The Mammalian Epigenome

Initial sequencing and analysis of the human genome

International Human Genome Sequencing Consortium, Whitehead Institute for Biomedical Research, C. F. G. R., Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., et al. (2001) · Nature · doi:10.1038/35057062 · Cited by 24,216

Translating the Histone Code

Jenuwein, T., & Allis, C. D. (2001) · Science · doi:10.1126/science.1063127 · Cited by 9,756

Genome sequencing in microfabricated high-density picolitre reactors

Margulies, M., Egholm, M., Altman, W. E., Attiya, S., Bader, J. S., Bemben, L. A., Berka, J., Braverman, M. S., Chen, Y.-J., Chen, Z., et al. (2005) · Nature · doi:10.1038/nature03959 · Cited by 7,693

DNA methylation patterns and epigenetic memory

Bird, A. (2002) · Genes & Development · doi:10.1101/gad.947102 · Cited by 7,124

DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development

Okano, M., Bell, D. W., Haber, D. A., & Li, E. (1999) · Cell · doi:10.1016/s0092-8674(00)81656-6 · Cited by 6,143

The fundamental role of epigenetic events in cancer

Jones, P. A., & Baylin, S. B. (2002) · Nature Reviews Genetics · doi:10.1038/nrg816 · Cited by 5,648

A bivalent chromatin structure marks key developmental genes in embryonic stem cells

Bernstein, B. E., Mikkelsen, T. S., Xie, X., Kamal, M., Huebert, D. J., Cuff, J., Fry, B., Meissner, A., Wernig, M., Plath, K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.02.041 · Cited by 5,361

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

Li, E., Bestor, T. H., & Jaenisch, R. (1992) · Cell · doi:10.1016/0092-8674(92)90611-f · Cited by 3,984

CpG Islands in vertebrate genomes

Gardiner‐Garden, M., & Frommer, M. (1987) · Journal of Molecular Biology · doi:10.1016/0022-2836(87)90689-9 · Cited by 3,417

Epigenetic Reprogramming in Mammalian Development

Reik, W., Dean, W., & Walter, J. (2001) · Science · doi:10.1126/science.1063443 · Cited by 3,078

Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy

Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,951

High-Resolution Profiling of Histone Methylations in the Human Genome

Barski, A., Cuddapah, S., Cui, K., Roh, T.-Y., Schones, D. E., Wang, Z., Wei, G., Chepelev, I., & Zhao, K. (2007) · Cell · doi:10.1016/j.cell.2007.05.009 · Cited by 6,845

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

Mikkelsen, T. S., Ku, M., Jaffe, D. B., Issac, B., Lieberman, E., Giannoukos, G., Alvarez, P., Brockman, W., Kim, T.-K., Koche, R. P., et al. (2007) · Nature · doi:10.1038/nature06008 · Cited by 4,129

Epigenetics in Cancer

Esteller, M. (2008) · New England Journal of Medicine · doi:10.1056/nejmra072067 · Cited by 3,767

Persistent epigenetic differences associated with prenatal exposure to famine in humans

Heijmans, B. T., Tobi, E. W., Stein, A. D., Putter, H., Blauw, G. J., Susser, E. S., Slagboom, P. E., & Lumey, L. H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806560105 · Cited by 3,082

Direct conversion of fibroblasts to functional neurons by defined factors

Vierbuchen, T., Ostermeier, A., Pang, Z. P., Kokubu, Y., Südhof, T. C., & Wernig, M. (2010) · Nature · doi:10.1038/nature08797 · Cited by 3,017

Epigenetics in cancer

Sharma, S., Kelly, T. K., & Jones, P. A. (2010) · Carcinogenesis · doi:10.1093/carcin/bgp220 · Cited by 2,637

Highly Integrated Single-Base Resolution Maps of the Epigenome in Arabidopsis

Lister, R., O’Malley, R. C., Tonti‐Filippini, J., Gregory, B. D., Berry, C. C., Millar, A. H., & Ecker, J. R. (2008) · Cell · doi:10.1016/j.cell.2008.03.029 · Cited by 2,424

Combinatorial patterns of histone acetylations and methylations in the human genome

Wang, Z., Zang, C., Rosenfeld, J. A., Schones, D. E., Barski, A., Cuddapah, S., Cui, K., Roh, T.-Y., Peng, W., Zhang, M. Q., et al. (2008) · Nature Genetics · doi:10.1038/ng.154 · Cited by 2,331

