Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

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Items 101–124 of 124

  1. Inhibiting amyloid-β cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design
    Cao, Qin, Shin, Woo Shik, Chan, Henry, Vuong, Celine K., Dubois, Bethany, Li, Binsen, Murray, Kevin A., Sawaya, Michael R., Feigon, Juli, Black, Douglas L. et al. · 2018 · Nature Chemistry
  2. Reduction of cholesterol synthesis in the mouse brain does not affect amyloid formation in Alzheimer's disease, but does extend lifespan
    Halford, Rebekkah W., Russell, David W. · 2009 · Proceedings of the National Academy of Sciences
  3. Tribbles Pseudokinase 3 Induces Both Apoptosis and Autophagy in Amyloid-β-induced Neuronal Death
    Saleem, Suraiya, Biswas, Subhas Chandra · 2017 · Journal of Biological Chemistry
  4. The generation and function of soluble apoE receptors in the CNS
    Rebeck, G William, LaDu, Mary Jo, Estus, Steven, Bu, Guojun, Weeber, Edwin J · 2006 · Molecular Neurodegeneration
  5. Anti-inflammatory and Immune Therapy for Alzheimers Disease: Current Status and Future Directions
    Walker, Douglas, Lue, Lih-Fen · 2007 · Current Neuropharmacology
  6. Olfactory dysfunction: its early temporal relationship and neural correlates in the pathogenesis of Alzheimer’s disease
    Daulatzai, Mak Adam · 2015 · Journal of Neural Transmission
  7. Expression of BC1 Impairs Spatial Learning and Memory in Alzheimer’s Disease Via APP Translation
    Zhang, Tongmei, Pang, Pei, Fang, Zemin, Guo, Yu, Li, Hao, Li, Xinyan, Tian, Tian, Yang, Xin, Chen, Wenting, Shu, Shu et al. · 2018 · Molecular Neurobiology
  8. Tau acts as a mediator forAlzheimer's disease‐related synaptic deficits
    Liao, Dezhi, Miller, Eric C., Teravskis, Peter J. · 2014 · European Journal of Neuroscience
  9. BACE1 SUMOylation increases its stability and escalates the protease activity in Alzheimer’s disease
    Bao, Jian, Qin, Min, Mahaman, Yacoubou Abdoul Razak, Zhang, Bin, Huang, Fang, Zeng, Kuan, Xia, Yiyuan, Ke, Dan, Wang, Qun, Liu, Rong et al. · 2018 · Proceedings of the National Academy of Sciences
  10. Using near-infrared enhanced thermozyme and scFv dual-conjugated Au nanorods for detection and targeted photothermal treatment of Alzheimer's disease
    Liu, Dongni, Li, Wei, Jiang, Xiaoyu, Bai, Shuju, Liu, Jiyang, Liu, Xutong, Shi, Yuhua, Kuai, Ziyu, Kong, Wei, Gao, Renjun et al. · 2019 · Theranostics
  11. Adaptors for disorders of the brain? The cancer signaling proteins NEDD9, CASS4, and PTK2B in Alzheimer’s disease
    Beck, Tim N., Nicolas, Emmanuelle, Kopp, Meghan C., Golemis, Erica A. · 2014 · Oncoscience
  12. Synaptic contact number and size in stratum radiatum CA1 of APP/PS1ΔE9 transgenic mice
    West, Mark J., Bach, Georg, Søderman, Andreas, Jensen, Jens Ledet · 2009 · Neurobiology of Aging
  13. Oligodendrocytes are a Novel Source of Amyloid Peptide Generation
    Skaper, Stephen D., Evans, Nicholas A., Soden, Peter E., Rosin, Claudia, Facci, Laura, Richardson, Jill C. · 2009 · Neurochemical Research
  14. A Promising Approach: Magnetic Nanosystems for Alzheimer’s Disease Theranostics
