, J., Stephens, B. M., Lin, D., Rajapakshe, K. I., Weston, B. R., Bhutani, M. S., et al. (2021) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-3925 · Cited by 128 · see citing works

Surgical adhesions in mice are derived from mesothelial cells and can be targeted by antibodies against mesothelial markers

Tsai, J. M., Sinha, R., Seita, J., Fernhoff, N. B., Christ, S., Koopmans, T., Krampitz, G. W., McKenna, K. M., Xing, L., Sandholzer, M., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aan6735 · Cited by 120 · see citing works

Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation

Mikami, N., Kawakami, R., Chen, K. Y., Sugimoto, A., Ohkura, N., & Sakaguchi, S. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1922600117 · Cited by 119 · see citing works

Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis

Koyama, Y., Wang, P., Liang, S., Iwaisako, K., Liu, X., Xu, J., Zhang, M., Sun, M., Cong, M., Karin, D., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88845 · Cited by 111 · see citing works

Strong CD28 costimulation suppresses induction of regulatory T cells from naive precursors through Lck signaling

Semple, K. M., Nguyen, A., Yu, Y., Wang, H., Anasetti, C., & Yu, X. (2011) · Blood · doi:10.1182/blood-2010-08-301275 · Cited by 93 · see citing works

Antigen-specific induced Foxp3 + regulatory T cells are generated following CD40/CD154 blockade

Ferrer, I. R., Wagener, M. E., Song, M., Kirk, A. D., Larsen, C. P., & Ford, M. L. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105500108 · Cited by 93 · see citing works

Targeting TGFβR2‐mutant tumors exposes vulnerabilities to stromal TGFβ blockade in pancreatic cancer

Huang, H., Zhang, Y., Gallegos, V., Sorrelle, N., Zaid, M. M., Toombs, J., Du, W., Wright, S., Hagopian, M., Wang, Z., et al. (2019) · EMBO Molecular Medicine · doi:10.15252/emmm.201910515 · Cited by 87 · see citing works

Mesothelial to mesenchyme transition as a major developmental and pathological player in trunk organs and their cavities

Koopmans, T., & Rinkevich, Y. (2018) · Communications Biology · doi:10.1038/s42003-018-0180-x · Cited by 78 · see citing works

A Bispecific Antibody-Based Approach for Targeting Mesothelin in Triple Negative Breast Cancer

del Bano, J., Florès-Florès, R., Josselin, E., Goubard, A., Ganier, L., Castellano, R., Chames, P., Baty, D., & Kerfélec, B. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01593 · Cited by 71 · see citing works

Wilms’ tumor 1 drives fibroproliferation and myofibroblast transformation in severe fibrotic lung disease

Sontake, V., Kasam, R. K., Sinner, D. I., Korfhagen, T. R., Reddy, G. B., White, E. S., Jegga, A. G., & Madala, S. K. (2018) · JCI Insight · doi:10.1172/jci.insight.121252 · Cited by 60 · see citing works

Improved Multiplex Immunohistochemistry for Immune Microenvironment Evaluation of Mouse Formalin-Fixed, Paraffin-Embedded Tissues

Sorrelle, N. B., Ganguly, D., Dominguez, A. T. A., Zhang, Y., Huang, H., Dahal, L. N., Phinney, N. Z., Žiemys, A., & Brekken, R. A. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1800878 · Cited by 50 · see citing works

Recent advances in understanding cancer-associated fibroblasts in pancreatic cancer

Huang, H., & Brekken, R. A. (2020) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00079.2020 · Cited by 47 · see citing works

The Next Wave of Stroma-Targeting Therapy in Pancreatic Cancer

Huang, H., & Brekken, R. A. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-3751 · Cited by 44 · see citing works

Visceral Adipose Tissue Mesothelial Cells: Living on the Edge or Just Taking Up Space?

Gupta, O. T., & Gupta, R. K. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.07.003 · Cited by 34 · see citing works

Pancreatic cancer: Advances and challenges

Halbrook, C. J., Lyssiotis, C. A., Pasca di Magliano, M., & Maitra, A. (2023) · Cell · doi:10.1016/j.cell.2023.02.014 · Cited by 1,321 · see citing works

The cancer-immunity cycle: Indication, genotype, and immunotype

Mellman, I., Chen, D. S., Powles, T. B., & Turley, S. J. (2023) · Immunity · doi:10.1016/j.immuni.2023.09.011 · Cited by 978 · see citing works

Cancer-associated fibroblasts in the single-cell era

Lavie, D., Ben‐Shmuel, A., Erez, N., & Scherz‐Shouval, R. (2022) · Nature Cancer · doi:10.1038/s43018-022-00411-z · Cited by 636 · see citing works

