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Hypoxia-Induced Lysyl Oxidase Is a Critical Mediator of Bone Marrow Cell Recruitment to Form the Premetastatic Niche
Open accessAbstract
Tumor cell metastasis is facilitated by "premetastatic niches" formed in destination organs by invading bone marrow-derived cells (BMDCs). Lysyl oxidase (LOX) is critical for premetastatic niche formation. LOX secreted by hypoxic breast tumor cells accumulates at premetastatic sites, crosslinks collagen IV in the basement membrane, and is essential for CD11b+ myeloid cell recruitment. CD11b+ cells adhere to crosslinked collagen IV and produce matrix metalloproteinase-2, which cleaves collagen, enhancing the invasion and recruitment of BMDCs and metastasizing tumor cells. LOX inhibition prevents CD11b+ cell recruitment and metastatic growth. CD11b+ cells and LOX also colocalize in biopsies of human metastases. Our findings demonstrate a critical role for LOX in premetastatic niche formation and support targeting LOX for the treatment and prevention of metastatic disease.
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“Specifically, hypoxia-induced lysyl oxidase contributes to the pre-metastatic niche in a process that includes collagen crosslinking and recruitment of CD11b + myeloid cells (Erler et al., 2009).”
From Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer (2016) · cites this paper as Erler et al., 2009
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“The BMDCs promote metastasis by producing chemokines that recruit tumor cells to the lung by mechanisms that include stimulation of tumor cell extravasation”
From Hypoxic control of metastasis (2016) · cites this paper as [92]
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Lysyl oxidase is essential for hypoxia-induced metastasis
Erler, J. T., Bennewith, K. L., Nicolau, M., Dornhöfer, N., Kong, C., Le, Q.-T., Chi, J.-T. A., Jeffrey, S. S., & Giaccia, A. J. (2006) · Nature · doi:10.1038/nature04695 · Cited by 1,309
Self-citationRetractedHanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219
Coussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111
Jemal, A., Siegel, R. L., Ward, E., Hao, Y., Xu, J., Murray, T., & Thun, M. J. (2008) · CA A Cancer Journal for Clinicians · doi:10.3322/ca.2007.0010 · Cited by 10,184
New functions for the matrix metalloproteinases in cancer progression
Egeblad, M., & Werb, Z. (2002) · Nature Reviews Cancer · doi:10.1038/nrc745 · Cited by 6,108
Cancer Metastasis: Building a Framework
Gupta, G. P., & Massagué, J. (2006) · Cell · doi:10.1016/j.cell.2006.11.001 · Cited by 4,333
Tensional homeostasis and the malignant phenotype
Paszek, M. J., Zahir, N., Johnson, K. R., Lakins, J. N., Rozenberg, G. I., Gefen, A., Reinhart-King, C. A., Margulies, S. S., Dembo, M., Boettiger, D., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.08.010 · Cited by 3,941
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
Kaplan, R. N., Riba, R. D., Zacharoulis, S., Bramley, A. H., Vincent, L., Costa, C., MacDonald, D. D., Jin, D. K., Shido, K., Kerns, S. A., et al. (2005) · Nature · doi:10.1038/nature04186 · Cited by 3,288
Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis
Condeelis, J. S., & Pollard, J. W. (2006) · Cell · doi:10.1016/j.cell.2006.01.007 · Cited by 2,677
Tumor Hypoxia: Definitions and Current Clinical, Biologic, and Molecular Aspects
Hockel, M., & Vaupel, P. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.4.266 · Cited by 2,662 · cited 1×
“Increased metastases, enhanced tumor progression, and decreased patient survival have been associated with primary tumors that contain large numbers of poorly oxygenated (hypoxic) tumor cells (Cairns et al., 2003; Hockel and Vaupel, 2001; Pouyssegur et al., 2006).”
