FKBP51 Affects Cancer Cell Response to Chemotherapy by Negatively Regulating Akt

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

Sarbassov, D. D., Guertin, D. A., Ali, S. M., & Sabatini, D. M. (2005) · Science · doi:10.1126/science.1106148 · Cited by 6,216

AKT/PKB signaling: navigating downstream

Manning, B. D., & Cantley, L. C. (2007) · Cell · doi:10.1016/j.cell.2007.06.009 · Cited by 6,115

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

Datta, S. R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., & Greenberg, M. E. (1997) · Cell · doi:10.1016/s0092-8674(00)80405-5 · Cited by 5,689

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

Brunet, A., Bonni, A., Zigmond, M. J., Lin, M. Z., Juo, P., Hu, L. S., Anderson, M. J., Arden, K. C., Blenis, J., & Greenberg, M. E. (1999) · Cell · doi:10.1016/s0092-8674(00)80595-4 · Cited by 5,594

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

Cross, D. A. E., Alessi, D. R., Cohen, P., Andjelkovich, M., & Hemmings, B. A. (1995) · Nature · doi:10.1038/378785a0 · Cited by 5,244

Mechanism of activation of protein kinase B by insulin and IGF‐1.

Alessi, D. R., Andjelković, M., Caudwell, B., Cron, P. D., MORRICE, N. A., Cohen, P., & Hemmings, B. A. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb01045.x · Cited by 3,014

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

Alessi, D. R., James, S. R., Downes, C. P., Holmes, A. B., Gaffney, P. R. J., Reese, C. B., & Cohen, P. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00122-9 · Cited by 2,874

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

Peso, L. D., González-Garcı́a, M., Page, C., Herrera, R., & Nuñez, G. (1997) · Science · doi:10.1126/science.278.5338.687 · Cited by 1,797

A receptor for the immuno-suppressant FK506 is a cis–trans peptidyl-prolyl isomerase

Harding, M. W., Gałat, A., Uehling, D., & Schreiber, S. L. (1989) · Nature · doi:10.1038/341758a0 · Cited by 1,396

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

Mayo, L. D., & Donner, D. B. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.181181198 · Cited by 1,230

FK506-binding protein 51 is a possible novel tumoral marker

Romano, S., D'Angelillo, A., Staibano, S., Ilardi, G., & Romano, M. F. (2010) · Cell Death and Disease · doi:10.1038/cddis.2010.32 · Cited by 27

With or without You: Co-Chaperones Mediate Health and Disease by Modifying Chaperone Function and Protein Triage

Altınok, S., Sanchez‐Hodge, R., Stewart, M., Smith, K., & Schisler, J. C. (2021) · Cells · doi:10.3390/cells10113121 · Cited by 27

Mediobasal hypothalamic FKBP51 acts as a molecular switch linking autophagy to whole-body metabolism

Häusl, A. S., Bajaj, T., Brix, L. M., Pöhlmann, M. L., Hafner, K., Angelis, M. D., Nagler, J., Dethloff, F., Balsevich, G., Schramm, K., et al. (2022) · Science Advances · doi:10.1126/sciadv.abi4797 · Cited by 27

ZNF281 Promotes Growth and Invasion of Pancreatic Cancer Cells by Activating Wnt/β-Catenin Signaling

Qian, Y., Li, J., & Xia, S. (2017) · Digestive Diseases and Sciences · doi:10.1007/s10620-017-4611-1 · Cited by 27

Deletion of the glucocorticoid receptor chaperone FKBP51 prevents glucocorticoid-induced skin atrophy

Baida, G. E., Bhalla, P., Yemelyanov, A. Y., Stechschulte, L. A., Shou, W., Readhead, B., Dudley, J. T., Sánchez, E. R., & Budunova, I. V. (2018) · Oncotarget · doi:10.18632/oncotarget.26194 · Cited by 28

Structural and Logical Analysis of a Comprehensive Hedgehog Signaling Pathway to Identify Alternative Drug Targets for Glioma, Colon and Pancreatic Cancer

Chowdhury, S., Pradhan, R., & Sarkar, R. R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069132 · Cited by 25

Overexpressed long noncoding RNA CRNDE with distinct alternatively spliced isoforms in multiple cancers

Ma, X., Zhang, W., Zhang, R., Li, J., Li, S., Ma, Y., Jin, W. Y., & Wang, K. (2018) · Frontiers of Medicine · doi:10.1007/s11684-017-0557-0 · Cited by 26

