Blinded by the Light: The Growing Complexity of p53

In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2

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The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

DeBerardinis, R. J., Lum, J. J., Hatzivassiliou, G., & Thompson, C. B. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.002 · Cited by 4,088

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

Christofk, H. R., Vander Heiden, M. G., Harris, M. H., Ramanathan, A., Gerszten, R. E., Wei, R., Fleming, M. D., Schreiber, S. L., & Cantley, L. C. (2008) · Nature · doi:10.1038/nature06734 · Cited by 2,820

A microRNA component of the p53 tumour suppressor network

He, L., He, X., Lim, L. P., de Stanchina, E., Xuan, Z., Liang, Y., Xue, W., Zender, L., Magnus, J., Ridzon, D., et al. (2007) · Nature · doi:10.1038/nature05939 · Cited by 2,692

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

Xue, W., Zender, L., Miething, C., Dickins, R. A., Hernando, E., Krizhanovsky, V., Cordon-Cardo, C., & Lowe, S. W. (2007) · Nature · doi:10.1038/nature05529 · Cited by 2,473

p53 in health and disease

Vousden, K. H., & Lane, D. P. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2147 · Cited by 2,351

TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis

Bensaad, K., Tsuruta, A., Selak, M. A., Vidal, M. N. C., Nakano, K., Bartrons, R., Gottlieb, E., & Vousden, K. H. (2006) · Cell · doi:10.1016/j.cell.2006.05.036 · Cited by 2,019

Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis

Chang, T.-C., Wentzel, E. A., Kent, O. A., Ramachandran, K., Mullendore, M., Lee, K. H., Feldmann, G., Yamakuchi, M., Ferlito, M., Lowenstein, C. J., et al. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.05.010 · Cited by 2,010

Transcriptional control of human p53-regulated genes

Riley, T., Sontag, E., Chen, P., & Levine, A. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2395 · Cited by 1,921

The systemic role of SIRT1 in exercise mediated adaptation

Radak, Z. O., Suzuki, K., Pósa, A., Petrovszki, Z., Koltai, E., & Boldogh, I. R. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101467 · Cited by 94

Aurora B Interacts with NIR-p53, Leading to p53 Phosphorylation in Its DNA-binding Domain and Subsequent Functional Suppression

Wu, L., Ma, C. A., Zhao, Y., & Jain, A. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.174755 · Cited by 94

Meiotic Recombination Provokes Functional Activation of the p53 Regulatory Network

Lu, W.-J., Chapo, J. A., Roig, I., & Abrams, J. (2010) · Science · doi:10.1126/science.1185640 · Cited by 94

Structure of human MDM2 complexed with RPL11 reveals the molecular basis of p53 activationPreprint

Zheng, J., Lang, Y., Zhang, Q., Cui, D., Sun, H., Jiang, L., Chen, Z., Zhang, R., Gao, Y., Tian, W., et al. (2015) · Genes & Development · doi:10.1101/gad.261792.115 · Cited by 94

Gene-specific repression of the p53 target gene PUMA via intragenic CTCF–Cohesin bindingPreprint

Gomes, N. P., & Espinosa, J. M. (2010) · Genes & Development · doi:10.1101/gad.1881010 · Cited by 94

p53, a Target of Estrogen Receptor (ER) α, Modulates DNA Damage-induced Growth Suppression in ER-positive Breast Cancer Cells

Berger, C. E., Qian, Y., Liu, G., Chen, H.-W., & Chen, X. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.367326 · Cited by 93

DNA Damage-induced Heterogeneous Nuclear Ribonucleoprotein K SUMOylation Regulates p53 Transcriptional Activation

Pelisch, F., Pozzi, B., Risso, G., Muñoz, M. J., & Srebrow, A. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.390120 · Cited by 93

Interaction between p53 N terminus and core domain regulates specific and nonspecific DNA binding

He, F., Borcherds, W. M., Song, T., Wei, X., Das, M., Chen, L., Daughdrill, G. W., & Chen, J. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1903077116 · Cited by 94

Reciprocal Crosstalk Between YAP1/Hippo Pathway and the p53 Family Proteins: Mechanisms and Outcomes in Cancer

