Cited by 10,883Genomics and Chromatin DynamicsEpigenetics and DNA MethylationChromatin Remodeling and Cancer

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Chromatin Modifications and Their Function

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Kouzarides, Tony·2007·Cell

DOI 10.1016/j.cell.2007.02.005

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Abstract

The surface of nucleosomes is studded with a multiplicity of modifications. At least eight different classes have been characterized to date and many different sites have been identified for each class. Operationally, modifications function either by disrupting chromatin contacts or by affecting the recruitment of nonhistone proteins to chromatin. Their presence on histones can dictate the higher-order chromatin structure in which DNA is packaged and can orchestrate the ordered recruitment of enzyme complexes to manipulate DNA. In this way, histone modifications have the potential to influence many fundamental biological processes, some of which may be epigenetically inherited.

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“…of Nucleic Acids Methylation of DNA and specific residues within histones plays a crucial role in the epigenetic regulation of chromatin-based processes, such as transcription and genomic organization (Goldberg et al., 2007; Klose and Bird, 2006; Kouzarides, 2007; Xhemalce et al., 2011).”
Self-citation
Comparative Analysis of Small Molecules and Histone Substrate Analogues as LSD1 Lysine Demethylase Inhibitors
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Authors: Kouzarides, T.
Affiliations: University of Cambridge (GB)
Corresponding author: Kouzarides, Tony
ORCID: Kouzarides, Tony
Venue: Cell
Publisher: Elsevier BV
Published: 2007-02
Volume: 128
Issue: 4
Pages: 693-705
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2007.02.005
OpenAlex: W2096083625
Cited by: 10,883
References: 91
Citations by year: 2026: 260 · 2025: 374 · 2024: 387 · 2023: 414 · 2022: 472 · 2021: 616 · 2020: 561 · 2019: 578 · 2018: 530 · 2017: 624 · 2016: 679 · 2015: 664 · 2014: 733 · 2013: 686 · 2012: 796
FWCI: 45.57
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2358 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Keywords: histone modifications, chromatin modification, nucleosome, chromatin structure, epigenetic inheritance, chromatin remodeling
MeSH terms: Animals, DNA, Enzymes, Histones, Humans, Nucleosomes, Protein Processing, Post-Translational, Chromatin Assembly and Disassembly, Epigenesis, Genetic

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