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Hypoxia-Induced Lysyl Oxidase Is a Critical Mediator of Bone Marrow Cell Recruitment to Form the Premetastatic Niche
Open accessAbstract
Tumor cell metastasis is facilitated by "premetastatic niches" formed in destination organs by invading bone marrow-derived cells (BMDCs). Lysyl oxidase (LOX) is critical for premetastatic niche formation. LOX secreted by hypoxic breast tumor cells accumulates at premetastatic sites, crosslinks collagen IV in the basement membrane, and is essential for CD11b+ myeloid cell recruitment. CD11b+ cells adhere to crosslinked collagen IV and produce matrix metalloproteinase-2, which cleaves collagen, enhancing the invasion and recruitment of BMDCs and metastasizing tumor cells. LOX inhibition prevents CD11b+ cell recruitment and metastatic growth. CD11b+ cells and LOX also colocalize in biopsies of human metastases. Our findings demonstrate a critical role for LOX in premetastatic niche formation and support targeting LOX for the treatment and prevention of metastatic disease.
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“Specifically, hypoxia-induced lysyl oxidase contributes to the pre-metastatic niche in a process that includes collagen crosslinking and recruitment of CD11b + myeloid cells (Erler et al., 2009).”
From Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer (2016) · cites this paper as Erler et al., 2009
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“The BMDCs promote metastasis by producing chemokines that recruit tumor cells to the lung by mechanisms that include stimulation of tumor cell extravasation”
From Hypoxic control of metastasis (2016) · cites this paper as [92]
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1 retracted
Lysyl oxidase is essential for hypoxia-induced metastasis
Erler, J. T., Bennewith, K. L., Nicolau, M., Dornhöfer, N., Kong, C., Le, Q.-T., Chi, J.-T. A., Jeffrey, S. S., & Giaccia, A. J. (2006) · Nature · doi:10.1038/nature04695 · Cited by 1,309
Self-citationRetractedHanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219
Coussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111
Jemal, A., Siegel, R. L., Ward, E., Hao, Y., Xu, J., Murray, T., & Thun, M. J. (2008) · CA A Cancer Journal for Clinicians · doi:10.3322/ca.2007.0010 · Cited by 10,184
New functions for the matrix metalloproteinases in cancer progression
Egeblad, M., & Werb, Z. (2002) · Nature Reviews Cancer · doi:10.1038/nrc745 · Cited by 6,108
Cancer Metastasis: Building a Framework
Gupta, G. P., & Massagué, J. (2006) · Cell · doi:10.1016/j.cell.2006.11.001 · Cited by 4,333
Tensional homeostasis and the malignant phenotype
Paszek, M. J., Zahir, N., Johnson, K. R., Lakins, J. N., Rozenberg, G. I., Gefen, A., Reinhart-King, C. A., Margulies, S. S., Dembo, M., Boettiger, D., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.08.010 · Cited by 3,941
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
Kaplan, R. N., Riba, R. D., Zacharoulis, S., Bramley, A. H., Vincent, L., Costa, C., MacDonald, D. D., Jin, D. K., Shido, K., Kerns, S. A., et al. (2005) · Nature · doi:10.1038/nature04186 · Cited by 3,288
Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis
Condeelis, J. S., & Pollard, J. W. (2006) · Cell · doi:10.1016/j.cell.2006.01.007 · Cited by 2,677
Tumor Hypoxia: Definitions and Current Clinical, Biologic, and Molecular Aspects
Hockel, M., & Vaupel, P. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.4.266 · Cited by 2,662 · cited 1×
“Increased metastases, enhanced tumor progression, and decreased patient survival have been associated with primary tumors that contain large numbers of poorly oxygenated (hypoxic) tumor cells (Cairns et al., 2003; Hockel and Vaupel, 2001; Pouyssegur et al., 2006).”
