Cited by 1,476MicroRNA in disease regulationExtracellular vesicles in diseaseBarrier Structure and Function Studies

The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.

Cancer-Secreted miR-105 Destroys Vascular Endothelial Barriers to Promote Metastasis

Open access

Zhou, Weiying, Fong, Miranda Y., Min, Yongfen, Somlo, George, Liu, Liang, Palomares, Melanie R., Yu, Yang, Chow, Amy, O’Connor, Sean Timothy Francis, Chin, Andrew R., Yen, Yun, Wang, Yafan, Marcusson, Eric G., Chu, Peiguo, Wu, Jun, Wu, Xiwei, Li, Arthur Xuejun, Li, Zhuo, Gao, Hanlin, Ren, Xiubao, Boldin, Mark P., Lin, Pengnian Charles, Wang, Shizhen Emily·2014·Cancer Cell

DOI 10.1016/j.ccr.2014.03.007PMC PMC4016197

Open this paper in CoChat — free account Open PDF

Abstract

Cancer-secreted microRNAs (miRNAs) are emerging mediators of cancer-host crosstalk. Here we show that miR-105, which is characteristically expressed and secreted by metastatic breast cancer cells, is a potent regulator of migration through targeting the tight junction protein ZO-1. In endothelial monolayers, exosome-mediated transfer of cancer-secreted miR-105 efficiently destroys tight junctions and the integrity of these natural barriers against metastasis. Overexpression of miR-105 in nonmetastatic cancer cells induces metastasis and vascular permeability in distant organs, whereas inhibition of miR-105 in highly metastatic tumors alleviates these effects. miR-105 can be detected in the circulation at the premetastatic stage, and its levels in the blood and tumor are associated with ZO-1 expression and metastatic progression in early-stage breast cancer.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.ccr.2014.03.007

Cites

62 of 62 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

RETRACTED: MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer
Taylor, D. D., & Gerçel-Taylor, Ç. (2008) · Gynecologic Oncology · doi:10.1016/j.ygyno.2008.04.033 · Cited by 2,333
Retracted
Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834
Circulating microRNAs as stable blood-based markers for cancer detection
Mitchell, P. S., Parkin, R. K., Kroh, E. M., Fritz, B. R., Wyman, S. K., Pogosova-Agadjanyan, E. L., Peterson, A., Noteboom, J., O'Briant, K. C., Allen, A., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804549105 · Cited by 7,969
MicroRNA signatures in human cancers
Calin, G. A., & Croce, C. M. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1997 · Cited by 7,668
Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids
Théry, C., Amigorena, S., Raposo, G., & Clayton, A. (2006) · Current Protocols in Cell Biology · doi:10.1002/0471143030.cb0322s30 · Cited by 5,766
Exosomes: composition, biogenesis and function
Théry, C., Zitvogel, L., & Amigorena, S. (2002) · Nature reviews. Immunology · doi:10.1038/nri855 · Cited by 5,355
The distribution of secondary growths in cancer of the breast.
Paget, S. (1889) · The Lancet · doi:10.1016/s0140-6736(00)49915-0 · Cited by 5,277
Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
Skog, J., Würdinger, T., van Rijn, S., Meijer, D. H., Gainche, L., Curry, W. T., Carter, B. S., Krichevsky, A. M., & Breakefield, X. O. (2008) · Nature Cell Biology · doi:10.1038/ncb1800 · Cited by 5,001
MicroRNA Gene Expression Deregulation in Human Breast Cancer
Iorio, M. V., Ferracin, M., Liu, C.-G., Veronese, A., Spizzo, R., Sabbioni, S., Magri, E., Pedriali, M., Fabbri, M., Campiglio, M., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1783 · Cited by 4,053
Dissemination and growth of cancer cells in metastatic sites
Chambers, A. F., Groom, A. C., & MacDonald, I. C. (2002) · Nature reviews. Cancer · doi:10.1038/nrc865 · Cited by 4,018

