Cited by 1,476MicroRNA in disease regulationExtracellular vesicles in diseaseBarrier Structure and Function Studies

The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.

Cancer-Secreted miR-105 Destroys Vascular Endothelial Barriers to Promote Metastasis

Open access

Zhou, Weiying, Fong, Miranda Y., Min, Yongfen, Somlo, George, Liu, Liang, Palomares, Melanie R., Yu, Yang, Chow, Amy, O’Connor, Sean Timothy Francis, Chin, Andrew R., Yen, Yun, Wang, Yafan, Marcusson, Eric G., Chu, Peiguo, Wu, Jun, Wu, Xiwei, Li, Arthur Xuejun, Li, Zhuo, Gao, Hanlin, Ren, Xiubao, Boldin, Mark P., Lin, Pengnian Charles, Wang, Shizhen Emily·2014·Cancer Cell

DOI 10.1016/j.ccr.2014.03.007PMC PMC4016197

Open this paper in CoChat — free account Open PDF

Abstract

Cancer-secreted microRNAs (miRNAs) are emerging mediators of cancer-host crosstalk. Here we show that miR-105, which is characteristically expressed and secreted by metastatic breast cancer cells, is a potent regulator of migration through targeting the tight junction protein ZO-1. In endothelial monolayers, exosome-mediated transfer of cancer-secreted miR-105 efficiently destroys tight junctions and the integrity of these natural barriers against metastasis. Overexpression of miR-105 in nonmetastatic cancer cells induces metastasis and vascular permeability in distant organs, whereas inhibition of miR-105 in highly metastatic tumors alleviates these effects. miR-105 can be detected in the circulation at the premetastatic stage, and its levels in the blood and tumor are associated with ZO-1 expression and metastatic progression in early-stage breast cancer.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.ccr.2014.03.007

Cites

62 of 62 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

RETRACTED: MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer
Taylor, D. D., & Gerçel-Taylor, Ç. (2008) · Gynecologic Oncology · doi:10.1016/j.ygyno.2008.04.033 · Cited by 2,333
Retracted
Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834
Circulating microRNAs as stable blood-based markers for cancer detection
Mitchell, P. S., Parkin, R. K., Kroh, E. M., Fritz, B. R., Wyman, S. K., Pogosova-Agadjanyan, E. L., Peterson, A., Noteboom, J., O'Briant, K. C., Allen, A., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804549105 · Cited by 7,969
MicroRNA signatures in human cancers
Calin, G. A., & Croce, C. M. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1997 · Cited by 7,668
Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids
Théry, C., Amigorena, S., Raposo, G., & Clayton, A. (2006) · Current Protocols in Cell Biology · doi:10.1002/0471143030.cb0322s30 · Cited by 5,766
Exosomes: composition, biogenesis and function
Théry, C., Zitvogel, L., & Amigorena, S. (2002) · Nature reviews. Immunology · doi:10.1038/nri855 · Cited by 5,355
The distribution of secondary growths in cancer of the breast.
Paget, S. (1889) · The Lancet · doi:10.1016/s0140-6736(00)49915-0 · Cited by 5,277
Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
Skog, J., Würdinger, T., van Rijn, S., Meijer, D. H., Gainche, L., Curry, W. T., Carter, B. S., Krichevsky, A. M., & Breakefield, X. O. (2008) · Nature Cell Biology · doi:10.1038/ncb1800 · Cited by 5,001
MicroRNA Gene Expression Deregulation in Human Breast Cancer
Iorio, M. V., Ferracin, M., Liu, C.-G., Veronese, A., Spizzo, R., Sabbioni, S., Magri, E., Pedriali, M., Fabbri, M., Campiglio, M., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1783 · Cited by 4,053
Dissemination and growth of cancer cells in metastatic sites
Chambers, A. F., Groom, A. C., & MacDonald, I. C. (2002) · Nature reviews. Cancer · doi:10.1038/nrc865 · Cited by 4,018