Pan-cancer single-cell analysis reveals the heterogeneity and plasticity of cancer-associated fibroblasts in the tumor microenvironment

Luo, H., Xia, X., Huang, L., An, H., Cao, M., Kim, G. D., Chen, H., Zhang, W., Shu, Y., Kong, X., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34395-2 · Cited by 585 · see citing works

Cancer-associated fibroblasts: from basic science to anticancer therapy

Yang, D., Liu, J., Qian, H., & Zhuang, Q. (2023) · Experimental &amp; Molecular Medicine · doi:10.1038/s12276-023-01013-0 · Cited by 572 · see citing works

Fibroblasts in cancer: Unity in heterogeneity

Chhabra, Y., & Weeraratna, A. T. (2023) · Cell · doi:10.1016/j.cell.2023.03.016 · Cited by 488 · see citing works

CD8+ T cells in the cancer-immunity cycle

Giles, J. R., Globig, A.-M., Kaech, S. M., & Wherry, E. J. (2023) · Immunity · doi:10.1016/j.immuni.2023.09.005 · Cited by 467 · see citing works

Stromal cells in the tumor microenvironment: accomplices of tumor progression?

Zhao, Y. F., Shen, M., Wu, L., Yang, H., Yao, Y., Yang, Q., Du, J., Liu, L., Li, Y., & Bai, Y. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06110-6 · Cited by 443 · see citing works

Define cancer-associated fibroblasts (CAFs) in the tumor microenvironment: new opportunities in cancer immunotherapy and advances in clinical trials

Zhang, H., Yue, X., Chen, Z., Liu, C., Wu, W., Zhang, N., Liu, Z., Yang, L., Jiang, Q., Cheng, Q., et al. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01860-5 · Cited by 435 · see citing works

Activated fibroblasts in cancer: Perspectives and challenges

Caligiuri, G., & Tuveson, D. A. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.02.015 · Cited by 431 · see citing works

Therapeutic developments in pancreatic cancer

Hu, Z., & O'Reilly, E. M. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00840-w · Cited by 425 · see citing works

Cancer vaccines: Building a bridge over troubled waters

Sellars, M., Wu, C. J., & Fritsch, E. F. (2022) · Cell · doi:10.1016/j.cell.2022.06.035 · Cited by 322 · see citing works

Cross-tissue human fibroblast atlas reveals myofibroblast subtypes with distinct roles in immune modulation

Gao, Y., Li, J., Cheng, W., Diao, T., Liu, H., Bo, Y., Liu, C., Zhou, W., Chen, M., Zhang, Y., et al. (2024) · Cancer Cell · doi:10.1016/j.ccell.2024.08.020 · Cited by 304 · see citing works

Signaling pathways in cancer‐associated fibroblasts: recent advances and future perspectives

Fang, Z., Meng, Q., Xu, J., Wang, W., Zhang, B., Liu, J., Liang, C., Hua, J., Zhao, Y., Yu, X., et al. (2022) · 癌症：英文版 · doi:10.1002/cac2.12392 · Cited by 292 · see citing works

Cancer-Associated Fibroblasts in Inflammation and Antitumor Immunity

Kennel, K. B., Bozlar, M., Valk, A. F. D., & Greten, F. R. (2022) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-22-1031 · Cited by 283 · see citing works

Conserved spatial subtypes and cellular neighborhoods of cancer-associated fibroblasts revealed by single-cell spatial multi-omics

Liu, Y., Sinjab, A. F., Min, J., Han, G., Paradiso, F., Zhang, Y., Wang, R., Pei, G., Dai, Y., Liu, Y., et al. (2025) · Cancer Cell · doi:10.1016/j.ccell.2025.03.004 · Cited by 249 · see citing works

Cancer associated fibroblasts in cancer development and therapy

Jia, H., Chen, X., Zhang, L., & Chen, M. (2025) · Journal of Hematology & Oncology · doi:10.1186/s13045-025-01688-0 · Cited by 252 · see citing works

Tumor cell-intrinsic epigenetic dysregulation shapes cancer-associated fibroblasts heterogeneity to metabolically support pancreatic cancer

Niu, N., Shen, X., Wang, Z., Chen, Y., Weng, Y., Yu, F., Tang, Y., Lu, P., Liu, M., Wang, L., et al. (2024) · Cancer Cell · doi:10.1016/j.ccell.2024.03.005 · Cited by 238 · see citing works

Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma

Zhang, T., Ren, Y., Yang, P., Wang, J., & Zhou, H. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05351-1 · Cited by 225 · see citing works

