Cited by 3,163Cancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancerCell death mechanisms and regulation

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Blinded by the Light: The Growing Complexity of p53

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Vousden, Karen H., Prives, Carol·2009·Cell

DOI 10.1016/j.cell.2009.04.037

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Abstract

While the tumor suppressor functions of p53 have long been recognized, the contribution of p53 to numerous other aspects of disease and normal life is only now being appreciated. This burgeoning range of responses to p53 is reflected by an increasing variety of mechanisms through which p53 can function, although the ability to activate transcription remains key to p53's modus operandi. Control of p53's transcriptional activity is crucial for determining which p53 response is activated, a decision we must understand if we are to exploit efficiently the next generation of drugs that selectively activate or inhibit p53.

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Authors: Vousden, K. H., & Prives, C.
Affiliations: Cancer Research UK Scotland Institute (GB)
Columbia University (US)
Corresponding author: Vousden, Karen H.
Prives, Carol
ORCID: Vousden, Karen H.
Prives, Carol
Venue: Cell
Publisher: Elsevier BV
Published: 2009-05
Volume: 137
Issue: 3
Pages: 413-431
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2009.04.037
OpenAlex: W2133959309
Semantic Scholar: 018e8ed8c8694d45cfd9ffaf967368345fe22af6
Cited by: 3,163
References: 232
Citations by year: 2026: 128 · 2025: 154 · 2024: 127 · 2023: 168 · 2022: 149 · 2021: 166 · 2020: 175 · 2019: 149 · 2018: 171 · 2017: 191 · 2016: 228 · 2015: 202 · 2014: 258 · 2013: 263 · 2012: 228
FWCI: 17.35
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1538 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
Funders: Cancer Research UK
National Cancer Institute (R01CA077742, CA77742)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords: p53, tumor suppressor, transcriptional activation, p53 activators, p53 inhibitors, p53 regulation
MeSH terms: Animals, Cell Survival, Cell Transformation, Neoplastic, Gene Expression Regulation, Humans, Mutation, Stress, Physiological, Transcriptional Activation, Tumor Suppressor Protein p53, Apoptosis, Cell Proliferation, Mice

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Blinded by the Light: The Growing Complexity of p53

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