ChIP–seq: advantages and challenges of a maturing technology

Park, P. J. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2641 · Cited by 2,217

The NIH Roadmap Epigenomics Mapping Consortium

Bernstein, B. E., Stamatoyannopoulos, J. A., Costello, J. F., Ren, B., Milosavljevic, A., Meissner, A., Kellis, M., Marra, M. A., Beaudet, A. L., Ecker, J. R., et al. (2010) · Nature Biotechnology · doi:10.1038/nbt1010-1045 · Cited by 1,892

CTCF: Master Weaver of the Genome

Phillips‐Cremins, J. E., & Corces, V. G. (2009) · Cell · doi:10.1016/j.cell.2009.06.001 · Cited by 1,585

A User's Guide to the Encyclopedia of DNA Elements (ENCODE)

The ENCODE Project Consortium (2011) · PLoS Biology · doi:10.1371/journal.pbio.1001046 · Cited by 1,515

Dissecting direct reprogramming through integrative genomic analysis

Mikkelsen, T. S., Hanna, J. H., Zhang, X., Ku, M., Wernig, M., Schorderet, P., Bernstein, B., Jaenisch, R., Lander, E. S., & Meissner, A. (2008) · Nature · doi:10.1038/nature07056 · Cited by 1,515

Initial genome sequencing and analysis of multiple myeloma

Chapman, M. A., Lawrence, M. S., Keats, J. J., Cibulskis, K., Sougnez, C. L., Schinzel, A. C., Harview, C. L., Brunet, J.-P., Ahmann, G. J., Adli, M., et al. (2011) · Nature · doi:10.1038/nature09837 · Cited by 1,457

Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions

Goldberg, A. D., Banaszynski, L. A., Noh, K., Lewis, P. W., Elsässer, S. J., Stadler, S. C., Dewell, S. B., Law, M. J., Guo, X., Li, X., et al. (2010) · Cell · doi:10.1016/j.cell.2010.01.003 · Cited by 1,351

Epigenome-wide association studies for common human diseases

Rakyan, V. K., Down, T. A., Balding, D. J., & Beck, S. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3000 · Cited by 1,288

Molecular regulation of stem cell quiescence

Cheung, T. H., & Rando, T. A. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3591 · Cited by 1,148

Charting histone modifications and the functional organization of mammalian genomes

Zhou, V. W., Goren, A., & Bernstein, B. E. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2905 · Cited by 1,147

Discovery and characterization of chromatin states for systematic annotation of the human genome

Ernst, J., & Kellis, M. (2010) · Nature Biotechnology · doi:10.1038/nbt.1662 · Cited by 1,075

A clustering approach for identification of enriched domains from histone modification ChIP-Seq data

Zang, C., Schones, D. E., Zeng, C., Cui, K., Zhao, K., & Peng, W. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp340 · Cited by 1,072

Base-Resolution Analysis of 5-Hydroxymethylcytosine in the Mammalian Genome

Yu, M., Hon, G. C., Szulwach, K. E., Song, C., Zhang, L., Kim, A., Li, X., Dai, Q., Shen, Y., Park, B., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.027 · Cited by 1,050

Transcriptional control of the inflammatory response

Medzhitov, R., & Horng, T. (2009) · Nature Reviews Immunology · doi:10.1038/nri2634 · Cited by 1,035

Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains

Ku, M., Koche, R. P., Rheinbay, E., Mendenhall, E. M., Endoh, M., Mikkelsen, T. S., Aiden, A. P., Nusbaum, C., Xie, X. S., Chi, A. S., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000242 · Cited by 1,053

FoxA1 Translates Epigenetic Signatures into Enhancer-Driven Lineage-Specific Transcription

Lupien, M., Eeckhoute, J., Meyer, C. A., Wang, Q., Zhang, Y., Li, W., Carroll, J. S., Liu, X. S., & Brown, M. (2008) · Cell · doi:10.1016/j.cell.2008.01.018 · Cited by 983

Lineage-Specific Polycomb Targets and De Novo DNA Methylation Define Restriction and Potential of Neuronal Progenitors

Mohn, F., Weber, M., Rebhan, M., Roloff, T. C., Richter, J., Stadler, M. B., Bibel, M., & Schübeler, D. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.05.007 · Cited by 970