Mutant KRAS Downregulates the Receptor for Leukemia Inhibitory Factor (LIF) to Enhance a Signature of Glycolysis in Pancreatic Cancer and Lung Cancer

Liu, S., Gandler, H. I., Tošić, I., Ye, D. Q., Giaccone, Z. T., & Frank, D. A. (2021) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-20-0633 · Cited by 28

Highlights on the Role of KRAS Mutations in Reshaping the Microenvironment of Pancreatic Adenocarcinoma

Hafezi, S., Saber-Ayad, M. M., & Abdel‐Rahman, W. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910219 · Cited by 28

Transposon-activated POU5F1B promotes colorectal cancer growth and metastasis

Simó‐Riudalbas, L., Offner, S., Planet, E., Duc, J., Abrami, L., Joye, S., Coudray, A., Coto‐Llerena, M., Ercan, C., Piscuoglio, S., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-32649-7 · Cited by 24

Downregulation of FKBP5 Promotes Atrial Arrhythmogenesis

Wang, X., Song, J., Yuan, Y., Li, L., Abu-Taha, I., Heijman, J., Sun, L. T., Dobrev, S., Kamler, M., Xie, L., et al. (2023) · Circulation Research · doi:10.1161/circresaha.122.322213 · Cited by 31

PAR1 signaling on tumor cells limits tumor growth by maintaining a mesenchymal phenotype in pancreatic cancer

Tekin, C., Shi, K., Daalhuisen, J. B., ten Brink, M. S., Bijlsma, M. F., & Spek, C. A. (2018) · Oncotarget · doi:10.18632/oncotarget.25880 · Cited by 26

Differential conformational dynamics in the closely homologous FK506-binding domains of FKBP51 and FKBP52

Mustafi, S. M., LeMaster, D. M., & Hernández, G. (2014) · Biochemical Journal · doi:10.1042/bj20140232 · Cited by 25

Peptidylprolylisomerases, Protein Folders, or Scaffolders? The Example of FKBP51 and FKBP52

Rein, T. (2020) · BioEssays · doi:10.1002/bies.201900250 · Cited by 25

Bioinformatics Data Mining Repurposes the JAK2 (Janus Kinase 2) Inhibitor Fedratinib for Treating Pancreatic Ductal Adenocarcinoma by Reversing the KRAS (Kirsten Rat Sarcoma 2 Viral Oncogene Homolog)-Driven Gene Signature

Liu, L.-W., Hsieh, Y., & Yang, P. (2020) · Journal of Personalized Medicine · doi:10.3390/jpm10030130 · Cited by 25

The inhibition of FKBP5 protects β-cell survival under inflammation stress via AKT/FOXO1 signaling

Liu, N., Li, R., Cao, J., Song, X., Ma, W., Liu, T., Wang, L., Zou, J., Zhang, B., Liu, Z., et al. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01506-x · Cited by 27

Coordinated silencing of the Sp1-mediated long noncoding RNA MEG3 by EZH2 and HDAC3 as a prognostic factor in pancreatic ductal adenocarcinoma

Han, T., Zhuo, M., Yuan, C., Xiao, X., Cui, J., Qin, G., Wang, L., & Jiao, F. (2020) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2019.0427 · Cited by 26

FKBP51 is involved in LPS-induced microglial activation via NF-κB signaling to mediate neuroinflammation

Gan, Y., Lin, W.-J., Fang, Y.-C., Tang, C., Lee, Y., & Jeng, C. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122867 · Cited by 24

Chemical systems biology reveals mechanisms of glucocorticoid receptor signaling

Bruno, N. E., Nwachukwu, J. C., Srinivasan, S., Nettles, C. C., Izard, T., Jin, Z., Nowak, J., Cameron, M. D., Boregowda, S. V., Phinney, D. G., et al. (2021) · Nature Chemical Biology · doi:10.1038/s41589-020-00719-w · Cited by 24

Comprehensive Analysis of Hexokinase 2 Immune Infiltrates and m6A Related Genes in Human Esophageal Carcinoma

Liu, X., Liu, J., Chen, Y., Li, F., Wu, R., Tan, F., Zeng, D.-B., Li, W., Zhou, H. K., Gao, Y. P., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.715883 · Cited by 24

METTL16 predicts a favorable outcome and primes antitumor immunity in pancreatic ductal adenocarcinoma

Lu, L., Zheng, D., Qu, J., Zhuang, Y., Peng, J., Lan, S., Zhang, S., & Huang, F. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.759020 · Cited by 24

