The DOI matches its Crossref record; 58 of the 59 references it cites were found in a registry or an index.
A Translational Profiling Approach for the Molecular Characterization of CNS Cell Types
Open accessAbstract
The cellular heterogeneity of the brain confounds efforts to elucidate the biological properties of distinct neuronal populations. Using bacterial artificial chromosome (BAC) transgenic mice that express EGFP-tagged ribosomal protein L10a in defined cell populations, we have developed a methodology for affinity purification of polysomal mRNAs from genetically defined cell populations in the brain. The utility of this approach is illustrated by the comparative analysis of four types of neurons, revealing hundreds of genes that distinguish these four cell populations. We find that even two morphologically indistinguishable, intermixed subclasses of medium spiny neurons display vastly different translational profiles and present examples of the physiological significance of such differences. This genetically targeted translating ribosome affinity purification (TRAP) methodology is a generalizable method useful for the identification of molecular changes in any genetically defined cell type in response to genetic alterations, disease, or pharmacological perturbations.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Expression of markers associated with canonical SPNs suggests eSPNs have been molecularly “camouflaged,” including in studies using mice that have employed Drd1 and Adora2a driven–transgenes to label and manipulate dSPNs or iSPNs (Heiman et al., 2008; Kozorovitskiy et al., 2012; Kravitz et al., 2012).”
From Molecular diversity and specializations among the cells of the adult mouse brain (2018) · cites this paper as Heiman et al., 2008
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Crossing these mice to microglia-specific Cre mice allows for the isolation of ribosome-associated mRNAs in a cell-type-specific fashion using eGFP-based immunoaffinity purification28,91,93.”
From Lymphoid gene expression supports neuroprotective microglia function (2025) · cites this paper as [91]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“The TRAP approach91,92 relies on the genetic labelling of the ribosomal protein L10a with the enhanced green fluorescent protein (eGFP) using Eef1a1LSL.eGFPL10a/+ mice60.”
From Lymphoid gene expression supports neuroprotective microglia function (2025) · cites this paper as [91]
In the citing paper
“These neurons are defined by their transcriptional profiles, including dopamine receptor 1 (D1) vs. dopamine receptor 2 (D2) expression, substance P and enkephalin, and other enriched genes (16–18).”
From Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression (2017) · cites this paper as [18]
In the citing paper
“These fractions harbor complexes containing multiple ribosomes (Figure 7A) identified as such by immuno-EM on the same gradient fraction prepared from a transgenic mouse expressing the tagged ribosomal protein EGFP-rpL10a (Heiman et al., 2008; Doyle et al., 2008) (Figure 7B).”
From FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism (2011) · cites this paper as Heiman et al., 2008
In the citing paper
“overexpression of an epitope-tagged ribosomal protein (referred to as ‘TRAP’ or ‘Ribo-tag’ methods) under the control of one such cell-type-specific promoter allows purification by immunoprecipitation of the transcripts bound by the polyribosome in the desired cells58”
From Decoding neuroproteomics: integrating the genome, translatome and functional anatomy (2014) · cites this paper as [58]
In the citing paper
“No statistical methods were used to pre-determine sample sizes but our sample sizes are similar to those reported in previous publications19,31,95,99,108.”
From Epigenetic regulation of brain region-specific microglia clearance activity (2018) · cites this paper as [19]
In the citing paper
“The bacTRAP technology enabled us to assay AD-relevant neuronal cell types with genome-wide coverage, measure transcripts ex vivo (as opposed to postmortem), and specifically capture actively translated (rather than all transcribed) genes.”