Raj, N., & Bam, R. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00159 · Cited by 94

Genes of the Mitochondrial Apoptotic Pathway in Mytilus galloprovincialis

Estévez-Calvar, N., Romero, A., Figueras, A. J., & Novoa, B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061502 · Cited by 93

Curcumin reduces cisplatin-induced neurotoxicity in NGF-differentiated PC12 cells

Mendonça, L. M., Machado, C. D. S., Teixeira, C. C. C., de Freitas, L. A. P., Bianchi, M. D. L. P., & Antunes, L. M. G. (2012) · NeuroToxicology · doi:10.1016/j.neuro.2012.09.011 · Cited by 92

Quantitative High Content Imaging of Cellular Adaptive Stress Response Pathways in Toxicity for Chemical Safety Assessment

Wink, S., Hiemstra, S. W., Huppelschoten, S., Danen, E. H. J., Niemeijer, M., Hendriks, G., Vrieling, H., Herpers, B., & van de Water, B. (2014) · Chemical Research in Toxicology · doi:10.1021/tx4004038 · Cited by 93

p53-Reactivating small molecules induce apoptosis and enhance chemotherapeutic cytotoxicity in head and neck squamous cell carcinoma

Roh, J., Kang, S. K., Minn, I., Califano, J. A., Sidransky, D., & Koch, W. M. (2010) · Oral Oncology · doi:10.1016/j.oraloncology.2010.10.011 · Cited by 92

The role of MDM2–p53 axis dysfunction in the hepatocellular carcinoma transformation

Cao, H., Chen, X., Wang, Z., Wang, L., Xia, Q., & Zhang, W. (2020) · Cell Death Discovery · doi:10.1038/s41420-020-0287-y · Cited by 93

p53 Represses the Oncogenic Sno-MiR-28 Derived from a SnoRNA

Yu, F., Bracken, C. P., Pillman, K. A., Lawrence, D., Goodall, G. J., Callen, D. F., & Neilsen, P. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0129190 · Cited by 92

Pathogenic bacterium Helicobacter pylori alters the expression profile of p53 protein isoforms and p53 response to cellular stresses

Wei, J., Noto, J. M., Zaika, E. I., Romero–Gallo, J., Correa, P., El-Rifai, W. M., Peek, R. M., & Zaika, A. I. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1205664109 · Cited by 92

In vivo analysis of p53 tumor suppressor function using genetically engineered mouse models

Brož, D. K., & Attardi, L. D. (2010) · Carcinogenesis · doi:10.1093/carcin/bgp331 · Cited by 92

p53 binds preferentially to genomic regions with high DNA-encoded nucleosome occupancyPreprint

Nili, E. L., Field, Y., Lubling, Y., Widom, J., Oren, M., & Segal, E. (2010) · Genome Research · doi:10.1101/gr.103945.109 · Cited by 92

p53 shades of Hippo

Furth, N., Aylon, Y., & Oren, M. (2017) · Cell Death and Differentiation · doi:10.1038/cdd.2017.163 · Cited by 91

A Structure-Guided Molecular Chaperone Approach for Restoring the Transcriptional Activity of the p53 Cancer Mutant Y220C

Bauer, M. R., Jones, R. N., Tareque, R. K., Springett, B. R., Dingler, F. A., Verduci, L., Patel, K. J., Fersht, A. R., Joerger, A. C., & Spencer, J. (2019) · Future Medicinal Chemistry · doi:10.4155/fmc-2019-0181 · Cited by 91

Effects of TP53 mutational status on gene expression patterns across 10 human cancer types

Parikh, N., Hilsenbeck, S. G., Creighton, C. J., Dayaram, T., Shuck, R. L., Shinbrot, E., Liu, X., Gibbs, R. A., Wheeler, D. A., & Donehower, L. A. (2013) · The Journal of Pathology · doi:10.1002/path.4321 · Cited by 91

The translation initiation factor DAP5 promotes IRES-driven translation of p53 mRNA

Weingarten-Gabbay, S., Khan, D., Liberman, N., Yoffe, Y., Bialik, S., Das, S., Oren, M., & Kimchi, A. (2013) · Oncogene · doi:10.1038/onc.2012.626 · Cited by 91