Flagged first, then by citations

Show all 62 references

Sorted by citations

Items 701–800 of 1,001

Exosomes in Parkinson: Revisiting Their Pathologic Role and Potential Applications
Ouerdane, Y., Hassaballah, M. Y., Nagah, A., Ibrahim, T. M., Mohamed, H. A. H., El-Baz, A., & Attia, M. S. (2022) · Pharmaceuticals · doi:10.3390/ph15010076 · Cited by 31
Stresses in the metastatic cascade: molecular mechanisms and therapeutic opportunitiesPreprint
Shen, M., & Kang, Y. (2020) · Genes & Development · doi:10.1101/gad.343251.120 · Cited by 31
The origin of brain malignancies at the blood–brain barrier
McDonald, B., Barth, K., & Schmidt, M. H. H. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04934-1 · Cited by 29
The Potential of MicroRNAs in Personalized Medicine against Cancers
Saumet, A., Mathelier, A., & Lecellier, C. (2014) · BioMed Research International · doi:10.1155/2014/642916 · Cited by 30
Extracellular vesicle-mediated nucleic acid transfer and reprogramming in the tumor microenvironment
Parayath, N. N., Padmakumar, S., & Amiji, M. M. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.04.009 · Cited by 31
Potential miRNAs for miRNA-Based Therapeutics in Breast Cancer
Wong, J. S., & Cheah, Y. K. (2020) · Non-Coding RNA · doi:10.3390/ncrna6030029 · Cited by 32
A review on exosome-based cancer therapy
Schulze, A. T. V., & Deng, F. (2020) · Journal of Cancer Metastasis and Treatment · doi:10.20517/2394-4722.2020.79 · Cited by 30
Diverse roles of EV-RNA in cancer progression
Cocks, A., Martinez‐Rodriguez, V., Vecchio, F. D., Schukking, M., Broseghini, E., Giannakopoulos, S., & Fabbri, M. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.11.022 · Cited by 31
High TSPAN8 expression in epithelial cancer cell‐derived small extracellular vesicles promote confined diffusion and pronounced uptake
Wang, T., Wang, X., Wang, H., Li, L., Zhang, C., Xiang, R., Tan, X., Li, Z., Jiang, C., Zheng, L., et al. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12167 · Cited by 30
Insights into the Molecular Mechanisms Mediating Extravasation in Brain Metastasis of Breast Cancer, Melanoma, and Lung Cancer
Alsabbagh, R., Ahmed, M., Alqudah, M. A. Y., Hamoudi, R., & Harati, R. (2023) · Cancers · doi:10.3390/cancers15082258 · Cited by 30
MicroRNA and Breast Cancer: Understanding Pathogenesis, Improving Management
Eastlack, S. C., & Alahari, S. K. (2015) · Non-Coding RNA · doi:10.3390/ncrna1010017 · Cited by 32
Transfer of Extracellular Vesicle-Associated-RNAs Induces Drug Resistance in ALK-Translocated Lung Adenocarcinoma
Kwok, H., Ning, Z., Chong, P., Wan, T. S. K., Ng, M. H. L., Ho, G. Y. F., Ip, M., & Lam, D. C.-L. (2019) · Cancers · doi:10.3390/cancers11010104 · Cited by 31
“miRNA could be packaged and enriched in EVs and then actively secreted in extracellular space for trans-cellular communication, taking part in oncogenic processes like tumour metastasis [23,31], angiogenesis [22], and chemoresistance [32].”
Background
Epigenetic regulation of breast cancer metastasis
Thakur, C., Qiu, Y., Pawar, A. S., & Chen, F. (2023) · Cancer and Metastasis Reviews · doi:10.1007/s10555-023-10146-7 · Cited by 31
“In breast cancer, the tumor cell–derived EV carrying miR-105 dismantled the endothelial cell barrier via decreasing the tight junction zonula occludens 1 (ZO-1) protein, thereby enhancing the metastasis at PMN [71].”
Non-coding RNAs as therapeutic targets in cancer and its clinical application
Leng, X., Zhang, M., Xu, Y., Wang, J., Ding, N., Yu, Y., Sun, S., Dai, W., Xue, X., Li, N., et al. (2024) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2024.02.001 · Cited by 31
“Promotes proliferation [387]. miR-127 Inhibits cell growth [388]. miR-105 Promotes metastasis [389]. miR-126, miR-335 Reduces overall tumour growth and proliferation; inhibits metastatic cell invasion [390]. miR-146a Reduces the activity of the pathway [391]. miR-17-5p Inhibits cell proliferation…”
Background
Implications of Extracellular Vesicle Transfer on Cellular Heterogeneity in Cancer: What Are the Potential Clinical Ramifications?
Zomer, A., & van Rheenen, J. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-2804 · Cited by 31
Different erythrocyte MicroRNA profiles in low- and high-altitude individuals.
Sun, L., Fan, F., Li, R., Niu, B., Zhu, L., Yu, S., Wang, S., Li, C., & Wang, D. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01099 · Cited by 25