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Items 301–400 of 999
Hypoxia and the phenomenon of immune exclusion
Pietrobon, V., & Marincola, F. M. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-020-02667-4 · Cited by 119
Angiogenesis inhibitors as therapeutic agents in cancer: Challenges and future directions
Lin, Z., Zhang, Q., & Luo, W. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.10.039 · Cited by 119
The regulation of pre-metastatic niche formation by neutrophils
Jabłońska, J., Lang, S., Sionov, R. V., & Granot, Z. (2017) · Oncotarget · doi:10.18632/oncotarget.22792 · Cited by 117
Minami, T., Jiang, S., Schadler, K., Suehiro, J.-I., Osawa, T., Oike, Y., Miura, M., Naito, M., Kodama, T., & Ryeom, S. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.07.021 · Cited by 111
Role of tumour-associated macrophages in cancer-related inflammation.
Sica, A. (2010) · PubMed · Cited by 117
Kim, H., Chung, H., Kim, J., Choi, D., Shin, Y., Kang, Y. G., Kim, B., Seo, S., Chung, S. H., & Seok, S. H. (2019) · Advanced Science · doi:10.1002/advs.201900195 · Cited by 118
Towards extracellular matrix normalization for improved treatment of solid tumors
Abyaneh, H. S., Regenold, M., McKee, T. D., Allen, C. J., & Gauthier, M. A. (2020) · Theranostics · doi:10.7150/thno.39995 · Cited by 120
Cancer Cell Colonisation in the Bone Microenvironment
Kan, C. W. S., Vargas, G., Pape, F. L., & Clézardin, P. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17101674 · Cited by 117
Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer
Lin, S., Kao, C., Lee, H.-J., Creighton, C. J., Ittmann, M., Tsai, S., Tsai, M., & Tsai, M. (2016) · Nature Communications · doi:10.1038/ncomms11418 · Cited by 117
Bakdash, G., Buschow, S. I., Gorris, M. A. J., Halilović, A., Hato, S. V., Sköld, A. E., Schreibelt, G., Sittig, S. P., Torensma, R., Boer, T. D., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-1695 · Cited by 123
Antifibrotic therapy to normalize the tumor microenvironment
Hauge, A., & Rofstad, E. K. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02376-y · Cited by 119
Zhong, L., Liao, D., Li, J., Liu, W., Wang, J., Zeng, C., Wang, X., Cao, Z., Zhang, R., Li, M., et al. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00414-1 · Cited by 118
Torres, S., García‐Palmero, I., Herrera, M., Bartolomé, R. A., Peña, C., Fernández‐Aceñero, M. J., Padilla, G., Peláez‐García, A., López-Lucendo, M. F., Rodríguez-Merlo, R., et al. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-3096 · Cited by 117
Structural ECM components in the premetastatic and metastatic niche
Høye, A. M., & Erler, J. T. (2016) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00326.2015 · Cited by 115
Self-citationCancer Tills the Premetastatic Field: Mechanistic Basis and Clinical Implications
Chin, A. R., & Wang, S. E. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-0028 · Cited by 119
Adaptive Stress Responses During Tumor Metastasis and Dormancy
Senft, D., & Ronai, Z. A. (2016) · Trends in cancer · doi:10.1016/j.trecan.2016.06.004 · Cited by 118
Role of Tumor-Associated Myeloid Cells in Breast Cancer
Cha, Y. J., & Koo, J. S. (2020) · Cells · doi:10.3390/cells9081785 · Cited by 114
Pre-clinical evaluation of small molecule LOXL2 inhibitors in breast cancer
Chang, J., Lucas, M. C., Leonte, L. E., García-Montolio, M., Singh, L. B., Findlay, A. D., Deodhar, M., Foot, J. S., Jarolimek, W., Timpson, P., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.15257 · Cited by 118