PCAF ubiquitin ligase activity inhibits Hedgehog/Gli1 signaling in p53-dependent response to genotoxic stress

Mazzà, D., Infante, P., Colicchia, V., Greco, A., Alfonsi, R., Siler, M., Antonucci, L., Pò, A., Smaele, E. D., Ferretti, E., et al. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.120 · Cited by 91

mTORC1 and p53

Hasty, P., Sharp, Z. D., Curiel, T. J., & Campisi, J. (2012) · Cell Cycle · doi:10.4161/cc.22912 · Cited by 92

Platelet-Derived Growth Factor-BB Protects Mesenchymal Stem Cells (MSCs) Derived From Immune Thrombocytopenia Patients Against Apoptosis and Senescence and Maintains MSC-Mediated Immunosuppression

Zhang, J., Feng, F., Wang, Q., Zhu, X., Fu, H., Xu, L., Liu, K., Huang, X., & Zhang, X. (2016) · Stem Cells Translational Medicine · doi:10.5966/sctm.2015-0360 · Cited by 91

Deubiquitylating Enzymes and DNA Damage Response Pathways

Jacq, X., Kemp, M. I., Martin, N. M. B., & Jackson, S. P. (2013) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-013-9635-3 · Cited by 90

Full p53 transcriptional activation potential is dispensable for tumor suppression in diverse lineages

Jiang, D., Brady, C. A., Johnson, T. M., Lee, E. Y., Park, E. J., Scott, M. P., & Attardi, L. D. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1111245108 · Cited by 90

P53‐induced miR‐30e‐5p inhibits colorectal cancer invasion and metastasis by targeting ITGA6 and ITGB1

Laudato, S., Patil, N., Abba, M. L., Leupold, J. H., Benner, A., Gaiser, T., Marx, A., & Allgayer, H. (2017) · International Journal of Cancer · doi:10.1002/ijc.30854 · Cited by 90

p53 transcriptionally regulates SQLE to repress cholesterol synthesis and tumor growth

Sun, H., Li, L., Li, W., Yang, F., Zhang, Z., Liu, Z., & Du, W. (2021) · EMBO Reports · doi:10.15252/embr.202152537 · Cited by 90

Structure of the p53 C‐terminus bound to 14‐3‐3: Implications for stabilization of the p53 tetramer

Schumacher, B., Mondry, J., Thiel, P., Weyand, M., & Ottmann, C. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.02.065 · Cited by 90

Genome-wide profiling reveals stimulus-specific functions of p53 during differentiation and DNA damage of human embryonic stem cells

Akdemir, K. C., Jain, A. K., Allton, K. L., Aronow, B. J., Xu, X., Cooney, A. J., Li, W., & Barton, M. C. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt866 · Cited by 90

The Fundamental Role of the p53 Pathway in Tumor Metabolism and Its Implication in Tumor Therapy

Shen, L., Sun, X. Y., Fu, Z., Yang, G., Li, J., & Yao, L. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-3040 · Cited by 89

Rapid recruitment of p53 to DNA damage sites directs DNA repair choice and integrity

Wang, Y., Ho, T. L. F., Hariharan, A., Goh, H. C., Wong, Y. L., Verkaik, N. S., Lee, M. Y., Tam, W. L., van Gent, D. C., Venkitaraman, A. R., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2113233119 · Cited by 89

Adenovirus E1B 55-Kilodalton Protein Is a p53-SUMO1 E3 Ligase That Represses p53 and Stimulates Its Nuclear Export through Interactions with Promyelocytic Leukemia Nuclear Bodies

Pennella, M. A., Liu, Y., Woo, J. L., Kim, C. A., & Berk, A. J. (2010) · Journal of Virology · doi:10.1128/jvi.01442-10 · Cited by 89

TSPAN12 is a critical factor for cancer–fibroblast cell contact-mediated cancer invasion

Otomo, R., Otsubo, C., Matsushima‐Hibiya, Y., Miyazaki, M., Tashiro, F., Ichikawa, H., Kohno, T., Ochiya, T., Yokota, J., Nakagama, H., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1412062112 · Cited by 88

