The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
Cancer-Secreted miR-105 Destroys Vascular Endothelial Barriers to Promote Metastasis
Open accessAbstract
Cancer-secreted microRNAs (miRNAs) are emerging mediators of cancer-host crosstalk. Here we show that miR-105, which is characteristically expressed and secreted by metastatic breast cancer cells, is a potent regulator of migration through targeting the tight junction protein ZO-1. In endothelial monolayers, exosome-mediated transfer of cancer-secreted miR-105 efficiently destroys tight junctions and the integrity of these natural barriers against metastasis. Overexpression of miR-105 in nonmetastatic cancer cells induces metastasis and vascular permeability in distant organs, whereas inhibition of miR-105 in highly metastatic tumors alleviates these effects. miR-105 can be detected in the circulation at the premetastatic stage, and its levels in the blood and tumor are associated with ZO-1 expression and metastatic progression in early-stage breast cancer.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Many studies have also demonstrated that extracellular miRNAs can exert biological functions in recipient cells to regulate their activity, thereby acting as intercellular signaling molecules.”
From Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation (2018) · cites this paper as [134]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
RETRACTED: MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer
Taylor, D. D., & Gerçel-Taylor, Ç. (2008) · Gynecologic Oncology · doi:10.1016/j.ygyno.2008.04.033 · Cited by 2,333
RetractedValadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834
Circulating microRNAs as stable blood-based markers for cancer detection
Mitchell, P. S., Parkin, R. K., Kroh, E. M., Fritz, B. R., Wyman, S. K., Pogosova-Agadjanyan, E. L., Peterson, A., Noteboom, J., O'Briant, K. C., Allen, A., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804549105 · Cited by 7,969
MicroRNA signatures in human cancers
Calin, G. A., & Croce, C. M. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1997 · Cited by 7,668
Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids
Théry, C., Amigorena, S., Raposo, G., & Clayton, A. (2006) · Current Protocols in Cell Biology · doi:10.1002/0471143030.cb0322s30 · Cited by 5,766
Exosomes: composition, biogenesis and function
Théry, C., Zitvogel, L., & Amigorena, S. (2002) · Nature reviews. Immunology · doi:10.1038/nri855 · Cited by 5,478
The distribution of secondary growths in cancer of the breast.
Paget, S. (1889) · The Lancet · doi:10.1016/s0140-6736(00)49915-0 · Cited by 5,277
Skog, J., Würdinger, T., van Rijn, S., Meijer, D. H., Gainche, L., Curry, W. T., Carter, B. S., Krichevsky, A. M., & Breakefield, X. O. (2008) · Nature Cell Biology · doi:10.1038/ncb1800 · Cited by 5,001
MicroRNA Gene Expression Deregulation in Human Breast Cancer
Iorio, M. V., Ferracin, M., Liu, C.-G., Veronese, A., Spizzo, R., Sabbioni, S., Magri, E., Pedriali, M., Fabbri, M., Campiglio, M., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1783 · Cited by 4,053
Dissemination and growth of cancer cells in metastatic sites
Chambers, A. F., Groom, A. C., & MacDonald, I. C. (2002) · Nature reviews. Cancer · doi:10.1038/nrc865 · Cited by 4,018
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
Peinado, H., Alečković, M., Lavotshkin, S., Matei, I., Costa-Silva, B., Moreno-Bueno, G., Hergueta-Redondo, M., Williams, C., García-Santos, G., Ghajar, C. M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2753 · Cited by 3,715
Arroyo, J. D., Chevillet, J. R., Kroh, E. M., Ruf, I. K., Pritchard, C. C., Gibson, D. F., Mitchell, P. S., Bennett, C. F., Pogosova-Agadjanyan, E. L., Stirewalt, D. L., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019055108 · Cited by 3,294
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
Kaplan, R. N., Riba, R. D., Zacharoulis, S., Bramley, A. H., Vincent, L., Costa, C., MacDonald, D. D., Jin, D. K., Shido, K., Kerns, S. A., et al. (2005) · Nature · doi:10.1038/nature04186 · Cited by 3,288
MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins
Vickers, K. C., Palmisano, B. T., Shoucri, B. M., Shamburek, R. D., & Remaley, A. T. (2011) · Nature Cell Biology · doi:10.1038/ncb2210 · Cited by 2,741
Characterization of extracellular circulating microRNA
Turchinovich, A., Weiz, L., Langheinz, A., & Burwinkel, B. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr254 · Cited by 1,941
MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response
Fabbri, M., Paone, A., Calore, F., Galli, R., Gaudio, E., Santhanam, R., Lovat, F., Fadda, P., Mao, C., Nuovo, G. J., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209414109 · Cited by 1,434
The metastatic niche: adapting the foreign soil
Psaila, B., & Lyden, D. C. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2621 · Cited by 1,344
Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration
Luga, V., Zhang, L., Viloria-Petit, A. M., Ogunjimi, A. A., Inanlou, M. R., Chiu, E., Buchanan, M., Hosein, A. N., Basik, M., & Wrana, J. L. (2012) · Cell · doi:10.1016/j.cell.2012.11.024 · Cited by 1,311 · cited 1×
“In contrast, exosomes secreted by stromal fibroblasts promote BC cell protrusion and motility through Wntplanar cell polarity signaling (Luga et al., 2012).”
