Cited by 1,231Cancer Cells and MetastasisImmune cells in cancerMechanisms of cancer metastasis

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Hypoxia-Induced Lysyl Oxidase Is a Critical Mediator of Bone Marrow Cell Recruitment to Form the Premetastatic Niche

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Erler, Janine T., Bennewith, Kevin L., Cox, Thomas R., Lang, Georgina, Bird, Demelza, Koong, Albert, Le, Quynh-Thu, Giaccia, Amato J.·2009·Cancer Cell

DOI 10.1016/j.ccr.2008.11.012PMC PMC3050620

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Abstract

Tumor cell metastasis is facilitated by "premetastatic niches" formed in destination organs by invading bone marrow-derived cells (BMDCs). Lysyl oxidase (LOX) is critical for premetastatic niche formation. LOX secreted by hypoxic breast tumor cells accumulates at premetastatic sites, crosslinks collagen IV in the basement membrane, and is essential for CD11b+ myeloid cell recruitment. CD11b+ cells adhere to crosslinked collagen IV and produce matrix metalloproteinase-2, which cleaves collagen, enhancing the invasion and recruitment of BMDCs and metastasizing tumor cells. LOX inhibition prevents CD11b+ cell recruitment and metastatic growth. CD11b+ cells and LOX also colocalize in biopsies of human metastases. Our findings demonstrate a critical role for LOX in premetastatic niche formation and support targeting LOX for the treatment and prevention of metastatic disease.

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1 retracted

Lysyl oxidase is essential for hypoxia-induced metastasis
Erler, J. T., Bennewith, K. L., Nicolau, M., Dornhöfer, N., Kong, C., Le, Q.-T., Chi, J.-T. A., Jeffrey, S. S., & Giaccia, A. J. (2006) · Nature · doi:10.1038/nature04695 · Cited by 1,309
Self-citation
Retracted
The hallmarks of cancer
Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219
Inflammation and cancer
Coussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111
Cancer Statistics, 2008
Jemal, A., Siegel, R. L., Ward, E., Hao, Y., Xu, J., Murray, T., & Thun, M. J. (2008) · CA A Cancer Journal for Clinicians · doi:10.3322/ca.2007.0010 · Cited by 10,184
New functions for the matrix metalloproteinases in cancer progression
Egeblad, M., & Werb, Z. (2002) · Nature Reviews Cancer · doi:10.1038/nrc745 · Cited by 6,108
Cancer Metastasis: Building a Framework
Gupta, G. P., & Massagué, J. (2006) · Cell · doi:10.1016/j.cell.2006.11.001 · Cited by 4,333
Tensional homeostasis and the malignant phenotype
Paszek, M. J., Zahir, N., Johnson, K. R., Lakins, J. N., Rozenberg, G. I., Gefen, A., Reinhart-King, C. A., Margulies, S. S., Dembo, M., Boettiger, D., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.08.010 · Cited by 3,941
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
Kaplan, R. N., Riba, R. D., Zacharoulis, S., Bramley, A. H., Vincent, L., Costa, C., MacDonald, D. D., Jin, D. K., Shido, K., Kerns, S. A., et al. (2005) · Nature · doi:10.1038/nature04186 · Cited by 3,288
Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis
Condeelis, J. S., & Pollard, J. W. (2006) · Cell · doi:10.1016/j.cell.2006.01.007 · Cited by 2,677
Tumor Hypoxia: Definitions and Current Clinical, Biologic, and Molecular Aspects
Hockel, M., & Vaupel, P. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.4.266 · Cited by 2,662 · cited 1×
“Increased metastases, enhanced tumor progression, and decreased patient survival have been associated with primary tumors that contain large numbers of poorly oxygenated (hypoxic) tumor cells (Cairns et al., 2003; Hockel and Vaupel, 2001; Pouyssegur et al., 2006).”