The Role of Snail in EMT and Tumorigenesis

Wang, Y., Shi, J., Chai, K., Ying, X., & Zhou, B. P. (2013) · Current Cancer Drug Targets · doi:10.2174/15680096113136660102 · Cited by 896

Super-resolution imaging reveals distinct chromatin folding for different epigenetic states

Boettiger, A. N., Bintu, B., Moffitt, J. R., Wang, S., Beliveau, B. J., Fudenberg, G., Imakaev, M., Mirny, L. A., Wu, C.-T., & Zhuang, X. (2016) · Nature · doi:10.1038/nature16496 · Cited by 871

Epigenetic inheritance in plants

Henderson, I. R., & Jacobsen, S. E. (2007) · Nature · doi:10.1038/nature05917 · Cited by 838

Histone modification levels are predictive for gene expression

Karlić, R., Chung, H., Lasserre, J., Vlahoviček, K., & Vingron, M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909344107 · Cited by 809

Rethinking how DNA methylation patterns are maintained

Jones, P. A., & Liang, G. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2651 · Cited by 799

Non-coding RNAs as regulators in epigenetics

Wei, J., Huang, K., Yang, C., & Kang, C. (2016) · Oncology Reports · doi:10.3892/or.2016.5236 · Cited by 797

Mechanisms and Metabolic Implications of Regional Differences among Fat Depots

Tchkonia, T., Thomou, T., Zhu, Y. Z., Karagiannides, I., Pothoulakis, C., Jensen, M. D., & Kirkland, J. L. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.03.008 · Cited by 768

Recent aspects of the effects of zinc on human health

Chasapis, C. T., Ntoupa, P.-S. A., Spiliopoulou, C., & Stefanidou, M. E. (2020) · Archives of Toxicology · doi:10.1007/s00204-020-02702-9 · Cited by 753

Endothelial to Mesenchymal Transition: Role in Physiology and in the Pathogenesis of Human Diseases

Piera-Velázquez, S., & Jiménez, S. A. (2019) · Physiological Reviews · doi:10.1152/physrev.00021.2018 · Cited by 688

A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis

Down, T. A., Rakyan, V. K., Turner, D., Flicek, P., Li, H., Kulesha, E., Gräf, S., Johnson, N., Herrero, J., Tomazou, E. M., et al. (2008) · Nature Biotechnology · doi:10.1038/nbt1414 · Cited by 650

Chromatin organization marks exon-intron structure

Schwartz, S., Meshorer, E., & Ast, G. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1659 · Cited by 638

Emerging functional and mechanistic paradigms of mammalian long non-coding RNAs

Moran, V. A., Perera, R. J., & Khalil, A. M. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks296 · Cited by 642

Aberrant Epigenetic Landscape in Cancer: How Cellular Identity Goes Awry

Berdasco, M., & Esteller, M. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.10.005 · Cited by 651

Whole-Genome Mapping of Histone H3 Lys4 and 27 Trimethylations Reveals Distinct Genomic Compartments in Human Embryonic Stem Cells

Zhao, X. D., Han, X., Chew, J. L., Liu, J., Chiu, K. P., Choo, A. B. H., Orlov, Y. L., Sung, W.-K. K., Shahab, A., Kuznetsov, V. A., et al. (2007) · Cell stem cell · doi:10.1016/j.stem.2007.08.004 · Cited by 626

Nucleosome-Interacting Proteins Regulated by DNA and Histone Methylation

Bartke, T., Vermeulen, M., Xhemalce, B., Robson, S. C., Mann, M., & Kouzarides, T. (2010) · Cell · doi:10.1016/j.cell.2010.10.012 · Cited by 611

Facultative Heterochromatin: Is There a Distinctive Molecular Signature?