Robust identification of common genomic biomarkers from multiple gene expression profiles for the prognosis, diagnosis, and therapies of pancreatic cancer

Hossen, M. B., Islam, M. A., Reza, M. S., Kibria, M. K., Horaira, M. A., Tuly, K. F., Faruqe, M. O., Kabir, F., & Mollah, M. N. H. (2022) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2022.106411 · Cited by 24

HOXC6 drives a therapeutically targetable pancreatic cancer growth and metastasis pathway by regulating MSK1 and PPP2R2B

Malvi, P., Chava, S., Cai, G., Hu, K., Zhu, L. J., Edwards, Y. J. K., Green, M. R., Gupta, R., & Wajapeyee, N. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.101285 · Cited by 24

Diacylglycerol Kinase δ Modulates Akt Phosphorylation through Pleckstrin Homology Domain Leucine-rich Repeat Protein Phosphatase 2 (PHLPP2)

Crotty, T. M., Nakano, T., Stafforini, D. M., & Topham, M. K. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.407379 · Cited by 24

Knockdown of CABYR-a/b Increases Chemosensitivity of Human Non–Small Cell Lung Cancer Cells through Inactivation of Akt

Qian, Z., Li, M., Wang, R., Xiao, Q., Wang, J., Li, M., He, D., & Xiao, X. (2013) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-13-0391 · Cited by 24

cGAS-STING signalings potentiate tumor progression via sustaining cancer stemness

Liu, F.-R., Jiang, M., Mei, Z., Lin, C.-J., & Tian, L. (2022) · Translational Oncology · doi:10.1016/j.tranon.2022.101404 · Cited by 24

The Role of FKBPs in Complex Disorders: Neuropsychiatric Diseases, Cancer, and Type 2 Diabetes Mellitus

Agam, G., Atawna, B., Damri, O., & Azab, A. N. (2024) · Cells · doi:10.3390/cells13100801 · Cited by 25

Amplified centrosomes may underlie aggressive disease course in pancreatic ductal adenocarcinoma

Mittal, K., Ogden, A., Reid, M. D., Rida, P. C. G., Varambally, S., & Aneja, R. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1068478 · Cited by 23

Loss of HNF6 expression correlates with human pancreatic cancer progression

Pekala, K. R., Ma, X., Kropp, P. A., Petersen, C. P., Hudgens, C. W., Chung, C. H., Shi, C., Merchant, N. B., Maitra, A., Means, A. L., et al. (2014) · Laboratory Investigation · doi:10.1038/labinvest.2014.47 · Cited by 22

Whole-transcriptome analysis of mouse adipose tissue in response to short-term caloric restriction

Kim, S.-S., Choi, K.-M., Kim, S., Park, T., Cho, I., Lee, J., & Lee, C. (2015) · Molecular Genetics and Genomics · doi:10.1007/s00438-015-1150-3 · Cited by 22

Loss of FKBP5 impedes adipocyte differentiation under both normoxia and hypoxic stress

Zhang, L., Qiu, B., Wang, T., Wang, J., Liu, M. R., Xu, Y., Wang, C., Deng, R., Williams, K. E., Yang, Z., et al. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.02.126 · Cited by 23

Regulation of FKBP51 and FKBP52 functions by post-translational modifications

Daneri-Becerra, C., Zgajnar, N. R., Lotufo, C. M., Ramos-Hryb, A. B., Piwien‐Pilipuk, G., & Galigniana, M. D. (2019) · Biochemical Society Transactions · doi:10.1042/bst20190334 · Cited by 23

USP15 promotes the apoptosis of degenerative nucleus pulposus cells by suppressing the PI3K/AKT signalling pathway

Yu, B., Shen, B., Ba, Z., Liu, Z., Yuan, J., Zhao, W., & Wu, D. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15971 · Cited by 23

Prognostic relevance of SMC family gene expression in human sarcoma

Zhou, J., Wu, G., Tong, Z., Sun, J., Su, J., Cao, Z., Luo, Y., & Wang, W. (2020) · Aging · doi:10.18632/aging.202455 · Cited by 23

FKBP51 plays an essential role in Akt ubiquitination that requires Hsp90 and PHLPP

Tufano, M., Marrone, L., DˈAmbrosio, C., Giacomo, V. D., Urzini, S., Xiao, Y., Matuozzo, M., Scaloni, A., Romano, M. F., & Romano, S. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05629-y · Cited by 22

The role of phosphoprotein phosphatases catalytic subunit genes in pancreatic cancer