Flagged first, then by citations

Show all 62 references

Sorted by citations

Items 401–500 of 1,001

Extracellular vesicles in cancer therapy
Wang, S. E. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.06.001 · Cited by 70
The roles of small extracellular vesicles in cancer and immune regulation and translational potential in cancer therapy
Qian, K., Fu, W., Li, T., Zhao, J., Lei, C., & Hu, S. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02492-1 · Cited by 72
Engineered extracellular vesicles as brain therapeutics
Lino, M. M., Simões, S., Tomatis, F., Albino, I., Barrera, A., Vivien, D., Sobrino, T., & Ferreira, L. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.08.037 · Cited by 68
Exosomes and Their Role in Cancer Progression
Liu, Y., Shi, K., Chen, Y., Wu, X.-R., Chen, Z., Cao, K., Tao, Y.-G., Chen, X., Liao, J., & Zhou, J. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.639159 · Cited by 37
High-grade ovarian cancer secreting effective exosomes in tumor angiogenesis.
Huan, Y., Ye, J., Yang, X., Zhang, L., Zhang, Z., & Chen, Y. (2015) · PubMed Central · Cited by 68
Microenvironment‐induced TIMP2 loss by cancer‐secreted exosomal miR‐4443 promotes liver metastasis of breast cancer
Wang, J., Zhang, Q., Wang, D., Yang, S., Zhou, S., Xu, H., Zhang, H., Zhong, S., & Feng, J. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29507 · Cited by 65
microRNAs Orchestrate Pathophysiology of Breast Cancer Brain Metastasis: Advances in Therapy
Kanchan, R. K., Siddiqui, J. A., Mahapatra, S., Batra, S. K., & Nasser, M. W. (2020) · Molecular Cancer · doi:10.1186/s12943-020-1140-x · Cited by 70
The Biology of Exosomes in Breast Cancer Progression: Dissemination, Immune Evasion and Metastatic Colonization
Giordano, C., Camera, G. L., Gelsomino, L., Barone, I., Bonofiglio, D., Andò, S., & Catalano, S. (2020) · Cancers · doi:10.3390/cancers12082179 · Cited by 71
Perineural Invasion in Adenoid Cystic Carcinoma of the Salivary Glands: Where We Are and Where We Need to Go
Liu, X., Yang, X., Zhan, C., Zhang, Y., Hou, J. L., & Yin, X. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01493 · Cited by 69
Oncogene-regulated release of extracellular vesicles
Kilinc, S., Paisner, R., Camarda, R., Gupta, S., Momčilović, O., Kohnz, R. A., Avşaroğlu, B., L’Étoile, N. D., Perera, R. M., Nomura, D. K., et al. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.05.014 · Cited by 70
Exosomal miR-375-3p breaks vascular barrier and promotes small cell lung cancer metastasis by targeting claudin-1
Mao, S., Zheng, S., Lu, Z., Wang, X., Wang, Y., Zhang, G., Xu, H., Huang, J., Lei, Y., Liu, C., et al. (2021) · Translational Lung Cancer Research · doi:10.21037/tlcr-21-356 · Cited by 67
“Recently, the effects of tumor-secreted exosomal miRNAs on vascular endothelial cells and their further promoting roles in cancer metastasis have attracted researchers’ attention, and many researches have shown that tumor-secreted exosomal miRNAs can promote metastasis by targeting vascular endothelial cells to induce…”
Influential
Mesenchymal Stem Cell-Derived Exosomes as an Emerging Paradigm for Regenerative Therapy and Nano-Medicine: A Comprehensive Review
Panda, B., Sharma, Y., Gupta, S., & Mohanty, S. (2021) · Life · doi:10.3390/life11080784 · Cited by 66
Cancer-cell-secreted miR-204-5p induces leptin signalling pathway in white adipose tissue to promote cancer-associated cachexia
Hu, Y., Liu, L., Chen, Y., Zhang, X., Zhou, H.-F., Hu, S. S., Xu, L., Li, M., Li, J., Cheng, S., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40571-9 · Cited by 73
“To seek the underlying mechanism, we referred to the previously reported small RNA sequencing inMDA-MB-231 sEVsversus MCF-10A sEVs 34 , and identi ﬁ ed miR-204-5p (hereafter as miR-204) overlappingly enriched in predicted candidates pool potentially targeting VHL (Supplementary Table 1) (Fig.”
MicroRNA and Metastasis
Ma, L. (2016) · Advances in cancer research · doi:10.1016/bs.acr.2016.07.004 · Cited by 69
Exosomes and cancer: From oncogenic roles to therapeutic applications
Mohammadi, S., Yousefi, F., Shabaninejad, Z., Movahedpour, A., Mahjoubin‐Tehran, M., Shafiee, A., Moradizarmehri, S., Hajighadimi, S., Savardashtaki, A., & Mirzaei, H. (2019) · IUBMB Life · doi:10.1002/iub.2182 · Cited by 67