microRNAs in the Antitumor Immune Response and in Bone Metastasis of Breast Cancer: From Biological Mechanisms to Therapeutics
Gomarasca, M., Maroni, P., Banfi, G., & Lombardi, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21082805 · Cited by 30
Circulating Exosomal Integrin β3 Is Associated with Intracranial Failure and Survival in Lung Cancer Patients Receiving Cranial Irradiation for Brain Metastases: A Prospective Observational Study
Chen, G.-Y., Cheng, J. C., Chen, Y., Yang, J. C., & Hsu, F. (2021) · Cancers · doi:10.3390/cancers13030380 · Cited by 29
Plant-derived xenomiRs and cancer: Cross-kingdom gene regulation
Alshehri, B. (2021) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2021.01.039 · Cited by 30
Engineered models of tumor metastasis with immune cell contributions
Graney, P. L., Tavakol, D. N., Chramiec, A. G., Ronaldson-Bouchard, K., & Vunjak‐Novakovic, G. (2021) · iScience · doi:10.1016/j.isci.2021.102179 · Cited by 30
Transcriptional overlap links DNA hypomethylation with DNA hypermethylation at adjacent promoters in cancer
Fain, J. S., Loriot, A. E., Diacofotaki, A., Tongelen, A. V., & Smet, C. D. (2021) · Scientific Reports · doi:10.1038/s41598-021-96844-0 · Cited by 29
Exosomes: A Forthcoming Era of Breast Cancer Therapeutics
Bondhopadhyay, B., Sisodiya, S., Alzahrani, F. A., Bakhrebah, M. A., Chikara, A., Kasherwal, V., Khan, A., Rani, J., Dar, S. A., Akhter, N., et al. (2021) · Cancers · doi:10.3390/cancers13184672 · Cited by 29
Protective effects of galangin against H2O2/UVB-induced dermal fibroblast collagen degradation via hsa-microRNA-4535-mediated TGFβ/Smad signaling
Lee, J., Ng, S., Ni, Y.-T., Liu, J., Chen, C., Padma, V. V., Huang, C., & Kuo, W. (2021) · Aging · doi:10.18632/aging.203750 · Cited by 31
Exosomal microRNA-23b-3p promotes tumor angiogenesis and metastasis by targeting PTEN in salivary adenoid cystic carcinoma
Hou, C.-X., Sun, N., Han, W., Meng, Y., Wang, C., Zhu, Q., Tang, Y., & Ye, J. (2022) · Carcinogenesis · doi:10.1093/carcin/bgac033 · Cited by 29
Exosomes and mimics as novel delivery platform for cancer therapy
Yang, F., Wang, M., & Guan, X. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1001417 · Cited by 30
Exosomes and cancer immunotherapy: A review of recent cancer research
Cao, Y., Xu, P., Shen, Y., Wu, W., Chen, M., Wang, F., Zhu, Y., Yan, F., Gu, W., & Lin, Y. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2022.1118101 · Cited by 28
The biological function of tumor-derived extracellular vesicles on metabolism
Fu, X., Song, J., Yan, W., Downs, B. M., Wang, W., & Li, J. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01111-6 · Cited by 30
Tumor Mesenchymal Stromal Cells Regulate Cell Migration of Atypical Teratoid Rhabdoid Tumor through Exosome-Mediated miR155/SMARCA4 Pathway
Yang, Y.-P., Nguyen, P. N. N., Ma, H.-I., Ho, W.-J., Chen, Y., Chien, Y., Yarmishyn, A. A., Huang, P., Lo, W., Wang, C., et al. (2019) · Cancers · doi:10.3390/cancers11050720 · Cited by 28
The Role of Exosomes in Thyroid Cancer and Their Potential Clinical Application
Feng, K., Ma, R., Zhang, L., Li, H., Tang, Y., Du, G., Niu, D., & Yin, D. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.596132 · Cited by 28
Calibration-free analysis of surface proteins on single extracellular vesicles enabled by DNA nanostructure
Guo, K., Li, Z., Win, A. A., Coreas, R., Adkins, G. B., Cui, X., Yan, D. M., Cao, M., Wang, S. E., & Zhong, W. (2021) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2021.113502 · Cited by 28
Hypoxic stress suppresses lung tumor-secreted exosomal miR101 to activate macrophages and induce inflammation
Li, J., Xu, P., Wu, D., Guan, M.-J., Weng, X., Lu, Y., Zeng, Y., & Chen, R. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04030-x · Cited by 28
Exosomes and Brain Metastases: A Review on Their Role and Potential Applications
Oliveira, F. D., Castanho, M. A. R. B., & Neves, V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910899 · Cited by 30
Formation, contents, functions of exosomes and their potential in lung cancer diagnostics and therapeutics
Xia, Z., Qing, B., Wang, W., Gu, L., Chen, H., & Yuan, Y. (2021) · Thoracic Cancer · doi:10.1111/1759-7714.14217 · Cited by 28
The Landscape of PDK1 in Breast Cancer
Wang, N., Fu, J., Li, Z., Jiang, N., Chen, Y., & Peng, J. (2022) · Cancers · doi:10.3390/cancers14030811 · Cited by 31
Extracellular vesicles as central regulators of blood vessel function in cancer
Kugeratski, F. G., Santi, A., & Zanivan, S. R. (2022) · Science Signaling · doi:10.1126/scisignal.aaz4742 · Cited by 31