Self-citationSetargew, Y. F. I., Wyllie, K., Grant, R. D., Chitty, J. L., & Cox, T. R. (2021) · Cancers · doi:10.3390/cancers13030491 · Cited by 114
Self-citationEnhanced Survival with Implantable Scaffolds That Capture Metastatic Breast Cancer Cells In Vivo
Rao, S. S., Bushnell, G. G., Azarin, S. M., Spicer, G. L. C., Aguado, B. A., Stoehr, J. R., Jiang, E. J., Backman, V., Shea, L. D., & Jeruss, J. S. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-2106 · Cited by 118
Quantitative extracellular matrix proteomics to study mammary and liver tissue microenvironments
Goddard, E. T., Hill, R. C., Barrett, A. S., Betts, C. B., Guo, Q., Maller, O., Borges, V. F., Hansen, K. C., & Schedin, P. S. (2016) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2016.10.014 · Cited by 113
Copper in cancer: from limiting nutrient to therapeutic target
Tang, X., Yan, Z., Miao, Y., Ha, W., Li, Z., Yang, L., & Mi, D. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1209156 · Cited by 116
Targeting fibronectin for cancer imaging and therapy
Han, Z., & Lu, Z. (2016) · Journal of Materials Chemistry B · doi:10.1039/c6tb02008a · Cited by 108
New and Paradoxical Roles of Matrix Metalloproteinases in the Tumor Microenvironment
Noël, A., Gutiérrez‐Fernández, A., Sounni, N. E., Behrendt, N., Maquoi, E., Lund, I. K., Cal, S., Høyer‐Hansen, G., & López-Otı́n, C. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00140 · Cited by 116
Targeting hypoxic tumour cells to overcome metastasis
Bennewith, K. L., & Dedhar, S. (2011) · BMC Cancer · doi:10.1186/1471-2407-11-504 · Cited by 109
Self-citationThe Different Routes to Metastasis via Hypoxia-Regulated Programs
Nobre, A. R., Entenberg, D. R., Wang, Y., Condeelis, J. S., & Aguirre‐Ghiso, J. A. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.06.008 · Cited by 106
Noncanonical TGF-β Signaling During Mammary Tumorigenesis
Parvani, J. G., Taylor, M. A., & Schiemann, W. P. (2011) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-011-9207-3 · Cited by 112
Understanding the role of stromal fibroblasts in cancer progression
Tripathi, M., Billet, S., & Bhowmick, N. A. (2012) · Cell Adhesion & Migration · doi:10.4161/cam.20419 · Cited by 116
Roles of Copper-Binding Proteins in Breast Cancer
Blockhuys, S., & Wittung-Stafshede, P. E. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040871 · Cited by 108
Takesue, S., Ohuchida, K., Shinkawa, T., Otsubo, Y., Matsumoto, S., Sagara, A., Yonenaga, A., Ando, Y., Kibe, S., Nakayama, H., et al. (2019) · International Journal of Oncology · doi:10.3892/ijo.2019.4951 · Cited by 106
Wang, Z., Xiong, S., Mao, Y., Chen, M., Ma, X., Zhou, X., Ma, Z., Liu, F., Huang, Z., Luo, Q., et al. (2016) · The Journal of Pathology · doi:10.1002/path.4747 · Cited by 105
Mechanoresponsive stem cells to target cancer metastases through biophysical cues
Liu, L., Zhang, S. X., Liao, W., Farhoodi, H. P., Wong, C. W., Chen, C. C., Ségaliny, A. I., Chacko, J. V., Nguyen, L., Lu, M., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aan2966 · Cited by 104
Peng, J., Yang, Q., Shi, K., Xiao, Y., Wei, X., & Qian, Z. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.06.007 · Cited by 105
Pre-metastatic Niche Formation in Different Organs Induced by Tumor Extracellular Vesicles
Dong, Q., Liu, X., Cheng, K., Sheng, J., Kong, J., & Liu, T. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.733627 · Cited by 110
Liu, W.-R., Tian, M., Yang, L., Lin, Y., Jin, L., Ding, Z., Shen, Y., Peng, Y., Gao, D., Zhou, J., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.2749 · Cited by 107
