The DOI matches its Crossref record; 67 of the 68 references it cites were found in a registry or an index.
Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair
Open accessAbstract
Bone marrow hematopoietic stem cells (HSCs) are crucial to maintain lifelong production of all blood cells. Although HSCs divide infrequently, it is thought that the entire HSC pool turns over every few weeks, suggesting that HSCs regularly enter and exit cell cycle. Here, we combine flow cytometry with label-retaining assays (BrdU and histone H2B-GFP) to identify a population of dormant mouse HSCs (d-HSCs) within the lin(-)Sca1+cKit+CD150+CD48(-)CD34(-) population. Computational modeling suggests that d-HSCs divide about every 145 days, or five times per lifetime. d-HSCs harbor the vast majority of multilineage long-term self-renewal activity. While they form a silent reservoir of the most potent HSCs during homeostasis, they are efficiently activated to self-renew in response to bone marrow injury or G-CSF stimulation. After re-establishment of homeostasis, activated HSCs return to dormancy, suggesting that HSCs are not stochastically entering the cell cycle but reversibly switch from dormancy to self-renewal under conditions of hematopoietic stress.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Loss of quiescence is a major factor leading to erosion of HSC self-renewal (31,32).”
From Txnip Enhances Fitness of Dnmt3a -Mutant Hematopoietic Stem Cells via p21 (2022) · cites this paper as [31]
In the citing paper
“Thus, as many HSCs remain quiescent for much of adult life54,55, the continuing accumulation of damage in these cells may eventually exceed a threshold that impairs stem cell function in aged animals.”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [54]
In the citing paper
“Although both cycling and quiescent hematopoietic stem cell (HSC) subpopulations (34) were correctly predicted to be less differentiated, only proliferative HSCs were significantly ranked above early progenitors (Fig. 3C).”
From Single-cell transcriptional diversity is a hallmark of developmental potential (2020) · cites this paper as [34]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Identification of stem cells in small intestine and colon by marker gene Lgr5
Barker, N., van Es, J. H., Kuipers, J., Kujala, P., van den Born, M., Cozijnsen, M., Haegebarth, A., Korving, J., Begthel, H., Peters, P. J., et al. (2007) · Nature · doi:10.1038/nature06196 · Cited by 5,687
Kiel, M. J., Yilmaz, Ö. H., Iwashita, T., Yilmaz, O. H., Terhorst, C., & Morrison, S. J. (2005) · Cell · doi:10.1016/j.cell.2005.05.026 · Cited by 3,168
Identification of the haematopoietic stem cell niche and control of the niche size
Zhang, J., Niu, C. S., Ye, L., Huang, H., He, X. C., Tong, W.-G., Ross, J., Haug, J., Johnson, T. J., Feng, J. Q., et al. (2003) · Nature · doi:10.1038/nature02041 · Cited by 2,948
Cotsarelis, G., Sun, T.-T., & Lavker, R. M. (1990) · Cell · doi:10.1016/0092-8674(90)90696-c · Cited by 2,276
Long-Term Lymphohematopoietic Reconstitution by a Single CD34-Low/Negative Hematopoietic Stem Cell
Osawa, M., Hanada, K., Hamada, H., & Nakauchi, H. (1996) · Science · doi:10.1126/science.273.5272.242 · Cited by 2,141
Defining the Epithelial Stem Cell Niche in Skin
Tumbar, T., Guasch, G., Greco, V., Blanpain, C., Lowry, W. E., Rendl, M., & Fuchs, E. (2004) · Science · doi:10.1126/science.1092436 · Cited by 2,031
Tie2/Angiopoietin-1 Signaling Regulates Hematopoietic Stem Cell Quiescence in the Bone Marrow Niche
Arai, F., Hirao, A., Ohmura, M., Sato, H., Matsuoka, S., Takubo, K., Ito, K., Koh, G. Y., & Suda, T. (2004) · Cell · doi:10.1016/j.cell.2004.07.004 · Cited by 1,958
Weissman, I. L. (2000) · Cell · doi:10.1016/s0092-8674(00)81692-x · Cited by 1,827
Models, mechanisms and clinical evidence for cancer dormancy
Aguirre‐Ghiso, J. A. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2256 · Cited by 1,756
Mutation selection and the natural history of cancer
Cairns, J. (1975) · Nature · doi:10.1038/255197a0 · Cited by 1,592
Flagged first, then by citations
1 of the 68 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Graf, T., and Trumpp, A. (2007). Poster: Haematopoietic stem cells, niches and differentiation pathways. Nature Reviews Immunology, www.nature.com/nri/posters/hsc/index.html.
Cited by
Sorted by citations
Items 401–500 of 1,004
Moving epithelia: Tracking the fate of mammalian limbal epithelial stem cells
Girolamo, N. D. (2015) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2015.04.002 · Cited by 87
Chavali, M., Klingener, M., Kokkosis, A. G., Garkun, Y., Felong, S., Maffei, A., & Aguirre, A. A. (2017) · Nature Communications · doi:10.1038/s41467-017-02440-0 · Cited by 85
Clonal-level lineage commitment pathways of hematopoietic stem cells in vivo
Lu, R., Czechowicz, A. D., Seita, J., Du, J., & Weissman, I. L. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1801480116 · Cited by 89
Adler, B. J., Green, D. E., Pagnotti, G. M., Chan, M. E., & Rubin, C. T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090639 · Cited by 87
Diverse roles of GSK-3: Tumor promoter–tumor suppressor, target in cancer therapy
McCubrey, J. A., Davis, N. M., Abrams, S. L., Montalto, G., Cervello, M., Bäsecke, J., Libra, M., Nicoletti, F., Cocco, L., Martelli, A. M., et al. (2013) · Advances in Biological Regulation · doi:10.1016/j.jbior.2013.09.013 · Cited by 85
MacNamara, K. C., Jones, M., Martin, O., & Winslow, G. M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028669 · Cited by 92
Ferreting out stem cells from their niches
Fuchs, E. V., & Horsley, V. (2011) · Nature Cell Biology · doi:10.1038/ncb0511-513 · Cited by 87
Rathinam, C., Matesic, L. E., & Flavell, R. A. (2011) · Nature Immunology · doi:10.1038/ni.2021 · Cited by 89
STAT5BN642H is a driver mutation for T cell neoplasia
Pham, H. T. T., Maurer, B., Prchal‐Murphy, M., Grausenburger, R., Grundschober, E., Javaheri, T., Nivarthi, H., Boersma, A., Kolbe, T., Elabd, M., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci94509 · Cited by 86
Shin, J. J., Schröder, M., Caiado, F., Wyman, S. K., Bray, N., Bordi, M., DeWitt, M. A., Vu, J. T., Kim, W., Hockemeyer, D. F., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108093 · Cited by 87
Metabolic regulation of somatic stem cells in vivo
Meacham, C. E., DeVilbiss, A. W., & Morrison, S. J. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00462-1 · Cited by 85
Using biomaterials to study stem cell mechanotransduction, growth and differentiation
McMurray, R. J., Dalby, M. J., & Tsimbouri, P. M. (2014) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.1957 · Cited by 86
Switching roles: the functional plasticity of adult tissue stem cells
Wabik, A., & Jones, P. H. (2015) · The EMBO Journal · doi:10.15252/embj.201490386 · Cited by 84
The Hematopoietic Oxidase NOX2 Regulates Self-Renewal of Leukemic Stem Cells
Adane, B., Ye, H., Khan, N., Pei, S., Minhajuddin, M., Stevens, B. M., Jones, C. L., D’Alessandro, A., Reisz, J. A., Zaberezhnyy, V., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.03.009 · Cited by 86
Imprinted Genes That Regulate Early Mammalian Growth Are Coexpressed in Somatic Stem Cells
Berg, J. S., Lin, K. K., Sonnet, C., Boles, N. C., Weksberg, D. C., Nguyen, H., Holt, L. J., Rickwood, D., Daly, R. J., & Goodell, M. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026410 · Cited by 84
DeGregori, J. V. (2012) · Oncogene · doi:10.1038/onc.2012.281 · Cited by 88
Emerging Topics on Disseminated Cancer Cell Dormancy and the Paradigm of Metastasis
Aguirre‐Ghiso, J. A., & Sosa, M. S. (2018) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030617-050446 · Cited by 84
FGF signaling facilitates postinjury recovery of mouse hematopoietic system
Zhao, M. L., Ross, J. T., Itkin, T., Perry, J. M., Venkatraman, A., Haug, J. S., Hembree, M. J., Deng, C., Lapidot, T., He, X. C., et al. (2012) · Blood · doi:10.1182/blood-2011-11-393991 · Cited by 86
A matter of life and death: stem cell survival in tissue regeneration and tumour formation
Soteriou, D., & Fuchs, Y. (2018) · Nature Reviews Cancer · doi:10.1038/nrc.2017.122 · Cited by 87
Sommerkamp, P., Romero-Mulero, M. C., Narr, A., Ladel, L., Hustin, L., Schönberger, K., Renders, S., Altamura, S., Zeisberger, P., Jäcklein, K., et al. (2021) · Blood · doi:10.1182/blood.2020007876 · Cited by 83
Self-citationTower, J. (2012) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.56 · Cited by 85
van der Wath, R. C., Wilson, A., Laurenti, E., Trumpp, A., & Lió, P. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006972 · Cited by 91
Self-citationMolecular mechanisms underlying lineage bias in aging hematopoiesis
Elias, H. K., Bryder, D., & Park, C. Y. (2016) · Seminars in Hematology · doi:10.1053/j.seminhematol.2016.11.002 · Cited by 80
Numerous niches for hematopoietic stem cells remain empty during homeostasis
Shimoto, M., Sugiyama, T., & Nagasawa, T. (2017) · Blood · doi:10.1182/blood-2016-09-740563 · Cited by 82
Hierarchy and Plasticity in the Intestinal Stem Cell Compartment
Yousefi, M., Li, L., & Lengner, C. J. (2017) · Trends in Cell Biology · doi:10.1016/j.tcb.2017.06.006 · Cited by 87
Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo
Kobayashi, H., Morikawa, T., Okinaga, A., Hamano, F., Hashidate‐Yoshida, T., Watanuki, S., Hishikawa, D., Shindou, H., Arai, F., Kabe, Y., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.06.008 · Cited by 87
The evolving definition of salivary gland stem cells
Rocchi, C., Barazzuol, L., & Coppes, R. P. (2021) · npj Regenerative Medicine · doi:10.1038/s41536-020-00115-x · Cited by 86
A multi-stem cell basis for craniosynostosis and calvarial mineralization
Bok, S., Yallowitz, A. R., Sun, J., McCormick, J., Cung, M., Hu, L., Lalani, S., Li, Z., Sosa, B. R., Baumgartner, T., et al. (2023) · Nature · doi:10.1038/s41586-023-06526-2 · Cited by 82
Pancreatic cancer stem cells – update and future perspectives
Lonardo, E., Hermann, P. C., & Heeschen, C. (2010) · Molecular Oncology · doi:10.1016/j.molonc.2010.06.002 · Cited by 82
The Ah receptor in stem cell cycling, regulation, and quiescence
Gasiewicz, T. A., Singh, K. P., & Bennett, J. A. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12361 · Cited by 84
Oligodendrocyte progenitors: Adult stem cells of the central nervous system?
Crawford, A. H., Stockley, J. H., Tripathi, R. B., Richardson, W. D., & Franklin, R. J. M. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.04.027 · Cited by 81
Metformin improves defective hematopoiesis and delays tumor formation in Fanconi anemia mice
Zhang, Q., Tang, W., Deater, M., Phan, N., Marcogliese, A. N., Li, H., Al-Dhalimy, M., Major, A. M., Olson, S. B., Monnat, R. J., et al. (2016) · Blood · doi:10.1182/blood-2015-11-683490 · Cited by 81
Lee, J.-M., Govindarajah, V., Goddard, B., Hinge, A. S., Muench, D. E., Filippi, M., Aronow, B. J., Cancelas, J. A., Salomonis, N., Grimes, H. L., et al. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20170690 · Cited by 83
Metabolism as master of hematopoietic stem cell fate
Ito, K., Bonora, M., & Ito, K. (2018) · International Journal of Hematology · doi:10.1007/s12185-018-2534-z · Cited by 85
New insights into hematopoietic differentiation landscapes from single-cell RNA sequencing
Watcham, S., Kuciński, I., & Göttgens, B. (2019) · Blood · doi:10.1182/blood-2018-08-835355 · Cited by 86
Venetoclax therapy and emerging resistance mechanisms in acute myeloid leukaemia
Nwosu, G. O., Ross, D. M., Powell, J. A., & Pitson, S. M. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06810-7 · Cited by 80
Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury.
Shao, L., Wang, Y., Chang, J., Luo, Y., Meng, A., & Zhou, D. (2013) · PubMed · doi:10.3978/j.issn.2218-676x.2013.07.03 · Cited by 87
A quiescent path to plant longevity
Heyman, J., Kumpf, R. P., & Veylder, L. D. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.03.004 · Cited by 77
Kulkarni, S. S., Singh, P. K., Ghosh, S. P., Posarac, A., & Singh, V. K. (2013) · Cytokine · doi:10.1016/j.cyto.2013.03.009 · Cited by 80
Renström, J., Istvánffy, R., Gauthier, K., Shimono, A., Mages, J., Jardon-Alvarez, A., Kröger, M., Schiemann, M., Busch, D. H., Esposito, I., et al. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.05.020 · Cited by 82
Piras, F., Riba, M., Petrillo, C., Lazarevic, D., Cuccovillo, I., Bartolaccini, S., Stupka, E., Gentner, B., Cittaro, D., Naldini, L., et al. (2017) · EMBO Molecular Medicine · doi:10.15252/emmm.201707922 · Cited by 75
Chen, J.-F., Luo, X., Xiang, L.-S., Li, H.-T., Zha, L., Li, N., He, J.-M., Xie, G.-F., Xie, X., & Liang, H.-J. (2106) · Oncotarget · doi:10.18632/oncotarget.9236 · Cited by 74
Clonal hematopoiesis and inflammation – the perpetual cycle
Avagyan, S., & Zon, L. I. (2023) · Trends in Cell Biology · doi:10.1016/j.tcb.2022.12.001 · Cited by 79
Bone marrow stem cells: current and emerging concepts
Méndez‐Ferrer, S., Scadden, D. T., & Sánchez‐Aguilera, A. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12641 · Cited by 79
Identification of a clonally expanding haematopoietic compartment in bone marrow
Wang, L., Benedito, R., Bixel, M. G., Zeuschner, D., Stehling, M., Savendahl, L. S., Haigh, J. J., Snippert, H. J. G., Clevers, H. C., Breier, G., et al. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.308 · Cited by 81
Spatial Genome Re-organization between Fetal and Adult Hematopoietic Stem Cells
Chen, C., Yu, W., Tober, J. M., Gao, P., He, B., Lee, K., Trieu, T., Blobel, G. A., Speck, N. A., & Tan, K. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.11.065 · Cited by 79
Molecular and cellular mechanisms of aging in hematopoietic stem cells and their niches
Zhang, L., Mack, R. M., Breslin, P., & Zhang, J. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00994-z · Cited by 80
A single dividing cell population with imbalanced fate drives oesophageal tumour growth
Frede, J., Greulich, P., Nagy, T., Simons, B. D., & Jones, P. H. (2016) · Nature Cell Biology · doi:10.1038/ncb3400 · Cited by 75
The Development of T Cells From Stem Cells in Mice and Humans
Famili, F., Wiekmeijer, A., & Staal, F. J. T. (2017) · Future Science OA · doi:10.4155/fsoa-2016-0095 · Cited by 84
Reconstitution of T Cell Subsets Following Allogeneic Hematopoietic Cell Transplantation
Dekker, L., de Koning, C. C. H., Lindemans, C. A., & Nierkens, S. (2020) · Cancers · doi:10.3390/cancers12071974 · Cited by 82
Zhang, C., Liu, J., Zou, T., Qi, Y., Yi, B., Dissanayaka, W. L., & Zhang, C. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02349-y · Cited by 85
Hou, Y., Li, W., Sheng, Y., Li, L., Huang, Y., Zhang, Z., Zhu, T., Peace, D. J., Quigley, J. G., Wu, W., et al. (2015) · Nature Immunology · doi:10.1038/ni.3204 · Cited by 82
Khandanpour, C., Sharif‐Askari, E., Vaßen, L., Gaudreau, M., Zhu, J., Paul, W. E., Okayama, T., Kosan, C., & Möröy, T. (2010) · Blood · doi:10.1182/blood-2010-04-280305 · Cited by 81
Normal Hematopoiesis Is a Balancing Act of Self-Renewal and RegenerationPreprint
Olson, O. C., Kang, Y.-A., & Passegue, E. A. (2020) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a035519 · Cited by 89
Two anatomically distinct niches regulate stem cell activity
Ema, H., & Suda, T. (2012) · Blood · doi:10.1182/blood-2012-04-424507 · Cited by 78
Theory and Practice of Lineage Tracing
Hsu, Y. (2015) · Stem Cells · doi:10.1002/stem.2123 · Cited by 75
Endosteal-like extracellular matrix expression on melt electrospun written scaffolds
Muerza-Cascante, M. L., Shokoohmand, A., Khosrotehrani, K., Haylock, D. N., Dalton, P. D., Hutmacher, D. W., & Loessner, D. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.12.040 · Cited by 75
Programming for T-lymphocyte fates: modularity and mechanismsPreprint
Rothenberg, E. V. (2019) · Genes & Development · doi:10.1101/gad.327163.119 · Cited by 75
Clonal dynamics of haematopoiesis across the human lifespanPreprint
Mitchell, E., Chapman, M. S., Williams, N., Dawson, K. J., Mende, N., Calderbank, E. F., Jung, H., Mitchell, T. J., Coorens, T. H. H., Spencer, D. H., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.08.16.456475 · Cited by 74
Self-citationHirche, C., Frenz, T., Haas, S. F., Döring, M., Borst, K., Tegtmeyer, P.-K., Brizić, I., Jordan, S., Keyser, K. A., Chhatbar, C., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.05.063 · Cited by 73
Self-citationCell cycle regulation of hematopoietic stem or progenitor cells
Hao, S., Chen, C., & Cheng, T. (2016) · International Journal of Hematology · doi:10.1007/s12185-016-1984-4 · Cited by 76
T Cell Development by the Numbers
Krueger, A., Ziętara, N., & Łyszkiewicz, M. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.10.007 · Cited by 71
Ganuza, M., Hall, T., Finkelstein, D., Wang, Y., Chabot, A., Kang, G., Bi, W., Wu, G., & McKinney‐Freeman, S. (2019) · Blood · doi:10.1182/blood-2018-09-873059 · Cited by 73
Low Doses of Imatinib Induce Myelopoiesis and Enhance Host Anti-microbial Immunity
Napier, R. J., Norris, B. A., Swimm, A. I., Giver, C. R., Harris, W. A. C., Laval, J., Napier, B. A., Patel, G., Crump, R., Peng, Z., et al. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1004770 · Cited by 73
Horn, M., Glauche, I., Müller, M. C., Hehlmann, R., Hochhaus, A., Loeffler, M., & Roeder, I. (2012) · Blood · doi:10.1182/blood-2012-07-441956 · Cited by 72
Lu, Y., Liu, M., Yang, J., Weissman, S. M., Pan, X., Katz, S. G., & Wang, S. (2021) · Cell Discovery · doi:10.1038/s41421-021-00266-1 · Cited by 70
Tao, L., Roberts, A. L., Dunphy, K. A., Bigelow, C., Yan, H., & Jerry, D. J. (2010) · Stem Cells · doi:10.1002/stem.552 · Cited by 75
CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells
Sinclair, A., Park, L., Shah, M., Drotar, M. E., Calaminus, S. D. J., Hopcroft, L. E. M., Kinstrie, R., Guitart, A. V., Dunn, K. M., Abraham, S. A., et al. (2016) · Blood · doi:10.1182/blood-2015-08-661785 · Cited by 75
Epigenetic regulation of hematopoietic stem cell aging
Beerman, I., & Rossi, D. J. (2014) · Experimental Cell Research · doi:10.1016/j.yexcr.2014.09.013 · Cited by 77
Melanocytes, melanocyte stem cells, and melanoma stem cells
Lang, D., Mascarenhas, J. B., & Shea, C. R. (2013) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2012.08.014 · Cited by 79
Identification of Quiescent, Stem-Like Cells in the Distal Female Reproductive Tract
Wang, Y., Sacchetti, A., van Dijk, M. R., van der Zee, M., van der Horst, P. H., Joosten, R., Burger, C. W., Grootegoed, J. A., Blok, L. J., & Fodde, R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040691 · Cited by 70
Murakami, S., Suzuki, T., Harigae, H., Roméo, P., Yamamoto, M. P., & Motohashi, H. (2017) · Molecular and Cellular Biology · doi:10.1128/mcb.00086-17 · Cited by 75
DNA damage tolerance in stem cells, ageing, mutagenesis, disease and cancer therapy
Pilzecker, B., Buoninfante, O. A., & Jacobs, H. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz531 · Cited by 76
Obesity-induced inflammation: The impact of the hematopoietic stem cell niche
Bowers, E., & Singer, K. (2021) · JCI Insight · doi:10.1172/jci.insight.145295 · Cited by 72
Ash1l controls quiescence and self-renewal potential in hematopoietic stem cells
Jones, M., Chase, J., Brinkmeier, M. L., Xu, J., Weinberg, D. N., Schira, J., Friedman, A. D., Malek, S. N., Grembecka, J. E., Cierpicki, T., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci78124 · Cited by 74
Integrating Physiological Regulation with Stem Cell and Tissue Homeostasis
Nakada, D., Levi, B. P., & Morrison, S. J. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.011 · Cited by 78
Effects of aging on hematopoietic stem and progenitor cells
Waterstrat, A., & Zant, G. E. V. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.05.002 · Cited by 72
Niche contributions to oncogenesis: emerging concepts and implications for the hematopoietic system
Raaijmakers, M. H. G. P. (2011) · Haematologica · doi:10.3324/haematol.2010.028035 · Cited by 71
Suppression of leukemia development caused by PTEN loss
Guo, W., Schubbert, S., Chen, J. Y., Valamehr, B. B., Mosessian, S., Shi, H., Dang, N. H., Garcia, C., Theodoro, M. F., Varella‐Garcia, M., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006937108 · Cited by 73
Asymmetric Cell Divisions and Asymmetric Cell Fates
Tajbakhsh, S., Rocheteau, P., & Roux, I. L. (2009) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.24.110707.175415 · Cited by 74
Corneal epithelial stem cells and their niche at a glance
Nowell, C. S., & Radtke, F. (2017) · Journal of Cell Science · doi:10.1242/jcs.198119 · Cited by 70
Freire, P. R., & Conneely, O. M. (2018) · Blood · doi:10.1182/blood-2017-07-795757 · Cited by 70
Aging of the hematopoietic system
Snoeck, H. (2013) · Current Opinion in Hematology · doi:10.1097/moh.0b013e3283623c77 · Cited by 73
Compartmentalized organization: a common and required feature of stem cell niches?
Greco, V., & Guo, S. (2010) · Development · doi:10.1242/dev.041103 · Cited by 69
Bihari, C., Anand, L., Rooge, S. B., Kumar, D., Saxena, P., Shubham, S., Sukriti, S., Trehanpati, N., Kumar, G., Pamecha, V., et al. (2016) · Hepatology · doi:10.1002/hep.28754 · Cited by 67
Infection-adapted emergency hematopoiesis promotes visceral leishmaniasis
Abidin, B. M., Hammami, A., Stäger, S., & Heinonen, K. M. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006422 · Cited by 67
Metabolic Regulation of Hematopoietic Stem Cells
Morganti, C., Cabezas‐Wallscheid, N., & Ito, K. (2022) · HemaSphere · doi:10.1097/hs9.0000000000000740 · Cited by 82
Tsapogas, P., Swee, L. K., Nusser, A., Nuber, N., Kreuzaler, M., Capoferri, G., Rolink, H., Ceredig, R. H., & Rolink, A. G. (2014) · Haematologica · doi:10.3324/haematol.2013.089482 · Cited by 67
Crozatier, M., & Vincent, A. (2011) · Disease Models & Mechanisms · doi:10.1242/dmm.007351 · Cited by 72
A storm in the niche: Iron, oxidative stress and haemopoiesis
Pilo, F., & Angelucci, E. (2017) · Blood Reviews · doi:10.1016/j.blre.2017.08.005 · Cited by 69
Hermetet, F., Buffière, A., Aznague, A., de Barros, J.-P. P., Bastie, J.-N., Delva, L., & Quéré, R. (2019) · Nature Communications · doi:10.1038/s41467-018-08228-0 · Cited by 73
Schneider, M. R., & Yarden, Y. (2015) · Oncogene · doi:10.1038/onc.2015.372 · Cited by 69
Hematopoietic Stem Cell Factors: Their Functional Role in Self-Renewal and Clinical Aspects
Mann, Z., Sengar, M., Verma, Y. K., Rajalingam, R., & Raghav, P. K. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.664261 · Cited by 69
Asai, T., Liu, Y., Giandomenico, S. D., Bae, N., Ndiaye‐Lobry, D., DeBlasio, A., Menéndez, S., Antipin, Y., Reva, B. A., Wevrick, R., et al. (2012) · Blood · doi:10.1182/blood-2011-11-393983 · Cited by 70
Fate Mapping and Quantitation of Hematopoiesis In Vivo
Höfer, T., Busch, K., Klapproth, K., & Rodewald, H.-R. (2016) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032414-112019 · Cited by 71
Soluble Signals and Remodeling in a Synthetic Gelatin‐Based Hematopoietic Stem Cell Niche
Gilchrist, A. E., Lee, S., Hu, Y., & Harley, B. A. C. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201900751 · Cited by 67
CDK6 Inhibition: A Novel Approach in AML Management
Uras, I. Z., Sexl, V., & Kollmann, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072528 · Cited by 65
Liu, L., Inoki, A., Fan, K., Mao, F., Shi, G., Jin, X., Zhao, M., Ney, G. M., Jones, M., Sun, S., et al. (2020) · Blood · doi:10.1182/blood.2020007975 · Cited by 62
Asymmetric organelle inheritance predicts human blood stem cell fate
Loeffler, D., Schneiter, F., Wang, W., Wehling, A., Kull, T., Lengerke, C., Manz, M. G., & Schroeder, T. (2021) · Blood · doi:10.1182/blood.2020009778 · Cited by 74
Unipotent Megakaryopoietic Pathway Bridging Hematopoietic Stem Cells and Mature Megakaryocytes
Nishikii, H., Kanazawa, Y., Umemoto, T., Goltsev, Y., Matsuzaki, Y., Matsushita, K., Yamato, M., Nolan, G. P., Negrin, R. S., & Chiba, S. (2015) · Stem Cells · doi:10.1002/stem.1985 · Cited by 64
Metadata
- Authors
- Wilson, A., Laurenti, E., Oser, G., van der Wath, R. C., Blanco-Bose, W., Jaworski, M., Offner, S., Dunant, C. F., Eshkind, L., Bockamp, E., Lió, P., MacDonald, H. R., & Trumpp, A.
- Affiliations
- Ludwig Cancer Research (CH)
- École Polytechnique Fédérale de Lausanne (CH)
- Johannes Gutenberg University Mainz (DE)
- German Cancer Research Center (DE)
- Corresponding author
- Trumpp, Andreas
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2008-12
- Volume
- 135
- Issue
- 6
- Pages
- 1118-1129
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2070154483
- Cited by
- 1,908
- References
- 68
- Citations by year
- 2026: 59 · 2025: 71 · 2024: 100 · 2023: 98 · 2022: 105 · 2021: 118 · 2020: 130 · 2019: 105 · 2018: 119 · 2017: 104 · 2016: 127 · 2015: 120 · 2014: 137 · 2013: 124 · 2012: 120
- FWCI
- 57.99
- Type
- journal article
- Language
- en
- Update notices
- erratum (2009-07-10)
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1689 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- Cambridge University Engineering Department Publications Database (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Bradlow Foundation
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Health Sciences › Medicine › Hematology › Blood disorders and treatments
- Keywords
- hematopoietic stem cells, stem cell quiescence, self-renewal, HSC quiescence, cell cycle, label-retaining cells, bromodeoxyuridine, bone marrow damage, granulocyte colony-stimulating factor, hematopoietic homeostasis, computational modeling, multilineage reconstitution
- MeSH terms
- Animals, Antigens, Differentiation, Bone Marrow, Bromouracil, Fluorouracil, Hematopoietic Stem Cells, Homeostasis, Mice, Transgenic, Uridine, Green Fluorescent Proteins, Mice, Adult Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