A novel cancer-germline transcript carrying pro-metastatic miR-105 andTET-targeting miR-767 induced by DNA hypomethylation in tumors
Loriot, A. E., Tongelen, A. V., Blanco, J., Klaessens, S., Cannuyer, J., van Baren, N., Decottignies, A., & Smet, C. D. (2014) · Epigenetics · doi:10.4161/epi.29628 · Cited by 66
“TET1 and TET3 are targets of miR-767 During the course of our research project, a study was published showing that miR-105 is expressed in metastatic breast cancer cells, and acts as a crucial promoter of cancer metastasis.(13) The study revealed indeed that miR-105 undergoes exosomemediated secretion, and destroys va…”
Exosomal miR-940 maintains SRC-mediated oncogenic activity in cancer cells: a possible role for exosomal disposal of tumor suppressor miRNAs
Rashed, M. H., Kanlikilicer, P., Rodriguez‐Aguayo, C., Pichler, M., Bayraktar, R., Bayraktar, E., Ivan, C., Filant, J., da Silva, A. M., Aslan, B., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.15525 · Cited by 63
Exosomes in Toxicology: Relevance to Chemical Exposure and Pathogenesis of Environmentally Linked Diseases
Harischandra, D. S., Ghaisas, S., Rokad, D., & Kanthasamy, A. G. (2017) · Toxicological Sciences · doi:10.1093/toxsci/kfx074 · Cited by 67
Exosomes from Plasmodium-infected hosts inhibit tumor angiogenesis in a murine Lewis lung cancer model
Yang, Y., Liu, Q., Lü, J., Adah, D., Yu, S., Zhao, S., Yao, Y., Li, Q., Li, Q., & Chen, X. (2017) · Oncogenesis · doi:10.1038/oncsis.2017.52 · Cited by 67
Clinical Relevance of Circulating, Cell-Free and Exosomal microRNAs in Plasma and Serum of Breast Cancer Patients
Schwarzenbach, H. (2017) · Oncology Research and Treatment · doi:10.1159/000478019 · Cited by 67
Extracellular Vesicles and MetastasisPreprint
Wang, S. E. (2019) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a037275 · Cited by 67
Decoding the Secret of Cancer by Means of Extracellular Vesicles
Kosaka, N. (2016) · Journal of Clinical Medicine · doi:10.3390/jcm5020022 · Cited by 65
Cancer-Derived Extracellular Vesicle-Associated MicroRNAs in Intercellular Communication: One Cell’s Trash Is Another Cell’s Treasure
Mills, J., Capece, M., Cocucci, E., Tessari, A., & Palmieri, D. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20246109 · Cited by 68
Exosomal Non-coding RNAs-Mediated Crosstalk in the Tumor Microenvironment
Chen, Q., Li, Y., Liu, Y., Xu, W., & Zhu, X. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.646864 · Cited by 65
Glioma stem cells invasive phenotype at optimal stiffness is driven by MGAT5 dependent mechanosensing
Marhuenda, E., Fabre, C., Zhang, C., Martin, M., Iskratsch, T., Saleh, A., Bauchet, L., Cambedouzou, J., Hugnot, J., Duffau, H., et al. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-01925-7 · Cited by 65
Non-coding RNAs in the regulation of blood–brain barrier functions in central nervous system disorders
Sun, P., Hamblin, M. H., & Yin, K. (2022) · Fluids and Barriers of the CNS · doi:10.1186/s12987-022-00317-z · Cited by 67
miR-105/Runx2 axis mediates FGF2-induced ADAMTS expression in osteoarthritis cartilage
Ji, Q., Xu, X., Xu, Y., Fan, Z., Kang, L., Li, L., Liang, Y., Guo, J., Tian, H. W., Li, Z., et al. (2016) · Journal of Molecular Medicine · doi:10.1007/s00109-016-1380-9 · Cited by 65
Essential role of miRNAs in orchestrating the biology of the tumor microenvironment
Frediani, J., & Fabbri, M. (2016) · Molecular Cancer · doi:10.1186/s12943-016-0525-3 · Cited by 64
Progress in exosome associated tumor markers and their detection methods
Shen, M., Di, K., He, H., Xia, Y., Xie, H., Huang, R., Liu, C., Yang, M., Zheng, S., He, N., et al. (2020) · Molecular Biomedicine · doi:10.1186/s43556-020-00002-3 · Cited by 65
Extracellular vesicles: A dive into their role in the tumor microenvironment and cancer progression
Lopez, K., Lai, S. W. T., Gonzalez, E. D. J. L., Dávila, R. G., & Shuck, S. C. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1154576 · Cited by 67
PFKFB3 promotes proliferation, migration and angiogenesis in nasopharyngeal carcinoma
Gu, M., Li, L., Zhang, Z., Chen, J., Zhang, W., Zhang, J., Han, L., Tang, M., You, B., Zhang, Q., et al. (2017) · Journal of Cancer · doi:10.7150/jca.19112 · Cited by 64
Tumor-derived exosomes promote tumor self-seeding in hepatocellular carcinoma by transferring miRNA-25-5p to enhance cell motility