From Selective Neuronal Vulnerability in Alzheimer’s Disease: A Network-Based Analysis (2020) · cites this paper as Heiman et al., 2008
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Gene Ontology: tool for the unification of biology
Ashburner, M., Ball, C. A., Blake, J. A., Botstein, D., Butler, H., Cherry, J. M., Davis, A. P., Dolinski, K., Dwight, S. S., Eppig, J. T., et al. (2000) · Nature Genetics · doi:10.1038/75556 · Cited by 43,206
Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
Edgar, R. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.1.207 · Cited by 13,288
Genome-wide atlas of gene expression in the adult mouse brain
Lein, E. S., Hawrylycz, M. J., Ao, N., Ayres, M., Bensinger, A., Bernard, A., Boe, A. F., Boguski, M. S., Brockway, K. S., Byrnes, E. J., et al. (2007) · Nature · doi:10.1038/nature05453 · Cited by 5,572
Di Chiara, G., & Imperato, A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5274 · Cited by 4,733
Cocaine Receptors on Dopamine Transporters Are Related to Self-Administration of Cocaine
Ritz, M. C., Lamb, R. J., Goldberg, S. R., & Kuhar, M. J. (1987) · Science · doi:10.1126/science.2820058 · Cited by 2,180
A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
Gong, S., Zheng, C., Doughty, M. L., Losos, K., Didkovsky, N., Schambra, U. B., Nowak, N. J., Joyner, A., Leblanc, G., Hatten, M. E., et al. (2003) · Nature · doi:10.1038/nature02033 · Cited by 2,108
Self-citationThe neostriatal mosaic: multiple levels of compartmental organization
Gerfen, C. R. (1992) · Trends in Neurosciences · doi:10.1016/0166-2236(92)90355-c · Cited by 1,471
Homer: a protein that selectively binds metabotropic glutamate receptors
Brakeman, P., Lanahan, A. A., O’Brien, R., Roche, K. W., Barnes, C. A., Huganir, R. L., & Worley, P. F. (1997) · Nature · doi:10.1038/386284a0 · Cited by 1,115
The neostriatal mosaic: multiple levels of compartmental organization in the basal ganglia
Gerfen, C. R. (1992) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.15.030192.001441 · Cited by 1,004
Application of a translational profiling approach for the comparative analysis of CNS cell types
Doyle, J. P., Dougherty, J. D., Heiman, M., Schmidt, E. F., Stevens, T. R., Ma, G., Bupp, S., Shrestha, P., Shah, R. D., Doughty, M. L., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.029 · Cited by 912
Self-citation
Flagged first, then by citations
1 of the 59 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 701–800 of 1,000
The transcription factor Traffic jam orchestrates the somatic piRNA pathway in Drosophila ovaries
Alizada, A., Martins, A., Mouniée, N., Suarez, J. V. R., Bertin, B., Gueguen, N., Mirouse, V., Papameletiou, A. M., Rivera, A. J., Lau, N. C., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115453 · Cited by 14
Integrating reproductive states and social cues in the control of sociosexual behaviors
Wang, Y., Song, X., Chen, X., Zhou, Y., Ma, J., Zhang, F., Wei, L., Qi, G., Yadav, N., Miao, B., et al. (2025) · Cell · doi:10.1016/j.cell.2025.04.035 · Cited by 17
Self-citationNoncanonical translation via deadenylated 3′ UTRs maintains primordial germ cells
Jin, Y. N., Schlueter, P. J., Jurisch‐Yaksi, N., Lam, P., Jin, S., Hwang, W. Y., Yeh, J.-R. J., Yoshigi, M., Ong, S., Schenone, M., et al. (2018) · Nature Chemical Biology · doi:10.1038/s41589-018-0098-0 · Cited by 18