Drug-induced regeneration in adult mice
Zhang, Y., Strehin, I. A., Bedelbaeva, K., Gourevitch, D., Clark, L. D., Leferovich, J. M., Messersmith, P. B., & Heber‐Katz, E. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.3010228 · Cited by 104
Li, Q., Zhu, C., Ni, B., Zhang, Z., Jiang, S., Hu, L.-P., Zhang, X.-X., Zhang, X.-X., Huang, P.-Q., Yang, Q., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.10.037 · Cited by 104
Reticker-Flynn, N. E., & Bhatia, S. N. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0760 · Cited by 103
The pre-metastatic niche in lymph nodes: formation and characteristics
Gillot, L., Baudin, L., Rouaud, L., Kridelka, F., & Noël, A. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03873-z · Cited by 108
Distant metastasis from oral cancer: A review and molecular biologic aspects
Irani, S. (2016) · Journal of International Society of Preventive and Community Dentistry · doi:10.4103/2231-0762.186805 · Cited by 102
Tumor-associated macrophages: a short compendium
Prenen, H., & Mazzone, M. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2997-3 · Cited by 103
Stella, G. M., Kolling, S., Benvenuti, S., & Bortolotto, C. (2019) · Cancers · doi:10.3390/cancers11071010 · Cited by 103
Frisbie, L. G., Buckanovich, R. J., & Coffman, L. G. (2022) · Stem Cells · doi:10.1093/stmcls/sxac036 · Cited by 107
Myeloid regulatory cells in tumor spreading and metastasis
Keskinov, A. A., & Shurin, M. R. (2014) · Immunobiology · doi:10.1016/j.imbio.2014.07.017 · Cited by 104
Kim, M. Y. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-981-32-9620-6_9 · Cited by 109
Cellular basis of hepatic fibrosis and its role in inflammation and cancer
Kocabayoglu, P. (2012) · Frontiers in Bioscience-Scholar · doi:10.2741/s368 · Cited by 101
Lysyl oxidase in cancer inhibition and metastasis
Johnston, K. A., & Lopez, K. M. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.01.006 · Cited by 100
Jain, S., Cohen, J., Ward, M. M., Kornhauser, N., Chuang, E., Cigler, T., Moore, A. L., Donovan, D., Lam, C., Cobham, M., et al. (2013) · Annals of Oncology · doi:10.1093/annonc/mds654 · Cited by 101
RKIP and HMGA2 regulate breast tumor survival and metastasis through lysyl oxidase and syndecan-2
Sun, M., Gomes, S. C. V., Chen, P. B., Frankenberger, C. A., Sankarasharma, D., Chung, C. H., Chada, K. K., & Rosner, M. R. (2013) · Oncogene · doi:10.1038/onc.2013.328 · Cited by 100
The role of bone-marrow-derived cells in tumor growth, metastasis initiation and progression
Gao, D., & Mittal, V. (2009) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2009.06.006 · Cited by 99
Control of Megakaryocyte Expansion and Bone Marrow Fibrosis by Lysyl Oxidase
Eliades, A., Papadantonakis, N., Bhupatiraju, A. V., Burridge, K. A., Johnston‐Cox, H., Migliaccio, A. R., Crispino, J. D., Lucero, H. A., Trackman, P. C., & Ravid, K. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.243113 · Cited by 98
Mauti, L. A., Bitoux, M. L., Baumer, K., Stehle, J., Golshayan, D., Provero, P., & Stamenkovic, I. (2011) · Journal of Clinical Investigation · doi:10.1172/jci41936 · Cited by 97
Sleeman, J. P., Schmid, A., & Thiele, W. (2009) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2009.05.005 · Cited by 97
Taylor, M. A., Amin, J., Kirschmann, D. A., & Schiemann, W. P. (2011) · Neoplasia · doi:10.1593/neo.101086 · Cited by 95
Blocking Surgically Induced Lysyl Oxidase Activity Reduces the Risk of Lung Metastases
