The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
p53 Acts as a Safeguard of Translational Control by Regulating Fibrillarin and rRNA Methylation in Cancer
Open accessAbstract
Summary Ribosomes are specialized entities that participate in regulation of gene expression through their rRNAs carrying ribozyme activity. Ribosome biogenesis is overactivated in p53-inactivated cancer cells, although involvement of p53 on ribosome quality is unknown. Here, we show that p53 represses expression of the rRNA methyl-transferase fibrillarin (FBL) by binding directly to FBL. High levels of FBL are accompanied by modifications of the rRNA methylation pattern, impairment of translational fidelity, and an increase of internal ribosome entry site (IRES)-dependent translation initiation of key cancer genes. FBL overexpression contributes to tumorigenesis and is associated with poor survival in patients with breast cancer. Thus, p53 acts as a safeguard of protein synthesis by regulating FBL and the subsequent quality and intrinsic activity of ribosomes.
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Cites
Molecular mechanisms and clinical applications of angiogenesis
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Requirement for p53 and p21 to Sustain G 2 Arrest After DNA Damage
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Cited by
Sloan, K. E., Warda, A. S., Sharma, S., Entian, K.-D., Lafontaine, D. L. J., & Bohnsack, M. T. (2017) · RNA Biology · doi:10.1080/15476286.2016.1259781 · Cited by 707
New frontiers in translational control of the cancer genome
Truitt, M. L., & Ruggero, D. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.27 · Cited by 378
IRES Trans-Acting Factors, Key Actors of the Stress Response
Godet, A.-C., David, F., Hantelys, F., Tatin, F., Lacazette, E., Garmy-Susini, B., & Prats, A.-C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040924 · Cited by 202
Self-citationAlterations of the translation apparatus during aging and stress response
Gonskikh, Y., & Polacek, N. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.04.003 · Cited by 140
The Role of Translation Control in Tumorigenesis and Its Therapeutic Implications
Xu, Y., & Ruggero, D. (2020) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030419-033420 · Cited by 67
Metadata
- Authors
- Marcel, V., Ghayad, S. E., Belin, S., Therizols, G., Morel, A.-P., Solano-Gonzàlez, E., Vendrell, J. A., Hacot, S., Mertani, H. C., Albaret, M. A., Bourdon, J.-C., Jordan, L., Thompson, A., Tafer, Y., Cong, R., Bouvet, P., Saurin, J.-C., Catez, F., Prats, A.-C., Puisieux, A., & Diaz, J.-J.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 24
- Issue
- 3
- Pages
- 318-330
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2066272205
- Cited by
- 358
- References
- 7
- FWCI
- 7.13
- Type
- journal article
- Language
- en
- Open access
- bronze
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