Liu, H., Chen, W., Zhi, X., Chen, E., Wei, T., Zhang, J., Shen, J., Hu, L., Zhao, B., Feng, X., et al. (2018) · Oncogene · doi:10.1038/s41388-018-0309-x · Cited by 65
Exosomal microRNA‑210 is a potentially non‑invasive biomarker for the diagnosis and prognosis of glioma
Lan, F., Yue, X., & Xia, T. (2020) · Oncology Letters · doi:10.3892/ol.2020.11249 · Cited by 66
Periostin + cancer‐associated fibroblasts promote lymph node metastasis by impairing the lymphatic endothelial barriers in cervical squamous cell carcinoma
Wei, W., Chen, X., Liang, L.-J., Wu, X., Wu, X., Chen-Fei, Z., Wang, Z., Fan, L., Hu, Z., Liang, L., et al. (2020) · Molecular Oncology · doi:10.1002/1878-0261.12837 · Cited by 64
Extracellular vesicles, the cornerstone of next-generation cancer diagnosis?
Weng, J., Xiang, X., Ding, L., Wong, A. L., Zeng, Q., Sethi, G., Wang, L., Lee, S. C., & Goh, B. C. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.05.011 · Cited by 59
Tumor exosome-mediated promotion of adhesion to mesothelial cells in gastric cancer cells
Arita, T., Ichikawa, D., Konishi, H., Komatsu, S., Shiozaki, A., Ogino, S., Fujita, Y., Hiramoto, H., Hamada, J., Shoda, K., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.10869 · Cited by 63
HCV-E2 inhibits hepatocellular carcinoma metastasis by stimulating mast cells to secrete exosomal shuttle microRNAs
Li, X., Zhen, S., Yu, Q., & Gong, Z. (2017) · Oncology Letters · doi:10.3892/ol.2017.6433 · Cited by 63
“Exosomes secreted by cancer cells can effectively disrupt tight junctions and vascular endothelial barrier integrity to promote tumor metastasis (13).”
Retracted
Exosomal microRNA: a Novel Biomarker for Breast Cancer
He, Y., Deng, F., Yang, S., Wang, D., Chen, X., Zhong, S., Zhao, J., & Tang, J. (2017) · Biomarkers in Medicine · doi:10.2217/bmm-2017-0305 · Cited by 64
A Review of Physical Activity and Circulating miRNA Expression: Implications in Cancer Risk and Progression
Dufresne, S., Rébillard, A., Muti, P. C., Friedenreich, C. M., & Brenner, D. R. (2017) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-16-0969 · Cited by 68
Feed‐forward loops between metastatic cancer cells and their microenvironment—the stage of escalation
Baumann, Z., der Maur, P. A., & Bentires‐Alj, M. (2022) · EMBO Molecular Medicine · doi:10.15252/emmm.202114283 · Cited by 61
“Another example is miR-105, which destroys endothelial barriers and promotes metastasis (Zhou et al , 2014).”
The roles of microRNAs in the regulation of tumor metastasis
Zhou, L., Liu, F., Wang, X., & Ouyang, G. (2015) · Cell & Bioscience · doi:10.1186/s13578-015-0028-8 · Cited by 63
Distribution Profiling of Circulating MicroRNAs in Serum
Ashby, J., Flack, K., Jiménez, L. A., Duan, Y., Khatib, A.-K., Somlo, G., Wang, S. E., Cui, X., & Zhong, W. (2014) · Analytical Chemistry · doi:10.1021/ac5028929 · Cited by 62
Extracellular Vesicles as Conduits of Non-Coding RNA Emission and Intercellular Transfer in Brain Tumors
Spinelli, C., Adnani, L., Choi, D., & Rak, J. W. (2018) · Non-Coding RNA · doi:10.3390/ncrna5010001 · Cited by 66
Exosomes: A Promising Avenue for the Diagnosis of Breast Cancer
Meng, Y., Sun, J. Y., Wang, X., Hu, T., Ma, Y., Kong, C., Piao, H., Yu, T., & Zhang, G. (2019) · Technology in Cancer Research & Treatment · doi:10.1177/1533033818821421 · Cited by 61
Exosomes in Liquid Biopsy: The Nanometric World in the Pursuit of Precision Oncology
Valencia, K., & Montuenga, L. M. (2021) · Cancers · doi:10.3390/cancers13092147 · Cited by 60
The role of extracellular vesicles in circulating tumor cell-mediated distant metastasis
Guo, S., Huang, J., Li, G., Chen, W., Li, Z., & Lei, J. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01909-5 · Cited by 65
“Moreover, a previous study [134] showed that EV-associated miR-105 in BC disrupts tight junctions by directly targeting the protein ZO-1.”
Result
Harnessing exosomes as cancer biomarkers in clinical oncology
Ghosh, S., Rajendran, R. L., Mahajan, A. A., Chowdhury, A., Bera, A., Guha, S., Chakraborty, K., Chowdhury, R., Paul, A., Jha, S., et al. (2024) · Cancer Cell International · doi:10.1186/s12935-024-03464-5 · Cited by 66
“For instance, exosomes can carry various micro-RNAs (miRNAs), such as miR-122 [41], which promotes metastasis; mir-9 [42], and miR-135b [43], which enhances angiogenesis; and miR-105, which induces vascular leakiness and promotes metastasis [44].”