Hang, J., Lau, S. Y. F., Yin, R., Zhu, L., Zhou, S., Yuan, X., & Wu, L. (2020) · Bioscience Reports · doi:10.1042/bsr20203282 · Cited by 21

Truncated O-Glycan-Bearing MUC16 Enhances Pancreatic Cancer Cells Aggressiveness via α4β1 Integrin Complexes and FAK Signaling

Rajesh, C., Sagar, S., Ashokkumar, R., Chemparathy, D. T., Peng, X. L., Yeh, J. J., Hollingsworth, M. A., & Radhakrishnan, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105459 · Cited by 23

Biological Characterization and Clinical Value of OAS Gene Family in Pancreatic Cancer

Gao, L., Li, J., Yang, R., He, Z., Yan, M., Cao, X., & Cao, J. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.884334 · Cited by 23

A carbazole alkaloid deactivates mTOR through the suppression of rictor and that induces apoptosis in lung cancer cells

Chatterjee, P., Seal, S., Mukherjee, S., Kundu, R., Bhuyan, M., Barua, N. C., Baruah, P. K., Babu, S. P. S., & Bhattacharya, S. (2015) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-015-2406-2 · Cited by 22

Cancer Cell Invasion in Three-dimensional Collagen Is Regulated Differentially by Gα13 Protein and Discoidin Domain Receptor 1-Par3 Protein Signaling

Chow, C. R., Ebine, K., Knab, L. M., Bentrem, D. J., Kumar, K., & Munshi, H. G. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.669606 · Cited by 22

Expression and localization of the immunophilin FKBP51 in colorectal carcinomas and primary metastases, and alterations following oxaliplatin-based chemotherapy

Rotoli, D., Morales, M., Maeso, M. D. C., García, M. D. P., Morales, A., Ávila, J., & Martı́n-Vasallo, P. (2016) · Oncology Letters · doi:10.3892/ol.2016.4772 · Cited by 22

Combining GRP78 suppression and MK2206-induced Akt inhibition decreases doxorubicin-induced P-glycoprotein expression and mitigates chemoresistance in human osteosarcoma

Xia, Y., Yang, L., Xue, G., Zhang, C., Guo, C., Yang, Y., Li, S., Zhang, L., Guo, Q., & Kong, L. (2016) · Oncotarget · doi:10.18632/oncotarget.10890 · Cited by 22

The Role of Peptidyl Prolyl Isomerases in Aging and Vascular Diseases

McClements, L., Annett, S., Yakkundi, A., & Robson, T. (2015) · Current Molecular Pharmacology · doi:10.2174/1874467208666150519115729 · Cited by 22

Identification of differentially expressed genes in pancreatic ductal adenocarcinoma and normal pancreatic tissues based on microarray datasets

Liu, L., Wang, S., Cen, C., Peng, S., Chen, Y., Li, X., Diao, N., Li, Q., Ma, L., & Han, P. (2019) · Molecular Medicine Reports · doi:10.3892/mmr.2019.10414 · Cited by 22

CD38 expression, function, and gene resequencing in a human lymphoblastoid cell line-based model system

Hartman, W. R., Pelleymounter, L. L., Moon, I., Kalari, K. R., Liu, M., Wu, T., Escande, C., Nin, V., Chini, E. N., & Weinshilboum, R. M. (2010) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428194.2010.483299 · Cited by 22

Gα15 in early onset of pancreatic ductal adenocarcinoma

Innamorati, G., Wilkie, T. M., Malpeli, G., Paiella, S., Grasso, S., Rusev, B. C., Leone, B. E., Valenti, M. T., Carbonare, L. D., Cheri, S., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-94150-3 · Cited by 21

Biological relevance of Hsp90‐binding immunophilins in cancer development and treatment

Mazaira, G. I., Camisay, M. F., Leo, S. A. D., Erlejman, A. G., & Galigniana, M. D. (2015) · International Journal of Cancer · doi:10.1002/ijc.29509 · Cited by 21

Immunohistochemical analysis of FKBP51 in human cancers

Staibano, S., Mascolo, M., Ilardi, G., Siano, M., & Rosa, G. D. (2011) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2011.04.001 · Cited by 21

Impact of genetic variation in FKBP5 on clinical response in pediatric acute myeloid leukemia patients: a pilot study

Mitra, A., Crews, K. R., Pounds, S. B., Cao, X., Downing, J. R., Raimondi, S. C., Campana, D., Ribeiro, R. C., Rubnitz, J. E., & Lamba, J. K. (2011) · Leukemia · doi:10.1038/leu.2011.74 · Cited by 21