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Primary Tumor Hypoxia Recruits CD11b+/Ly6Cmed/Ly6G+ Immune Suppressor Cells and Compromises NK Cell Cytotoxicity in the Premetastatic Niche
Sceneay, J., Chow, M. T., Chen, A., Halse, H. M., Wong, C. S. F., Andrews, D. M., Sloan, E. K., Parker, B. S., Bowtell, D. D. L., Smyth, M. J., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-3873 · Cited by 375
Molecular networks that regulate cancer metastasis
Spano, D., Heck, C., Antonellis, P. D., Christofori, G., & Zollo, M. (2012) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2012.03.006 · Cited by 367
CXCL1 Is Critical for Premetastatic Niche Formation and Metastasis in Colorectal Cancer
Wang, D., Sun, H., Wei, J., Cen, B., & DuBois, R. N. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-3199 · Cited by 365
Recruitment of monocytes/macrophages by tissue factor-mediated coagulation is essential for metastatic cell survival and premetastatic niche establishment in mice
Gil‐Bernabé, A. M., Ferjancic, S., Tlalka, M., Zhao, L., Allen, P. D., Im, J. H., Watson, K., Hill, S. A., Amirkhosravi, A., Francis, J. L., et al. (2012) · Blood · doi:10.1182/blood-2011-08-376426 · Cited by 361
Strategies for the discovery and development of therapies for metastatic breast cancer
Eckhardt, B. L., Francis, P. A., Parker, B. S., & Anderson, R. L. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd2372 · Cited by 353
Role of the gut microbiota in anticancer therapy: from molecular mechanisms to clinical applications
Zhao, L.-Y., Mei, J.-X., Yu, G., Lei, L., Zhang, W.-H., Liu, K., Chen, X.-L., Kołat, D., Yang, K., & Hu, J.-K. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01406-7 · Cited by 359
Macrophage immunomodulation by breast cancer-derived exosomes requires Toll-like receptor 2-mediated activation of NF-κB
Chow, A. Y., Zhou, W., Liu, L., Fong, M., Champer, J., Haute, D. V., Chin, A. R., Ren, X., Gugiu, B. G., Meng, Z., et al. (2014) · Scientific Reports · doi:10.1038/srep05750 · Cited by 345
CD44v6 Dependence of Premetastatic Niche Preparation by Exosomes
Jung, T., Castellana, D., Klingbeil, P., Hernández, I. C., Vitacolonna, M., Orlicky, D. J., Roffler, S. R., Brodt, P., & Zöller, M. (2009) · Neoplasia · doi:10.1593/neo.09822 · Cited by 341
A framework for the development of effective anti-metastatic agents
Anderson, R. L., Balasas, T., Callaghan, J., Coombes, R. C., EVANS, J., Hall, J. A., Kinrade, S. A., Jones, D., Jones, P. S., Jones, R. J., et al. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-018-0134-8 · Cited by 349
Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma
Chen, P., Zhao, D., Li, J., Liang, X., Li, J., Chang, A. H., Henry, V. K., Lan, Z., Spring, D. J., Rao, G., et al. (2019) · Cancer Cell · doi:10.1016/j.ccell.2019.05.003 · Cited by 344
Reduction of Liver Metastasis Stiffness Improves Response to Bevacizumab in Metastatic Colorectal Cancer
Shen, Y., Wang, X., Lu, J., Salfenmoser, M., Wirsik, N. M., Schleußner, N., Imle, A., Valls, A. F., Radhakrishnan, P., Liang, J., et al. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.05.005 · Cited by 342
The role of tumor-associated macrophages in gastric cancer development and their potential as a therapeutic target
Gambardella, V., Castillo, J., Tarazona, N., Gimeno-Valiente, F., Martínez‐Ciarpaglini, C., Cabeza-Segura, M., Roselló, S., Roda, D., Huerta, M., Cervantes, A. M. R., et al. (2020) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2020.102015 · Cited by 337