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Khan, S., Zafar, A., & Naseem, I. (2020) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2020.103818 · Cited by 26
Role of Fibulin-5 in Metastatic Organ Colonization
Møller, H. D., Ralfkiær, U., Cremers, N., Frankel, M., Pedersen, R. T., Klingelhöfer, J., Yanagisawa, H., Grigorian, M., Guldberg, P., Sleeman, J. P., et al. (2011) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-11-0093 · Cited by 26
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Hwang, B. W., Kim, S. J., Park, K. M., Kim, H., Yeom, J., Yang, J., Jeong, H., Jung, H., Kim, K., Sung, Y. C., et al. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.10.034 · Cited by 26
Bång-Rudenstam, A., Cerezo-Magaña, M., & Belting, M. (2019) · Cancer and Metastasis Reviews · doi:10.1007/s10555-019-09786-5 · Cited by 25
Zhang, J., Han, X., Shi, H., Gao, Y., Qiao, X., Li, H., Wei, M., & Zeng, X. (2019) · Molecular and Cellular Probes · doi:10.1016/j.mcp.2019.101498 · Cited by 26
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Liu, Y., & Wang, R. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.583708 · Cited by 27
AI-guided biomaterials and biofabrication strategies for enhanced tumor extracellular matrix mimicry
Yan, J., Hu, M., Zhao, P., Zhang, C., Lin, J., Shen, Y., Chen, H., Zhang, W., Tang, M., & Luan, X. (2025) · Cell Biomaterials · doi:10.1016/j.celbio.2025.100188 · Cited by 25
Pal, S. K., Kortylewski, M., Yu, H., & Figlin, R. A. (2010) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-10-0873 · Cited by 25
Joint inflammation related citrullination of functional arginines in extracellular proteins
Sipilä, K. H., Ranga, V., Rappu, P., Mali, M., Pirilä, L., Heino, I., Jokinen, J., Käpylä, J., Johnson, M. S., & Heino, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-08597-4 · Cited by 25
Store operated calcium channels in cancer progression
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Behzatoğlu, K. (2021) · Pathology & Oncology Research · doi:10.3389/pore.2021.609472 · Cited by 27
Extracellular mRNA transported to the nucleus exerts translation-independent function
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Nairon, K. G., DePalma, T. J., Zent, J. M., Leight, J. L., & Skardal, A. (2022) · iScience · doi:10.1016/j.isci.2022.104645 · Cited by 24
Baumann, R. P., Ishiguro, K., Penketh, P. G., Shyam, K., Zhu, R., & Sartorelli, A. C. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.02.019 · Cited by 25
Regulation of Inflammation-Mediated Chronic Diseases by Botanicals
Sung, B., Prasad, S., Gupta, S. C., Patchva, S., & Aggarwal, B. B. (2012) · Advances in botanical research · doi:10.1016/b978-0-12-394591-4.00003-9 · Cited by 28
Bioreductively Activated Lysyl Oxidase Inhibitors against Hypoxic Tumours
Granchi, C., Funaioli, T., Erler, J. T., Giaccia, A. J., Macchia, M., & Minutolo, F. (2009) · ChemMedChem · doi:10.1002/cmdc.200900247 · Cited by 25
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Isola, A. L., & Chen, S. (2016) · Frontiers in Genetics · doi:10.3389/fgene.2016.00056 · Cited by 25
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Arvelo, F. A., Sojo, F. J., & Cotte, C. (2016) · ecancermedicalscience · doi:10.3332/ecancer.2016.701 · Cited by 25
Fang, M., Yuan, J., Chen, M., Sun, Z., Liu, L., Cheng, G., Ying, H., Yang, S., & Chen, M. (2018) · Oncology Letters · doi:10.3892/ol.2018.7946 · Cited by 25
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Caley, M. P., King, H. A., Shah, N., Wang, K., Rodríguez, M., Gronau, J. H., Waxman, J., & Sturge, J. (2015) · Clinical & Experimental Metastasis · doi:10.1007/s10585-015-9765-7 · Cited by 24
Suwara, J., & Hartman, M. L. (2025) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-025-03486-5 · Cited by 26
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Liang, W. H., Huang, X., Carlos, C. J. J., & Lü, X. (2020) · Clinical & Translational Oncology · doi:10.1007/s12094-020-02367-x · Cited by 24
Todd, V. M., Vecchi, L. A., Clements, M. E., Snow, K. P., Ontko, C. D., Himmel, L. E., Pinelli, C. J., Rafat, M., & Johnson, R. W. (2021) · Communications Biology · doi:10.1038/s42003-021-02648-3 · Cited by 25