Ozdemir, A. T., Lagler, M., Lagoun, S., Malagon‐Vina, H., Lasztóczi, B., & Klausberger, T. (2020) · Cell Reports · doi:10.1016/j.celrep.2019.12.102 · Cited by 14
Waes, V. V., Carr, B., Beverley, J. A., & Steiner, H. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2012.07852.x · Cited by 16
Chew, L., DeBoy, C. A., & Senatorov, V. V. (2014) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2014.08.017 · Cited by 13
Wang, Y., & Jiao, Y. (2013) · Methods in molecular biology · doi:10.1007/978-1-4614-9408-9_18 · Cited by 14
Uncovering Discrete Synaptic Proteomes to Understand Neurological Disorders
Wang, Y., & Savas, J. N. (2018) · Proteomes · doi:10.3390/proteomes6030030 · Cited by 12
Cell Type-Specific Transcriptome Profiling Reveals a Role for Thioredoxin During Tumor Initiation
Korte, B. G., Giese, M. A., Ramakrishnan, G., Ma, S., Bennin, D. A., Rindy, J., Dewey, C. N., & Anna Huttenlocher, A. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.818893 · Cited by 13
Human Tissues Exhibit Diverse Composition of Translation Machinery
Anisimova, A. S., Kolyupanova, N. M., Makarova, N. E., Egorov, A. A., Kulakovskiy, I. V., & Dmitriev, S. E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24098361 · Cited by 15
Ribosome profiling: a powerful tool in oncological research
Su, D., Ding, C., Qiu, J., Yang, G., Wang, R., Liu, Y., Tao, J., Luo, W., Weng, G., & Zhang, T. (2024) · Biomarker Research · doi:10.1186/s40364-024-00562-4 · Cited by 15
Zhai, S., Otsuka, S., Xu, J., Clarke, V. R. J., Tkatch, T., Wokosin, D. L., Xie, Z., Tanimura, A., Agarwal, H. K., Ellis‐Davies, G. C. R., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114540 · Cited by 13
Self-citationBrowne, C. J., Mews, P., Estill, M. S., Zhou, X., Holt, L. M., Futamura, R., Shen, L., Zhang, B., & Nestler, E. J. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03004-1 · Cited by 13
Temporally and Spatially Restricted Gene Expression Profiling
Tallafuß, A., Washbourne, P., & Postlethwait, J. H. (2014) · Current Genomics · doi:10.2174/1389202915666140602230106 · Cited by 13
Miyazaki, H., Yamanaka, T., Oyama, F., Kino, Y., Kurosawa, M., Yamada-Kurosawa, M., Yamano, R., Shimogori, T., Hattori, N., & Nukina, N. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.012983 · Cited by 12
Sukhanov, I., Dorotenko, A. R., Fesenko, Z. S., Savchenko, A. A., Efimova, E. V., Mor, M. S., Владимировна, Б. И., Sotnikova, T. D., & Gainetdinov, R. R. (2022) · Biomolecules · doi:10.3390/biom13010009 · Cited by 13
Rahimian, R., Guruswamy, R., Boutej, H., Cordeau, P., Weng, Y. C., & Križ, J. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.01.004 · Cited by 13
Mouse Transgenesis in a Single Locus with Independent Regulation for Multiple Fluorophores
Dougherty, J. D., Zhang, J., Feng, H., Gong, S., & Heintz, N. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040511 · Cited by 13
Self-citationBellesi, M., de Vivo, L., Tononi, G., & Cirelli, C. (2015) · Genomics Data · doi:10.1016/j.gdata.2015.08.031 · Cited by 13
Omics approaches for subcellular translation studies
Koppel, I., & Fainzilber, M. (2018) · Molecular Omics · doi:10.1039/c8mo00172c · Cited by 12
Epigenetic mechanisms in Alzheimer's disease
Balázs, R. (2014) · Degenerative Neurological and Neuromuscular Disease · doi:10.2147/dnnd.s37341 · Cited by 15