Hypoxia‐inducing factors as master regulators of stemness properties and altered metabolism of cancer‐ and metastasis‐initiating cells
Mimeault, M., & Batra, S. K. (2013) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12004 · Cited by 339
Tumor-Host Interactions: A Far-Reaching Relationship
McAllister, S. S., & Weinberg, R. A. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2010.28.4257 · Cited by 333
RETRACTED ARTICLE: HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs
Zhang, H., Wong, C. C. L., Wei, H., Gilkes, D. M., Korangath, P., Chaturvedi, P., Schito, L., Chen, J., Krishnamachary, B., Winnard, P. T., et al. (2012) · Oncogene · doi:10.1038/onc.2011.365 · Cited by 326
Retracted
Copper depletion modulates mitochondrial oxidative phosphorylation to impair triple negative breast cancer metastasis
Ramchandani, D., Berisa, M., Tavarez, D. A., Li, Z., Miele, M. M., Bai, Y., Lee, S. B., Ban, Y., Dephoure, N., Hendrickson, R. C., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-27559-z · Cited by 317
FoxM1: A Master Regulator of Tumor Metastasis
Raychaudhuri, P., & Park, H. J. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-0640 · Cited by 308
Myeloid Progenitor Cells in the Premetastatic Lung Promote Metastases by Inducing Mesenchymal to Epithelial Transition
Gao, D., Joshi, N., Choi, H., Ryu, S., Hahn, M., Catena, R., Sadik, H., Argani, P., Wagner, P. L., Vahdat, L. T., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-2905 · Cited by 311
Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features
Azab, A. K., Hu, J., Quang, P., Azab, F., Pitsillides, C. M., Awwad, R. A., Thompson, B. D., Maiso, P., Sun, J. D., Hart, C. P., et al. (2012) · Blood · doi:10.1182/blood-2011-09-380410 · Cited by 299
Macrophages as Key Drivers of Cancer Progression and Metastasis
Nielsen, S. R., & Schmid, M. C. (2017) · Mediators of Inflammation · doi:10.1155/2017/9624760 · Cited by 308
Exercise-dependent regulation of the tumour microenvironment
Koelwyn, G. J., Quail, D. F., Zhang, X., White, R. M., & Jones, L. W. (2017) · Nature reviews. Cancer · doi:10.1038/nrc.2017.78 · Cited by 307
Breast cancer lung metastasis: Molecular biology and therapeutic implications
Jin, L., Han, B., Siegel, E. L., Cui, Y., Giuliano, A. E., & Cui, X. (2018) · Cancer Biology & Therapy · doi:10.1080/15384047.2018.1456599 · Cited by 308
Chronic stress increases metastasis via neutrophil-mediated changes to the microenvironment
He, X., Gao, Y., Ng, D., Michalopoulou, E., George, S., Adrover, J. M., Sun, L., Albrengues, J., Daßler‐Plenker, J., Han, X., et al. (2024) · Cancer Cell · doi:10.1016/j.ccell.2024.01.013 · Cited by 311
RETRACTED: Collagen Prolyl Hydroxylases Are Essential for Breast Cancer Metastasis
Gilkes, D. M., Chaturvedi, P., Bajpai, S., Wong, C. C., Wei, H., Pitcairn, S., Hubbi, M. E., Wirtz, D., & Semenza, G. L. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-3963 · Cited by 296
Retracted
Defining the human copper proteome and analysis of its expression variation in cancers
Blockhuys, S., Celauro, E., Hildesjö, C., Feizi, A., Stål, O., Fierro-González, J. C., & Wittung-Stafshede, P. E. (2016) · Metallomics · doi:10.1039/c6mt00202a · Cited by 303
Antiangiogenic therapy, hypoxia, and metastasis: risky liaisons, or not?
De Bock, K., Mazzone, M., & Carmeliet, P. (2011) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2011.83 · Cited by 293
The immune system in cancer metastasis: friend or foe?