Loss of endothelial EMCN drives tumor lung metastasis through the premetastatic niche
Zhang, G., Li, M., Zhou, D.-D., Yang, X., Zhang, W., & Gao, R. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03649-4 · Cited by 28
The role of non-coding RNAs in extracellular vesicles in breast cancer and their diagnostic implications
Samuels, M. E., Jones, W., Towler, B. P., Turner, C., Robinson, S., & Giamas, G. (2023) · Oncogene · doi:10.1038/s41388-023-02827-y · Cited by 33
“Transfer of miR-105 from BC cells to ECs occurs in an EV-mediated fashion [56]. miR-105 is upregulated in metastatic BC cell lines compared to primary breast cell lines and even more so in EVs, indicating selective packaging of miR-105 into EVs. miR-105 targets Zonula occludens-1 (ZO-1), reducing…”
Non-coding RNAs’ function in cancer development, diagnosis and therapy
Zhang, X., Xu, X., Song, J., Xu, Y., Qian, H., Jin, J., & Liang, Z. F. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115527 · Cited by 29
Exosomes: Emerging Players of Intercellular Communication in Tumor Microenvironment
Maheshwari, S., Singh, A. K., Arya, R. K., Pandey, D., Singh, A., & Datta, D. B. (2014) · Discoveries · doi:10.15190/d.2014.18 · Cited by 28
Aberrant Expression of miR-362 Promotes Lung Cancer Metastasis through Downregulation of Sema3A
Luo, D., Zhang, Z., Zhang, Z., Li, J., Cui, J., Shi, W., Dong, X., Yuan, L., Lin, P., Chen, Z., et al. (2018) · Journal of Immunology Research · doi:10.1155/2018/1687097 · Cited by 28
Potential value of circulatory microRNA122 gene expression as a prognostic and metastatic prediction marker for breast cancer
Saleh, A. A., Soliman, S. E.-S., Habib, M. S. E., Gohar, S. F., & Abo-Zeid, G. S. (2019) · Molecular Biology Reports · doi:10.1007/s11033-019-04727-5 · Cited by 28
Diversity of Vascular Niches in Bones and Joints During Homeostasis, Ageing, and Diseases
Kumar, N. R., Saraber, P. J. M. H., Ding, Z., & Kusumbe, A. P. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.798211 · Cited by 29
Paper-based biosensors as point-of-care diagnostic devices for the detection of cancers: a review of innovative techniques and clinical applications
Mahmoodpour, M., Kiasari, B. A., Karimi, M., Abroshan, A., Shamshirian, D., Hosseinalizadeh, H., Delavari, A., & Mirzei, H. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1131435 · Cited by 28
Advancements in liquid biopsy for breast Cancer: Molecular biomarkers and clinical applications
Qiu, P., Yu, X., Zheng, F., Gu, X., Huang, Q., Qin, K., Hu, Y., Liu, B., Xu, T., Zhang, T., et al. (2025) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2025.102979 · Cited by 34
Prognostic relevance of miR‐137 in patients with hepatocellular carcinoma
Sakabe, T., Azumi, J., Umekita, Y., Toriguchi, K., Hatano, E., Hirooka, Y., & Shiota, G. (2016) · Liver International · doi:10.1111/liv.13213 · Cited by 27
Epithelial-Mesenchymal Plasticity in Organotropism Metastasis and Tumor Immune Escape
Nan, X., Wang, J., Liu, H. N., Wong, S. T. C., & Zhao, H. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8050747 · Cited by 27
Rab27a plays a dual role in metastatic propensity of pancreatic cancer
Kren, N. P., Michaud, D. E., Bagchi, S., Greene, K. G., & Pylayeva‐Gupta, Y. (2020) · Scientific Reports · doi:10.1038/s41598-020-64248-1 · Cited by 27
MicroRNAs in breast cancer: New maestros defining the melody
Khalife, H., Skafi, N., Fayyad‐Kazan, M., & Badran, B. M. (2020) · Cancer Genetics · doi:10.1016/j.cancergen.2020.08.005 · Cited by 28
Cancer-secreted miRNAs regulate amino-acid-induced mTORC1 signaling and fibroblast protein synthesis
Fong, M., Yan, W., Ghassemian, M., Wu, X., Zhou, X., Cao, M., Jiang, L., Wang, J., Liu, X., Zhang, J., et al. (2020) · EMBO Reports · doi:10.15252/embr.202051239 · Cited by 27
“IHC and ISH were performed as previously described (Tsuyada et al , 2012; Zhou et al , 2014; Fong et al , 2015), using anti-RAGC (Cell Signaling Technology; #5466; 1:4,000 dilution) and probes for miR-105 and miR-204 (Exiqon; Denmark; #38476-15 and #619857-360, respectively).”
Influential
MicroRNAs and Extracellular Vesicles as Distinctive Biomarkers of Precocious and Advanced Stages of Breast Cancer Brain Metastases Development
Figueira, I., Godinho-Pereira, J., Galego, S., Maia, J., Haskó, J., Molnár, K., Malhó, R., Costa‐Silva, B., Wilhelm, I., Krizbai, I. A., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105214 · Cited by 28