FKBP51 regulates decidualization through Ser473 dephosphorylation of AKT

Wei, M., Gao, Y., Lu, B., Jiao, Y., Liu, X., Cui, B., Hu, S., Sun, L., Mao, S., Dong, J., et al. (2018) · Reproduction · doi:10.1530/rep-17-0625 · Cited by 21

Regulation of eIF4F Translation Initiation Complex by the Peptidyl Prolyl Isomerase FKBP7 in Taxane-resistant Prostate Cancer

Garrido, M. F., Martin, N. J.-P., Bertrand, M., Gaudin, C., Commo, F., Kalaany, N. E., Nakouzi, N. A., Fazli, L., Nery, E. D., Camonis, J., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-0704 · Cited by 21

Restoration of FKBP51 protein promotes the progression of castration resistant prostate cancer

Yu, J., Sun, L., Hao, T., Zhang, B., Chen, X., Li, H., Zhang, Z., Zhu, S., Quan, C., Niu, Y., et al. (2019) · Annals of Translational Medicine · doi:10.21037/atm.2019.11.127 · Cited by 21

Cell-type-specific regulation of raft-associated Akt signaling

Liu, Y., Yang, G., Bu, X., Liu, G., Ding, J., Li, P., & Jia, W. W.-G. (2011) · Cell Death and Disease · doi:10.1038/cddis.2011.28 · Cited by 21

FKBP51 regulates cell motility and invasion via RhoA signaling

Takaoka, M., Ito, S., Miki, Y., & Nakanishi, A. (2016) · Cancer Science · doi:10.1111/cas.13153 · Cited by 21

Analysis of FK506, timcodar (VX‐853) and FKBP51 and FKBP52 chaperones in control of glucocorticoid receptor activity and phosphorylation

Hinds, T. D., Stechschulte, L. A., Elkhairi, F., & Sanchez, E. R. (2014) · Pharmacology Research & Perspectives · doi:10.1002/prp2.76 · Cited by 20

Identification of Upregulated HNRNPs Associated with Poor Prognosis in Pancreatic Cancer

Qiao, L., Xie, N., Bai, Y., Li, Y., Shi, Y., Wang, J., & Liu, N. (2019) · BioMed Research International · doi:10.1155/2019/5134050 · Cited by 20

MAL2 interacts with IQGAP1 to promote pancreatic cancer progression by increasing ERK1/2 phosphorylation

Zhang, B., Xiao, J., Cheng, X. C., & Liu, T. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.02.146 · Cited by 20

Phosphatase PHLPP2 regulates the cellular response to metabolic stress through AMPK

Yan, Y., Krecke, K. N., Bapat, A. S., Yang, T., Lopresti, M. W., Mashek, D. G., & Kelekar, A. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04196-4 · Cited by 20

Apoptosis-associated speck-like protein containing a CARD regulates the growth of pancreatic ductal adenocarcinoma

Koizumi, M., Watanabe, T., Masumoto, J., Sunago, K., Imamura, Y., Kanemitsu, K., Kumagi, T., & Hiasa, Y. (2021) · Scientific Reports · doi:10.1038/s41598-021-01465-2 · Cited by 20

Overexpressing PLOD Family Genes Predict Poor Prognosis in Pancreatic Cancer

Zhang, J., Tian, Y. Z., Mo, S. J., & Fu, X. F. (2022) · International Journal of General Medicine · doi:10.2147/ijgm.s341332 · Cited by 19

Hsp90-Binding Immunophilins As A Potential New Platform for Drug Treatment

Erlejman, A. G., Lagadari, M., & Galigniana, M. D. (2013) · Future Medicinal Chemistry · doi:10.4155/fmc.13.7 · Cited by 20

Role of FK506 Binding Proteins in Neurodegenerative Disorders

Chattopadhaya, S., Harikishore, A., & Yoon, H. S. (2011) · Current Medicinal Chemistry · doi:10.2174/092986711798194441 · Cited by 20

SPATIAL: A System-level PAThway Impact AnaLysis approach

Bokanizad, B., Tagett, R., Ansari, S., Helmi, B. H., & Drăghici, S. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw429 · Cited by 21

Everolimus induces Met inactivation by disrupting the FKBP12/Met complex

Raimondo, L., D’Amato, V., Servetto, A., Rosa, R., Marciano, R., Formisano, L., Mauro, C. D., Orsini, R. C., Cascetta, P., Ciciola, P., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.9484 · Cited by 20