Janssen, L. M. E., Ramsay, E. E., Logsdon, C. D., & Overwijk, W. W. (2017) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-017-0283-9 · Cited by 298
Extracellular matrix components in breast cancer progression and metastasis
Óskarsson, T. (2013) · The Breast · doi:10.1016/j.breast.2013.07.012 · Cited by 304
TGF-β upregulates miR-181a expression to promote breast cancer metastasis
Taylor, M. A., Sossey‐Alaoui, K., Thompson, C. L., Danielpour, D., & Schiemann, W. P. (2012) · Journal of Clinical Investigation · doi:10.1172/jci64946 · Cited by 294
Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy
Miller, B. W., Morton, J. P., Pinese, M., Saturno, G., Jamieson, N. B., McGhee, E. J., Timpson, P., Leach, J. D. G., McGarry, L., Shanks, E. J., et al. (2015) · EMBO Molecular Medicine · doi:10.15252/emmm.201404827 · Cited by 299
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Wang, Y., Ding, Y., Guo, N., & Wang, S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00172 · Cited by 289
The evolution of the cancer niche during multistage carcinogenesis
Barcellos‐Hoff, M. H., Lyden, D. C., & Wang, T. C. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3536 · Cited by 289
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Xiao, Q., & Ge, G. (2012) · Cancer Microenvironment · doi:10.1007/s12307-012-0105-z · Cited by 289
The fibrotic tumor stroma
Yamauchi, M., Barker, T. H., Gibbons, D. L., & Kurie, J. M. (2018) · Journal of Clinical Investigation · doi:10.1172/jci93554 · Cited by 282
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Gilkes, D. M., & Semenza, G. L. (2013) · Future Oncology · doi:10.2217/fon.13.92 · Cited by 274
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Zöllner, S. K., Amatruda, J. F., Bauer, S., Collaud, S., de Álava, E., DuBois, S. G., Hardes, J., Hartmann, W., Kovar, H., Metzler, M., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10081685 · Cited by 292
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Lelièvre, P., Sancey, L., Coll, J., Deniaud, A., & Busser, B. (2020) · Cancers · doi:10.3390/cancers12123594 · Cited by 278
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Zhao, J., Wen, X., Li, T. X., Li, T., Xu, C., Wen, X., Melancon, M. P., Gupta, S. K., Shen, B., Peng, W., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08782-1 · Cited by 274
Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis
Vennin, C., Chin, V. T., Warren, S. C., Lucas, M. C., Herrmann, D., Magenau, A., Mélénec, P., Walters, S. N., del Monte‐Nieto, G., Conway, J. R. W., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aai8504 · Cited by 266
Self-citation
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Marsh, T., Pietras, K., & McAllister, S. S. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.10.013 · Cited by 277
Microenvironment and tumor cell plasticity: An easy way out
Taddei, M. L., Giannoni, E., Comito, G., & Chiarugi, P. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.01.042 · Cited by 272
The matrix environmental and cell mechanical properties regulate cell migration and contribute to the invasive phenotype of cancer cells
Mierke, C. T. (2019) · Reports on Progress in Physics · doi:10.1088/1361-6633/ab1628 · Cited by 267
Cuproptosis: A novel therapeutic target for overcoming cancer drug resistance
Wang, Y., Chen, Y., Zhang, J., Yang, Y., Fleishman, J. S., Wang, Y., Wang, J., Chen, J., Li, Y., & Wang, H. (2023) · Drug Resistance Updates · doi:10.1016/j.drup.2023.101018 · Cited by 275
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Toyokuni, S., Ito, F., Yamashita, K., Okazaki, Y., & Akatsuka, S. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.04.024 · Cited by 252
Current and emerging concepts in tumour metastasis
Coghlin, C., & Murray, G. I. (2010) · The Journal of Pathology · doi:10.1002/path.2727 · Cited by 263