Background
The role of exosomal non-coding RNAs in cancer metastasis
Wang, J.-P., Tang, Y.-Y., Fan, C.-M., Guo, C. J., Zhou, Y., Li, Z., Li, X.-L., Li, Y., Li, G.-Y., Xiong, W., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.23552 · Cited by 61
Involvement of Extracellular Vesicles in Vascular-Related Functions in Cancer Progression and Metastasis
Kikuchi, S., Yoshioka, Y., Prieto‐Vila, M., & Ochiya, T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20102584 · Cited by 64
Exosomes in cancer therapy: a novel experimental strategy.
Gao, D., & Jiang, L. (2018) · Europe PMC (PubMed Central) · Cited by 61
Tumor-derived extracellular vesicles: insights into bystander effects of exosomes after irradiation
Jabbari, N., Karimipour, M., Khaksar, M., Akbariazar, E., Heidarzadeh, M., Mojarad, B., Aftab, H., Rahbarghazi‬, R., & Rezaie, J. (2019) · Lasers in Medical Science · doi:10.1007/s10103-019-02880-8 · Cited by 63
miRNAs as potential game-changers in bone diseases: Future medicinal and clinical uses
Doghish, A. S., Elballal, M. S., Elazazy, O. E., Elesawy, A. E., Shahin, R. K., Midan, H. M., Sallam, A.-A. M., Elbadry, A. M. M., Mohamed, A. K. I., Ishak, N. W., et al. (2023) · Pathology - Research and Practice · doi:10.1016/j.prp.2023.154440 · Cited by 60
MicroRNA-99a inhibits tumor aggressive phenotypes through regulating HOXA1 in breast cancer cells
Wang, X., Li, Y., Qi, W., Zhang, N., Sun, M., Huo, Q., Cai, C., Lv, S., & Yang, Q. (2015) · Oncotarget · doi:10.18632/oncotarget.5355 · Cited by 60
“In addition, Zhou et al. declared that miR-105 secreted by cancer cells promotes tumor metastasis by targeting the mRNA encoding the tight junction protein ZO-1 [26].”
Function of extracellular vesicle-associated miRNAs in metastasis
Dhondt, B., Rousseau, Q., Wever, O. D., & Hendrix, A. (2016) · Cell and Tissue Research · doi:10.1007/s00441-016-2430-x · Cited by 61
Macrophage PPARγ inhibits Gpr132 to mediate the anti-tumor effects of rosiglitazone
Cheng, W. Y., Huynh, H., Chen, P., Peña‐Llopis, S., & Wan, Y. (2016) · eLife · doi:10.7554/elife.18501 · Cited by 60
New Insight into Inter-kingdom Communication: Horizontal Transfer of Mobile Small RNAs
Zhou, G., Zhou, Y., & Chen, X. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00768 · Cited by 61
Role of exosomes and exosomal microRNAs in hepatocellular carcinoma: Potential in diagnosis and antitumour treatments (Review)
Pan, J., Zhou, H. K., Zhao, X., Ding, H., Li, W., Li, Q., & Pan, Y. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3383 · Cited by 59
“Previous studies have shown that tumour exosome-secreted miR-105 destroys vascular endothelial barriers to promote metastasis in early-stage breast cancer (74).”
Decoding the Biology of Exosomes in Metastasis
Adem, B., Vieira, P. F., & Melo, S. A. (2019) · Trends in cancer · doi:10.1016/j.trecan.2019.11.007 · Cited by 64
Prognosis and targeting of pre-metastatic niche
Zhou, Y., Han, M. Y., & Gao, J. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.06.037 · Cited by 62
Extracellular Vesicles Are Key Regulators of Tumor Neovasculature
Kuriyama, N., Yoshioka, Y., Kikuchi, S., Azuma, N., & Ochiya, T. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.611039 · Cited by 58
The Mechanism of Asparagine Endopeptidase in the Progression of Malignant Tumors: A Review
Zhang, W., & Lin, Y. (2021) · Cells · doi:10.3390/cells10051153 · Cited by 58
Exosomal and intracellular miR-320b promotes lymphatic metastasis in esophageal squamous cell carcinoma
Liu, T., Li, P., Li, J., Qi, Q., Sun, Z., Shi, S., Xie, Y., Liu, S., Wang, Y., Du, L., et al. (2021) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2021.09.003 · Cited by 59
Exosomes-mediated tumor metastasis through reshaping tumor microenvironment and distant niche
Luo, X., Li, Y., Hua, Z., Xue, X., Wang, X., Pang, M., Xiao, C., Zhao, H., Lü, A., & Liu, Y. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.11.050 · Cited by 63
Pre-metastatic niche: from revealing the molecular and cellular mechanisms to the clinical applications in breast cancer metastasis
Li, Y., Li, M., Su, K., Zong, S., Zhang, H., & Xiong, L. (2023) · Theranostics · doi:10.7150/thno.82700 · Cited by 61