Vacca, M., Tripathi, K. P., Speranza, L., Cigliano, R. A., Scalabrì, F., Marracino, F., Madonna, M., Sanseverino, W., Perrone‐Capano, C., Guarracino, M. R., et al. (2016) · BMC Bioinformatics · doi:10.1186/s12859-015-0859-7 · Cited by 13
Wang, N., Zhang, S., Langfelder, P., Ramanathan, L., Plascencia, M., Gao, F., Vaca, R., Gu, X., Deng, L., Dionisio, L. E., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.09.602815 · Cited by 13
Bagheri, A., Astaf’ev, A. A., Al-Hashimy, T., & Jiang, P. (2022) · Cells · doi:10.3390/cells11192966 · Cited by 12
Liu, W., Xie, H., Liu, X., Xu, S., Cheng, S., Wang, Z., Xie, T., Zhang, Z. C., & Han, J. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112277 · Cited by 12
Spiny projection neurons exhibit transcriptional signatures within subregions of the dorsal striatum
Roman, K. M., Dinasarapu, A. R., VanSchoiack, A., Ross, P. M., Kroeppler, D., Jinnah, H. A., & Hess, E. J. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113435 · Cited by 12
Shaik, S. M., Cao, Y., Gogola, J. V., Dodiya, H. B., Zhang, X., Boutej, H., Han, W., Križ, J., & Sisodia, S. S. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00668-7 · Cited by 12
Mice lacking Astn2 have ASD-like behaviors and altered cerebellar circuit properties
Hanzel, M., Fernando, K., Maloney, S. E., Horn, Z., Gong, S., Mätlik, K., Zhao, J., Pasolli, H. A., Heissel, S., Dougherty, J. D., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2405901121 · Cited by 11
Self-citationHaetzel, L. M., Iafrati, J., Cording, K. R., Farhan, M., Noveir, S. D., Rumbaugh, G., & Bateup, H. S. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.1264-23.2024 · Cited by 12
Current Understanding of PDE10A in the Modulation of Basal Ganglia Circuitry
Schülke, J.-P., & Brandon, N. J. (2017) · Advances in neurobiology · doi:10.1007/978-3-319-58811-7_2 · Cited by 11
Forget, B., Martín‐García, E., Godino, A., Rodriguez, L. D., Kappès, V., Poirier, P., Andrianarivelo, A., Senabre, E., Allichon, M., Marias, M., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01328-2 · Cited by 14
Pardo, M., Gregorio, S., Montalban, E., Pujadas, L., Elias-Tersa, A., Masachs, N., Vílchez-Acosta, A., Parent, A., Auladell, C., Girault, J., et al. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1143319 · Cited by 12
RNA-Binding Protein Immunopurification-Microarray (RIP-Chip) Analysis to Profile Localized RNAs
Galgano, A., & Gerber, A. P. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-005-8_23 · Cited by 12
Hippocampal gene profiling: Toward a systems biology of the hippocampus
Valor, L. M., & Barco, Á. (2010) · Hippocampus · doi:10.1002/hipo.20888 · Cited by 12
Functional genomics of the brain: uncovering networks in the CNS using a systems approach
Konopka, G. (2010) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.139 · Cited by 12
McClure, C. D., & Southall, T. D. (2015) · Advances in genetics · doi:10.1016/bs.adgen.2015.06.003 · Cited by 12
Proteomics and Neurodegenerative Disorders: Advancements in the Diagnostic Analysis
Puranik, N., Yadav, D., Yadav, S. K., Chavda, V. K., & Jin, J. (2020) · Current Protein and Peptide Science · doi:10.2174/1389203721666200511094222 · Cited by 12
Acharjee, S., Gordon, P. M. K., Lee, B. H., Read, J. L., Workentine, M. L., Sharkey, K. A., & Pittman, Q. J. (2021) · Scientific Reports · doi:10.1038/s41598-021-93590-1 · Cited by 13