EGFR-activated myofibroblasts promote metastasis of pancreatic cancer

Mucciolo, G., Henríquez, J. A., Jihad, M., Teles, S. P., Manansala, J. S., Li, W., Ashworth, S., Lloyd, E. G., Cheng, P. S. W., Luo, W., et al. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.12.002 · Cited by 215 · see citing works

Context-Specific Determinants of the Immunosuppressive Tumor Microenvironment in Pancreatic Cancer

Falcomatà, C., Bärthel, S., Schneider, G., Rad, R., Schmidt‐Supprian, M., & Saur, D. (2023) · Cancer Discovery · doi:10.1158/2159-8290.cd-22-0876 · Cited by 213 · see citing works

CAFs Interacting With TAMs in Tumor Microenvironment to Enhance Tumorigenesis and Immune Evasion

Günaydın, G. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.668349 · Cited by 205 · see citing works

Cancer-Associated Fibroblasts: Master Tumor Microenvironment Modifiers

Wright, K., Ly, T., Kriet, M., Czirók, A., & Thomas, S. M. (2023) · Cancers · doi:10.3390/cancers15061899 · Cited by 188 · see citing works

The advent of immune stimulating CAFs in cancer

Tsoumakidou, M. (2023) · Nature reviews. Cancer · doi:10.1038/s41568-023-00549-7 · Cited by 188 · see citing works

Combined MEK and STAT3 Inhibition Uncovers Stromal Plasticity by Enriching for Cancer-Associated Fibroblasts With Mesenchymal Stem Cell-Like Features to Overcome Immunotherapy Resistance in Pancreatic Cancer

Datta, J., Dai, X., Bianchi, A., Silva, I. D. C., Mehra, S., Garrido, V. T., Lamichhane, P., Singh, S. P., Zhou, Z., Dosch, A. R., et al. (2021) · Gastroenterology · doi:10.1053/j.gastro.2022.07.076 · Cited by 182 · see citing works

Antiandrogen treatment induces stromal cell reprogramming to promote castration resistance in prostate cancer

Wang, H., Li, N., Liu, Q., Guo, J., Pan‐Hammarström, Q., Cheng, B., Xu, J., Dong, B., Yang, G., Yang, B., et al. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.05.016 · Cited by 172 · see citing works

Deciphering the spatial landscape and plasticity of immunosuppressive fibroblasts in breast cancer

Croizer, H., Mhaidly, R., Kieffer, Y., Gentric, G., Djerroudi, L., Leclère, R., Pelon, F., Robley, C., Bohec, M., Meng, A., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-47068-z · Cited by 159 · see citing works

Barriers and opportunities in pancreatic cancer immunotherapy

Ju, Y., Xu, D., Liao, M.-M., Sun, Y., Bao, W.-D., Yao, F., & Ma, L. (2024) · npj Precision Oncology · doi:10.1038/s41698-024-00681-z · Cited by 167 · see citing works

The crosstalk between macrophages and cancer cells potentiates pancreatic cancer cachexia

Liu, M., Ren, Y., Zhou, Z., Yang, J., Shi, X., Cai, Y., Arreola, A. X., Luo, W., Fung, K.-M. A., Xu, C., et al. (2024) · Cancer Cell · doi:10.1016/j.ccell.2024.03.009 · Cited by 157 · see citing works

Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition

Glaviano, A., Lau, H., Carter, L. M., Lee, E. H. C., Lam, H. Y., Okina, E., Tan, D. J. J., Tan, W., Ang, H. L., Carbone, D., et al. (2025) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01634-6 · Cited by 162 · see citing works

Regulatory T cell-mediated immunosuppression orchestrated by cancer: towards an immuno-genomic paradigm for precision medicine

Kumagai, S., Itahashi, K., & Nishikawa, H. (2024) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-024-00870-6 · Cited by 163 · see citing works

CAF-induced physical constraints controlling T cell state and localization in solid tumours

Arpinati, L., Carradori, G., & Scherz‐Shouval, R. (2024) · Nature reviews. Cancer · doi:10.1038/s41568-024-00740-4 · Cited by 160 · see citing works

Methylation across the central dogma in health and diseases: new therapeutic strategies

Liu, R., Zhao, E., Yu, H., Yuan, C., Abbas, M. N., & Cui, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01528-y · Cited by 147 · see citing works

The heterogeneity of cancer‐associated fibroblast subpopulations: Their origins, biomarkers, and roles in the tumor microenvironment

Yamamoto, Y., Kasashima, H., Fukui, Y., Tsujio, G., Yashiro, M., & Maeda, K. (2022) · Cancer Science · doi:10.1111/cas.15609 · Cited by 138 · see citing works

Antigen-presenting cancer associated fibroblasts enhance antitumor immunity and predict immunotherapy response