Development and translational imaging of a TP53 porcine tumorigenesis model

Sieren, J. C., Meyerholz, D. K., Wang, X., Davis, B. T., Newell, J. D., Hammond, E., Rohret, J. A., Rohret, F., Struzynski, J. T., Goeken, J. A., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci75447 · Cited by 88

p53 Loss in Breast Cancer Leads to Myc Activation, Increased Cell Plasticity, and Expression of a Mitotic Signature with Prognostic Value

Santoro, A., Vlachou, T., Luzi, L., Melloni, G. E. M., Mazzarella, L., D’Elia, E., Xieraili, A., Pasi, C. E., Reavie, L. B., Bonetti, P., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2018.12.071 · Cited by 88

Pharmacological reactivation of p53 in the era of precision anticancer medicine

Tuval, A., Strandgren, C., Heldin, A., Palomar-Siles, M., & Wiman, K. G. (2023) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-023-00842-2 · Cited by 97

Proline dehydrogenase (oxidase) in cancer

Liu, W., & Phang, J. M. (2012) · BioFactors · doi:10.1002/biof.1036 · Cited by 88

P53 Status as a Predictive Biomarker for Patients Receiving Neoadjuvant Radiation-Based Treatment: A Meta-Analysis in Rectal Cancer

Chen, M., Wu, X., Yu, R., Li, C., Wang, L., Shen, W., & Lu, P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045388 · Cited by 88

The Regulation of Aging and Longevity: A New and Complex Role of p53

Feng, Z., Lin, M., & Wu, R. (2011) · Genes & Cancer · doi:10.1177/1947601911410223 · Cited by 88

The role of p53 in glucose metabolism

Cheung, E. C., & Vousden, K. H. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.12.006 · Cited by 88

Immunohistochemical detection of Polo-like kinase-1 (PLK1) in primary breast cancer is associated with TP53mutation and poor clinical outcome

King, S., Purdie, C. A., Bray, S. E., Quinlan, P., Jordan, L. B., Thompson, A. M., & Meek, D. W. (2012) · Breast Cancer Research · doi:10.1186/bcr3136 · Cited by 88

The Tail That Wags the Dog: How the Disordered C-Terminal Domain Controls the Transcriptional Activities of the p53 Tumor-Suppressor Protein

Laptenko, O., Tong, D. R., Manfredi, J. J., & Prives, C. L. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.08.011 · Cited by 88

Characterization of the p53 Cistrome – DNA Binding Cooperativity Dissects p53's Tumor Suppressor Functions

Schlereth, K., Heyl, C., Krampitz, A.-M., Mernberger, M., Finkernagel, F., Scharfe, M., Jarek, M., Leich, E., Rosenwald, A., & Stiewe, T. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003726 · Cited by 87

NFκB/p53 crosstalk—a promising new therapeutic target

Schneider, G., & Krämer, O. H. (2011) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2010.10.003 · Cited by 87

Clinical significance of p53 protein expression and TP53 variation status in colorectal cancer

Kim, K. M., Ahn, A.-R., Park, H. S., Jang, K. Y., Moon, W. S., Kang, M. J., Ha, G. W., Lee, M. R., & Chung, M. J. (2022) · BMC Cancer · doi:10.1186/s12885-022-10039-y · Cited by 87

p53-dependent and p53-independent anticancer effects of different histone deacetylase inhibitors

Sonnemann, J., Marx, C., Becker, S., Wittig, S., Palani, C. D., Krämer, O. H., & Beck, J. F. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.742 · Cited by 87

Multiple distinct molecular mechanisms influence sensitivity and resistance to MDM2 inhibitors in adult acute myelogenous leukemia

Long, J., Parkin, B. L., Ouillette, P. D., Bixby, D. L., Shedden, K., Erba, H. P., Wang, S., & Malek, S. N. (2010) · Blood · doi:10.1182/blood-2010-01-261628 · Cited by 87

How Parkinson's disease meets nucleolar stress

Parlato, R., & Liss, B. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.12.014 · Cited by 87

p53 in stem cells

Solozobova, V. (2011) · World Journal of Biological Chemistry · doi:10.4331/wjbc.v2.i9.202 · Cited by 87

Postnatal telomere dysfunction induces cardiomyocyte cell-cycle arrest through p21 activation

Aix, E., Gutiérrez‐Gutiérrez, Ó., Sánchez-Ferrer, C., Aguado, T., & Flores, I. (2016) · The Journal of Cell Biology · doi:10.1083/jcb.201510091 · Cited by 87

The Roles of p53 in Mitochondrial Dynamics and Cancer Metabolism: The Pendulum between Survival and Death in Breast Cancer?