CXCR3 and Cognate Ligands are Associated with Immune Cell Alteration and Aggressiveness of Pancreatic Ductal Adenocarcinoma

Cannon, A. C., Thompson, C. M., Maurer, H. C., Atri, P., Bhatia, R., West, S. C., Ghersi, D., Olive, K. P., Sushil Kumar, K., & Batra, S. K. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-1359 · Cited by 19

Dual-Targeting AKT2 and ERK in cancer stem-like cells in neuroblastoma

Kim, K. W., Kim, J. Y., Qiao, J., Clark, R. A., Powers, C. M., Correa, H., & Chung, D. H. (2019) · Oncotarget · doi:10.18632/oncotarget.27210 · Cited by 19

Pan-Cancer Analysis of Prognostic and Immune Infiltrates for CXCs

Long, L., Yao, W., Yan, S. R., Dong, X., Lv, Z., Jing, Q., Wang, Q., Ma, B., Hao, C., Xue, D., et al. (2021) · Cancers · doi:10.3390/cancers13164153 · Cited by 19

A novel immunomodulatory function of PHLPP1: inhibition of iNOS via attenuation of STAT1 ser727 phosphorylation in mouse macrophages

Alamuru-Yellapragada, N. P., Behera, S., Butchar, J. P., Tridandapani, S., Suraj, S. K., Babu, P. P., Hasnain, S. E., Ehtesham, N. Z., & Parsa, K. V. L. (2014) · Journal of Leukocyte Biology · doi:10.1189/jlb.0713360 · Cited by 19

Ecto-5′-Nucleotidase and Thiopurine Cellular Circulation: Association with Cytotoxicity

Li, F., Fridley, B. L., Matimba, A., Kalari, K. R., Pelleymounter, L. L., Moon, I., Ji, Y., Jenkins, G. D., Batzler, A. J., Wang, L., et al. (2010) · Drug Metabolism and Disposition · doi:10.1124/dmd.110.035220 · Cited by 19

Commitment of Scaffold Proteins in the Onco-Biology of Human Colorectal Cancer and Liver Metastases after Oxaliplatin-Based Chemotherapy

Rotoli, D., Morales, M., Ávila, J., Maeso, M. D. C., García, M. Á., Mobasheri, A., & Martı́n-Vasallo, P. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040891 · Cited by 19

Indispensable role of STIL in the regulation of cancer cell motility through the lamellipodial accumulation of ARHGEF7–PAK1 complex

Ito, H., Tsunoda, T., Riku, M., Inaguma, S., Inoko, A., Murakami, H., Ikeda, H., Matsuda, M., & Kasai, K. (2019) · Oncogene · doi:10.1038/s41388-019-1115-9 · Cited by 20

The mechanobiome: a goldmine for cancer therapeutics

Parajón, E., Surcel, A., & Robinson, D. N. (2020) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00409.2020 · Cited by 18

Expression and prognostic analyses of the insulin-like growth factor 2 mRNA binding protein family in human pancreatic cancer

Cui, X., Hu, S.-Y., Zhu, C., & Qin, X. (2020) · BMC Cancer · doi:10.1186/s12885-020-07590-x · Cited by 19

Integrative analysis of gene expression profiles reveals specific signaling pathways associated with pancreatic duct adenocarcinoma

Li, J., Tan, W., Peng, L., Zhang, J., Huang, X., Cui, Q., Zheng, J., Tan, W., Wu, C. H., & Lin, D. (2018) · 癌症：英文版 · doi:10.1186/s40880-018-0289-9 · Cited by 18

The expression and survival significance of sodium glucose transporters in pancreatic cancer

Du, J., Gu, J., Deng, J., Kong, L., Guo, Y., Jin, C., Bao, Y., Fu, D., & Li, J. (2022) · BMC Cancer · doi:10.1186/s12885-021-09060-4 · Cited by 18

A Peptidisc-Based Survey of the Plasma Membrane Proteome of a Mammalian Cell

Zhao, Z., Khurana, A., Antony, F., Young, J. W., Hewton, K. G., Brough, Z., Zhong, T., Parker, S. J., & Duong, F. (2023) · Molecular & Cellular Proteomics · doi:10.1016/j.mcpro.2023.100588 · Cited by 22

EZH2-mediated epigenetic silencing of tumor-suppressive let-7c/miR-99a cluster by hepatitis B virus X antigen enhances hepatocellular carcinoma progression and metastasis