Pandolfini, L., Luzi, E., Bressan, D., Ucciferri, N., Bertacchi, M., Brandi, R., Rocchiccioli, S., D’Onofrio, M., & Cremisi, F. (2016) · Genome biology · doi:10.1186/s13059-016-0952-x · Cited by 12
Purgianto, A., Loweth, J. A., Miao, J. J., Milovanovic, M., & Wolf, M. E. (2016) · Brain Research · doi:10.1016/j.brainres.2016.04.014 · Cited by 11
Age-Related Neurometabolomic Signature of Mouse Brain
Chen, S., Lee, J., Truong, T. M., Alhassen, S., Baldi, P., & Alachkar, A. (2021) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.1c00259 · Cited by 11
Cullen, P., Gammerdinger, W., Sui, S. J. H., Mazumder, A. G., & Sun, D. (2024) · Glia · doi:10.1002/glia.24571 · Cited by 15
Sankaranarayanan, I., Kume, M., Mohammed, A., Mwirigi, J. M., Inturi, N. N., Munro, G., Petersen, K. A., Tavares‐Ferreira, D., & Price, T. J. (2025) · Pain · doi:10.1097/j.pain.0000000000003523 · Cited by 11
Wuest, S. E., Schmid, M. W., & Grossniklaus, U. (2012) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2012.12.001 · Cited by 11
Tasic, B., Levi, B. P., & Menon, V. (2017) · Springer eBooks · doi:10.1007/978-3-319-57363-2_18 · Cited by 10
The Secret Life of RNA: Lessons from Emerging Methodologies
Médioni, C., & Besse, F. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-7213-5_1 · Cited by 11
G Protein-Coupled Receptors As Regulators of Localized Translation: The Forgotten Pathway?
Trefier, A., Pellissier, L. P., Musnier, A., Reiter, É., Guillou, F., & Crépieux, P. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00017 · Cited by 10
Environmental epigenetics of sex differences in the brain
Marrocco, J., Einhorn, N. R., & McEwen, B. S. (2020) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64123-6.00015-1 · Cited by 12
Bertin, B., Renaud, Y., Jagla, T., Lavergne, G., Dondi, C., Ponte, J. P. D., Junion, G., & Jagla, K. (2021) · Scientific Reports · doi:10.1038/s41598-021-92506-3 · Cited by 11
Goeke, C. M., Zhang, X., Hashimoto, J. G., & Guizzetti, M. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.136422 · Cited by 11
Harb, K., Richter, M., Neelagandan, N., Magrinelli, E., Harfoush, H., Kuechler, K., Henis, M., Hermanns-Borgmeyer, I., de Anda, F. C., & Duncan, K. E. (2022) · eLife · doi:10.7554/elife.55199 · Cited by 11
Regulation of the hippocampal translatome by Apoer2-ICD release
Wasser, C. R., Werthmann, G. C., Hall, E. M., Kuhbandner, K., Wong, C. H. Y., Durakoglugil, M. S., & Herz, J. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00652-1 · Cited by 11
Song, R. S., Tolentino, R. E., Sobie, E. A., & Neves, S. R. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.749747 · Cited by 12
Differential mitochondrial morphology in ventral striatal projection neuron subtypes
Chandra, R., Calarco, C. A., & Lobo, M. K. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24511 · Cited by 14
DNA sequencing methods in human genetics and disease research
Lehrach, H. (2013) · F1000Prime Reports · doi:10.12703/p5-34 · Cited by 12
Epigenetics, Brain and Behavior
Sassone‐Corsi, P., & Christen, Y. (2012) · Research and perspectives in neurosciences · doi:10.1007/978-3-642-27913-3 · Cited by 11
Plassmeyer, S. P., Florian, C. P., Kasper, M. J., Chase, R., Mueller, S., Liu, Y., White, K. M., Jungers, C. F., Djuranovic, S. P., Djuranović, S., et al. (2023) · medRxiv · doi:10.1101/2023.11.02.23297961 · Cited by 11