Rachman-Tzemah, C., Zaffryar‐Eilot, S., Grossman, M., Ribero, D., Timaner, M., Mäki, J. M., Myllyharju, J., Bertolini, F., Hershkovitz, D., Sagi, I., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.04.005 · Cited by 96
Global secretome analysis identifies novel mediators of bone metastasis
Blanco, M. A., LeRoy, G., Khan, Z., Alečković, M., Zee, B. M., Garcia, B. A., & Kang, Y. (2012) · Cell Research · doi:10.1038/cr.2012.89 · Cited by 93
Lohela, M. K., Casbon, A.-J., Olow, A., Bonham, L., Branstetter, D. G., Weng, N., Smith, J., & Werb, Z. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1419899111 · Cited by 97
5-Lipoxygenase Antagonist therapy: a new approach towards targeted cancer chemotherapy
Bishayee, K., & Khuda‐Bukhsh, A. R. (2013) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmt064 · Cited by 95
Liu, Y. L., Bager, C. L., Willumsen, N., Ramchandani, D., Kornhauser, N., Lu, L., Cobham, M. V., Andreopoulou, E., Cigler, T., Moore, A. L., et al. (2021) · npj Breast Cancer · doi:10.1038/s41523-021-00313-w · Cited by 94
LOXL2 in Epithelial Cell Plasticity and Tumor Progression
Cano, A., Santamarı́a, P. G., & Moreno‐Bueno, G. (2012) · Future Oncology · doi:10.2217/fon.12.105 · Cited by 94
The innate and adaptive infiltrating immune systems as targets for breast cancer immunotherapy
Law, A. M. K., Lim, E., Ormandy, C. J., & Gallego‐Ortega, D. (2017) · Endocrine Related Cancer · doi:10.1530/erc-16-0404 · Cited by 103
HIF2α in the uterine stroma permits embryo invasion and luminal epithelium detachment
Matsumoto, L., Hirota, Y., Saito‐Fujita, T., Takeda, N., Tanaka, T., Hiraoka, T., Akaeda, S., Fujita, H., Shimizu‐Hirota, R., Igaue, S., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci98931 · Cited by 95
Decoding Melanoma Development and Progression: Identification of Therapeutic Vulnerabilities
Eddy, K., Shah, R., & Chen, S. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.626129 · Cited by 104
Contributions of the Host Microenvironment to Cancer-Induced Bone Disease
Olechnowicz, S. W. Z., & Edwards, C. M. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-2645 · Cited by 98
Martín, A. L., Salvador, F., Moreno‐Bueno, G., Floristán, A., Ruiz‐Herguido, C., Cuevas, E. P., Morales, S., Santos, V., Csiszár, K., Dubus, P. R., et al. (2015) · The EMBO Journal · doi:10.15252/embj.201489975 · Cited by 93
Recent advances in understanding the complexities of metastasis
Chitty, J. L., Filipe, E. C., Lucas, M. C., Herrmann, D., Cox, T. R., & Timpson, P. (2018) · F1000Research · doi:10.12688/f1000research.15064.2 · Cited by 97
Self-citationIrreversible Electroporation: An Emerging Immunomodulatory Therapy on Solid Tumors
Zhang, N., Li, Z., Han, X., Zhu, Z., Li, Z., Zhao, Y., Liu, Z., & Lv, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.811726 · Cited by 93
Avnet, S., Lemma, S., Cortini, M., Pellegrini, P., Perut, F., Zini, N., Kusuzaki, K., Chano, T., Grisendi, G., Dominici, M., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.11503 · Cited by 92
Wei, Z., Shan, Y., Li, T., Liu, Y., Zhu, Z., Liu, Z., Wu, Y., Chen, W., Wang, A., & Lu, Y. (2017) · Molecular Carcinogenesis · doi:10.1002/mc.22686 · Cited by 92
Charting the unexplored extracellular matrix in cancer
Filipe, E. C., Chitty, J. L., & Cox, T. R. (2018) · International Journal of Experimental Pathology · doi:10.1111/iep.12269 · Cited by 94
Self-citationCopper homeostasis and cuproptosis in central nervous system diseases
Zhu, Z., Song, M. S., Ren, J., Liang, L., Mao, G., & Chen, M. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-07206-3 · Cited by 103
Metastatic cancer stem cells: from the concept to therapeutics.