Song, J.-Q., Wei, R.-Y., Liu, C.-C., Zhao, Z.-X., Liu, X.-J., Wang, Y.-N., Liu, F.-L., & Liu, X.-W. (2025) · Nature Communications · doi:10.1038/s41467-025-57465-7 · Cited by 151 · see citing works

Cancer-associated fibroblasts: a versatile mediator in tumor progression, metastasis, and targeted therapy

Guo, T., & Xu, J. (2024) · Cancer and Metastasis Reviews · doi:10.1007/s10555-024-10186-7 · Cited by 131 · see citing works

Advancing engineering design strategies for targeted cancer nanomedicine

Gomerdinger, V. F., Nabar, N., & Hammond, P. T. (2025) · Nature reviews. Cancer · doi:10.1038/s41568-025-00847-2 · Cited by 150 · see citing works

CAFs orchestrates tumor immune microenvironment—A new target in cancer therapy?

Zhang, C., Fei, Y., Wang, H., Hu, S., Liu, C., Hu, R., & Du, Q. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1113378 · Cited by 129 · see citing works

From gatekeepers to providers: regulation of immune functions by cancer-associated fibroblasts

Arpinati, L., & Scherz‐Shouval, R. (2023) · Trends in cancer · doi:10.1016/j.trecan.2023.01.007 · Cited by 126 · see citing works

Mesothelin CAR T Cells Secreting Anti-FAP/Anti-CD3 Molecules Efficiently Target Pancreatic Adenocarcinoma and its Stroma

Wehrli, M., Guinn, S. R., Birocchi, F., Kuo, A., Sun, Y., Larson, R. C., Almazan, A. J., Scarfò, I., Bouffard, A. A., Bailey, S. R., et al. (2024) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-23-3841 · Cited by 127 · see citing works

Senescence Defines a Distinct Subset of Myofibroblasts That Orchestrates Immunosuppression in Pancreatic Cancer

Belle, J. I., Sen, D., Baer, J. M., Liu, X., Lander, V. E., Ye, J., Sells, B. E., Knolhoff, B. L., Ahmad, F. F., Kang, L., et al. (2024) · Cancer Discovery · doi:10.1158/2159-8290.cd-23-0428 · Cited by 123 · see citing works

Neoadjuvant PARPi or chemotherapy in ovarian cancer informs targeting effector Treg cells for homologous-recombination-deficient tumors

Luo, Y., Xia, Y., Liu, D., Li, X., Li, H., Liu, J., Zhou, D., Dong, Y. J., Li, X., Qian, Y., et al. (2024) · Cell · doi:10.1016/j.cell.2024.06.013 · Cited by 115 · see citing works

Epithelial and stromal co-evolution and complicity in pancreatic cancer

Hingorani, S. R. (2023) · Nature Reviews Cancer · doi:10.1038/s41568-022-00530-w · Cited by 108 · see citing works

Co-cultures of colon cancer cells and cancer-associated fibroblasts recapitulate the aggressive features of mesenchymal-like colon cancer

Strating, E., Verhagen, M. P., Wensink, G. E., Dünnebach, E., Wijler, L. A., Aranguren, I., la Cruz, A. S. D., Peters, N. A., Hageman, J. H., van der Net, M. C., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1053920 · Cited by 120 · see citing works

Immunosuppressive tumor microenvironment in the progression, metastasis, and therapy of hepatocellular carcinoma: from bench to bedside

Yin, Y., Feng, W., Chen, J., Chen, X., Wang, G., Wang, S., Xu, X., Nie, Y., Fan, D., Wu, K., et al. (2024) · Experimental Hematology and Oncology · doi:10.1186/s40164-024-00539-x · Cited by 118 · see citing works

Single-cell profiling to explore pancreatic cancer heterogeneity, plasticity and response to therapy

Bärthel, S., Falcomatà, C., Rad, R., Theis, F. J., & Saur, D. (2023) · Nature Cancer · doi:10.1038/s43018-023-00526-x · Cited by 101 · see citing works

Novel strategies for cancer immunotherapy: counter-immunoediting therapy

Liu, S., Sun, Q., & Ren, X. (2023) · Journal of Hematology & Oncology · doi:10.1186/s13045-023-01430-8 · Cited by 98 · see citing works

Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma therapy: Challenges and opportunities

Qin, Q., Yu, R., Eriksson, J., Tsai, H., & Zhu, H. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216859 · Cited by 97 · see citing works

Single‐Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Esophageal Squamous Cell Carcinoma

Jia, Y., Zhang, B., Zhang, C., Kwong, D. L., Chang, Z., Li, S., Wang, Z., Han, H., Li, J., Zhong, Y., et al. (2023) · Advanced Science · doi:10.1002/advs.202204565 · Cited by 89 · see citing works

BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling

Shaashua, L., Ben-Shmuel, A., Pevsner-Fischer, M., Friedman, G., Levi-Galibov, O., Nandakumar, S., Barki, D., Nevo, R., Brown, L. E., Zhang, W., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34081-3 · Cited by 79 · see citing works

Drug resistance and tumor immune microenvironment: An overview of current understandings (Review)

Liu, Y., Liang, J., Zhang, Y., & Guo, Q. (2024) · International Journal of Oncology · doi:10.3892/ijo.2024.5684 · Cited by 88 · see citing works

FGF19‐Induced Inflammatory CAF Promoted Neutrophil Extracellular Trap Formation in the Liver Metastasis of Colorectal Cancer

Li, C., Chen, T., Liu, J., Wang, Y., Zhang, C., Guo, L., Shi, D., Zhang, T., Wang, X., & Li, J. (2023) · Advanced Science · doi:10.1002/advs.202302613 · Cited by 87 · see citing works

T-cell infiltration and its regulatory mechanisms in cancers: insights at single-cell resolution

Yang, W., Liu, S., Mao, M., Gong, Y., Li, X., Lei, T., Liu, C., Wu, S., & Hu, Q. (2024) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-024-02960-w · Cited by 85 · see citing works

Transcription factors in fibroblast plasticity and CAF heterogeneity

Melchionna, R., Trono, P., Carlo, A. D., Modugno, F. D., & Nisticò, P. (2023) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-023-02934-4 · Cited by 87 · see citing works

Cancer‐Associated Fibroblast‐Induced Remodeling of Tumor Microenvironment in Recurrent Bladder Cancer

Liang, T., Tao, T., Wu, K., Liu, L., Xu, W., Zhou, D., Hu, F., Ding, Q., Huang, G., & Wu, S. (2023) · Advanced Science · doi:10.1002/advs.202303230 · Cited by 84 · see citing works

Cancer-associated fibroblasts as therapeutic targets for cancer: advances, challenges, and future prospects

Cao, Z., Quazi, S., Arora, S., Osellame, L. D., Burvenich, I. J. G., Janes, P. W., & Scott, A. M. (2025) · Journal of Biomedical Science · doi:10.1186/s12929-024-01099-2 · Cited by 85 · see citing works

Differential integrated stress response and asparagine production drive symbiosis and therapy resistance of pancreatic adenocarcinoma cells

Halbrook, C. J., Thurston, G., Boyer, S., Anaraki, C., Jiménez, J. A., McCarthy, A., Steele, N. G., Kerk, S. A., Hong, H. S., Lin, L., et al. (2022) · Nature Cancer · doi:10.1038/s43018-022-00463-1 · Cited by 80 · see citing works

Single-cell multi-stage spatial evolutional map of esophageal carcinogenesis

Chang, J., Lu, J., Liu, Q., Xiang, T., Zhang, S., Yi, Y., Li, D., Liu, T., Liu, Z., Chen, X., et al. (2025) · Cancer Cell · doi:10.1016/j.ccell.2025.02.009 · Cited by 80 · see citing works

The Desmoplastic Stroma of Pancreatic Cancer: Multilayered Levels of Heterogeneity, Clinical Significance, and Therapeutic Opportunities

Masugi, Y. (2022) · Cancers · doi:10.3390/cancers14133293 · Cited by 81 · see citing works

Treg–tissue cell interactions in repair and regeneration

Loffredo, L. F., Savage, T. M., Ringham, O. R., & Arpaia, N. (2024) · The Journal of Experimental Medicine · doi:10.1084/jem.20231244 · Cited by 79 · see citing works

Immunological synapse formation between T regulatory cells and cancer-associated fibroblasts promotes tumour development

Varveri, A., Papadopoulou, M., Papadovasilakis, Z., Compeer, E. B., Legaki, A., Delis, A. D., Damaskou, V., Boon, L., Papadogiorgaki, S., Samiotaki, M. K., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-49282-1 · Cited by 80 · see citing works

Macrophage-fibroblast JAK/STAT dependent crosstalk promotes liver metastatic outgrowth in pancreatic cancer

Raymant, M., Astuti, Y., Álvaro‐Espinosa, L., Green, D. M., Quaranta, V., Bellomo, G., Glenn, M. A., Chandran-Gorner, V., Palmer, D. H., Halloran, C. M., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-47949-3 · Cited by 76 · see citing works

Integrative analysis of spatial and single-cell transcriptome data from human pancreatic cancer reveals an intermediate cancer cell population associated with poor prognosis