Trojer, P., & Reinberg, D. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.09.011 · Cited by 686

QUMA: quantification tool for methylation analysis

Kumaki, Y., Oda, M., & Okano, M. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn294 · Cited by 606

Genome-scale analysis of aberrant DNA methylation in colorectal cancerPreprint

Hinoue, T., Weisenberger, D. J., Lange, C., Shen, H., Byun, H., Van, D., Malik, S., Pan, F., Noushmehr, H., van, C., et al. (2011) · Genome Research · doi:10.1101/gr.117523.110 · Cited by 618

Next-generation genomics: an integrative approach

Hawkins, R. D., Hon, G. C., & Ren, B. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2795 · Cited by 608

Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapies

Urdinguio, R. G., Sanchez-Mut, J. V., & Esteller, M. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70262-5 · Cited by 598

Mapping Human Epigenomes

Rivera, C. M., & Ren, B. (2013) · Cell · doi:10.1016/j.cell.2013.09.011 · Cited by 550

Dynamic histone H3 methylation during gene induction: HYPB/Setd2 mediates all H3K36 trimethylation

Edmunds, J. W., Mahadevan, L. C., & Clayton, A. L. (2008) · The EMBO Journal · doi:10.1038/sj.emboj.7601967 · Cited by 547

A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

Vedadi, M., Baršytė-Lovejoy, D., Liu, F., Rival‐Gervier, S., Allali‐Hassani, A., Labrie, V., Wigle, T. J., DiMaggio, P. A., Wasney, G. A., Siarheyeva, A., et al. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.599 · Cited by 547

Neuronal Activity-Regulated Gene Transcription in Synapse Development and Cognitive Function

West, A. E., & Greenberg, M. E. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005744 · Cited by 532

Decoding the Epigenetic Language of Neuronal Plasticity

Borrelli, E., Nestler, E. J., Allis, C. D., & Sassone‐Corsi, P. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.012 · Cited by 546

Cross talk between microRNA and epigenetic regulation in adult neurogenesis

Szulwach, K. E., Li, X., Smrt, R. D., Li, Y., Luo, Y., Lin, L., Santistevan, N. J., Li, W., Zhao, X., & Jin, P. (2010) · Journal of Cell Biology · doi:10.1083/jcb.200908151 · Cited by 493

Disease variants alter transcription factor levels and methylation of their binding sites

Bonder, M. J., Luijk, R., Zhernakova, D. V., Moed, M., Deelen, P., Vermaat, M., van Iterson, M., van Dijk, F., van Galen, M., Bot, J. J., et al. (2016) · Nature Genetics · doi:10.1038/ng.3721 · Cited by 462

Epigenetics in cancer: Targeting chromatin modifications

Ellis, L., Atadja, P. W., & Johnstone, R. W. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-0860 · Cited by 488

Noncoding RNA in development

Amaral, P., & Mattick, J. S. (2008) · Mammalian Genome · doi:10.1007/s00335-008-9136-7 · Cited by 492

Adaptive Transgenerational Plasticity in Plants: Case Studies, Mechanisms, and Implications for Natural Populations

Herman, J. J., & Sultan, S. E. (2011) · Frontiers in Plant Science · doi:10.3389/fpls.2011.00102 · Cited by 467

Cellular dynamics associated with the genome-wide epigenetic reprogramming in migrating primordial germ cells in mice

Seki, Y., Yamaji, M., Yabuta, Y., Sano, M., Shigeta, M., Matsui, Y., Saga, Y., Tachibana, M., Shinkai, Y., & Saitou, M. (2007) · Development · doi:10.1242/dev.005611 · Cited by 475

Dynamics of 5-Hydroxymethylcytosine and Chromatin Marks in Mammalian Neurogenesis

Hahn, M. A., Qiu, R., Wu, X., Li, A. X., Zhang, H., Wang, J., Jui, J., Jin, S., Jiang, Y., Pfeifer, G. P., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.01.011 · Cited by 455

Mechanisms and models of somatic cell reprogramming

Buganim, Y., Faddah, D. A., & Jaenisch, R. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3473 · Cited by 467

An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1

Konze, K. D., Ma, A., Li, F., Baršytė-Lovejoy, D., Parton, T., MacNevin, C. J., Liu, F., Gao, C., Huang, X., Kuznetsova, E., et al. (2013) · ACS Chemical Biology · doi:10.1021/cb400133j · Cited by 463

Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60

Sun, Y., Jiang, X., Xu, Y., Ayrapetov, M. K., Moreau, L. A., Whetstine, J. R., & Price, B. D. (2009) · Nature Cell Biology · doi:10.1038/ncb1982 · Cited by 454

Promoter CpG Methylation Contributes to ES Cell Gene Regulation in Parallel with Oct4/Nanog, PcG Complex, and Histone H3 K4/K27 Trimethylation