Liao, W., Ye, Y., Deng, Y., Bian, X., & Ding, Y.-Q. (2014) · Europe PMC (PubMed Central) · Cited by 91
Canesin, G., Cuevas, E. P., Santos, V., López‐Menéndez, C., Moreno‐Bueno, G., Huang, Y., Csiszár, K., Portillo, F., Peinado, H., Lyden, D. C., et al. (2014) · Oncogene · doi:10.1038/onc.2014.23 · Cited by 91
Libring, S., Shinde, A. B., Chanda, M. K., Nuru, M., George, H., Saleh, A. M., Abdullah, A., Kinzer‐Ursem, T. L., Calve, S., Wendt, M. K., et al. (2020) · Cancers · doi:10.3390/cancers12051270 · Cited by 91
Concepts of metastasis in flux: The stromal progression model
Sleeman, J. P., Christofori, G., Fodde, R., Collard, J. G., Berx, G., Decraene, C., & Rüegg, C. (2012) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2012.02.007 · Cited by 90
Long, Y., Lu, Z., Xu, S., Li, M., Wang, X., Zhang, Z., & He, Q. (2019) · Nano Letters · doi:10.1021/acs.nanolett.9b03883 · Cited by 90
The Role of the ECM in Lung Cancer Dormancy and Outgrowth
Parker, A. L., & Cox, T. R. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01766 · Cited by 95
Self-citationCombined experimental and computational characterization of crosslinked collagen-based hydrogels
Valero, C., Amaveda, H., Mora, M., & García‐Aznar, J. M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0195820 · Cited by 90
Bosiljcic, M., Cederberg, R. A., Hamilton, M. J., LePard, N. E., Harbourne, B., Collier, J. L., Halvorsen, E. C., Shi, R., Franks, S. E., Kim, A. Y., et al. (2019) · Breast Cancer Research · doi:10.1186/s13058-019-1189-x · Cited by 89
Self-citationExosomes in hypoxia-induced remodeling of the tumor microenvironment
Kumar, A., & Deep, G. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.05.018 · Cited by 89
Redox-Based Escape Mechanism from Death: The Cancer Lesson
Pani, G., Giannoni, E., Galeotti, T., & Chiarugi, P. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2739 · Cited by 92
Extracellular matrix-mediated regulation of cancer stem cells and chemoresistance
Brown, Y., Hua, S., & Tanwar, P. S. (2019) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2019.02.002 · Cited by 90
Nanotechnology-enhanced immunotherapy for metastatic cancer
Zhang, P., Meng, J., Li, Y., Chen, Y., Hou, Y., Tang, W., McHugh, K. J., & Jing, L. (2021) · The Innovation · doi:10.1016/j.xinn.2021.100174 · Cited by 88
Lysyl Oxidase Family Enzymes and Their Role in Tumor Progression
Liburkin-Dan, T., Toledano, S., & Neufeld, G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23116249 · Cited by 88
Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface
Tang, H., Leung, L. M. H., Saturno, G., Virós, A., Smith, D. L., Leva, G. D., Morrison, E., Niculescu‐Duvaz, D., Lopes, F., Johnson, L. D., et al. (2017) · Nature Communications · doi:10.1038/ncomms14909 · Cited by 93
Rachidi, S., Qin, T., Sun, S., Zheng, W., & Li, Z. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057911 · Cited by 86
Razorenova, O. V., Finger, E. C., Colavitti, R., Chernikova, S. B., Boiko, A. D., Chan, C. K. F., Krieg, A. J., Bedogni, B., LaGory, E. L., Weissman, I. L., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011777108 · Cited by 91
Self-citationMoon, H.-J., Finney, J., Xu, L., Moore, D., Welch, D. R., & Mure, M. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.c113.502310 · Cited by 86
Role of Microenvironment on the Fate of Disseminating Cancer Stem Cells
Ingangi, V., Minopoli, M., Ragone, C., Motti, M. L., & Carriero, M. V. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00082 · Cited by 88
Deep, G., Jain, A., Kumar, A., Agarwal, C., Kim, S., Leevy, W. M., & Agarwal, R. (2020) · Molecular Carcinogenesis · doi:10.1002/mc.23157 · Cited by 86
The roles of epigenetics in cancer progression and metastasis