Gong, L., Zhang, Y., Yang, Y., Yan, Q., Ren, J., Luo, J., Tiu, Y. C., Fang, X., Liu, B., Lam, R. H. W., et al. (2022) · Hepatology Communications · doi:10.1002/hep4.1966 · Cited by 24
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Ormseth, B., Onuma, A. E., Zhang, H., & Tsung, A. (2022) · Cancers · doi:10.3390/cancers14153731 · Cited by 29
Mohamedali, K. A., Li, Z., Starbuck, M. W., Wan, X., Yang, J., Kim, S., Zhang, W., Rosenblum, M. G., & Navone, N. M. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-2943 · Cited by 25
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Dai, S., Ren, P., Ren, J. L., Yang, L., & Li, W. (2021) · International Journal of Medical Sciences · doi:10.7150/ijms.56928 · Cited by 19
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Zheng, J., Jia, L., Mori, S., & Kodama, T. (2018) · BMC Cancer · doi:10.1186/s12885-018-4538-8 · Cited by 23
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Ko, G. H., Rugira, T., Jin, H., Joo, Y. N., & Kim, H. J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218027 · Cited by 22
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Lin, H., Chiang, M., Chang, P., & Chau, L. (2015) · Cancer Science · doi:10.1111/cas.12604 · Cited by 22
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Aguado, B. A., Wu, J., Azarin, S. M., Nanavati, D. M., Rao, S. S., Bushnell, G. G., Medicherla, C. B., & Shea, L. D. (2015) · Scientific Reports · doi:10.1038/srep17566 · Cited by 22
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Groenendijk, F. H., Zwart, W. T., Floore, A. N., Akbari, S., & Bernards, R. (2013) · Cited by 22
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Grzelak, C. A., & Ghajar, C. M. (2017) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2017.06.002 · Cited by 21
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Pires, I. M., Blokland, N. J. G., Broos, A. W., Poujade, F.-A., Senra, J. M., Eccles, S. A., Span, P. N., Harvey, A., & Hammond, E. M. (2014) · Cancer Biology & Therapy · doi:10.4161/cbt.29822 · Cited by 21
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Lima, F. T., Seba, V., SILVA, G. H. D. O., Torrezan, G. S., Polaquini, C. R., Pinhanelli, V. C., Baek, S. J., Fachin, A. L., Regasini, L. O., & Marins, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19071909 · Cited by 20
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Bustelo, X. R. (2012) · BioEssays · doi:10.1002/bies.201200041 · Cited by 20
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Mareel, M., & Santos, S. C. R. (2011) · The International Journal of Developmental Biology · doi:10.1387/ijdb.113386mm · Cited by 20
Waghorn, P. A., Oliveira, B. L., Jones, C. M., Tager, A. M., & Caravan, P. D. (2017) · Journal of Chromatography B · doi:10.1016/j.jchromb.2017.08.032 · Cited by 20
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Friesenhengst, A., Pribitzer-Winner, T., & Schreiber, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105579 · Cited by 21
Baumann, R. P., Penketh, P. G., Ishiguro, K., Shyam, K., Zhu, Y. L., & Sartorelli, A. C. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.12.004 · Cited by 20
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Kameyama, H., Dondapati, P., Simmons, R., Leslie, M., Langenheim, J. F., Sun, Y., Yi, M., Rottschaefer, A., Pathak, R., Nuguri, S., et al. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.101330 · Cited by 20
Xiao, P., Li, C., Liu, Y., Gao, Y., Liang, X., Liu, C., & Yang, W. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1333543 · Cited by 20
Iriondo, O., Mecenas, D., Li, Y., Chin, C. R., Thomas, A., Moriarty, A., Marker, R., Wang, Y. J., Hendrick, H., Amzaleg, Y., et al. (2024) · Cancer Research · doi:10.1158/0008-5472.can-23-2028 · Cited by 19
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Howell, A., Landberg, G., & Bergh, J. C. S. (2009) · Breast Cancer Research · doi:10.1186/bcr2435 · Cited by 19
Nilsson, M., Hägglöf, C., Hammarsten, P., Thysell, E., Stattin, P. E., Egevad, L., Granfors, T., Jernberg, E., Wikström, P., Bergström, S. H., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140985 · Cited by 19