Pancreatic cancer cell-derived exosomes induce epithelial-mesenchymal transition in human pancreatic cancer cells themselves partially via transforming growth factor β1
Nakayama, F., Miyoshi, M., Kimoto, A., Kawano, A., Miyashita, K., Kamoshida, S., Shimizu, K., & Hori, Y. (2022) · Medical Molecular Morphology · doi:10.1007/s00795-022-00321-0 · Cited by 27
Frontier Review of the Molecular Mechanisms and Current Approaches of Stem Cell-Derived Exosomes
Chen, L.-Y., Kao, T., Chen, C.-C., Niaz, N., Lee, H., Chen, Y., Kuo, C., & Shen, Y. (2023) · Cells · doi:10.3390/cells12071018 · Cited by 29
Vasculature organotropism in drug delivery
Amruta, A., Iannotta, D., Cheetham, S. W., Lammers, T., & Wolfram, J. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.115054 · Cited by 29
EV-miRNA-Mediated Intercellular Communication in the Breast Tumor Microenvironment
Sepúlveda, F., Mayorga-Lobos, C., Guzmán, K., Durán-Jara, E., & Lobos‐González, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713085 · Cited by 29
Circulating Exosomes Isolated from Septic Mice Induce Cardiovascular Hyperpermeability Through Promoting Podosome Cluster Formation
Mu, X., Wang, X., Huang, W. C., Wang, R., Essandoh, K., Li, Y., Pugh, A. M., Peng, J., Deng, S., Wang, Y., et al. (2017) · Shock · doi:10.1097/shk.0000000000000928 · Cited by 27
miR-93-5p suppresses cellular senescence by directly targeting Bcl-w and p21
Choi, J. Y., Shin, H. J., & Bae, I. H. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.10.010 · Cited by 27
Replication study: Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
Kim, J., Afshari, A., Sengupta, R., Sebastiano, V., Gupta, A. A., Kim, Y. H., Reproducibility Project: Cancer Biology, Iorns, E. J., Tsui, R., Denis, A., et al. (2018) · eLife · doi:10.7554/elife.39944 · Cited by 27
“Since that publication, additional studies have reported in different models that tumor derived exosomes administered to mice prior to tumor cell injection increased metastatic burden by inducing pre-metastatic niche formation (Costa-Silva et al., 2015; Fong et al., 2015; Hoshino et al., 2015; Liu et al., 2016; Pleban…”
Empowering Exosomes with Aptamers for Precision Theranostics
Zheng, L., Li, J., Li, Y., Sun, W., Ma, L., Qu, F., & Tan, W. (2025) · Small Methods · doi:10.1002/smtd.202400551 · Cited by 21
Engineered Extracellular Vesicles as a New Class of Nanomedicine
Wen, X., Hao, Z., Yin, H., Min, J., Wang, X., Sun, S., & Ruan, G. (2024) · Chem & Bio Engineering · doi:10.1021/cbe.4c00122 · Cited by 26
Extracellular Vesicles in Cancer
Clancy, J. W., & D’Souza‐Schorey, C. (2018) · The Cancer Journal · doi:10.1097/ppo.0000000000000306 · Cited by 26
Endothelial Microvesicles Induce Pulmonary Vascular Leakage and Lung Injury During Sepsis
Zheng, D., Zhang, J., Zhang, Z., Kuang, L., Zhu, Y., Wu, Y., Xue, M., Zhao, H., Duan, C., Liu, L., et al. (2020) · Frontiers in Cell and Developmental Biology · doi:10.2139/ssrn.3543574 · Cited by 26
The Multifaceted Role of Extracellular Vesicles in Glioblastoma: microRNA Nanocarriers for Disease Progression and Gene Therapy
Simionescu, N., Zonda, R., Petrovici, A. R., & Georgescu, A. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13070988 · Cited by 28
Role of exosomes and its emerging therapeutic applications in the pathophysiology of non-infectious diseases
Shivji, G. G., Dhar, R., & Devi, A. (2022) · Biomarkers · doi:10.1080/1354750x.2022.2067233 · Cited by 26
Recent Advances in Detection for Breast-Cancer-Derived Exosomes
Tang, Q., Xiao, X., Li, R., He, H., Li, S., & Ma, C. (2022) · Molecules · doi:10.3390/molecules27196673 · Cited by 27
Formation of pre-metastatic niches induced by tumor extracellular vesicles in lung metastasis
Liu, Y., Mao, D., Wang, H., Che, X., & Chen, Y. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106669 · Cited by 27
Complex metastatic niches: already a target for therapy?
Ordóñez‐Morán, P., & Huelsken, J. (2014) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2014.06.012 · Cited by 26
miRNAs in Health and Disease: A Focus on the Breast Cancer Metastatic Cascade towards the Brain
Sereno, M., Videira, M., Wilhelm, I., Krizbai, I. A., & Brito, M. A. (2020) · Cells · doi:10.3390/cells9081790 · Cited by 28
The Interplay between Tumour Microenvironment Components in Malignant Melanoma
Amălinei, C., Grigoraş, A., Lozneanu, L., Căruntu, I.-D., Giuşcă, S. E., & Balan, R. A. (2022) · Medicina · doi:10.3390/medicina58030365 · Cited by 27