Secreted Monocytic miR-150 Enhances Targeted Endothelial Cell Migration
Zhang, Y., Liu, D., Chen, X., Li, J., Li, L., Bian, Z., Sun, F., Lu, J., Yin, Y., Cai, X. F., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.06.010 · Cited by 1,219
Exosomes Released by Melanoma Cells Prepare Sentinel Lymph Nodes for Tumor Metastasis
Hood, J. L., San, R. S., & Wickline, S. A. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-4455 · Cited by 1,056
Crosstalk of tight junction components with signaling pathways
González-Mariscal, L., Tapia, R., & Chamorro, D. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.08.018 · Cited by 759
Circulating microRNAs as Novel Minimally Invasive Biomarkers for Breast Cancer
Heneghan, H., Miller, N., Lowery, A., Sweeney, K., Newell, J., & Kerin, M. J. (2010) · Annals of Surgery · doi:10.1097/sla.0b013e3181cc939f · Cited by 685
Selective Release of MicroRNA Species from Normal and Malignant Mammary Epithelial Cells
Pigati, L., Yaddanapudi, S. C., Iyengar, R., Kim, D.-J., Hearn, S., Danforth, D. N., Hastings, M. L., & Duelli, D. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013515 · Cited by 601
Regulation of In Situ to Invasive Breast Carcinoma Transition
Hu, M., Yao, J., Carroll, D. K., Weremowicz, S., Chen, H., Carrasco, D. R., Richardson, A. L., Violette, S. M., Nikolskaya, T., Nikolsky, Y., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.03.007 · Cited by 513
Loss of tight junction barrier function and its role in cancer metastasis
Martin, T. A., & Jiang, W. G. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2008.11.005 · Cited by 493
Newman, A. C., Nakatsu, M. N., Chou, W., Gershon, P. D., & Hughes, C. C. W. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-05-0393 · Cited by 492
Zhuang, G., Wu, X., Jiang, Z., Kasman, I. M., Yao, J. J., Guan, Y., Oeh, J., Modrusan, Z. D., Bais, C., Sampath, D., et al. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.183 · Cited by 482
Wang, S. E., Narasanna, A., Pérez-Torres, M., Xiang, B., Wu, F. Y., Yang, S., Carpenter, G. F., Gazdar, A. F., Muthuswamy, S. K., & Arteaga, C. L. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.05.023 · Cited by 479
Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structure
Shen, L., Black, E. D., Witkowski, E. D., Lencer, W. I., Guerriero, V., Schneeberger, E. E., & Turner, J. R. (2006) · Journal of Cell Science · doi:10.1242/jcs.02915 · Cited by 467
Circulating microRNAs as blood-based markers for patients with primary and metastatic breast cancer
Roth, C., Rack, B. K., Müller, V., Janni, W., Pantel, K., & Schwarzenbach, H. (2010) · Breast Cancer Research · doi:10.1186/bcr2766 · Cited by 431
Improved targeting of miRNA with antisense oligonucleotides
Davis, S. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl183 · Cited by 422
Tsuyada, A., Chow, A., Wu, J., Somlo, G., Chu, P. G., Loera, S., Luu, T. H., Li, A. X., Wu, X., Ye, W., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-3567 · Cited by 420
Transfer of MicroRNAs by Embryonic Stem Cell Microvesicles
Yuan, A., Farber, E. L., Rapoport, A. L., Tejada, D., Deniskin, R., Akhmedov, N. B., & Farber, D. B. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004722 · Cited by 416
Systematic evaluation of microRNA processing patterns in tissues, cell lines, and tumors
Lee, E. J., Baek, M., Gusev, Y., Brackett, D. J., Nuovo, G. J., & Schmittgen, T. D. (2008) · RNA · doi:10.1261/rna.804508 · Cited by 414
Unravelling the complexity of metastasis — molecular understanding and targeted therapies
Sethi, N. S., & Kang, Y. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3125 · Cited by 405