    Chaparro, Catarina I. P., Simões, Beatriz T., Borges, João P., Castanho, Miguel A. R. B., Soares, Paula I. P., Neves, Vera · 2023 · Pharmaceutics
  15. Age-related changes of neuron numbers in the frontal cortex of a transgenic mouse model of Alzheimer’s disease
    Lemmens, Marijke A. M., Sierksma, Annerieke S. R., Rutten, Bart P. F., Dennissen, Frank, Steinbusch, Harry W. M., Lucassen, Paul J., Schmitz, Christoph · 2011 · Brain Structure and Function
  16. Influential role of 7-Ketocholesterol in the progression of Alzheimer’s disease
    Mahalakshmi, K., Parimalanandhini, D., Sangeetha, R., Livya Catherene, M., Beulaja, M., Thiagarajan, R., Arumugam, M., Janarthanan, S., Manikandan, R. · 2021 · Prostaglandins & Other Lipid Mediators
  17. Aβ impairs nicotinic regulation of inhibitory synaptic transmission and interneuron excitability in prefrontal cortex
    Chen, Guo-Jun, Xiong, Zhe, Yan, Zhen · 2013 · Molecular Neurodegeneration
  18. Effect and mechanism of fuzhisan and donepezil on the sirtuin 1 pathway and amyloid precursor protein metabolism in PC12 cells
    GUO, PENG, WANG, DESHENG, WANG, XIAOMIN, FENG, HONGLIN, TANG, YING, SUN, RUIHONG, ZHENG, YAN, DONG, LIN, ZHAO, JIAYING, ZHANG, XIN et al. · 2016 · Molecular Medicine Reports
  19. Evidence for three loci modifying age‐at‐onset of Alzheimer's disease in early‐onset PSEN2 families
    Marchani, Elizabeth E., Bird, Thomas D., Steinbart, Ellen J., Rosenthal, Elisabeth, Yu, Chang‐En, Schellenberg, Gerard D., Wijsman, Ellen M. · 2010 · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
  20. Genetic Variation in N-Methyl-D-Aspartate Receptor Subunit NR3A but Not NR3B Influences Susceptibility to Alzheimer’s Disease
    Liu, Hsin-Ping, Lin, Wei-Yong, Liu, Shu-Hsiang, Wang, Wen-Fu, Tsai, Chon-Haw, Wu, Bor-Tsang, Wang, Chien-Kuo, Tsai, Fuu-Jen · 2009 · Dementia and Geriatric Cognitive Disorders
  21. Emergence of distinct and heterogeneous strains of amyloid beta with advanced Alzheimer’s disease pathology in Down syndrome
    Maxwell, Alison M., Yuan, Peng, Rivera, Brianna M., Schaaf, Wilder, Mladinov, Mihovil, Prasher, Vee P., Robinson, Andrew C., DeGrado, William F., Condello, Carlo · 2021 · Acta Neuropathologica Communications
  22. Cyclopamine Modulates γ-Secretase-mediated Cleavage of Amyloid Precursor Protein by Altering Its Subcellular Trafficking and Lysosomal Degradation
    Vorobyeva, Anna G., Lee, Randall, Miller, Sean, Longen, Charles, Sharoni, Michal, Kandelwal, Preeti J., Kim, Felix J., Marenda, Daniel R., Saunders, Aleister J. · 2014 · Journal of Biological Chemistry
  23. Gamma secretase modulators and BACE inhibitors reduce Aβ production without altering gene expression in Alzheimer’s disease iPSC-derived neurons and mice
    Cusulin, Carlo, Wells, Isabelle, Badillo, Solveig, Duran-Pacheco, Gonzalo Christian, Baumann, Karlheinz, Patsch, Christoph · 2019 · Molecular and Cellular Neuroscience
  24. Inhibition of Acyl‐CoenzymeA: Cholesterol Acyltransferase 1 promotes shedding of soluble triggering receptor on myeloid cells 2 (TREM2) and low‐density lipoprotein receptor 1 (LRP1)‐dependent phagocytosis of amyloid beta protein in microglia
    Hovde, Moriah J., Maaser‐Hecker, Anna, Bae, Jun‐Seok, Tanzi, Rudolph E. · 2025 · Alzheimer's & Dementia