Metastatic Dissemination: Role of Tumor-Derived Extracellular Vesicles and Their Use as Clinical Biomarkers
Giusti, I., Poppa, G., di Fazio, G., D’Ascenzo, S., & Dolo, V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119590 · Cited by 26
Single‐Cell Isolation Chip Integrated with Multicolor Barcode Array for High‐Throughput Single‐Cell Exosome Profiling in Tissue Samples
Wang, C., Zhang, Y., Wang, J., Han, Y., Wang, Y., Sun, M., Liang, Y., Huang, M., Yu, Y., Hu, H., et al. (2024) · Advanced Materials · doi:10.1002/adma.202411259 · Cited by 26
Liquid biopsy in gynecological cancers: a translational framework from molecular insights to precision oncology and clinical practice
Martinelli, C. V., Ercoli, A., Vizzielli, G., Burk, S. R., Cuomo, M., Satasiya, V., Kacem, H., Braccia, S., Mazzarotti, G., Miriello, I., et al. (2025) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-025-03371-1 · Cited by 26
Reduced miR-105-1 levels are associated with poor survival of patients with non‑small cell lung cancer
Lu, G., Fu, D., Jia, C., Chai, L., Han, Y., Liu, J., Wu, T., Xie, R., Chang, Z., Yang, H., et al. (2017) · Oncology Letters · doi:10.3892/ol.2017.7228 · Cited by 25
“However, another in vitro study revealed that cancer-secreted miR-105 destroyed vascular endothelial barriers and promoted cancer metastasis (14).”
MicroRNAs and Metastasis
Solé, C., & Lawrie, C. H. (2019) · Cancers · doi:10.3390/cancers12010096 · Cited by 27
The role of exosomes in tumour immunity under radiotherapy: eliciting abscopal effects?
Yin, T., Xin, H., Yu, J., & Teng, F. (2021) · Biomarker Research · doi:10.1186/s40364-021-00277-w · Cited by 25
Prion Protein of Extracellular Vesicle Regulates the Progression of Colorectal Cancer
Yun, C.-W., Lee, J., Go, G., Jeon, J., Yoon, S., & Lee, S. H. (2021) · Cancers · doi:10.3390/cancers13092144 · Cited by 25
Extracellular Vesicles as Mediators of Cancer Disease and as Nanosystems in Theranostic Applications
Burgos-Ravanal, R., Campos, A. V., Díaz‐Vesga, M. C., González, M. F., León, D., Lobos‐González, L., Leyton, L., Kogan, M. J., & Quest, A. F. G. (2021) · Cancers · doi:10.3390/cancers13133324 · Cited by 26
Circulating exosomal miRNAs and cancer early diagnosis
Zhu, L., Zhao, L., Wang, Q., Zhong, S., Guo, X., Zhu, Y., Bao, J., Xu, K., & Liu, S. (2021) · Clinical & Translational Oncology · doi:10.1007/s12094-021-02706-6 · Cited by 25
Exosomal HMGA2 protein from EBV-positive NPC cells destroys vascular endothelial barriers and induces endothelial-to-mesenchymal transition to promote metastasis
Li, D.-K., Chen, X.-R., Wang, L., Wang, J., Li, J.-K., Zhou, Z., Li, X., Cai, L., Zhong, S.-S., Zhang, J., et al. (2022) · Cancer Gene Therapy · doi:10.1038/s41417-022-00453-6 · Cited by 25
Circulating MicroRNAs as Cancer Biomarkers in Liquid Biopsies
Suárez, B., Solé, C., Márquez, M., Nanetti, F., & Lawrie, C. H. (2022) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-08356-3_2 · Cited by 27
Exosomes; multifaceted nanoplatform for targeting brain cancers
Mardi, N., Salahpour‐Anarjan, F., Nemati, M., Baher, N. S., Rahbarghazi‬, R., & Zarebkohan, A. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216077 · Cited by 25
Exosome Content–Mediated Signaling Pathways in Multiple Sclerosis
Mohammadinasr, M., Montazersaheb, S., Ayromlou, H., Hosseini, V., Molavi, O., & Hejazi, M. S. (2024) · Molecular Neurobiology · doi:10.1007/s12035-023-03862-2 · Cited by 28
“Accordingly, more research is needed to uncover exosomes’ potential benefits and limitations as a therapeutic tool in modulating BBB permeability [36, 46].”
Aged breast matrix bound vesicles promote breast cancer invasiveness
Yang, J., Bahçecioğlu, G., Ronan, G., & Zorlutuna, P. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122493 · Cited by 24
Identification of Biomarkers for Breast Cancer Using Databases
Lee, E., & Moon, A. (2016) · Journal of Cancer Prevention · doi:10.15430/jcp.2016.21.4.235 · Cited by 25
Breast Cancer Brain Metastases: Clonal Evolution in Clinical Context
Saunus, J. M., Reed, A. E. M., Lim, M., & Lakhani, S. R. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18010152 · Cited by 25
“Mechanistically this can involve vascular permeabilisation, angiogenesis, and extracellular matrix remodelling [16-18].”
Background
Clinical Perspectives in Brain MetastasisPreprint
Deshpande, K., Buchanan, I. A., Martirosian, V., & Neman, J. (2019) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a037051 · Cited by 25