Wu, C.-S., Chien, Y., Yen, C., Wu, J., Bai, L., & Yu, Y. (2023) · Cancer Cell International · doi:10.1186/s12935-023-03002-9 · Cited by 18

Pharmacogenomics of Cytarabine in Childhood Leukemia

Lamba, J. K. (2011) · Pharmacogenomics · doi:10.2217/pgs.11.148 · Cited by 18

FKBPL: a marker of good prognosis in breast cancer

Nelson, L., McKeen, H. D., Marshall, A., Mulrane, L., Starczynski, J., Storr, S. J., Lanigan, F. T., Byrne, C., Arthur, K., Hegarty, S. M., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.3528 · Cited by 18

Immunization with a Peptide Containing MHC Class I and II Epitopes Derived from the Tumor Antigen SIM2 Induces an Effective CD4 and CD8 T-Cell Response

Kissick, H. T., Sanda, M. G., Dunn, L., & Arredouani, M. S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093231 · Cited by 18

Steroid Receptor-Associated Immunophilins: Candidates for Diverse Drug-Targeting Approaches in Disease

Ratajczak, T. (2015) · Current Molecular Pharmacology · doi:10.2174/1874467208666150519113639 · Cited by 18

Gene expression profile analysis of pancreatic cancer based on microarray data

Long, J., Liu, Z., Wu, X., Xu, Y., & Ge, C. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5021 · Cited by 18

High expression of PDE4D correlates with poor prognosis and clinical progression in pancreaticductal adenocarcinoma

Liu, F., Ma, J., Wang, K., Li, Z., Jiang, Q., Chen, H., Li, W., & Xia, J.-T. (2019) · Journal of Cancer · doi:10.7150/jca.35443 · Cited by 18

CCAAT/Enhancer-Binding Protein Delta (C/EBPδ): A Previously Unrecognized Tumor Suppressor that Limits the Oncogenic Potential of Pancreatic Ductal Adenocarcinoma Cells

Hartl, L., Duitman, J., Aberson, H. L., Chen, K., Dijk, F., Roelofs, J. J. T. H., Dings, M. P. G., Hooijer, G. K. J., Hernanda, P. Y., Pan, Q., et al. (2020) · Cancers · doi:10.3390/cancers12092546 · Cited by 18

GPRC5A: An emerging prognostic biomarker for predicting malignancy of Pancreatic Cancer based on bioinformatics analysis

Qian, X., Jiang, C., Shen, S., & Zou, X. (2021) · Journal of Cancer · doi:10.7150/jca.52578 · Cited by 18

Prognostic and Predictive Value of Cadherin 11 for Patients with Gastric Cancer and Its Correlation with Tumor Microenvironment: Results from Microarray Analysis

Feng, Z., Li, X., Ren, Z., Feng, J., He, X., & You, C. (2020) · BioMed Research International · doi:10.1155/2020/8107478 · Cited by 17

N6 ‐methyladenosine RNA demethylase FTO regulates extracellular matrix‐related genes and promotes pancreatic cancer cell migration and invasion

Wang, W., He, Y., Wu, L., Zhai, L., Chen, L., Yao, L., Yu, K., & Tang, Z. (2022) · Cancer Medicine · doi:10.1002/cam4.5054 · Cited by 17

Coupling of Conformational Transitions in the N-terminal Domain of the 51-kDa FK506-binding Protein (FKBP51) Near Its Site of Interaction with the Steroid Receptor Proteins

LeMaster, D. M., Mustafi, S. M., Brecher, M. B., Zhang, J., Heroux, A., Li, H., & Hernández, G. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.650655 · Cited by 18

Quantitative Proteomic Analysis of Differentially Expressed Proteins and Downstream Signaling Pathways in Chronic Bladder Ischemia

Su, N., Choi, H.-P., Wang, F., Su, H., Fei, Z., Yang, J.-H., & Azadzoi, K. M. (2015) · The Journal of Urology · doi:10.1016/j.juro.2015.09.079 · Cited by 17

Robust Microarray Meta-Analysis Identifies Differentially Expressed Genes for Clinical Prediction

Phan, J. H., Young, A. N., & Wang, M. D. (2012) · The Scientific World JOURNAL · doi:10.1100/2012/989637 · Cited by 17

Androgen Receptor and Androgen-Responsive Gene FKBP5 Are Independent Prognostic Indicators for Esophageal Adenocarcinoma

Smith, E., Palethorpe, H. M., Ruszkiewicz, A. R., Edwards, S., Leach, D. A., Underwood, T., Need, E. F., & Drew, P. A. (2015) · Digestive Diseases and Sciences · doi:10.1007/s10620-015-3909-0 · Cited by 17