Kim, S., Leem, G., Choi, J., Koh, Y., Lee, S., Nam, S., Kim, J. S., Park, C. H., Hwang, H. K., Min, K. I., et al. (2024) · Genome Medicine · doi:10.1186/s13073-024-01287-7 · Cited by 74 · see citing works

The importance of being CAFs (in cancer resistance to targeted therapies)

Rizzolio, S., Giordano, S., & Corso, S. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02524-w · Cited by 74 · see citing works

Functional heterogeneity of fibroblasts in primary tumors and metastases

Cheng, P. S. W., Zaccaria, M., & Biffi, G. (2024) · Trends in cancer · doi:10.1016/j.trecan.2024.11.005 · Cited by 76 · see citing works

Pancreatic cancer-associated fibroblasts modulate macrophage differentiation via sialic acid-Siglec interactions

Boelaars, K., Rodríguez, E., Huinen, Z. R., Liu, C., Wang, D., Springer, B. O., Olesek, K., Kruijssen, L. J. W., van Ee, T., Lindijer, D., et al. (2024) · Communications Biology · doi:10.1038/s42003-024-06087-8 · Cited by 72 · see citing works

Mechanisms of PDAC subtype heterogeneity and therapy response

Espinet, E., Klein, L., Puré, E., & Singh, S. K. (2022) · Trends in cancer · doi:10.1016/j.trecan.2022.08.005 · Cited by 70 · see citing works

Cancer-associated fibroblasts in cancer drug resistance and cancer progression: a review

Masuda, H. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02566-x · Cited by 73 · see citing works

Tumor immune microenvironment-based therapies in pancreatic ductal adenocarcinoma: time to update the concept

Luo, W., Wen, T., & Qu, X. (2024) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-023-02935-3 · Cited by 68 · see citing works

PanIN and CAF transitions in pancreatic carcinogenesis revealed with spatial data integration

Bell, A. T. F., Mitchell, J. T., Kiemen, A. L., Lyman, M. R., Fujikura, K., Lee, J. W., Coyne, E. M., Shin, S. M., Nagaraj, S., Deshpande, A. M., et al. (2024) · Cell Systems · doi:10.1016/j.cels.2024.07.001 · Cited by 70 · see citing works

Macrophages and fibroblasts as regulators of the immune response in pancreatic cancer

Shakiba, M., & Tuveson, D. A. (2025) · Nature Immunology · doi:10.1038/s41590-025-02134-6 · Cited by 75 · see citing works

Improving outcomes of patients with pancreatic cancer

Dreyer, S. B., Beer, P. A., Hingorani, S. R., & Biankin, A. V. (2025) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-025-01019-9 · Cited by 66 · see citing works

The tumour microenvironment in pancreatic cancer — new clinical challenges, but more opportunities

Kung, H., Zheng, K., Zimmerman, J. W., & Zheng, L. (2025) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-025-01077-z · Cited by 69 · see citing works

The axis of tumor-associated macrophages, extracellular matrix proteins, and cancer-associated fibroblasts in oncogenesis

Yu, S., Wang, S., Wang, X., & Xu, X. (2024) · Cancer Cell International · doi:10.1186/s12935-024-03518-8 · Cited by 65 · see citing works

Overcoming immunotherapy resistance in gastric cancer: insights into mechanisms and emerging strategies

Luo, D. Y., Zhou, J., Ruan, S., Zhang, B., Zhu, H., Que, Y., Ying, S., Li, X., Hu, Y., & Song, Z. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07385-7 · Cited by 68 · see citing works

Single-cell resolution spatial analysis of antigen-presenting cancer-associated fibroblast niches

Chen, X., Zhou, Z., Xie, L., Qiao, K., Jia, Y., Liu, S., Yazgan, Z., Rossi, F., Liu, Y., Zhang, B., et al. (2025) · Cancer Cell · doi:10.1016/j.ccell.2025.09.001 · Cited by 63 · see citing works

Targets of tumor microenvironment for potential drug development

Zhang, L., Wang, Z., Liu, K., Liu, Y., Wang, S., Jiang, W., Lu, F., & Dang, Y. (2024) · MedComm – Oncology · doi:10.1002/mog2.68 · Cited by 63 · see citing works

Unlocking the crucial role of cancer-associated fibroblasts in tumor metastasis: Mechanisms and therapeutic prospects

Liu, Y., Zhang, X., Gu, W., Su, H., Wang, X., Wang, X., Zhang, J., Xu, M., & Sheng, W. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.05.031 · Cited by 62 · see citing works

Regulatory T cells in solid tumor immunotherapy: effect, mechanism and clinical application