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Hiratsuka, S., Tomita, T., Mishima, T., Matsunaga, Y., Omori, T., Ishibashi, S., Yamaguchi, S., Hosogane, T., Watarai, H., Omori‐Miyake, M., et al. (2018) · EMBO Molecular Medicine · doi:10.15252/emmm.201708643 · Cited by 19
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Qi, Y., Sun, D., Zhai, X., Chen, F., Niu, J., & Zhu, H. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06556-6 · Cited by 17
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Lee, J. W., & Beatty, G. L. (2020) · Cell Cycle · doi:10.1080/15384101.2020.1728013 · Cited by 18
Hu, C., Zhao, Y., Wang, X., & Zhu, T. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.651620 · Cited by 20
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González, L. O., Eiró, N., Fraile, M., Béridze, N., Escaf, A. R., Escaf, S., Gómez, J. M. F., & Vizoso, F. J. (2022) · Cancers · doi:10.3390/cancers14184412 · Cited by 20
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Roweth, H. G. (2023) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0043-1776005 · Cited by 19
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Mima, K., Fukagawa, T., Kurashige, J., Takano, Y., Uchi, R., Ueo, H., Matsumura, T., Ishibashi, M., Sawada, G., Takahashi, Y., et al. (2013) · Oncology Letters · doi:10.3892/ol.2013.1392 · Cited by 18
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Liu, Y., Ciotti, G. E., & Eisinger‐Mathason, T. S. K. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-12734-3_4 · Cited by 17
Zhao, W., Lv, M., Yang, X., Zhou, J., Xing, B., & Zhang, Z. (2022) · Carcinogenesis · doi:10.1093/carcin/bgac035 · Cited by 18
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UBR7 in concert with EZH2 inhibits the TGF-β signaling leading to extracellular matrix remodeling
Adhikari, S., Singh, V., Nandi, S., Ghosal, M., Raj, N. S., Khanna, J., Bhattacharya, A., Kabiraj, A., Mondal, A., Vasudevan, M., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114394 · Cited by 17
Qian, S., Wang, G., Meng, J., Jiang, S., Zhou, L., Lu, J., Ding, Z., Zhuo, S., & Liu, Z. (2022) · Optics Express · doi:10.1364/oe.452767 · Cited by 17
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Zhang, W., Pal, S. K., Liu, X., Yang, C., Allahabadi, S., Bhanji, S., Figlin, R. A., Yu, H., & Reckamp, K. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065121 · Cited by 17
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Metadata
- Authors
- Erler, J. T., Bennewith, K. L., Cox, T. R., Lang, G., Bird, D., Koong, A., Le, Q.-T., & Giaccia, A. J.
- Affiliations
- Institute of Cancer Research (GB)
- BC Cancer Agency (CA)
- Stanford Medicine (US)
- Corresponding author
- Giaccia, Amato J.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 15
- Issue
- 1
- Pages
- 35-44
- ISSN
- 1535-6108 (ISSN-L)
- PMC
- PMC3050620
- OpenAlex
- W2159744630
- Cited by
- 1,231
- References
- 40
- Citations by year
- 2026: 38 · 2025: 45 · 2024: 61 · 2023: 66 · 2022: 62 · 2021: 82 · 2020: 78 · 2019: 96 · 2018: 80 · 2017: 71 · 2016: 90 · 2015: 72 · 2014: 74 · 2013: 87 · 2012: 72
- FWCI
- 37.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cancer Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Cancer Research UK
- National Cancer Institute (P01CA067166, T32CA009151)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
- Keywords
- lysyl oxidase, pre-metastatic niche, metastasis, bone marrow-derived cells, hypoxia, breast cancer, CD11b+ myeloid cells, basement membrane, MMP-2, collagen degradation, metastasis prevention
- MeSH terms
- Animals, Hypoxia, Basement Membrane, Bone Marrow Cells, Breast Neoplasms, Cell Differentiation, Cell Movement, Cell Separation, Enzyme Activation, Humans, Lung Neoplasms, Protein-Lysine 6-Oxidase, Mice, Nude, Neoplasm Metastasis, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Neoplastic, Disease Progression, Matrix Metalloproteinase 2, Myeloid Cells, Xenograft Model Antitumor Assays, Collagen Type IV, Cell Line, Tumor, Mice
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