Moulder, D. E., Hatoum, D., Tay, E. S. E., Lin, Y., & McGowan, E. M. (2018) · Cancers · doi:10.3390/cancers10060189 · Cited by 87

Chemotherapy in Esophageal Cancer

Kelsen, D. P. (2023) · Frontiers research topics · doi:10.3389/978-2-8325-4252-1 · Cited by 87

Regulation of the p53 transcriptional response by structurally diverse core promoters

Morachis, J. M., Murawsky, C. M., & Emerson, B. M. (2010) · Genes & Development · doi:10.1101/gad.1856710 · Cited by 86

p53 dynamics vary between tissues and are linked with radiation sensitivity

Stewart-Ornstein, J., Iwamoto, Y., Miller, M. A., Prytyskach, M., Ferretti, S., Holzer, P., Kallen, J. A., Furet, P., Jambhekar, A., Forrester, W. C., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21145-z · Cited by 86

Bcl-2 Modulation in p53 Signaling Pathway by Flavonoids: A Potential Strategy towards the Treatment of Cancer

Rahman, N., Khan, H. Z., Zia, A., Khan, A., Fakhri, S., Aschner, M., Gul, K., & Saso, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111315 · Cited by 86

Synthesis, in Vitro, and in Cell Studies of a New Series of [Indoline-3,2′-thiazolidine]-Based p53 Modulators

Bertamino, A., Soprano, M., Musella, S., Rusciano, M. R., Sala, M., Vernieri, E., Sarno, V. D., Limatola, A., Carotenuto, A., Cosconati, S., et al. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm400311n · Cited by 86

Dual roles of Drosophila p53 in cell death and cell differentiation

Fan, Y., Lee, T. V., Xu, D., Chen, Z., Lamblin, A.-F., Steller, H., & Bergmann, A. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.182 · Cited by 86

SLC25A1, or CIC, is a novel transcriptional target of mutant p53 and a negative tumor prognostic marker

Kolukula, V. K., Sahu, G., Wellstein, A., Rodriguez, O. C., Preet, A., Iacobazzi, V., D’Orazi, G., Albanese, C., Palmieri, F., & Avantaggiati, M. L. (2014) · Oncotarget · doi:10.18632/oncotarget.1831 · Cited by 86

HIPK2: A tumour suppressor that controls DNA damage‐induced cell fate and cytokinesis

Hofmann, T. G., Glas, C., & Bitomsky, N. (2012) · BioEssays · doi:10.1002/bies.201200060 · Cited by 86

A distinct p53 target gene set predicts for response to the selective p53–HDM2 inhibitor NVP-CGM097

Jeay, S., Gaulis, S., Ferretti, S., Bitter, H., Ito, M., Valat, T., Murakami, M., Ruetz, S., Guthy, D. A., Rynn, C., et al. (2015) · eLife · doi:10.7554/elife.06498 · Cited by 85

A neuroprotective phase precedes striatal degeneration upon nucleolar stress

Kreiner, G., Bierhoff, H., Armentano, M., Parkitna, J. M. R., Sowodniok, K., Naranjo, J. R., Bonfanti, L., Liss, B., Schütz, G., Grummt, I., et al. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.66 · Cited by 85

Targeting p53-MDM2-MDMX Loop for Cancer Therapy

Zhang, Q., Zeng, S. X., & Lu, H. (2014) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-017-9211-0_16 · Cited by 85