“By targeting the tight junction protein ZO-1 released by the tumor cells, miRNA-105 or the exogenous exosomal miRNA-105 can change vascular permeability in distant tissues and induce metastasis [84].”
BackgroundInfluential
Whom to blame for metastasis, the epithelial–mesenchymal transition or the tumor microenvironment?
Pietilä, M., Ivaska, J., & Mani, S. A. (2016) · Cancer Letters · doi:10.1016/j.canlet.2015.12.033 · Cited by 63
Cancer-derived extracellular vesicles: the ‘soil conditioner’ in breast cancer metastasis?
Chin, A. R., & Wang, S. E. (2016) · Cancer and Metastasis Reviews · doi:10.1007/s10555-016-9639-8 · Cited by 62
Urinary exosomal proteins as (pan‐)cancer biomarkers: insights from the proteome
Erozenci, L. A., Böttger, F., Bijnsdorp, I. V., & Jiménez, C. R. (2019) · FEBS Letters · doi:10.1002/1873-3468.13487 · Cited by 61
PLEK2 mediates metastasis and vascular invasion via the ubiquitin‐dependent degradation of SHIP2 in non‐small cell lung cancer
Wu, D., Deng, S., Zhou, J., Han, R., Liu, T., Zhang, T., Li, J., Chen, J., & Xu, Y. X. (2019) · International Journal of Cancer · doi:10.1002/ijc.32675 · Cited by 59
Apoptotic and Nonapoptotic Activities of Pterostilbene against Cancer
Chen, R.-J., Kuo, H.-C., Cheng, L.-H., Lee, Y., Chang, W., Wang, B.-J., Wang, Y.-J., & Cheng, H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19010287 · Cited by 60
Interplay between SOX9 transcription factor and microRNAs in cancer
Ashrafizadeh, M., Zarrabi, A., Orouei, S., Zabolian, A., Saleki, H., Azami, N., Bejandi, A. K., Mirzaei, S., Janaghard, M. N., Hushmandi, K., et al. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.04.185 · Cited by 57
Role for extracellular vesicles in the tumour microenvironment
O’Loghlen, A. (2017) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0488 · Cited by 62
MiRNAs at the Crossroads between Innate Immunity and Cancer: Focus on Macrophages
Curtale, G. (2018) · Cells · doi:10.3390/cells7020012 · Cited by 58
TAK1 regulates endothelial cell necroptosis and tumor metastasis
Yang, L., Joseph, S., Sun, T., Hoffmann, J. M., Thevissen, S., Offermanns, S., & Strilić, B. (2019) · Cell Death and Differentiation · doi:10.1038/s41418-018-0271-8 · Cited by 59
microRNA exchange via extracellular vesicles in cancer
Vu, L. T., Gong, J., Pham, T. T., Kim, Y., & Le, M. T. N. (2020) · Cell Proliferation · doi:10.1111/cpr.12877 · Cited by 55
Dissecting miRNA facilitated physiology and function in human breast cancer for therapeutic intervention
Sengupta, D., Deb, M., Kar, S., Pradhan, N., Parbin, S., Kirtana, R., Singh, S. P., Suma, S. G., Niharika, N., Roy, A., et al. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.05.017 · Cited by 57
Interactions between cancer cells and normal cells via miRNAs in extracellular vesicles
Nishida‐Aoki, N., & Ochiya, T. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1811-0 · Cited by 59
Extracellular vesicles: An overview of biogenesis, function, and role in breast cancer
Zha, Q. B., Yao, Y. F., Ren, Z. J., Li, X. J., & Tang, J. H. (2017) · Tumor Biology · doi:10.1177/1010428317691182 · Cited by 61
The Role of micro RNAs in Breast Cancer Metastasis: Preclinical Validation and Potential Therapeutic Targets
Weidle, U. H., Dickopf, S., Hintermair, C., Kollmorgen, G., Birzele, F., & Brinkmann, U. (2018) · Cancer Genomics & Proteomics · doi:10.21873/cgp.20062 · Cited by 57
“Pre-treatment of mice with exosomes exhibiting high levels of miR-105 derived from MDA-MB-231 cells, but not those derived from MCF-7 cells, mediated metastasis of MDA-MB-231 cells to the lungs and the brain after intracardiac injection (83).”
BackgroundInfluential
Exosomes in Head and Neck Squamous Cell Carcinoma
Cheng, X., Song, F., Zheng, Y., Lv, J., Wang, Q. F., & Xu, N. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00894 · Cited by 58
Exosomal MicroRNAs and Organotropism in Breast Cancer Metastasis
Wong, G. L., Jalboush, S. A., & Lo, H. (2020) · Cancers · doi:10.3390/cancers12071827 · Cited by 57
Tumor-Derived EV-Encapsulated miR-181b-5p Induces Angiogenesis to Foster Tumorigenesis and Metastasis of ESCC
Wang, Y., Lu, J., Chen, L., Bian, H., Hu, J., Li, D., Xia, C., & Xu, H. (2020) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2020.03.002 · Cited by 55
Extracellular vesicle-mediated pre-metastatic niche formation via altering host microenvironments