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Wong, C. C., Tse, A. P., Huang, Y., Zhu, Y., Chiu, D. K., Lai, R. K., Au, S. L., Kai, A. K., Lee, J. M., Wei, L. L., et al. (2014) · Hepatology · doi:10.1002/hep.27320 · Cited by 263
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Venning, F. A., Wullkopf, L., & Erler, J. T. (2015) · Frontiers in Oncology · doi:10.3389/fonc.2015.00224 · Cited by 256
Self-citation
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Deep, G., & Agarwal, R. (2010) · Cancer and Metastasis Reviews · doi:10.1007/s10555-010-9237-0 · Cited by 255
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Gilkes, D. M., Bajpai, S., Wong, C. C., Chaturvedi, P., Hubbi, M. E., Wirtz, D., & Semenza, G. L. (2013) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-12-0629 · Cited by 252
Retracted
Hypoxia-inducible factor 1 and breast cancer metastasis
Liu, Z.-J., Semenza, G. L., & Zhang, H.-F. (2015) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b1400221 · Cited by 265
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Deng, J., Liu, Y., Lee, H., Herrmann, A., Zhang, W., Zhang, C., Shen, S., Priceman, S. J., Kujawski, M., Pal, S. K., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.03.039 · Cited by 254
LOXL2-Mediated Matrix Remodeling in Metastasis and Mammary Gland Involution
Barker, H. E., Chang, J., Cox, T. R., Lang, G., Bird, D., Nicolau, M. M., Evans, H., Gartland, A., & Erler, J. T. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2868 · Cited by 253
Self-citation
Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes
Sbardella, D., Fasciglione, G. F., Gioia, M., Ciaccio, C., Tundo, G. R., Marini, S., & Coletta, M. (2011) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.10.015 · Cited by 251
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Mu, W., Rana, S., & Zöller, M. (2013) · Neoplasia · doi:10.1593/neo.13786 · Cited by 248
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Medeiros, B., & Allan, A. L. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092272 · Cited by 248
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Chandler, C., Liu, T., Buckanovich, R. J., & Coffman, L. G. (2019) · Translational research · doi:10.1016/j.trsl.2019.02.006 · Cited by 257
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Lee, S. L. C., Rouhi, P., Jensen, L. D., Zhang, D., Ji, H. L., Hauptmann, G., Ingham, P. W., & Cao, Y. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909228106 · Cited by 247
Tumor-associated fibrosis as a regulator of tumor immunity and response to immunotherapy
Jiang, H., Hegde, S., & DeNardo, D. G. (2017) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-017-2003-1 · Cited by 246
High-mobility group box 1 activates caspase-1 and promotes hepatocellular carcinoma invasiveness and metastases
Yan, W., Chang, Y., Liang, X., Cardinal, J. S., Huang, H., Thorne, S. H., Monga, S. P., Geller, D. A., Lotze, M. T., & Tsung, A. (2012) · Hepatology · doi:10.1002/hep.25572 · Cited by 244
Hypoxia: Signaling the Metastatic Cascade
Rankin, E. B., Nam, J.-M., & Giaccia, A. J. (2016) · Trends in cancer · doi:10.1016/j.trecan.2016.05.006 · Cited by 249
Self-citation
Hypoxia-inducible factor–dependent breast cancer–mesenchymal stem cell bidirectional signaling promotes metastasis
Chaturvedi, P., Gilkes, D. M., Wong, C. C., Gupta, K., Luo, W., Zhang, H., Wei, H., Takano, N., Schito, L., Levchenko, A., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci64993 · Cited by 244
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Kong, J., Tian, H., Zhang, F., Zhang, Z., Li, J., Liu, X., Li, X., Liu, J., Li, X., Jin, D., et al. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1101-4 · Cited by 251
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Shanbhag, V., Jasmer, K. J., Zhu, S., Martin, A. L., Gudekar, N., Khan, A. A., Ladomersky, E., Singh, K., Weisman, G. A., & Petris, M. J. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1817473116 · Cited by 237
