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Chromatin Modifications and Their Function
Open accessAbstract
The surface of nucleosomes is studded with a multiplicity of modifications. At least eight different classes have been characterized to date and many different sites have been identified for each class. Operationally, modifications function either by disrupting chromatin contacts or by affecting the recruitment of nonhistone proteins to chromatin. Their presence on histones can dictate the higher-order chromatin structure in which DNA is packaged and can orchestrate the ordered recruitment of enzyme complexes to manipulate DNA. In this way, histone modifications have the potential to influence many fundamental biological processes, some of which may be epigenetically inherited.
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“Combinatorial PTM patterns—the so-called “histone code”—are interpreted by reader proteins that recruit effector complexes to regulate chromatin accessibility (Kouzarides, 2007; Campos and Reinberg, 2009).”
From Histone modifications and depression: epigenetic mechanisms, therapeutic targets, and translational outlook (2026) · cites this paper as Kouzarides, 2007
In the citing paper
“This is in agreement with previous studies investigating the role of HDACiongeneexpression changes in HL60 cells (2, 29, 30, 35, 43).”
From Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability (2013) · cites this paper as [2]
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“Enzymes responsible for methylation of histone H3 at lysine 4, 9, and 27, in particular, are essential for embryogenesis (Kouzarides, 2007; Vastenhouw and Schier, 2012).”
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Metadata
- Authors
- Kouzarides, T.
- Affiliations
- University of Cambridge (GB)
- Corresponding author
- Kouzarides, Tony
- ORCID
- Kouzarides, Tony
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2007-02
- Volume
- 128
- Issue
- 4
- Pages
- 693-705
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2096083625
- Cited by
- 10,883
- References
- 91
- Citations by year
- 2026: 260 · 2025: 374 · 2024: 387 · 2023: 414 · 2022: 472 · 2021: 616 · 2020: 561 · 2019: 578 · 2018: 530 · 2017: 624 · 2016: 679 · 2015: 664 · 2014: 733 · 2013: 686 · 2012: 796
- FWCI
- 45.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- histone modifications, chromatin modification, nucleosome, chromatin structure, epigenetic inheritance, chromatin remodeling
- MeSH terms
- Animals, DNA, Enzymes, Histones, Humans, Nucleosomes, Protein Processing, Post-Translational, Chromatin Assembly and Disassembly, Epigenesis, Genetic
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