Li, Y., Zheng, Y., Tan, X., Du, Y., Wei, Y., & Liu, S. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1367373 · Cited by 60
MicroRNA as New Tools for Prostate Cancer Risk Assessment and Therapeutic Intervention: Results from Clinical Data Set and Patients’ Samples
Cannistraci, A., Pace, A. L. D., Maria, R. D., & Bonci, D. (2014) · BioMed Research International · doi:10.1155/2014/146170 · Cited by 57
Extracellular Vesicles and Cancer: A Focus on Metabolism, Cytokines, and Immunity
Lucchetti, D., Tenore, C. R., Colella, F., & Sgambato, A. (2020) · Cancers · doi:10.3390/cancers12010171 · Cited by 57
Chemotherapy-induced metastasis: molecular mechanisms and clinical therapies
Su, J.-X., Li, S.-J., Zhou, X., Zhang, Z., Yu, Y., Liu, S.-L., & Qi, Q. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-023-01093-8 · Cited by 56
Dual-microRNA-Controlled Electrochemiluminescence Biosensor for Breast Cancer Diagnosis and Supplemental Identification of Breast Cancer Metastasis
Ye, Z., Ma, M., Chen, Y., Liu, R., Zhang, Y., Ma, P., & Song, D. (2024) · Analytical Chemistry · doi:10.1021/acs.analchem.3c05766 · Cited by 55
Decoding the interplay between genetic and non-genetic drivers of metastasis
Karras, P., Black, J. R., McGranahan, N., & Marine, J. (2024) · Nature · doi:10.1038/s41586-024-07302-6 · Cited by 60
MicroRNA in Metabolic Re-Programming and Their Role in Tumorigenesis
Tomasetti, M., Amati, M., Santarelli, L., & Neužil, J. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17050754 · Cited by 57
Potential relevance of microRNAs in inter-species epigenetic communication, and implications for disease pathogenesis
Perge, P., Nagy, Z., Decmann, Á., Igaz, I., & Igaz, P. (2016) · RNA Biology · doi:10.1080/15476286.2016.1251001 · Cited by 57
miR-218 inhibited tumor angiogenesis by targeting ROBO1 in gastric cancer
Zhang, X., Dong, J., He, Y., Zhao, M., Liu, Z., Wang, N., Jiang, M., Zhang, Z., Liu, G., Liu, H., et al. (2017) · Gene · doi:10.1016/j.gene.2017.03.022 · Cited by 55
Concise Review: An (Im)Penetrable Shield: How the Tumor Microenvironment Protects Cancer Stem Cells
Relation, T., Dominici, M., & Horwitz, E. M. (2017) · Stem Cells · doi:10.1002/stem.2596 · Cited by 55
Macrophages exposed to HIV viral protein disrupt lung epithelial cell integrity and mitochondrial bioenergetics via exosomal microRNA shuttling
Yuan, Z., Petree, J. R., Lee, F. E.-H., Fan, X., Salaita, K. S., Guidot, D. M., & Sadikot, R. T. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1803-y · Cited by 55
Extracellular vesicle‐associated organotropic metastasis
Mo, Z., Cheong, J. Y. A., Xiang, L., Le, M. T. N., Grimson, A., & Zhang, D. X. (2020) · Cell Proliferation · doi:10.1111/cpr.12948 · Cited by 54
Simultaneous detection of multiple targets involved in the PI3K/AKT pathway for investigating cellular migration and invasion with a multicolor fluorescent nanoprobe
Luan, M., Li, N., Pan, W., Yang, L., Yu, Z., & Tang, B. (2016) · Chemical Communications · doi:10.1039/c6cc07605j · Cited by 54
Discovery of extracellular vesicles derived miR-181a-5p in patient's serum as an indicator for bone-metastatic prostate cancer
Wang, Y., Fang, Y., Dong, B., Du, X., Wang, J., Wang, X., Gao, W., & Xue, W. (2020) · Theranostics · doi:10.7150/thno.49186 · Cited by 56
Minireview: Emerging Roles for Extracellular Vesicles in Diabetes and Related Metabolic Disorders
Lakhter, A. J., & Sims, E. K. (2015) · Molecular Endocrinology · doi:10.1210/me.2015-1206 · Cited by 55
MicroRNA-92b represses invasion-metastasis cascade of esophageal squamous cell carcinoma
Ma, G., Jing, C., Lin, L., Huang, F., Ding, F., Wang, B., Lin, D., Luo, A., & Liu, Z. (2016) · Oncotarget · doi:10.18632/oncotarget.7747 · Cited by 54
Extracellular vesicles in lung cancer—From bench to bedside
Kadota, T., Yoshioka, Y., Fujita, Y., Kuwano, K., & Ochiya, T. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.03.001 · Cited by 55
Highly sensitive detection of exosomes by 3D plasmonic photonic crystal biosensor
Zhu, S., Li, H., Yang, M., & Pang, S. W. (2018) · Nanoscale · doi:10.1039/c8nr07051b · Cited by 54
MALAT1 regulates miR-34a expression in melanoma cells
Li, F., Li, X., Qiao, L., Liu, W., Xu, C., & Wang, X. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1620-3 · Cited by 56