Marion‐Poll, L., Roussarie, J.-P., Taing, L., Dard-Dascot, C., Servant, N., Jaszczyszyn, Y., Jordi, E., Mulugeta, E., Hervé, D., Bourc’his, D., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-04269-w · Cited by 11
Self-citationA single-cell trajectory atlas of striatal development
Anderson, A. G., Kulkarni, A., & Konopka, G. (2023) · Scientific Reports · doi:10.1038/s41598-023-36255-5 · Cited by 9
Biological Roles of Local Protein Synthesis in Axons: A Journey of Discovery
Holt, C. E. (2024) · Annual Review of Genetics · doi:10.1146/annurev-genet-072220-030822 · Cited by 10
Chongtham, A., Sharma, A., Nath, B., Murtha, K., Gorbachev, K., Ramakrishnan, A., Schmidt, E. F., Shen, L., & Pereira, A. C. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114967 · Cited by 10
Cell-Type Identification in the Autonomic Nervous System
Liu, D.-S., & Xu, T. (2018) · Neuroscience Bulletin · doi:10.1007/s12264-018-0284-9 · Cited by 10
Mansuri, M. S., Peng, G., Wilson, R. S., Lam, T. T., Zhao, H., Williams, K. R., & Nairn, A. C. (2020) · Proteomes · doi:10.3390/proteomes8040027 · Cited by 9
Gaspari, S., Quenneville, S., Sánchez-Archidona, A. R., Thorens, B., & Croizier, S. (2022) · The Journal of Comparative Neurology · doi:10.1002/cne.25312 · Cited by 10
Inducible CRISPR Epigenome Systems Mimic Cocaine Induced Bidirectional Regulation of Nab2 and Egr3
Choi, E. Y., Franco, D., Stapf, C. A., Gordin, M., Chow, A., Cover, K. K., Chandra, R., & Lobo, M. K. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.1802-22.2022 · Cited by 11
Shining the Light on Astrocytic Ensembles
Delgado, L., & Navarrete, M. (2023) · Cells · doi:10.3390/cells12091253 · Cited by 12
Hrabak, M., Moon, C. J., Bolaños-Guzmán, C. A., & Steiner, H. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03688-y · Cited by 9
In vivo Interrogation of Central Nervous System Translatome by Polyribosome Fractionation
Lou, W. P.-K., Baser, A., Klußmann, S., & Martín-Villalba, A. (2014) · Journal of Visualized Experiments · doi:10.3791/51255 · Cited by 10
Zhou, M., Gresack, J. E., Cheng, J., Uryu, K., Brichta, L., Greengard, P., & Flajolet, M. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0233-z · Cited by 10
Self-citationKhan, A. M., Grant, A. H., Martinez, A., Burns, G., Thatcher, B. S., Anekonda, V. T., Thompson, B. W., Roberts, Z. S., Moralejo, D. H., & Blevins, J. E. (2018) · Advances in neurobiology · doi:10.1007/978-3-319-94593-4_6 · Cited by 9
Dopamine receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
Beaulieu, J., Borrelli, E., Carlsson, A., Caron, M. G., Civelli, O., Espinoza, S., Fisone, G., Gainetdinov, R. R., Grandy, D. K., Kebabian, J. W., et al. (2019) · IUPHAR/BPS Guide to Pharmacology CITE · doi:10.2218/gtopdb/f20/2019.4 · Cited by 10
Growth control of root architecture
Topp, C. N., & Benfey, P. N. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-381466-1.00024-9 · Cited by 11
Psychostimulant-Induced Gene Regulation in Striatal Circuits
Steiner, H. (2016) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-802206-1.00031-3 · Cited by 9
Systems biology in the central nervous system: A brief perspective on essential recent advancements
Dougherty, J. D., Yang, C., & Lake, A. M. (2017) · Current Opinion in Systems Biology · doi:10.1016/j.coisb.2017.04.011 · Cited by 10
Davis, M. I., & Puhl, H. L. (2011) · PLoS ONE · doi:10.1371/annotation/83671a73-38e3-4ba4-b016-81264138a0ac · Cited by 10
Imai, H., Utsumi, D., Torihara, H., Takahashi, K., Kuroyanagi, H., & Yamashita, A. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad545 · Cited by 9
Nousch, M. (2020) · G3 Genes Genomes Genetics · doi:10.1534/g3.120.401644 · Cited by 9
Avila‐Gutierrez, K., Slaoui, L., Alvear‐Perez, R., Kozlowski, E., Oudart, M., Augustin, E., Claveau, C., Mailly, P., Monnet, H., Mignon, V., et al. (2024) · Glia · doi:10.1002/glia.24503 · Cited by 9
Astrocyte Extracellular Matrix Modulates Neuronal Dendritic Development
Hashimoto, J. G., Margolies, N., Zhang, X., Karpf, J. A., Song, Y., Gorham, N., Davis, B. A., Zhang, F., Linhardt, R. J., Carbone, L., et al. (2025) · Glia · doi:10.1002/glia.70020 · Cited by 9
Schreiweis, C., Irinopoulou, T., Vieth, B., Laddada, L., Oury, F., Burguière, E., Enard, W., & Groszer, M. (2019) · Cortex · doi:10.1016/j.cortex.2019.01.008 · Cited by 9
McLachlan, I. G., & Flavell, S. W. (2019) · BIO-PROTOCOL · doi:10.21769/bioprotoc.3328 · Cited by 9
Kim, N., Li, Y., Yu, R., Kwon, H.-S., Song, A., Jun, M.-H., Jeong, J.-Y., Lee, J. H., Lim, H., Kim, M. J., et al. (2024) · eLife · doi:10.7554/elife.96891 · Cited by 9
Freedom of expression: cell‐type‐specific gene profiling
Otsuki, L., Cheetham, S. W., & Brand, A. H. (2014) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.149 · Cited by 9
Thellmann, M., Andersen, T. G., & Vermeer, J. E. M. (2020) · Journal of Visualized Experiments · doi:10.3791/60919 · Cited by 9
Yang, L. M., Stout, L., Rauchman, M. I., & Ornitz, D. M. (2020) · Developmental Dynamics · doi:10.1002/dvdy.211 · Cited by 11
miR-142-3p regulates cortical oligodendrocyte gene co-expression networks associated with tauopathy
Hinman, J. D., Ngo, K. J., Kim, D., Chen, C.-D., Abraham, C. R., Ghanbari, M., Ikram, M. A., Kushner, S. A., Kawaguchi, R., Coppola, G., et al. (2020) · Human Molecular Genetics · doi:10.1093/hmg/ddaa252 · Cited by 11
Marques, R. F., & Duncan, K. E. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.317960 · Cited by 8
Presynaptic cGMP sets synaptic strength in the striatum and is important for motor learning
Fieblinger, T., Pérez‐Alvarez, A., Lamothe‐Molina, P. J., Gee, C. E., & Oertner, T. G. (2022) · EMBO Reports · doi:10.15252/embr.202154361 · Cited by 8
Epigenetic Mechanisms of Mental Retardation
Schaefer, A., Tarakhovsky, A., & Greengard, P. (2010) · Springer eBooks · doi:10.1007/978-3-7643-8989-5_7 · Cited by 9
Self-citationDefining functional gene‐circuit interfaces in the mouse nervous system
Soden, M. E., Gore, B. B., & Zweifel, L. S. (2013) · Genes Brain & Behavior · doi:10.1111/gbb.12082 · Cited by 9
655 Functional analysis of CDKN2A/p16INK4a 5 UTR variants predisposing to melanoma
Bisio, A., Nasti, S., Pastorino, L., Gargiulo, S., Jordan, J., Provenzani, A., Quattrone, A., Bianchi‐Scarrà, G., Ghiorzo, P., & Inga, A. (2010) · European Journal of Cancer Supplements · doi:10.1016/s1359-6349(10)71454-3 · Cited by 9
Histone bivalency in CNS developmentPreprint
Mätlik, K., Govek, E., & Hatten, M. E. (2025) · Genes & Development · doi:10.1101/gad.352306.124 · Cited by 10
Bandyadka, S., Lebo, D. P. V., Mondragon, A. A., Serizier, S. B., Kwan, J., Peterson, J. S., Chasse, A. Y., Jenkins, V., Calikyan, A., Ortega, A., et al. (2025) · PLoS Genetics · doi:10.1371/journal.pgen.1011220 · Cited by 8
Self-citationOntogeny specification and epigenetic regulation of macrophage plasticity
Huang, H.-Y., Zheng, X.-N., & Tian, L. H. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1676953 · Cited by 8
Cell Type‐Specific mTORC1 Signaling and Translational Control in Synaptic Plasticity and Memory
Huang, Z., Mahmood, N., Wiebe, S. A., Khoutorsky, A., Lacaille, J., & Sonenberg, N. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70281 · Cited by 10
Mito, M., Kadota, M., Tanaka, K. Y., Furuta, Y., Abe, K., Iwasaki, S., & Nakagawa, S. (2018) · Scientific Reports · doi:10.1038/s41598-018-19494-9 · Cited by 8
Translational regulation enhances distinction of cell types in the nervous system
Ichinose, T., Kondo, S., Kanno, M., Shichino, Y., Mito, M., Iwasaki, S., & Tanimoto, H. (2024) · eLife · doi:10.7554/elife.90713 · Cited by 8
The 18S rRNA methyltransferase DIMT-1 regulates lifespan in the germline later in life
Rothi, M. H., Sarkar, G. C., Haddad, J. A., Mitchell, W., Ying, K., Pohl, N. K., Sotomayor-Mena, R. G., Natale, J., Dellacona, S., Gladyshev, V. N., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-62323-7 · Cited by 9
Translational Control Mechanisms in Angiogenesis and Vascular Biology
Yao, P., Eswarappa, S. M., & Fox, P. L. (2015) · Current Atherosclerosis Reports · doi:10.1007/s11883-015-0506-9 · Cited by 8
The alternative life of RNA —sequencing meets single molecule approaches
Moya, S. M. F., Ehses, J., & Kiebler, M. A. (2017) · FEBS Letters · doi:10.1002/1873-3468.12639 · Cited by 8
Metadata
- Authors
- Heiman, M., Schaefer, A., Gong, S., Peterson, J. D., Day, M., Ramsey, K. E., Suárez-Fariñas, M., Schwarz, C., Stephan, D. A., Surmeier, D. J., Greengard, P., & Heintz, N.
- Affiliations
- Rockefeller University (US)
- Northwestern University (US)
- Translational Genomics Research Institute (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Heintz, Nathaniel
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2008-11
- Volume
- 135
- Issue
- 4
- Pages
- 738-748
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC2696821
- OpenAlex
- W2150626351
- Cited by
- 1,134
- References
- 59
- Citations by year
- 2026: 28 · 2025: 61 · 2024: 57 · 2023: 65 · 2022: 55 · 2021: 60 · 2020: 79 · 2019: 76 · 2018: 93 · 2017: 76 · 2016: 70 · 2015: 70 · 2014: 97 · 2013: 70 · 2012: 55
- FWCI
- 16.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1755 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health (1f32da021487-01)
- National Institute on Aging (AG09464, P01AG009464)
- National Institute of Mental Health (MH-074866, P50MH074866)
- National Institute on Drug Abuse (5F32DA021487, DA10044, P01DA010044, F32 DA021487)
- National Institute of Neurological Disorders and Stroke (NS 34696, R01NS034696, R37NS034696)
- National Center for Research Resources (UL1RR024143)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
- Keywords
- translating ribosome affinity purification, polysomal mRNA, neuronal cell types, medium spiny neurons, translational profiling, BAC transgenic mice, cell type-specific gene expression
- MeSH terms
- Animals, Brain, Central Nervous System, Cocaine, Genetic Techniques, Immunohistochemistry, Mice, Transgenic, Models, Biological, Neurons, Ribosomes, Protein Biosynthesis, Dopamine Uptake Inhibitors, Chromosomes, Artificial, Bacterial, Green Fluorescent Proteins, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