Fouse, S. D., Shen, Y., Pellegrini, M. A., Cole, S. W., Meissner, A., Neste, L. V., Jaenisch, R., & Fan, G. (2008) · Cell stem cell · doi:10.1016/j.stem.2007.12.011 · Cited by 456

DNA methylation: An epigenetic mark of cellular memory

Kim, M., & Costello, J. (2017) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.10 · Cited by 450

Epigenetic-Mediated Dysfunction of the Bone Morphogenetic Protein Pathway Inhibits Differentiation of Glioblastoma-Initiating Cells

Lee, J., Son, M. J., Woolard, K., Donin, N. M., Li, A., Cheng, C. H., Kotliarova, S. E., Kotliarov, Y., Walling, J., Ahn, S. J., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2007.12.005 · Cited by 446

Single-cell DNA methylome sequencing and bioinformatic inference of epigenomic cell-state dynamics

Farlik, M., Sheffield, N. C., Nuzzo, A., Datlinger, P., Schönegger, A., Klughammer, J., & Bock, C. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.02.001 · Cited by 422

MAnorm: a robust model for quantitative comparison of ChIP-Seq data sets

Shao, Z., Zhang, Y., Yuan, G., Orkin, S. H., & Waxman, D. J. (2012) · Genome biology · doi:10.1186/gb-2012-13-3-r16 · Cited by 410

Epigenetic reprogramming in mouse pre-implantation development and primordial germ cells

Saitou, M., Kagiwada, S., & Kurimoto, K. (2011) · Development · doi:10.1242/dev.050849 · Cited by 435

A DNA methylation fingerprint of 1628 human samplesPreprint

Fernández, A. F., Assenov, Y., Martín-Subero, J. I., Bálint, B., Siebert, R., Taniguchi, H., Yamamoto, H., Hidalgo, M. M., Tan, A. C., Galm, O., et al. (2011) · Genome Research · doi:10.1101/gr.119867.110 · Cited by 427

Personalized Medicine: Progress and Promise

Chan, I. S., & Ginsburg, G. S. (2011) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-082410-101446 · Cited by 409

SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability

Li, L., Shi, L., Yang, S., Yan, R., Zhang, D., Yang, J., He, L., Li, W., Yi, X., Sun, L., et al. (2016) · Nature Communications · doi:10.1038/ncomms12235 · Cited by 400

An atlas of dynamic chromatin landscapes in mouse fetal development

Gorkin, D. U., Barozzi, I., Zhao, Y., Zhang, Y., Huang, H., Lee, A. Y., Li, B., Chiou, J., Wildberg, A., Ding, B., et al. (2020) · Nature · doi:10.1038/s41586-020-2093-3 · Cited by 374

Functional Specificity among Ribosomal Proteins Regulates Gene Expression

Komili, S., Farny, N. G., Roth, F. P., & Silver, P. A. (2007) · Cell · doi:10.1016/j.cell.2007.08.037 · Cited by 398

Induced pluripotent stem cells: current progress and potential for regenerative medicine

Amabile, G., & Meissner, A. (2009) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2008.12.003 · Cited by 391

RNA regulation of epigenetic processes

Mattick, J. S., Amaral, P., Dinger, M. E., Mercer, T. R., & Mehler, M. F. (2009) · BioEssays · doi:10.1002/bies.080099 · Cited by 387

Frequent switching of Polycomb repressive marks and DNA hypermethylation in the PC3 prostate cancer cell line

Gal‐Yam, E. N., Egger, G., Iniguez, L., Holster, H., Einarsson, S. O., Zhang, X., Lin, J., Liang, G., Jones, P. A., & Tanay, A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806437105 · Cited by 371

UHRF1 targets DNMT1 for DNA methylation through cooperative binding of hemi-methylated DNA and methylated H3K9

Liu, X., Gao, Q., Li, P., Zhao, Q., Zhang, J., Li, J., Koseki, H., & Wong, J. (2013) · Nature Communications · doi:10.1038/ncomms2562 · Cited by 391

Finding the fifth base: Genome-wide sequencing of cytosine methylationPreprint

Lister, R., & Ecker, J. R. (2009) · Genome Research · doi:10.1101/gr.083451.108 · Cited by 390

