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Cited by 901

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

The Role of the Granuloma in Expansion and Dissemination of Early Tuberculous Infection

Open access
Davis, J. Muse, Ramakrishnan, Lalita·2009·Cell
DOI 10.1016/j.cell.2008.11.014
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Abstract

SUMMARY Granulomas, organized aggregates of immune cells, form in response to persistent stimuli and are hallmarks of tuberculosis. Tuberculous granulomas have long been considered host-protective structures formed to contain infection. However, work in zebrafish infected with Mycobacterium marinum suggests that granulomas contribute to early bacterial growth. Here we use quantitative intravital microscopy to reveal distinct steps of granuloma formation and assess their consequence for infection. Intracellular mycobacteria use theESX-1/RD1virulence locus to induce recruitment of new macrophages to, and their rapid movement within, nascent granulomas. This motility enables multiple arriving macrophages to efficiently find and phagocytose infected macrophages undergoing apoptosis, leading to rapid, iterative expansion of infected macrophages and thereby bacterial numbers. The primary granuloma then seeds secondary granulomas via egress of infected macrophages. Our direct observations provide insight into how pathogenic mycobacteria exploit the granuloma during the innate immune phase for local expansion and systemic dissemination.

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Metadata

Authors
Davis, J. M., & Ramakrishnan, L.
Venue
Cell
Publisher
Elsevier BV
Published
2009-01
Volume
136
Issue
1
Pages
37-49
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2008.11.014
OpenAlex
W2064964564
Cited by
901
References
3
FWCI
42.51
Type
journal article
Language
en
Open access
bronze

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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