Diversity of Intercellular Communication Modes: A Cancer Biology Perspective
Ebrahim, T., Ebrahim, A. S., & Kandouz, M. (2024) · Cells · doi:10.3390/cells13060495 · Cited by 25
“For instance, proteomic analysis of EVs collected from the NCI-60 human tumor cell line panel showed that they reflect the proteomes of their cells of origin [552], and showed an association between the abundance of a subgroup of proteins and specific cancer hallmark signatures [553].”
Background
Selective capture of iodine and toxic anionic dyes of a novel quaternary ammonium salt pillar[5]arene polymer with antibacterial activity
Chen, Y., Yang, M., Zhou, S.-L., Hu, C.-N., Yang, Y.-H., Zhang, Z., & Yang, L.-J. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.159974 · Cited by 24
Distinct Cargos of Small Extracellular Vesicles Derived from Hypoxic Cells and Their Effect on Cancer Cells
Walbrecq, G., Margue, C., Behrmann, I., & Kreis, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21145071 · Cited by 24
MicroRNAs in Metastasis and the Tumour Microenvironment
Solé, C., & Lawrie, C. H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094859 · Cited by 24
Metabolic Pathway of Monounsaturated Lipids Revealed by In-Depth Structural Lipidomics by Mass Spectrometry
Cheng, S., Zhang, D., Feng, J., Hu, Q., Tan, A., Xie, Z., Chen, Q., Huang, H., Wei, Y., Ouyang, Z., et al. (2023) · Research · doi:10.34133/research.0087 · Cited by 24
Cancer‐cell‐secreted extracellular vesicles target p53 to impair mitochondrial function in muscle
Ruan, X., Cao, M., Yan, W., Jones, Y., Gustafsson, Å. B., Patel, H. H., Schenk, S., & Wang, S. E. (2023) · EMBO Reports · doi:10.15252/embr.202256464 · Cited by 23
“These procedures were carried out as reported in Fong et al (2015), Yan et al (2018) and Zhou et al (2014).”
Exosomes in carcinogenesis: molecular palkis carry signals for the regulation of cancer progression and metastasis
Subramanian, A., Gupta, V. G., Sarkar, S., Maity, G., Banerjee, S., Ghosh, A., Harris, L., Christenson, L. K., Hung, W., Bansal, A. K., et al. (2016) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-016-0338-6 · Cited by 24
Intimate cross-talk between cancer cells and the tumor microenvironment of B-cell lymphomas: The key role of exosomes
Xu, B., & Wang, T. (2017) · Tumor Biology · doi:10.1177/1010428317706227 · Cited by 24
Secreted molecules inducing epithelial-to-mesenchymal transition in cancer development
Pozza, E. D., Forciniti, S., Palmieri, M., & Dando, I. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.06.027 · Cited by 24
MicroRNAs in Renal Diseases: A Potential Novel Therapeutic Target
Petrillo, F., Iervolino, A., Zacchia, M., Simeoni, A., Masella, C., Capolongo, G., Perna, A., Capasso, G., & Trepiccione, F. (2017) · Kidney Diseases · doi:10.1159/000481730 · Cited by 22
Inhibition of cancer cell migration with CuS@mSiO2-PEG nanoparticles by repressing MMP-2/MMP-9 expression
Deng, G., Zhou, F., Wu, Z., Zhang, F., Niu, K., Kang, Y., Liu, X., Wang, Q., Wang, Y., & Wang, Q. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s148487 · Cited by 24
“16 Therefore, inhibiting metastasis may be more essential for local tumor destruction.”
microRNA as a systemic intervention in the specific breast cancer subtypes with C‐MYC impacts; introducing subtype‐based appraisal tool
Pourteimoor, V., Paryan, M., & Mohammadi‐Yeganeh, S. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26399 · Cited by 24
Perspective: bidirectional exosomal transport between cancer stem cells and their fibroblast-rich microenvironment during metastasis formation
Valcz, G., Buzás, E. I., Szállási, Z., Kalmár, A., Krenács, T., Tulassay, Z., Igaz, P., & Molnár, B. (2018) · npj Breast Cancer · doi:10.1038/s41523-018-0071-9 · Cited by 27
Extracellular Matrix Structure and Interaction with Immune Cells in Adult Astrocytic Tumors
Vito, A. D., Donato, A., Bria, J., Conforti, F. S., Torre, D. L., Malara, N., & Donato, G. (2024) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-024-01488-z · Cited by 23
“Interestingly, the increased vascular permeability induced by the cancer cells-released cytokines, chemokines, and microRNAs could also contribute (Zhou et al. 2014; Tominaga et al. 2015).”
Background
The Inner and Outer Qualities of Extracellular Vesicles for Translational Purposes in Breast Cancer
Schwich, E., & Rebmann, V. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00584 · Cited by 24