Pan, Y., Zhou, H., Sun, Z., Zhu, Y., Zhang, Z., Han, J., Liu, Y., & Wang, Q. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07544-w · Cited by 64 · see citing works

Amphiregulin couples IL1RL1 + regulatory T cells and cancer-associated fibroblasts to impede antitumor immunity

Sun, R., Zhao, H., Gao, D. S., Ni, A., Li, H., Chen, L., Lu, X., Chen, K., & Lu, B. (2023) · Science Advances · doi:10.1126/sciadv.add7399 · Cited by 59 · see citing works

Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth

Donahue, K. L., Watkoske, H. R., Kadiyala, P., Du, W., Brown, K. L., Scales, M. K., Elhossiny, A. M., Espinoza, C. E., Opsahl, E. L. L., Griffith, B. D., et al. (2024) · Cancer Discovery · doi:10.1158/2159-8290.cd-24-0100 · Cited by 58 · see citing works

The tumor microenvironment is an ecosystem sustained by metabolic interactions

Kay, E. J., & Zanivan, S. R. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115432 · Cited by 60 · see citing works

Pan-Cancer Single-Cell Analysis Revealing the Heterogeneity of Cancer- Associated Fibroblasts in Skin Tumors

Zhang, Y., Zhao, Z., Huang, W., Kim, B. S., Li, L., Li, X., Hou, M., Li, L., Zhang, Y., Xi, W., et al. (2024) · Current Gene Therapy · doi:10.2174/0115665232331353240911080642 · Cited by 59 · see citing works

Single-cell RNA sequencing and spatial transcriptomics reveal the heterogeneity and intercellular communication of cancer-associated fibroblasts in gastric cancer

Zhang, X., Ren, B., Liu, B., Wang, R. Y., Li, S., Zhao, Y., & Zhou, W. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06376-8 · Cited by 57 · see citing works

CAF-immune cell crosstalk and its impact in immunotherapy

Maia, A. R. R., Schöllhorn, A., Schuhmacher, J., & Gouttefangeas, C. (2022) · Seminars in Immunopathology · doi:10.1007/s00281-022-00977-x · Cited by 56 · see citing works

Current Landscape of Cancer Immunotherapy: Harnessing the Immune Arsenal to Overcome Immune Evasion

Mitra, A., Kumar, A., Amdare, N. P., & Pathak, R. (2024) · Biology · doi:10.3390/biology13050307 · Cited by 60 · see citing works

Dissecting FAP+ Cell Diversity in Pancreatic Cancer Uncovers an Interferon-Response Subtype of Cancer-Associated Fibroblasts with Tumor-Restraining Properties

Cumming, J., Maneshi, P., Dongre, M., Alsaed, T., Dehghan-Nayeri, M. J., Ling, A., Pietras, K., Patthey, C., & Öhlund, D. (2025) · Cancer Research · doi:10.1158/0008-5472.can-23-3252 · Cited by 57 · see citing works

Multifaced roles of desmoplastic reaction and fibrosis in pancreatic cancer progression: Current understanding and future directions

Sato, H., Hara, T., Meng, S., Tsuji, Y., Arao, Y., Saito, Y., Sasaki, K., Kobayashi, S., Doki, Y., Eguchi, H., et al. (2023) · Cancer Science · doi:10.1111/cas.15890 · Cited by 52 · see citing works

Notch Signaling Regulates Immunosuppressive Tumor-Associated Macrophage Function in Pancreatic Cancer

Yan, W., Menjivar, R. E., Bonilla, M. E., Steele, N. G., Kemp, S. B., Du, W., Donahue, K. L., Brown, K. L., Carpenter, E. S., Avritt, F. R., et al. (2023) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-23-0037 · Cited by 52 · see citing works

Microbiome dysbiosis, neutrophil recruitment and mesenchymal transition of mesothelial cells promotes peritoneal metastasis of colorectal cancer

Li, Q., Xiao, Y., Han, L., Luo, W., Dai, W., Fang, H., Wang, R., Xu, Y., Cai, S., Goel, A., et al. (2025) · Nature Cancer · doi:10.1038/s43018-025-00910-9 · Cited by 51 · see citing works

Role of the Tumor Microenvironment in Regulating Pancreatic Cancer Therapy Resistance

Deng, D., Patel, R. H., Chiang, C.-Y., & Hou, P. (2022) · Cells · doi:10.3390/cells11192952 · Cited by 50 · see citing works

Single-cell transcriptomic profiling uncovers cellular complexity and microenvironment in gastric tumorigenesis associated with Helicobacter pylori

Li, N., Chen, S., Xu, X., Wang, H., Zheng, P., Xiao, F., Ke, H., Lei, Y., Zhou, Y., Yang, X., et al. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.10.012 · Cited by 50 · see citing works

A bird’s eye view of fibroblast heterogeneity: A pan‐disease, pan‐cancer perspective

Pradhan, R., Krishnamurty, A. T., Fletcher, A. L., Turley, S. J., & Müller, S. (2021) · Immunological Reviews · doi:10.1111/imr.12990 · Cited by 51 · see citing works

Targeting Fibrosis: The Bridge That Connects Pancreatitis and Pancreatic Cancer

Huang, C., Iovanna, J., & Santofimia‐Castaño, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094970 · Cited by 52 · see citing works

Regulatory T cells: masterminds of immune equilibrium and future therapeutic innovations

Ge, J., Yin, X., & Chen, L. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1457189 · Cited by 50 · see citing works

Macropinocytosis maintains CAF subtype identity under metabolic stress in pancreatic cancer

Zhang, Y., Li, L., Murad, R., Maganti, S., Manceau, A., Faso, H. A., Neff, M., Galapate, C. M., Grenier, S. F., Carrette, F., et al. (2025) · Cancer Cell · doi:10.1016/j.ccell.2025.06.021 · Cited by 49 · see citing works

Cancer associated fibroblasts serve as an ovarian cancer stem cell niche through noncanonical Wnt5a signaling

Fang, Y., Xiao, X., Wang, J., Dasari, S., Pépin, D., Nephew, K. P., Zamarin, D., & Mitra, A. K. (2024) · npj Precision Oncology · doi:10.1038/s41698-023-00495-5 · Cited by 48 · see citing works

Targeting the tumor microenvironment, a new therapeutic approach for prostate cancer

Fang, B., Lu, Y., Li, X., Yu, W., Ye, D., Wei, G., & Zhu, Y. (2024) · Prostate Cancer and Prostatic Diseases · doi:10.1038/s41391-024-00825-z · Cited by 48 · see citing works

At the Interface of Tumor-Associated Macrophages and Fibroblasts: Immune-Suppressive Networks and Emerging Exploitable Targets

Timperi, E., Croizer, H., Khantakova, D., Rana, M., Molgora, M., Guerriero, J. L., Mechta-Grigoriou, F., & Romano, E. (2024) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-24-1690 · Cited by 49 · see citing works

Extracellular Galectin 4 Drives Immune Evasion and Promotes T-cell Apoptosis in Pancreatic Cancer

Lidström, T., Cumming, J., Gaur, R., Frängsmyr, L., Pateras, I. S., Mickert, M. J., Franklin, O., Forsell, M. N. E., Arnberg, N., Dongre, M., et al. (2022) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-21-1088 · Cited by 47 · see citing works

Abstract C078: Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer

Huang, H., Wang, Z., Zhang, Y., Pradhan, R., Ganguly, D., Chandra, R., Murimwa, G. Z., Wright, S., Gu, X., Maddipati, R., et al. (2022) · Cancer Research · doi:10.1158/1538-7445.panca22-c078 · Cited by 2 · see citing works

Antigen-presenting cancer-associated fibroblasts in pancreatic ductal adenocarcinoma differentially regulate Treg phenotype and function via CXCL9 and CCL22 3293

Maru, S. Y., Mitchell, J. T., Wetzel, M., Groß, N., Andaloori, L., Howe, K., Kartalia, E., Mo, G., Leatherman, J. M., Ho, W. J., et al. (2025) · The Journal of Immunology · doi:10.1093/jimmun/vkaf283.1109

Antigen-presenting cancer-associated fibroblasts in murine pancreatic tumors differentially control regulatory T cell phenotype and function via CXCL9 and CCL22Preprint

Maru, S. Y., Wetzel, M., Mitchell, J. T., Groß, N., Andaloori, L., Howe, K., Kartalia, E., Mo, G., Leatherman, J. M., Ho, W. J., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.27.645833 · Cited by 4 · see citing works

Abstract 2577: Antigen-presenting CAFs in PDAC differentially regulate Treg phenotype and function via CXCL9 and CCL22

Maru, S. Y., Mitchell, J. T., Wetzel, M., Groß, N., Andaloori, L., Howe, K., Kartalia, E., Mo, G., Leatherman, J. M., Ho, W. J., et al. (2025) · Cancer Research · doi:10.1158/1538-7445.am2025-2577

Antigen-presenting cancer-associated fibroblasts in murine pancreatic tumors differentially regulate T-cell phenotype and function

Maru, S. Y., Wetzel, M., Mitchell, J. T., Groß, N., Andaloori, L., Howe, K. L., Kartalia, E., Mo, G., Leatherman, J., Ho, W. J., et al. (2026) · The Journal of Immunology · doi:10.1093/jimmun/vkag165