Cited by 252Antifungal resistance and susceptibilityCentral Venous Catheters and HemodialysisInfective Endocarditis Diagnosis and Management

Intravascular Catheter Exchange and Duration of Candidemia

Rex, J. H., Bennett, J. E., Sugar, A. M., Pappas, P. G., Serody, J., Edwards, J. E., Washburn, R. G., NIAID Mycoses Study Group +1 more·1995·Clinical Infectious Diseases

Abstract

During a comparative trial of amphotericin B vs. fluconazole for treatment of candidemia in nonneutropenic patients, data on the management of intravascular catheters were collected. Complete records were available for 91% of the 206 study patients. For the subset of patients with a catheter in place at the time of their first positive blood culture, removal and replacement of all intravascular catheters without exchange over a guidewire from a preexisting line on or before the first day the study drug was administered were associated with a reduction in the subsequent mean duration (+/- SE) of candidemia, from 5.6 +/ -0.8 days to 2.6 +/- 0.5 days (P < .001).

Integrity signals

Registry

Crossref · 10.1093/clinids/21.4.994

Cites

7 of 7 references verified0 citation errors · 0 not checkable

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  • Venous catheter infection and IC guidelines, including the current IDSA guidelines, recommend removal of any intravascular catheter that is positive for a fungal pathogen (i.e., Candida) based on evidence from large retrospective and observational studies.

    “Venous catheter infection and IC guidelines, including the current IDSA guidelines, recommend removal of any intravascular catheter that is positive for a fungal pathogen (ie, Candida) based on evidence from large retrospective and observational studies.”

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Authors
Rex, J. H., Bennett, J. E., Sugar, A. M., Pappas, P. G., Serody, J., Edwards, J. E., Washburn, R. G., NIAID Mycoses Study Group, & Candidemia Study Group
Venue
Clinical Infectious Diseases
Published
1995-10-01
Volume
21
Issue
4
Pages
994-996
ISSN
  • 1058-4838 (ISSN-L)
  • 1537-6591
OpenAlex
W2163752788
Cited by
252
References
7
Citations by year
2025: 1 · 2024: 1 · 2022: 1 · 2021: 5 · 2020: 3 · 2019: 4 · 2018: 2 · 2017: 8 · 2016: 4 · 2015: 7 · 2014: 14 · 2013: 14 · 2012: 18
FWCI
5.46
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (n01ai015082-002)
  • National Institute of Allergy and Infectious Diseases (N01 AI15082)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Health Sciences › Health Professions › Emergency Medical Services › Central Venous Catheters and Hemodialysis
  • Health Sciences › Medicine › Epidemiology › Infective Endocarditis Diagnosis and Management
Keywords
candidemia, catheter removal, amphotericin B, fluconazole, non-neutropenic patients, antifungal therapy, catheter-related infection
MeSH terms
Amphotericin B, Antifungal Agents, Candidiasis, Catheterization, Humans, Time Factors, Fluconazole

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