Authors: Zhou, W., Fong, M. Y., Min, Y., Somlo, G., Liu, L., Palomares, M. R., Yu, Y., Chow, A., O’Connor, S. T. F., Chin, A. R., Yen, Y., Wang, Y., Marcusson, E. G., Chu, P., Wu, J., Wu, X., Li, A. X., Li, Z., Gao, H., Ren, X., Boldin, M. P., Lin, P. C., & Wang, S. E.
Affiliations: City Of Hope National Medical Center (US)
National Cancer Institute (US)
Regulus Therapeutics (United States) (US)
Tianjin Medical University Cancer Institute and Hospital (CN)
Corresponding author: Wang, Shizhen Emily
ORCID: Zhou, Weiying
Liu, Liang
Palomares, Melanie R.
Yu, Yang
Chow, Amy
Yen, Yun
Wang, Yafan
Marcusson, Eric G.
Wu, Jun
Wu, Xiwei
Li, Zhuo
Gao, Hanlin
Ren, Xiubao
Boldin, Mark P.
Wang, Shizhen Emily
Venue: Cancer Cell
Publisher: Elsevier BV
Published: 2014-04
Volume: 25
Issue: 4
Pages: 501-515
ISSN: 1535-6108 (ISSN-L)
DOI: 10.1016/j.ccr.2014.03.007
PMC: PMC4016197
OpenAlex: W2143839116
Cited by: 1,476
References: 62
Citations by year: 2026: 61 · 2025: 91 · 2024: 113 · 2023: 145 · 2022: 164 · 2021: 175 · 2020: 148 · 2019: 152 · 2018: 118 · 2017: 111 · 2016: 97 · 2015: 72 · 2014: 28
FWCI: 32.89
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 378 d)
Locations: Cancer Cell (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: American Association for Cancer Research
Breast Cancer Research Foundation (12-60-26-WANG)
Celgene
National Institutes of Health
National Key Research and Development Program of China (2012CB9333004)
National Cancer Institute (P30CA-33572, R01CA166020, R01CA163586, P30CA033572)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Keywords: miR-105, metastasis, breast cancer, ZO-1, tight junctions, endothelial barrier integrity, exosomes, vascular permeability, metastatic progression
MeSH terms: Breast Neoplasms, Cell Movement, Endothelium, Vascular, Female, Humans, Neoplasm Metastasis, Biomarkers, Tumor, MicroRNAs, Cell Line, Tumor, Cell Growth Processes

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Cancer-Secreted miR-105 Destroys Vascular Endothelial Barriers to Promote Metastasis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks