Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective
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- Inhibiting amyloid-β cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based designCao, Qin, Shin, Woo Shik, Chan, Henry, Vuong, Celine K., Dubois, Bethany, Li, Binsen, Murray, Kevin A., Sawaya, Michael R., Feigon, Juli, Black, Douglas L. et al. · 2018 · Nature Chemistry
- Reduction of cholesterol synthesis in the mouse brain does not affect amyloid formation in Alzheimer's disease, but does extend lifespanHalford, Rebekkah W., Russell, David W. · 2009 · Proceedings of the National Academy of Sciences
- Tribbles Pseudokinase 3 Induces Both Apoptosis and Autophagy in Amyloid-β-induced Neuronal DeathSaleem, Suraiya, Biswas, Subhas Chandra · 2017 · Journal of Biological Chemistry
- The generation and function of soluble apoE receptors in the CNSRebeck, G William, LaDu, Mary Jo, Estus, Steven, Bu, Guojun, Weeber, Edwin J · 2006 · Molecular Neurodegeneration
- Anti-inflammatory and Immune Therapy for Alzheimers Disease: Current Status and Future DirectionsWalker, Douglas, Lue, Lih-Fen · 2007 · Current Neuropharmacology
- Olfactory dysfunction: its early temporal relationship and neural correlates in the pathogenesis of Alzheimer’s diseaseDaulatzai, Mak Adam · 2015 · Journal of Neural Transmission
- Expression of BC1 Impairs Spatial Learning and Memory in Alzheimer’s Disease Via APP TranslationZhang, Tongmei, Pang, Pei, Fang, Zemin, Guo, Yu, Li, Hao, Li, Xinyan, Tian, Tian, Yang, Xin, Chen, Wenting, Shu, Shu et al. · 2018 · Molecular Neurobiology
- Tau acts as a mediator forAlzheimer's disease‐related synaptic deficitsLiao, Dezhi, Miller, Eric C., Teravskis, Peter J. · 2014 · European Journal of Neuroscience
- BACE1 SUMOylation increases its stability and escalates the protease activity in Alzheimer’s diseaseBao, Jian, Qin, Min, Mahaman, Yacoubou Abdoul Razak, Zhang, Bin, Huang, Fang, Zeng, Kuan, Xia, Yiyuan, Ke, Dan, Wang, Qun, Liu, Rong et al. · 2018 · Proceedings of the National Academy of Sciences
- Using near-infrared enhanced thermozyme and scFv dual-conjugated Au nanorods for detection and targeted photothermal treatment of Alzheimer's diseaseLiu, Dongni, Li, Wei, Jiang, Xiaoyu, Bai, Shuju, Liu, Jiyang, Liu, Xutong, Shi, Yuhua, Kuai, Ziyu, Kong, Wei, Gao, Renjun et al. · 2019 · Theranostics
- Adaptors for disorders of the brain? The cancer signaling proteins NEDD9, CASS4, and PTK2B in Alzheimer’s diseaseBeck, Tim N., Nicolas, Emmanuelle, Kopp, Meghan C., Golemis, Erica A. · 2014 · Oncoscience
- Synaptic contact number and size in stratum radiatum CA1 of APP/PS1ΔE9 transgenic miceWest, Mark J., Bach, Georg, Søderman, Andreas, Jensen, Jens Ledet · 2009 · Neurobiology of Aging
- Oligodendrocytes are a Novel Source of Amyloid Peptide GenerationSkaper, Stephen D., Evans, Nicholas A., Soden, Peter E., Rosin, Claudia, Facci, Laura, Richardson, Jill C. · 2009 · Neurochemical Research
- A Promising Approach: Magnetic Nanosystems for Alzheimer’s Disease TheranosticsChaparro, Catarina I. P., Simões, Beatriz T., Borges, João P., Castanho, Miguel A. R. B., Soares, Paula I. P., Neves, Vera · 2023 · Pharmaceutics