Authors: Zhou, W., Fong, M. Y., Min, Y., Somlo, G., Liu, L., Palomares, M. R., Yu, Y., Chow, A., O’Connor, S. T. F., Chin, A. R., Yen, Y., Wang, Y., Marcusson, E. G., Chu, P., Wu, J., Wu, X., Li, A. X., Li, Z., Gao, H., Ren, X., Boldin, M. P., Lin, P. C., & Wang, S. E.
Affiliations: City Of Hope National Medical Center (US)
National Cancer Institute (US)
Regulus Therapeutics (United States) (US)
Tianjin Medical University Cancer Institute and Hospital (CN)
Corresponding author: Wang, Shizhen Emily
ORCID: Zhou, Weiying
Liu, Liang
Palomares, Melanie R.
Yu, Yang
Chow, Amy
Yen, Yun
Wang, Yafan
Marcusson, Eric G.
Wu, Jun
Wu, Xiwei
Li, Zhuo
Gao, Hanlin
Ren, Xiubao
Boldin, Mark P.
Wang, Shizhen Emily
Venue: Cancer Cell
Publisher: Elsevier BV
Published: 2014-04
Volume: 25
Issue: 4
Pages: 501-515
ISSN: 1535-6108 (ISSN-L)
DOI: 10.1016/j.ccr.2014.03.007
PMC: PMC4016197
OpenAlex: W2143839116
Cited by: 1,476
References: 62
Citations by year: 2026: 61 · 2025: 91 · 2024: 113 · 2023: 145 · 2022: 164 · 2021: 175 · 2020: 148 · 2019: 152 · 2018: 118 · 2017: 111 · 2016: 97 · 2015: 72 · 2014: 28
FWCI: 32.89
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 378 d)
Locations: Cancer Cell (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: American Association for Cancer Research
Breast Cancer Research Foundation (12-60-26-WANG)
Celgene
National Institutes of Health
National Key Research and Development Program of China (2012CB9333004)
National Cancer Institute (P30CA-33572, R01CA166020, R01CA163586, P30CA033572)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Keywords: miR-105, metastasis, breast cancer, ZO-1, tight junctions, endothelial barrier integrity, exosomes, vascular permeability, metastatic progression
MeSH terms: Breast Neoplasms, Cell Movement, Endothelium, Vascular, Female, Humans, Neoplasm Metastasis, Biomarkers, Tumor, MicroRNAs, Cell Line, Tumor, Cell Growth Processes

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Cancer-Secreted miR-105 Destroys Vascular Endothelial Barriers to Promote Metastasis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks