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Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair
Open accessAbstract
Bone marrow hematopoietic stem cells (HSCs) are crucial to maintain lifelong production of all blood cells. Although HSCs divide infrequently, it is thought that the entire HSC pool turns over every few weeks, suggesting that HSCs regularly enter and exit cell cycle. Here, we combine flow cytometry with label-retaining assays (BrdU and histone H2B-GFP) to identify a population of dormant mouse HSCs (d-HSCs) within the lin(-)Sca1+cKit+CD150+CD48(-)CD34(-) population. Computational modeling suggests that d-HSCs divide about every 145 days, or five times per lifetime. d-HSCs harbor the vast majority of multilineage long-term self-renewal activity. While they form a silent reservoir of the most potent HSCs during homeostasis, they are efficiently activated to self-renew in response to bone marrow injury or G-CSF stimulation. After re-establishment of homeostasis, activated HSCs return to dormancy, suggesting that HSCs are not stochastically entering the cell cycle but reversibly switch from dormancy to self-renewal under conditions of hematopoietic stress.
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“Loss of quiescence is a major factor leading to erosion of HSC self-renewal (31,32).”
From Txnip Enhances Fitness of Dnmt3a -Mutant Hematopoietic Stem Cells via p21 (2022) · cites this paper as [31]
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“Thus, as many HSCs remain quiescent for much of adult life54,55, the continuing accumulation of damage in these cells may eventually exceed a threshold that impairs stem cell function in aged animals.”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [54]
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“Although both cycling and quiescent hematopoietic stem cell (HSC) subpopulations (34) were correctly predicted to be less differentiated, only proliferative HSCs were significantly ranked above early progenitors (Fig. 3C).”
From Single-cell transcriptional diversity is a hallmark of developmental potential (2020) · cites this paper as [34]
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Cites
Identification of stem cells in small intestine and colon by marker gene Lgr5
Barker, N., van Es, J. H., Kuipers, J., Kujala, P., van den Born, M., Cozijnsen, M., Haegebarth, A., Korving, J., Begthel, H., Peters, P. J., et al. (2007) · Nature · doi:10.1038/nature06196 · Cited by 5,687
Kiel, M. J., Yilmaz, Ö. H., Iwashita, T., Yilmaz, O. H., Terhorst, C., & Morrison, S. J. (2005) · Cell · doi:10.1016/j.cell.2005.05.026 · Cited by 3,168
Identification of the haematopoietic stem cell niche and control of the niche size
Zhang, J., Niu, C. S., Ye, L., Huang, H., He, X. C., Tong, W.-G., Ross, J., Haug, J., Johnson, T. J., Feng, J. Q., et al. (2003) · Nature · doi:10.1038/nature02041 · Cited by 2,948
Cotsarelis, G., Sun, T.-T., & Lavker, R. M. (1990) · Cell · doi:10.1016/0092-8674(90)90696-c · Cited by 2,276
Long-Term Lymphohematopoietic Reconstitution by a Single CD34-Low/Negative Hematopoietic Stem Cell
Osawa, M., Hanada, K., Hamada, H., & Nakauchi, H. (1996) · Science · doi:10.1126/science.273.5272.242 · Cited by 2,141
Defining the Epithelial Stem Cell Niche in Skin
Tumbar, T., Guasch, G., Greco, V., Blanpain, C., Lowry, W. E., Rendl, M., & Fuchs, E. (2004) · Science · doi:10.1126/science.1092436 · Cited by 2,031
Tie2/Angiopoietin-1 Signaling Regulates Hematopoietic Stem Cell Quiescence in the Bone Marrow Niche
Arai, F., Hirao, A., Ohmura, M., Sato, H., Matsuoka, S., Takubo, K., Ito, K., Koh, G. Y., & Suda, T. (2004) · Cell · doi:10.1016/j.cell.2004.07.004 · Cited by 1,958
Weissman, I. L. (2000) · Cell · doi:10.1016/s0092-8674(00)81692-x · Cited by 1,827
Models, mechanisms and clinical evidence for cancer dormancy
Aguirre‐Ghiso, J. A. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2256 · Cited by 1,756
Mutation selection and the natural history of cancer
Cairns, J. (1975) · Nature · doi:10.1038/255197a0 · Cited by 1,592
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- Graf, T., and Trumpp, A. (2007). Poster: Haematopoietic stem cells, niches and differentiation pathways. Nature Reviews Immunology, www.nature.com/nri/posters/hsc/index.html.
Cited by
Sorted by citations
Items 101–200 of 1,004
Causes and Consequences of Hematopoietic Stem Cell Heterogeneity
Haas, S. F., Trumpp, A., & Milsom, M. D. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.04.003 · Cited by 362
Self-citationAntibiotics impair murine hematopoiesis by depleting the intestinal microbiota
Josefsdottir, K. S., Baldridge, M. T., Kadmon, C. S., & King, K. Y. (2017) · Blood · doi:10.1182/blood-2016-03-708594 · Cited by 343
Bowling, S., Sritharan, D., Osorio, F. G., Nguyen, M., Cheung, P., Rodriguez-Fraticelli, A., Patel, S. H., Yuan, W.-C., Fujiwara, Y., Li, B. E., et al. (2020) · Cell · doi:10.1016/j.cell.2020.04.048 · Cited by 346
Yu, W., Liu, X., Shen, J., Jovanović, O., Pohl, E. E., Gerson, S. L., Finkel, T., Broxmeyer, H. E., & Qu, C. (2013) · Cell stem cell · doi:10.1016/j.stem.2012.11.022 · Cited by 362
CDK6 Levels Regulate Quiescence Exit in Human Hematopoietic Stem Cells
Laurenti, E., Frelin, C., Xie, S. Z.-J., Ferrari, R., Dunant, C. F., Zandi, S., Neumann, A. L., Plumb, I., Doulatov, S. R., Chen, J., et al. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.01.017 · Cited by 339
Self-citationChronic Exposure to a TLR Ligand Injures Hematopoietic Stem Cells
Esplin, B. L., Shimazu, T., Welner, R. S., Garrett, K. P., Nie, L., Zhang, Q., Humphrey, M. B., Yang, Q., Borghesi, L., & Kincade, P. W. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003438 · Cited by 336
Ludin, A., Gur‐Cohen, S., Golan, K., Kaufmann, K. B., Itkin, T., Medaglia, C., Lu, X., Ledergor, G., Kollet, Ó., & Lapidot, T. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.5941 · Cited by 349
Pietras, E. M., Lakshminarasimhan, R., Techner, J.-M., Fong, S., Flach, J., Binnewies, M., & Passegué, E. (2014) · Journal of Experimental Medicine · doi:10.1084/jem.20131043 · Cited by 323
Hematopoietic Stem Cell Injury Induced by Ionizing Radiation
Shao, L., Luo, Y., & Zhou, D. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5635 · Cited by 344
Garza, L. A., Yang, C., Zhao, T., Blatt, H. B., Lee, M. S., He, H., Stanton, D. C., Carrasco, L., Spiegel, J. H., Tobias, J. W., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44478 · Cited by 330
When stem cells grow old: phenotypes and mechanisms of stem cell aging
Schultz, M. B., & Sinclair, D. A. (2016) · Development · doi:10.1242/dev.130633 · Cited by 341
Slowly dividing neural progenitors are an embryonic origin of adult neural stem cells
Furutachi, S., Miya, H., Watanabe, T., Kawai, H., Yamasaki, N., Harada, Y., Imayoshi, I., Nelson, M., Nakayama, K. I., Hirabayashi, Y., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.3989 · Cited by 329
Tissue Stem Cells: Architects of Their Niches
Fuchs, E., & Blau, H. M. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.09.011 · Cited by 332
Metabolic Reprogramming of Stem Cell Epigenetics
Ryall, J. G., Cliff, T. S., Dalton, S., & Sartorelli, V. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.11.012 · Cited by 339
Xie, H., Xu, J., Hsu, J. H.-R., Nguyen, M., Fujiwara, Y., Peng, C., & Orkin, S. H. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.10.001 · Cited by 334
Stem Cell Quiescence: Dynamism, Restraint, and Cellular Idling
van Velthoven, C. T. J., & Rando, T. A. (2019) · Cell stem cell · doi:10.1016/j.stem.2019.01.001 · Cited by 329
Hematopoietic progenitor cells as integrative hubs for adaptation to and fine-tuning of inflammation
Chavakis, T., Mitroulis, I., & Hajishengallis, G. (2019) · Nature Immunology · doi:10.1038/s41590-019-0402-5 · Cited by 330
Maintaining Tissue Homeostasis: Dynamic Control of Somatic Stem Cell Activity
Biteau, B., Hochmuth, C. E., & Jasper, H. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.10.004 · Cited by 322
Notch Signaling in the Regulation of Stem Cell Self-Renewal and Differentiation
Liu, J., Sato, C., Cerletti, M., & Wagers, A. J. (2010) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(10)92012-7 · Cited by 318
A family business: stem cell progeny join the niche to regulate homeostasis
Hsu, Y., & Fuchs, E. V. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3272 · Cited by 316
Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activity
Laurenti, E., Varnum-Finney, B., Wilson, A., Ferrero, I., Blanco-Bose, W. E., Ehninger, A., Knoepfler, P. S., Cheng, P.-F., MacDonald, H. R., Eisenman, R. N., et al. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.09.005 · Cited by 305
Self-citationYahata, T., Takanashi, T., Muguruma, Y., Ibrahim, A. A., Matsuzawa, H., Uno, T., Sheng, Y., Onizuka, M., Ito, M., Kato, S., et al. (2011) · Blood · doi:10.1182/blood-2011-01-330050 · Cited by 313
Noncanonical Wnt Signaling Maintains Hematopoietic Stem Cells in the Niche
Sugimura, R., He, X., Venkatraman, A., Arai, F., Box, A., Semerad, C. L., Haug, J. S., Peng, L., Zhong, X.-B., Suda, T., et al. (2012) · Cell · doi:10.1016/j.cell.2012.05.041 · Cited by 306
Dynamic variation in cycling of hematopoietic stem cells in steady state and inflammation
Takizawa, H., Regoes, R. R., Boddupalli, C. S., Bonhoeffer, S., & Manz, M. G. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20101643 · Cited by 309
Caiado, F., Pietras, E. M., & Manz, M. G. (2021) · Journal of Experimental Medicine · doi:10.1084/jem.20201541 · Cited by 289
Bogeska, R., Mikecin, A.-M., Kaschutnig, P., Fawaz, M., Büchler-Schäff, M., Le, D., Ganuza, M., Vollmer, A., Paffenholz, S. V., Asada, N., et al. (2022) · Cell Stem Cell · doi:10.1016/j.stem.2022.06.012 · Cited by 299
Hematopoietic stem cells count and remember self-renewal divisions
Bernitz, J. M., Kim, H. S., MacArthur, B., Sieburg, H., & Moore, K. (2016) · Cell · doi:10.1016/j.cell.2016.10.022 · Cited by 285
Snyder, R. (2012) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph9082875 · Cited by 287
A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion
Xia, P., Wang, S., Ye, B., Du, Y., Li, C., Xiong, Z., Qu, Y., & Fan, Z. (2018) · Immunity · doi:10.1016/j.immuni.2018.03.016 · Cited by 285
TGF-β signaling in the control of hematopoietic stem cells
Blank, U., & Karlsson, S. (2015) · Blood · doi:10.1182/blood-2014-12-618090 · Cited by 290
Unravelling stem cell dynamics by lineage tracing
Blanpain, C., & Simons, B. D. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3625 · Cited by 286
Chaperone-mediated autophagy sustains haematopoietic stem-cell function
Dong, S., Wang, Q., Kao, Y.-R., Diaz, A., Tasset, I., Kaushik, S., Thiruthuvanathan, V., Zintiridou, A., Nieves, E., Dzieciatkowska, M., et al. (2021) · Nature · doi:10.1038/s41586-020-03129-z · Cited by 275
Specification of haematopoietic stem cell fate via modulation of mitochondrial activity
Vannini, N., Girotra, M., Naveiras, O., Nikitin, G. F., Campos, V., Giger, S., Roch, A., Auwerx, J. H., & Lütolf, M. P. (2016) · Nature Communications · doi:10.1038/ncomms13125 · Cited by 292
Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause
Scognamiglio, R., Cabezas-Wallscheid, N., Thier, M. C., Altamura, S., Reyes, A., Prendergast, Á. M., Baumgärtner, D., Carnevalli, L. S., Atzberger, A., Haas, S., et al. (2016) · Cell · doi:10.1016/j.cell.2015.12.033 · Cited by 271
Self-citationNew paradigms on hematopoietic stem cell differentiation
Cheng, H., Zheng, Z., & Cheng, T. (2019) · Protein & Cell · doi:10.1007/s13238-019-0633-0 · Cited by 350
Chronic Infection Depletes Hematopoietic Stem Cells through Stress-Induced Terminal Differentiation
Matatall, K. A., Jeong, M., Chen, S., Sun, D., Chen, F., Mo, Q., Kimmel, M., & King, K. Y. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.11.031 · Cited by 262
Schaftenaar, F. H., Frodermann, V., Kuiper, J., & Lutgens, E. (2016) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000302 · Cited by 276
Single-cell lineage tracing unveils a role for TCF15 in haematopoiesis
Rodriguez-Fraticelli, A., Weinreb, C., Wang, S., Migueles, R. P., Jankovic, M., Usart, M., Klein, A. M., Lowell, S., & Camargo, F. D. (2020) · Nature · doi:10.1038/s41586-020-2503-6 · Cited by 265
The endosteal ‘osteoblastic’ niche and its role in hematopoietic stem cell homing and mobilization
Lévesque, J.-P., Helwani, F., & Winkler, I. G. (2010) · Leukemia · doi:10.1038/leu.2010.214 · Cited by 280
CDK6 as a key regulator of hematopoietic and leukemic stem cell activation
Scheicher, R., Hoelbl‐Kovacic, A., Bellutti, F., Tigan, A.-S., Prchal‐Murphy, M., Heller, G., Schneckenleithner, C., Salazar‐Roa, M., Zöchbauer‐Müller, S., Zuber, J. A., et al. (2014) · Blood · doi:10.1182/blood-2014-06-584417 · Cited by 265
Single-cell analysis reveals the continuum of human lympho-myeloid progenitor cells
Karamitros, D., Stoilova, B., Aboukhalil, Z., Hamey, F., Reinisch, A., Samitsch, M., Quek, L. S., Otto, G., Repapi, E., Doondeea, J. B., et al. (2017) · Nature Immunology · doi:10.1038/s41590-017-0001-2 · Cited by 277
The replication rate of human hematopoietic stem cells in vivo
Catlin, S. N., Busque, L., Gale, R. E., Guttorp, P., & Abkowitz, J. L. (2011) · Blood · doi:10.1182/blood-2010-08-303537 · Cited by 259
Regulation of Inflammation- and Infection-Driven Hematopoiesis
Boettcher, S., & Manz, M. G. (2017) · Trends in Immunology · doi:10.1016/j.it.2017.01.004 · Cited by 272
Oxidative stress, redox regulation and diseases of cellular differentiation
Ye, Z., Zhang, J., Townsend, D. M., & Tew, K. D. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2014.11.010 · Cited by 271
Marie-Egyptienne, D. T., Lohse, I., & Hill, R. P. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.11.019 · Cited by 264
Restraining Lysosomal Activity Preserves Hematopoietic Stem Cell Quiescence and Potency
Liang, R. H.-S., Arif, T., Kalmykova, S., Kasianov, A. S., Miao, L., Menon, V., Qiu, J., Bernitz, J. M., Moore, K. A., Lin, F., et al. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.01.013 · Cited by 256
Cellular barcoding tool for clonal analysis in the hematopoietic system
Gerrits, A., Dykstra, B. J., Kalmykowa, O. J., Klauke, K., Verovskaya, E. V., Broekhuis, M., de Haan, G., & Bystrykh, L. V. (2010) · Blood · doi:10.1182/blood-2009-06-229757 · Cited by 253
Somatic Mutations Reveal Lineage Relationships and Age-Related Mutagenesis in Human Hematopoiesis
Osorio, F. G., Huber, A. R., Oka, R., Verheul, M., Patel, S. H., Hasaart, K., de la Fonteijne, L., Varela, I., Camargo, F. D., & van Boxtel, R. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.11.014 · Cited by 246
Leukemic stem cells and therapy resistance in acute myeloid leukemia
Stelmach, P., & Trumpp, A. (2023) · Haematologica · doi:10.3324/haematol.2022.280800 · Cited by 273
Self-citationHow I treat patients who mobilize hematopoietic stem cells poorly
To, L. B., Lévesque, J.-P., & Herbert, K. E. (2011) · Blood · doi:10.1182/blood-2011-06-318220 · Cited by 250
Winkler, I. G., Barbier, V., Wadley, R. B., Zannettino, A. C. W., Williams, S., & Lévesque, J.-P. (2010) · Blood · doi:10.1182/blood-2009-07-233437 · Cited by 246
Quiescent tissue stem cells evade immune surveillance
Agudo, J., Park, E. S., Rose, S. A., Alibo, E., Sweeney, R., Dhainaut, M., Kobayashi, K. S., Sachidanandam, R., Baccarini, A., Merad, M., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.02.001 · Cited by 244
Shin, J. Y., Hu, W., Naramura, M., & Park, C. Y. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20131128 · Cited by 234
No Evidence for Cardiomyocyte Number Expansion in Preadolescent Mice
Alkass, K., Panula, J., Westman, M., Wu, T., Guerquin‐Kern, J., & Bergmann, O. (2015) · Cell · doi:10.1016/j.cell.2015.10.035 · Cited by 249
Fetal liver hematopoietic stem cell niches associate with portal vessels
Khan, J. A., Mendelson, A., Kunisaki, Y., Birbrair, A., Kou, Y., Estape, A. A., Pinho, S., Ciero, P., Nakahara, F., Ma’ayan, A., et al. (2015) · Science · doi:10.1126/science.aad0084 · Cited by 260
Quantifying T lymphocyte turnover
de Boer, R. J., & Perelson, A. S. (2013) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2012.12.025 · Cited by 242
The hematopoietic stem cell niche: from embryo to adult
Gao, X., Xu, C., Asada, N., & Frenette, P. S. (2018) · Development · doi:10.1242/dev.139691 · Cited by 247
Hematopoietic Stem Cell Metabolism during Development and Aging
Nakamura‐Ishizu, A., Ito, K., & Suda, T. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.06.029 · Cited by 245
The role of glutathione S-transferase P in signaling pathways and S-glutathionylation in cancer
Tew, K. D., Manevich, Y., Grek, C. L., Xiong, Y., Uys, J. D. K., & Townsend, D. M. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.04.013 · Cited by 239
Defining Adult Stem Cells by Function, not by Phenotype
Clevers, H., & Watt, F. M. (2018) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-062917-012341 · Cited by 245
STAT3 controls myeloid progenitor growth during emergency granulopoiesis
Zhang, H., Nguyen-Jackson, H., Panopoulos, A. D., Li, H. S., Murray, P. J., & Watowich, S. S. (2010) · Blood · doi:10.1182/blood-2009-12-259630 · Cited by 232
Delving deeper: MCL-1's contributions to normal and cancer biology
Perciavalle, R. M., & Opferman, J. T. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2012.08.011 · Cited by 233
The analysis, roles and regulation of quiescence in hematopoietic stem cells
Nakamura‐Ishizu, A., Takizawa, H., & Suda, T. (2014) · Development · doi:10.1242/dev.106575 · Cited by 254
Adhesion to osteopontin in the bone marrow niche regulates lymphoblastic leukemia cell dormancy
Boyerinas, B., Zafrir, M., Yesilkanal, A. E., Price, T. T., Hyjek, E. M., & Sipkins, D. A. (2013) · Blood · doi:10.1182/blood-2012-12-475483 · Cited by 232
Vannini, N., Campos, V., Girotra, M., Trachsel, V., Rojas-Sutterlin, S., Tratwal, J., Ragusa, S., Stefanidis, E., Ryu, D., Rainer, P. Y., et al. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.02.012 · Cited by 218
Roles of Nrf2 in cell proliferation and differentiation
Murakami, S., & Motohashi, H. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.030 · Cited by 226
Haematopoietic stem cell self-renewal in vivo and ex vivo
Wilkinson, A. C., Igarashi, K. J., & Nakauchi, H. (2020) · Nature Reviews Genetics · doi:10.1038/s41576-020-0241-0 · Cited by 226
Lütolf, M. P., & Blau, H. M. (2009) · Advanced Materials · doi:10.1002/adma.200802582 · Cited by 226
Myocardial Infarction Activates CCR2+ Hematopoietic Stem and Progenitor Cells
Dutta, P., Sager, H. B., Stengel, K. R., Naxerova, K., Courties, G., Sáez, B., Silberstein, L., Heidt, T., Sebas, M., Sun, Y., et al. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.04.008 · Cited by 226
Cell Cycle Regulation of Stem Cells by MicroRNAs
Mens, M. M. J., & Ghanbari, M. (2018) · Stem Cell Reviews and Reports · doi:10.1007/s12015-018-9808-y · Cited by 224
Intermediate-Term Hematopoietic Stem Cells with Extended but Time-Limited Reconstitution Potential
Benveniste, P. M., Frelin, C., Janmohamed, S., Barbara, M., Herrington, R., Hyam, D., & Iscove, N. N. (2010) · Cell stem cell · doi:10.1016/j.stem.2009.11.014 · Cited by 219
Attenuation of miR-126 Activity Expands HSC In Vivo without Exhaustion
Lechman, E. R., Gentner, B., van Galen, P., Giustacchini, A., Saini, M., Boccalatte, F. E., Hiramatsu, H., Restuccia, U., Bachi, A., Voisin, V., et al. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2012.09.001 · Cited by 208
A matter of life and death: self‐renewal in stem cells
Fuchs, E. V., & Chen, T. (2012) · EMBO Reports · doi:10.1038/embor.2012.197 · Cited by 221
Triana, S., Vonficht, D., Jopp-Saile, L., Raffel, S., Lutz, R., Leonce, D., Antes, M., Hernández-Malmierca, P., Ordoñez-Rueda, D., Ramasz, B., et al. (2021) · Nature Immunology · doi:10.1038/s41590-021-01059-0 · Cited by 195
Self-citationEarly myeloid lineage choice is not initiated by random PU.1 to GATA1 protein ratios
Hoppe, P. S., Schwarzfischer, M., Loeffler, D., Kokkaliaris, K. D., Hilsenbeck, O., Moritz, N., Endele, M., Filipczyk, A. A., Gambardella, A. R., Ahmed, N., et al. (2016) · Nature · doi:10.1038/nature18320 · Cited by 220
Acute loss of TET function results in aggressive myeloid cancer in mice
An, J., González‐Avalos, E., Chawla, A., Jeong, M., López-Moyado, I. F., Li, W., Goodell, M. A., Chávez, L., Ko, M., & Rao, A. (2015) · Nature Communications · doi:10.1038/ncomms10071 · Cited by 215
Tigan, A.-S., Bellutti, F., Kollmann, K., Tebb, G., & Sexl, V (2016) · Oncogene · doi:10.1038/onc.2015.407 · Cited by 204
Balancing dormant and self-renewing hematopoietic stem cells
Wilson, A., Laurenti, E., & Trumpp, A. (2009) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2009.08.005 · Cited by 214
Self-citationHinge, A. S., He, J., Bartram, J., Javier, J. E., Xu, J., Fjellman, E., Sesaki, H., Li, T., Yu, J., Wunderlich, M., et al. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.01.016 · Cited by 206
Sprüssel, A., Schulte, J. H., Weber, S., Necke, M., Händschke, K., Thor, T., Pajtler, K. W., Schramm, A., König, K., Diehl, L., et al. (2012) · Leukemia · doi:10.1038/leu.2012.157 · Cited by 203
Fgd5 identifies hematopoietic stem cells in the murine bone marrow
Gazit, R., Mandal, P. K., Ebina, W., Ben‐Zvi, A., Nombela‐Arrieta, C., Silberstein, L. E., & Rossi, D. J. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20130428 · Cited by 201
Qian, P., He, X., Paulson, A., Li, Z., Fang, T., Perry, J. M., Guo, F., Zhao, M. L., Zhi, L., Venkatraman, A., et al. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.11.001 · Cited by 203
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Goldman, J. A., & Poss, K. D. (2020) · Nature Reviews Genetics · doi:10.1038/s41576-020-0239-7 · Cited by 200
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Onai, N., Kurabayashi, K., Hosoi-Amaike, M., Toyama‐Sorimachi, N., Matsushima, K., Inaba, K., & Ohteki, T. (2013) · Immunity · doi:10.1016/j.immuni.2013.04.006 · Cited by 212
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Kurth, T. B., Dell’Accio, F., Crouch, V., Augello, A., Sharpe, P. T., & Bari, C. D. (2011) · Arthritis & Rheumatism · doi:10.1002/art.30234 · Cited by 194
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Rossi, L., Lin, K. K., Boles, N. C., Yang, L., King, K. Y., Jeong, M., Mayle, A., & Goodell, M. A. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.08.006 · Cited by 205
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Self-citation
Metadata
- Authors
- Wilson, A., Laurenti, E., Oser, G., van der Wath, R. C., Blanco-Bose, W., Jaworski, M., Offner, S., Dunant, C. F., Eshkind, L., Bockamp, E., Lió, P., MacDonald, H. R., & Trumpp, A.
- Affiliations
- Ludwig Cancer Research (CH)
- École Polytechnique Fédérale de Lausanne (CH)
- Johannes Gutenberg University Mainz (DE)
- German Cancer Research Center (DE)
- Corresponding author
- Trumpp, Andreas
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2008-12
- Volume
- 135
- Issue
- 6
- Pages
- 1118-1129
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2070154483
- Cited by
- 1,908
- References
- 68
- Citations by year
- 2026: 59 · 2025: 71 · 2024: 100 · 2023: 98 · 2022: 105 · 2021: 118 · 2020: 130 · 2019: 105 · 2018: 119 · 2017: 104 · 2016: 127 · 2015: 120 · 2014: 137 · 2013: 124 · 2012: 120
- FWCI
- 57.99
- Type
- journal article
- Language
- en
- Update notices
- erratum (2009-07-10)
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1689 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- Cambridge University Engineering Department Publications Database (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Bradlow Foundation
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Health Sciences › Medicine › Hematology › Blood disorders and treatments
- Keywords
- hematopoietic stem cells, stem cell quiescence, self-renewal, HSC quiescence, cell cycle, label-retaining cells, bromodeoxyuridine, bone marrow damage, granulocyte colony-stimulating factor, hematopoietic homeostasis, computational modeling, multilineage reconstitution
- MeSH terms
- Animals, Antigens, Differentiation, Bone Marrow, Bromouracil, Fluorouracil, Hematopoietic Stem Cells, Homeostasis, Mice, Transgenic, Uridine, Green Fluorescent Proteins, Mice, Adult Stem Cells
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