- Age-related changes of neuron numbers in the frontal cortex of a transgenic mouse model of Alzheimer’s diseaseLemmens, Marijke A. M., Sierksma, Annerieke S. R., Rutten, Bart P. F., Dennissen, Frank, Steinbusch, Harry W. M., Lucassen, Paul J., Schmitz, Christoph · 2011 · Brain Structure and Function
- Influential role of 7-Ketocholesterol in the progression of Alzheimer’s diseaseMahalakshmi, K., Parimalanandhini, D., Sangeetha, R., Livya Catherene, M., Beulaja, M., Thiagarajan, R., Arumugam, M., Janarthanan, S., Manikandan, R. · 2021 · Prostaglandins & Other Lipid Mediators
- Aβ impairs nicotinic regulation of inhibitory synaptic transmission and interneuron excitability in prefrontal cortexChen, Guo-Jun, Xiong, Zhe, Yan, Zhen · 2013 · Molecular Neurodegeneration
- Effect and mechanism of fuzhisan and donepezil on the sirtuin 1 pathway and amyloid precursor protein metabolism in PC12 cellsGUO, PENG, WANG, DESHENG, WANG, XIAOMIN, FENG, HONGLIN, TANG, YING, SUN, RUIHONG, ZHENG, YAN, DONG, LIN, ZHAO, JIAYING, ZHANG, XIN et al. · 2016 · Molecular Medicine Reports
- Evidence for three loci modifying age‐at‐onset of Alzheimer's disease in early‐onset PSEN2 familiesMarchani, Elizabeth E., Bird, Thomas D., Steinbart, Ellen J., Rosenthal, Elisabeth, Yu, Chang‐En, Schellenberg, Gerard D., Wijsman, Ellen M. · 2010 · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
- Genetic Variation in N-Methyl-D-Aspartate Receptor Subunit NR3A but Not NR3B Influences Susceptibility to Alzheimer’s DiseaseLiu, Hsin-Ping, Lin, Wei-Yong, Liu, Shu-Hsiang, Wang, Wen-Fu, Tsai, Chon-Haw, Wu, Bor-Tsang, Wang, Chien-Kuo, Tsai, Fuu-Jen · 2009 · Dementia and Geriatric Cognitive Disorders
- Emergence of distinct and heterogeneous strains of amyloid beta with advanced Alzheimer’s disease pathology in Down syndromeMaxwell, Alison M., Yuan, Peng, Rivera, Brianna M., Schaaf, Wilder, Mladinov, Mihovil, Prasher, Vee P., Robinson, Andrew C., DeGrado, William F., Condello, Carlo · 2021 · Acta Neuropathologica Communications
- Cyclopamine Modulates γ-Secretase-mediated Cleavage of Amyloid Precursor Protein by Altering Its Subcellular Trafficking and Lysosomal DegradationVorobyeva, Anna G., Lee, Randall, Miller, Sean, Longen, Charles, Sharoni, Michal, Kandelwal, Preeti J., Kim, Felix J., Marenda, Daniel R., Saunders, Aleister J. · 2014 · Journal of Biological Chemistry
- Gamma secretase modulators and BACE inhibitors reduce Aβ production without altering gene expression in Alzheimer’s disease iPSC-derived neurons and miceCusulin, Carlo, Wells, Isabelle, Badillo, Solveig, Duran-Pacheco, Gonzalo Christian, Baumann, Karlheinz, Patsch, Christoph · 2019 · Molecular and Cellular Neuroscience
- Inhibition of Acyl‐CoenzymeA: Cholesterol Acyltransferase 1 promotes shedding of soluble triggering receptor on myeloid cells 2 (TREM2) and low‐density lipoprotein receptor 1 (LRP1)‐dependent phagocytosis of amyloid beta protein in microgliaHovde, Moriah J., Maaser‐Hecker, Anna, Bae, Jun‐Seok, Tanzi, Rudolph E. · 2025 · Alzheimer's & Dementia