Circulating microRNAs in breast cancer and healthy subjects
Zhu, W., Qin, W., Atasoy, U., & Sauter, E. R. (2009) · BMC Research Notes · doi:10.1186/1756-0500-2-89 · Cited by 360
Structural and Functional Regulation of Tight Junctions by RhoA and Rac1 Small GTPases
Jou, T.-S., Schneeberger, E. E., & James Nelson, W. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.142.1.101 · Cited by 354
MCF10DCIS.com Xenograft Model of Human Comedo Ductal Carcinoma In Situ
Miller, F. R., Santner, S. J., Tait, L. R., & Dawson, P. J. (2000) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/92.14.1185a · Cited by 344
Lipid-based carriers of microRNAs and intercellular communication
Vickers, K. C., & Remaley, A. T. (2012) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328350a425 · Cited by 314
Jung, E., Santarpia, L., Kim, J., Esteva, F. J., Moretti, E., Buzdar, A. U., Leo, A. D., Le, X., Bast, R. C., Park, S., et al. (2011) · Cancer · doi:10.1002/cncr.26565 · Cited by 301
Seeding and Propagation of Untransformed Mouse Mammary Cells in the Lung
Podsypanina, K., Du, Y. N., Jechlinger, M., Beverly, L. J., Hambardzumyan, D., & VARMUS, H. E. (2008) · Science · doi:10.1126/science.1161621 · Cited by 300
Competitive Interactions of Cancer Cells and Normal Cells via Secretory MicroRNAs
Kosaka, N., Iguchi, H., Yoshioka, Y., Hagiwara, K., Takeshita, F., & Ochiya, T. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.288662 · Cited by 267
Wang, Y.-Z., Yu, Y., Tsuyada, A., Ren, X., Wu, X., Stubblefield, K., Rankin-Gee, E., & Wang, S. E. (2010) · Oncogene · doi:10.1038/onc.2010.531 · Cited by 263
Pulmonary Vascular Destabilization in the Premetastatic Phase Facilitates Lung Metastasis
Huang, Y., Song, N., Ding, Y., Yuan, S., Li, X., Cai, H., Shi, H., & Luo, Y. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4382 · Cited by 257
Wu, X., Somlo, G., Yu, Y., Palomares, M. R., Li, A. X., Zhou, W., Chow, A. Y., Yen, Y., Rossi, J. J., Gao, H., et al. (2012) · Journal of Translational Medicine · doi:10.1186/1479-5876-10-42 · Cited by 254
Cell-to-cell miRNA transfer: From body homeostasis to therapy
Redis, R. S., Calin, S., Yang, Y., You, M. J., & Călin, G. A. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.08.003 · Cited by 177
Itoh, M., & Bissell, M. (2003) · Journal of mammary gland biology and neoplasia · doi:10.1023/b:jomg.0000017431.45314.07 · Cited by 159
Rac Regulates Endothelial Morphogenesis and Capillary Assembly
Connolly, J. O., Simpson, N., Hewlett, L. J., & Hall, A. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-01-0006 · Cited by 157
Martin, T. A., Watkins, G., Mansel, R. E., & Jiang, W. G. (2004) · European Journal of Cancer · doi:10.1016/j.ejca.2004.08.008 · Cited by 154
Modulation of TLR2 Protein Expression by miR-105 in Human Oral Keratinocytes
Benakanakere, M. R., Li, Q., Eskan, M. A., Singh, A. V., Zhao, J., Galicia, J. C., Stathopoulou, P. G., Knudsen, T. B., & Kinane, D. F. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.013862 · Cited by 147
Georgiadis, A., Tschernutter, M., Bainbridge, J. W., Balaggan, K. S., Mowat, F. M., West, E. L., Munro, P., Thrasher, A. J., Matter, K., Balda, M. S., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015730 · Cited by 135
Metastatic breast cancer: an updating
Nicolini, A., Giardino, R., Carpi, A., Ferrari, P., Anselmi, L., Colosimo, S., Conte, M., Fini, M., Giavaresi, G., Berti, P., et al. (2006) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2006.07.086 · Cited by 122
Tight Junctions: A Barrier to the Initiation and Progression of Breast Cancer?