Quantitative Proteomic Analysis of Histone Modifications

Huang, H., Lin, S., Garcia, B. A., & Zhao, Y. (2015) · Chemical Reviews · doi:10.1021/cr500491u · Cited by 383

Epigenetic modifications in pluripotent and differentiated cells

Meissner, A. (2010) · Nature Biotechnology · doi:10.1038/nbt.1684 · Cited by 394

Genome-wide approaches to studying chromatin modifications

Schones, D. E., & Zhao, K. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2270 · Cited by 379

The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine‐specific demethylase 1

Lin, Y., Wu, Y., Li, J., Dong, C., Ye, X., Chi, Y., Evers, B. M., & Zhou, B. P. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.63 · Cited by 375

The functional role of long non-coding RNAs and epigenetics

Cao, J. (2014) · Biological Procedures Online · doi:10.1186/1480-9222-16-11 · Cited by 368

Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells

Fiskus, W. C., Wang, Y., Sreekumar, A., Buckley, K. M., Shi, H., Jillella, A., Üstün, C., Rao, R., Fernandez, P., Chen, J., et al. (2009) · Blood · doi:10.1182/blood-2009-03-213496 · Cited by 372

Raman Spectroscopy for Chemical Biology Research

Dodo, K., Fujita, K., & Sodeoka, M. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c05359 · Cited by 341

Diet induced epigenetic changes and their implications for health

McKay, J. A., & Mathers, J. C. (2011) · Acta Physiologica · doi:10.1111/j.1748-1716.2011.02278.x · Cited by 347

ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a

Gao, X., Tate, P. H., Hu, P., Tjian, R., Skarnes, W. C., & Wang, Z. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801802105 · Cited by 336

Whole-genome fingerprint of the DNA methylome during human B cell differentiation

Kulis, M., Merkel, A., Heath, S. C., Queirós, A. C., Schuyler, R. P., Castellano, G., Beekman, R., Raineri, E., Esteve‐Codina, A., Clot, G., et al. (2015) · Nature Genetics · doi:10.1038/ng.3291 · Cited by 336

DNA Methylation, Its Mediators and Genome Integrity

Meng, H., Cao, Y., Qin, J., Song, X., Zhang, Q., Shi, Y. S., & Cao, L. (2015) · International Journal of Biological Sciences · doi:10.7150/ijbs.11218 · Cited by 346

GlcNAcylation of histone H2B facilitates its monoubiquitination

Fujiki, R., Hashiba, W., Sekine, H., Yokoyama, A., Chikanishi, T., Ito, S., Imai, Y., Kim, J., He, H. H., Igarashi, K., et al. (2011) · Nature · doi:10.1038/nature10656 · Cited by 340

Malleability, plasticity, and individuality: How children learn and develop in context1

Cantor, P., Osher, D., Berg, J., Steyer, L., & Rose, T. (2019) · Applied Developmental Science · doi:10.1080/10888691.2017.1398649 · Cited by 328

Epigenetics of endometriosis

Guo, S.-W. (2009) · Molecular Human Reproduction · doi:10.1093/molehr/gap064 · Cited by 328

H3K27 Demethylases, at Long Last

Swigut, T., & Wysocka, J. (2007) · Cell · doi:10.1016/j.cell.2007.09.026 · Cited by 327

MYCN and the epigenome

He, S., Liu, Z., Oh, D., & Thiele, C. J. (2013) · Frontiers in Oncology · doi:10.3389/fonc.2013.00001 · Cited by 330

Epigenetic variation during the adult lifespan: cross-sectional and longitudinal data on monozygotic twin pairs

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Molecular Regulation of H3K4 Trimethylation by Wdr82, a Component of Human Set1/COMPASS

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Physical exercise as an epigenetic modulator of brain plasticity and cognition

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Discrete Roles of STAT4 and STAT6 Transcription Factors in Tuning Epigenetic Modifications and Transcription during T Helper Cell Differentiation

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Inhibitors of Protein Methyltransferases and Demethylases

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Non-coding RNAs, epigenetics and complexity

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The DNA Methylome of Human Peripheral Blood Mononuclear Cells

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Genome-wide approaches to studying chromatin modifications

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Analyses of Genome-Wide Histone Modifications in the Mammalian Genome

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Editorial

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The functional genome: epigenetics and epigenomics

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Grand challenge in chromatin epigenomics: everything, everywhere, all at once

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