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Lin, T.-C., Yang, C.-H., Cheng, L.-H., Chang, W., Lin, Y.-R., & Cheng, H.-C. (2019) · Cells · doi:10.3390/cells9010027 · Cited by 241
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Chan, N., Willis, A. D., Kornhauser, N., Ward, M. M., Lee, S. B., Nackos, E., Seo, B. R., Chuang, E., Cigler, T., Moore, A. L., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-1326 · Cited by 238
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Rømer, A. M. A., Thorseth, M., & Madsen, D. H. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.791453 · Cited by 237
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Taylor, M. A., Parvani, J. G., & Schiemann, W. P. (2010) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-010-9181-1 · Cited by 235
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Miyake, M., Hori, S., Morizawa, Y., Tatsumi, Y., Nakai, Y., Anai, S., Torimoto, K., Aoki, K., Tanaka, N., Shimada, K., et al. (2016) · Neoplasia · doi:10.1016/j.neo.2016.08.002 · Cited by 230
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Luo, W., Chang, R., Zhong, J., Pandey, A., & Semenza, G. L. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217394109 · Cited by 228
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Wong, C. C., Zhang, H., Gilkes, D. M., Chen, J., Wei, H., Chaturvedi, P., Hubbi, M. E., & Semenza, G. L. (2012) · Journal of Molecular Medicine · doi:10.1007/s00109-011-0855-y · Cited by 226
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Gomis, R. R., & Gawrzak, S. (2016) · Molecular Oncology · doi:10.1016/j.molonc.2016.09.009 · Cited by 202
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Gao, Y., Xiao, Q., Ma, H.-M., Li, L., Liu, J., Feng, Y., Fang, Z., Wu, J., Han, X., Zhang, J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004952107 · Cited by 190
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Guo, Z., Chen, D., Yao, L., Sun, Y., Li, D., Le, J., Dian, Y., Zeng, F., Chen, X., & Deng, G. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02192-0 · Cited by 221
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Authors: Erler, J. T., Bennewith, K. L., Cox, T. R., Lang, G., Bird, D., Koong, A., Le, Q.-T., & Giaccia, A. J.
Affiliations: Institute of Cancer Research (GB)
BC Cancer Agency (CA)
Stanford Medicine (US)
Corresponding author: Giaccia, Amato J.
ORCID: Erler, Janine T.
Bennewith, Kevin L.
Cox, Thomas R.
Koong, Albert
Le, Quynh-Thu
Giaccia, Amato J.
Venue: Cancer Cell
Publisher: Elsevier BV
Published: 2009-01
Volume: 15
Issue: 1
Pages: 35-44
ISSN: 1535-6108 (ISSN-L)
DOI: 10.1016/j.ccr.2008.11.012
PMC: PMC3050620
OpenAlex: W2159744630
Cited by: 1,231
References: 40
Citations by year: 2026: 38 · 2025: 45 · 2024: 61 · 2023: 66 · 2022: 62 · 2021: 82 · 2020: 78 · 2019: 96 · 2018: 80 · 2017: 71 · 2016: 90 · 2015: 72 · 2014: 74 · 2013: 87 · 2012: 72
FWCI: 37.78
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1658 d)
Locations: Cancer Cell (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Cancer Research UK
National Cancer Institute (P01CA067166, T32CA009151)
Topics: Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
Keywords: lysyl oxidase, pre-metastatic niche, metastasis, bone marrow-derived cells, hypoxia, breast cancer, CD11b+ myeloid cells, basement membrane, MMP-2, collagen degradation, metastasis prevention
MeSH terms: Animals, Hypoxia, Basement Membrane, Bone Marrow Cells, Breast Neoplasms, Cell Differentiation, Cell Movement, Cell Separation, Enzyme Activation, Humans, Lung Neoplasms, Protein-Lysine 6-Oxidase, Mice, Nude, Neoplasm Metastasis, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Neoplastic, Disease Progression, Matrix Metalloproteinase 2, Myeloid Cells, Xenograft Model Antitumor Assays, Collagen Type IV, Cell Line, Tumor, Mice

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Hypoxia-Induced Lysyl Oxidase Is a Critical Mediator of Bone Marrow Cell Recruitment to Form the Premetastatic Niche

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