Brennan, K., Offiah, G., McSherry, E. A., & Hopkins, A. M. (2010) · BioMed Research International · doi:10.1155/2010/460607 · Cited by 108
Yu, Y., Wang, Y., Ren, X., Tsuyada, A., Li, A., Liu, L. J., & Wang, S. E. (2010) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-10-0362 · Cited by 86
Regulation of small GTPases at epithelial cell-cell junctions
Citi, S., Spadaro, D., Schneider, Y., Stutz, J., & Pulimeno, P. (2011) · Molecular membrane biology · doi:10.3109/09687688.2011.603101 · Cited by 77
Polette, M., Gilles, C., Nawrocki‐Raby, B., Lohi, J., Hunziker, W., Foidart, J., & Birembaut, P. L. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4230 · Cited by 73
Elhassan, M. O., Christie, J. L., & Duxbury, M. S. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.318865 · Cited by 66
miR-105 Inhibits Prostate Tumour Growth by Suppressing CDK6 Levels
Honeywell, D. R., Cabrita, M. A., Zhao, H., Dimitroulakos, J., & Addison, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070515 · Cited by 46
Yardley, D. A. (2010) · Clinical Breast Cancer · doi:10.3816/cbc.2010.n.009 · Cited by 40
Management of advanced breast cancer
Orlando, L., Colleoni, M. A., Fedele, P., Cusmai, A., Rizzo, P., D’Amico, M., Chetri, M. C., & Cinieri, S. (2007) · Annals of Oncology · doi:10.1093/annonc/mdm230 · Cited by 31
7. MANAGEMENT OF ADVANCED BREAST CANCER
Rubens, R. (2001) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2001.tb11161.x · Cited by 20
THE MANAGEMENT OF ADVANCED BREAST CANCER
Rubens, R. D. (1970) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1970.tb63183.x · Cited by 14
Cited by
Sorted by citations
The biology , function , and biomedical applications of exosomes
Kalluri, R., & LeBleu, V. S. (2020) · Science · doi:10.1126/science.aau6977 · Cited by 10,770
“miR-105 from breast cancer cell–derived exosomes suppresses endothelial tight junction ZO-1 (zonular occludens 1) expression, resulting in increased metastasis by impairing the integrity of blood vessels and enhancing vascular permeability (165).”
Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation
O'Brien, J., Hayder, H., Zayed, Y., & Peng, C. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00402 · Cited by 5,287
Tumour exosome integrins determine organotropic metastasis
Hoshino, A., Costa-Silva, B., Shen, T.-L., Rodrigues, G., Hashimoto, A., Tesic Mark, M., Molina, H., Kohsaka, S., Di Giannatale, A., Ceder, S., et al. (2015) · Nature · doi:10.1038/nature15756 · Cited by 5,101
Communication by Extracellular Vesicles: Where We Are and Where We Need to Go
Tkach, M., & Théry, C. (2016) · Cell · doi:10.1016/j.cell.2016.01.043 · Cited by 3,444
Exosome and Exosomal MicroRNA: Trafficking, Sorting, and Function
Zhang, J., Li, S., Li, L., Li, M., Guo, C., Yao, J., & Mi, S. (2015) · Genomics, Proteomics & Bioinformatics · doi:10.1016/j.gpb.2015.02.001 · Cited by 1,901
“For example, exosomal miR-105 released from the breast cancer cell lines MCF-10A and MDA-MB-231 reduced ZO - 1 gene expression in endothelial cells and promoted metastases to the lung and brain [70].”
Background
Metadata
- Authors
- Zhou, W., Fong, M. Y., Min, Y., Somlo, G., Liu, L., Palomares, M. R., Yu, Y., Chow, A., O’Connor, S. T. F., Chin, A. R., Yen, Y., Wang, Y., Marcusson, E. G., Chu, P., Wu, J., Wu, X., Li, A. X., Li, Z., Gao, H., Ren, X., Boldin, M. P., Lin, P. C., & Wang, S. E.
- Affiliations
- City Of Hope National Medical Center (US)
- National Cancer Institute (US)
- Regulus Therapeutics (United States) (US)
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Corresponding author
- Wang, Shizhen Emily
- ORCID
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2014-04
- Volume
- 25
- Issue
- 4
- Pages
- 501-515
- ISSN
- 1535-6108 (ISSN-L)
- PMC
- PMC4016197
- OpenAlex
- W2143839116
- Cited by
- 1,476
- References
- 62
- Citations by year
- 2026: 61 · 2025: 91 · 2024: 113 · 2023: 145 · 2022: 164 · 2021: 175 · 2020: 148 · 2019: 152 · 2018: 118 · 2017: 111 · 2016: 97 · 2015: 72 · 2014: 28
- FWCI
- 32.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cancer Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- American Association for Cancer Research
- Breast Cancer Research Foundation (12-60-26-WANG)
- Celgene
- National Institutes of Health
- National Key Research and Development Program of China (2012CB9333004)
- National Cancer Institute (P30CA-33572, R01CA166020, R01CA163586, P30CA033572)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Keywords
- miR-105, metastasis, breast cancer, ZO-1, tight junctions, endothelial barrier integrity, exosomes, vascular permeability, metastatic progression
- MeSH terms
- Breast Neoplasms, Cell Movement, Endothelium, Vascular, Female, Humans, Neoplasm Metastasis, Biomarkers, Tumor, MicroRNAs, Cell Line, Tumor, Cell Growth Processes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