Deregulation and Targeting of TP53 Pathway in Multiple Myeloma

Jovanović, K., Escure, G., Demonchy, J., Willaume, A., de Wyngaert, Z. V., Farhat, M.-M., Chauvet, P., Facon, T. T. F., Quesnel, B., & Manier, S. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2018.00665 · Cited by 86

Structure of p53 binding to the BAX response element reveals DNA unwinding and compression to accommodate base-pair insertion

Chen, Y., Zhang, X., Machado, A. C. D., Ding, Y. C., Chen, Z., Qin, P. Z., Rohs, R., & Chen, L. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt584 · Cited by 85

Histone deacetylase 2 controls p53 and is a critical factor in tumorigenesis

Wagner, T., Brand, P., Heinzel, T., & Krämer, O. H. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.07.010 · Cited by 85

The Role of p53 in Ribosomopathies

Fumagalli, S., & Thomas, G. (2011) · Seminars in Hematology · doi:10.1053/j.seminhematol.2011.02.004 · Cited by 85

Base changes in tumour DNA have the power to reveal the causes and evolution of cancer

Hollstein, M. C., Alexandrov, L. B., Wild, C. P., Ardin, M., & Zavadil, J. (2016) · Oncogene · doi:10.1038/onc.2016.192 · Cited by 85

Rbm24, a target of p53, is necessary for proper expression of p53 and heart development

Zhang, M., Zhang, Y., Xu, E., Mohibi, S., de Anda, D. M., Jiang, Y., Zhang, J., & Chen, X. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-017-0029-8 · Cited by 85

Therapeutic targeting of p53 by small molecules

Selivanova, G. (2010) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2010.02.006 · Cited by 84

The Progress and Development of GLUT1 Inhibitors Targeting Cancer Energy Metabolism

Meng, Y., Xu, X. J., Luan, H., Li, L., Dai, W., Li, Z., & Bian, J. (2019) · Future Medicinal Chemistry · doi:10.4155/fmc-2019-0052 · Cited by 85

p53 at the crossroads of tumor immunity

Efe, G., Rustgi, A. K., & Prives, C. L. (2024) · Nature Cancer · doi:10.1038/s43018-024-00796-z · Cited by 84

Distinct p53 genomic binding patterns in normal and cancer-derived human cells

Botcheva, K., McCorkle, S., McCombie, W. R., Dunn, J. J., & Anderson, C. W. (2011) · Cell Cycle · doi:10.4161/cc.10.24.18383 · Cited by 84

Loss of p53-mediated cell-cycle arrest, senescence and apoptosis promotes genomic instability and premature aging

Li, T., Liu, X., Jiang, L., Manfredi, J. J., Zha, S., & Gu, W. (2016) · Oncotarget · doi:10.18632/oncotarget.7864 · Cited by 84

Dysfunction of the MDM2/p53 axis is linked to premature aging

Lessel, D., Wu, D., Trujillo, C., Ramezani, T., Lessel, I., Alwasiyah, M. K., Saha, B., Hisama, F. M., Rading, K., Goebel, I., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci92171 · Cited by 84

Validation of MdmX as a therapeutic target for reactivating p53 in tumors

Garcia, D., Warr, M. R., Martins, C. P., Brown Swigart, L., Passegué, E., & Evan, G. I. (2011) · Genes & Development · doi:10.1101/gad.16722111 · Cited by 83

Reviving the guardian of the genome: Small molecule activators of p53

Nguyen, D., Liao, W., Zeng, S. X., & Lu, H. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.03.013 · Cited by 84

Tumor Suppressor p53 Inhibits Systemic Autoimmune Diseases by Inducing Regulatory T Cells

Kawashima, H., Takatori, H., Suzuki, K., Iwata, A., Yokota, M., Suto, A., Minamino, T., Hirose, K., & Nakajima, H. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300509 · Cited by 84

Mitochondrial Liaisons of p53

Galluzzi, L., Morselli, E., Kepp, O., Vitale, I., Pinti, M., & Kroemer, G. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3504 · Cited by 83

Molecular mechanisms of asbestos-induced lung epithelial cell apoptosis

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Identification of a New Class of MDM2 Inhibitor That Inhibits Growth of Orthotopic Pancreatic Tumors in Mice

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