PRPF40A as a potential diagnostic and prognostic marker is upregulated in pancreatic cancer tissues and cell lines: an integrated bioinformatics data analysis

Huo, Z., Zhai, S., Weng, Y., Qian, H., Tang, X., Shi, Y., Deng, X., Wang, Y., & Shen, B. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s206039 · Cited by 17

Comprehensive Analysis of Prognostic and Immune Infiltrates for E2F Transcription Factors in Human Pancreatic Adenocarcinoma

Liu, X., Gao, Y., Liu, C., Chen, X., Zhou, L.-M., Yang, J.-W., Kui, X.-Y., & Pei, Z. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.606735 · Cited by 17

Identification of Prognostic and Therapeutic Biomarkers among FAM83 Family Members for Pancreatic Ductal Adenocarcinoma

Ma, Z., Zhou, Z., Zhuang, H., Li, Z., Ma, Z., Huang, B., Liu, C., Gong, Y., Zou, Y., Zheng, Z., et al. (2021) · Disease Markers · doi:10.1155/2021/6682697 · Cited by 18

Transcriptional epigenetic regulation of Fkbp1/Pax9 genes is associated with impaired sensitivity to platinum treatment in ovarian cancer

Soto, J. A., Rodríguez‐Antolín, C., Vera, O., Pernía, O., Esteban‐Rodríguez, I., Diestro, M. D., Benitez, J. J., Sánchez‐Cabo, F., Álvarez-Gallego, R., de Castro, J., et al. (2021) · Clinical Epigenetics · doi:10.1186/s13148-021-01149-8 · Cited by 17

Identification of Novel Molecular Therapeutic Targets and Their Potential Prognostic Biomarkers Among Kinesin Superfamily of Proteins in Pancreatic Ductal Adenocarcinoma

Yang, Y., Gao, L., Weng, N., Li, J., Liu, J. L., Zhou, Y., Liao, R., Xiong, Q., Xu, Y., Varela-Ramı́rez, A., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.708900 · Cited by 17

Cadmium regulates FKBP5 through miR-9-5p and induces carp lymphocyte apoptosis

Luan, P., Zhang, H., Zhang, X., Hu, G., & Zhang, Z. (2021) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2021.12.006 · Cited by 17

Tousled-like kinase 1: a novel factor with multifaceted role in mCRPC progression and development of therapy resistance

Khalil, M. I., & Benedetti, A. D. (2022) · Cancer Drug Resistance · doi:10.20517/cdr.2021.109 · Cited by 17

The heat shock protein-90 co-chaperone, Cyclophilin 40, promotes ALK-positive, anaplastic large cell lymphoma viability and its expression is regulated by the NPM-ALK oncoprotein

Pearson, J., Mohammed, Z., Bacani, J., Lai, R., & Ingham, R. (2012) · BMC Cancer · doi:10.1186/1471-2407-12-229 · Cited by 17

Role of transgelin-2 in diabetes-associated pancreatic ductal adenocarcinoma

Sun, Y., He, W., Luo, M., Zhou, Y., Chang, G., Ren, W., Wu, K., Li, X., Shen, J., Zhao, X., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.17519 · Cited by 17

A Molecular Link between AKT Regulation and Chemotherapeutic Response

Dibble, C. C., & Manning, B. D. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.08.011 · Cited by 30

InterAKTions with FKBPs - Mutational and Pharmacological Exploration

Fabian, A., März, A., Neimanis, S., Biondi, R. M., Kozany, C., & Hausch, F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057508 · Cited by 51

FKBP51 regulation of AKT/protein kinase B phosphorylation

Wang, L. (2011) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2011.03.008 · Cited by 52

FKBP51 plays an essential role in Akt ubiquitination that requires Hsp90 and PHLPP

Tufano, M., Marrone, L., DˈAmbrosio, C., Giacomo, V. D., Urzini, S., Xiao, Y., Matuozzo, M., Scaloni, A., Romano, M. F., & Romano, S. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05629-y · Cited by 22

The Phosphatase PHLPP1 Regulates Akt2, Promotes Pancreatic Cancer Cell Death, and Inhibits Tumor Formation

Nitsche, C. J., Edderkaoui, M., Moore, R. M., Eibl, G., Kasahara, N., Treger, J. M., Grippo, P. J., Mayerle, J. V., Lerch, M. M., & Gukovskaya, A. S. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.10.026 · Cited by 98