Chen, J. F.-Y., & Yan, Q. (2021) · Biochemical Journal · doi:10.1042/bcj20210084 · Cited by 89
Cell communication networks in cancer invasion
Calvo, F., & Sahai, E. A. (2011) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2011.04.010 · Cited by 89
Zaffryar‐Eilot, S., Marshall, D. C. L., Voloshin, T., Bar‐Zion, A., Spangler, R., Kessler, O., Ghermazien, H., Brekhman, V., Suss-Toby, E., Adam, D., et al. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt241 · Cited by 86
Le, Q., Harris, J., Magliocco, A. M., Kong, C. S., Diaz, R., Shin, B., Cao, H., Trotti, A., Erler, J. T., Chung, C. H., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.20.6003 · Cited by 91
Self-citationHypoxia and Bone Metastatic Disease
Johnson, R. W., Sowder, M. E., & Giaccia, A. J. (2017) · Current Osteoporosis Reports · doi:10.1007/s11914-017-0378-8 · Cited by 92
Self-citationThe emerging role of targeting cancer metabolism for cancer therapy
Farhadi, P., Yarani, R., Dokaneheifard, S., & Mansouri, K. (2020) · Tumor Biology · doi:10.1177/1010428320965284 · Cited by 86
Tumour–adipose tissue crosstalk: fuelling tumour metastasis by extracellular vesicles
de Lope, L. R., Leaman, O., López, A. A., Hergueta‐Redondo, M., & Peinado, H. (2017) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0485 · Cited by 84
Lysyl oxidase secreted by tumour endothelial cells promotes angiogenesis and metastasis
Osawa, T., Ohga, N., Akiyama, K., Hida, Y., Kitayama, K., Kawamoto, T., Yamamoto, K., Maishi, N., Kondoh, M., Onodera, Y., et al. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.535 · Cited by 87
MYC activation cooperates with Vhl and Ink4a/Arf loss to induce clear cell renal cell carcinoma
Bailey, S. T., Smith, A. M., Kardos, J., Wobker, S. E., Wilson, H. L., Krishnan, B., Saito, R., Lee, H. J., Zhang, J., Eaton, S. C., et al. (2017) · Nature Communications · doi:10.1038/ncomms15770 · Cited by 86
Mechanical forces in the tumor microenvironment: roles, pathways, and therapeutic approaches
Zhang, Y., Fu, Q., Sun, W., Yue, Q., He, P., Niu, D., & Zhang, M. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06306-8 · Cited by 92
Metadata
- Authors
- Erler, J. T., Bennewith, K. L., Cox, T. R., Lang, G., Bird, D., Koong, A., Le, Q.-T., & Giaccia, A. J.
- Affiliations
- Institute of Cancer Research (GB)
- BC Cancer Agency (CA)
- Stanford Medicine (US)
- Corresponding author
- Giaccia, Amato J.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 15
- Issue
- 1
- Pages
- 35-44
- ISSN
- 1535-6108 (ISSN-L)
- PMC
- PMC3050620
- OpenAlex
- W2159744630
- Cited by
- 1,231
- References
- 40
- Citations by year
- 2026: 38 · 2025: 45 · 2024: 61 · 2023: 66 · 2022: 62 · 2021: 82 · 2020: 78 · 2019: 96 · 2018: 80 · 2017: 71 · 2016: 90 · 2015: 72 · 2014: 74 · 2013: 87 · 2012: 72
- FWCI
- 37.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cancer Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Cancer Research UK
- National Cancer Institute (P01CA067166, T32CA009151)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
- Keywords
- lysyl oxidase, pre-metastatic niche, metastasis, bone marrow-derived cells, hypoxia, breast cancer, CD11b+ myeloid cells, basement membrane, MMP-2, collagen degradation, metastasis prevention
- MeSH terms
- Animals, Hypoxia, Basement Membrane, Bone Marrow Cells, Breast Neoplasms, Cell Differentiation, Cell Movement, Cell Separation, Enzyme Activation, Humans, Lung Neoplasms, Protein-Lysine 6-Oxidase, Mice, Nude, Neoplasm Metastasis, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Neoplastic, Disease Progression, Matrix Metalloproteinase 2, Myeloid Cells, Xenograft Model Antitumor Assays, Collagen Type IV, Cell Line, Tumor, Mice
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