Cited by 3,163Cancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancerCell death mechanisms and regulation

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Blinded by the Light: The Growing Complexity of p53

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Vousden, Karen H., Prives, Carol·2009·Cell

DOI 10.1016/j.cell.2009.04.037

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Abstract

While the tumor suppressor functions of p53 have long been recognized, the contribution of p53 to numerous other aspects of disease and normal life is only now being appreciated. This burgeoning range of responses to p53 is reflected by an increasing variety of mechanisms through which p53 can function, although the ability to activate transcription remains key to p53's modus operandi. Control of p53's transcriptional activity is crucial for determining which p53 response is activated, a decision we must understand if we are to exploit efficiently the next generation of drugs that selectively activate or inhibit p53.

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Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation
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Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice
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p53: new roles in metabolism
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DYRK2 Is Targeted to the Nucleus and Controls p53 via Ser46 Phosphorylation in the Apoptotic Response to DNA Damage
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Specific loss of apoptotic but not cell‐cycle arrest function in a human tumor derived p53 mutant.
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The p53MH algorithm and its application in detecting p53-responsive genes
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Distinct p53 acetylation cassettes differentially influence gene-expression patterns and cell fate
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A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53
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Mutant p53 protein localized in the cytoplasm inhibits autophagy
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Activation of AMP-activated Protein Kinase Induces p53-dependent Apoptotic Cell Death in Response to Energetic Stress
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Inhibition of tumor angiogenesis by p53: a new role for the guardian of the genome
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Declining p53 function in the aging process: A possible mechanism for the increased tumor incidence in older populations
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MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation
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iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72–polymorphic p53
Bergamaschi, D., Samuels, Y., Sullivan, A., Zvelebil, M., Breyssens, H., Bisso, A., Sal, G. D., Syed, N., Smith, P. D., Gasco, M., et al. (2006) · Nature Genetics · doi:10.1038/ng1879 · Cited by 260
Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo
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Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3βPreprint
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E4F1 Is an Atypical Ubiquitin Ligase that Modulates p53 Effector Functions Independently of Degradation
Cam, L. L., Linares, L. K., Paul, C., Julien, E., Lacroix, M., Hatchi, E., Triboulet, R., Bossis, G., Shmueli, A., Rodríguez, M. S., et al. (2006) · Cell · doi:10.1016/j.cell.2006.09.031 · Cited by 251
Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation
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p53 in recombination and repair
Gatz, S. A., & Wiesmüller, L. (2006) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4401903 · Cited by 242
Polymorphisms in the p53 pathway
Pietsch, E. C., Humbey, O., & Murphy, M. E. (2006) · Oncogene · doi:10.1038/sj.onc.1209367 · Cited by 236
Functional Analysis of the Roles of Posttranslational Modifications at the p53 C Terminus in Regulating p53 Stability and Activity
Feng, L., Lin, T., Uranishi, H., Gu, W., & Xu, Y. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.13.5389-5395.2005 · Cited by 236
Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response
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Nutlin-3a Activates p53 to Both Down-regulate Inhibitor of Growth 2 and Up-regulate mir-34a, mir-34b, and mir-34c Expression, and Induce Senescence
Kumamoto, K., Spillare, E. A., Fujita, K., Horikawa, I., Yamashita, T., Appella, E., Nagashima, M., Takenoshita, S., Yokota, J., & Harris, C. C. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2780 · Cited by 231
The tumor suppressor protein p53 is required for neurite outgrowth and axon regeneration
Giovanni, S. D., Knights, C. D., Rao, M., Yakovlev, A. G., Beers, J., Catania, J., Avantaggiati, M. L., & Faden, A. I. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601292 · Cited by 229
MDMX: from bench to bedside
Marine, J.-C. W., Dyer, M. A., & Jochemsen, A. G. (2007) · Journal of Cell Science · doi:10.1242/jcs.03362 · Cited by 228
p21/CDKN1A Mediates Negative Regulation of Transcription by p53
Löhr, K., Möritz, C., Contente, A., & Dobbelstein, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212517200 · Cited by 227
p53‐dependent neuronal cell death in a DJ‐1‐deficient zebrafish model of Parkinson's disease
Bretaud, S., Allen, C. E., Ingham, P. W., & Bandmann, O. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04291.x · Cited by 219
ASPP: a new family of oncogenes and tumour suppressor genes
Sullivan, A., & Lü, X. (2007) · British Journal of Cancer · doi:10.1038/sj.bjc.6603525 · Cited by 215
In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute
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p53 C-Terminal Phosphorylation by CHK1 and CHK2 Participates in the Regulation of DNA-Damage-induced C-Terminal Acetylation
Ou, Y.-H., Chung, P.-H., Sun, T.-P., & Shieh, S.-Y. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-08-0689 · Cited by 211
Characterization of genome-wide p53-binding sites upon stress response
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Methylation-Acetylation Interplay Activates p53 in Response to DNA Damage
Ivanov, G. S., Ivanova, T., Kurash, J. K., Ivanov, A. V., Chuikov, S., Gizatullin, F., Herrera-Medina, E. M., Rauscher, F. J., Reinberg, D., & Barlev, N. A. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00460-07 · Cited by 210
Direct p53 Transcriptional Repression: In Vivo Analysis of CCAAT-Containing G2/M Promoters
Imbriano, C., Gurtner, A., Cocchiarella, F., Agostino, S. D., Basile, V., Gostissa, M., Dobbelstein, M., Sal, G. D., Piaggio, G., & Mantovani, R. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.9.3737-3751.2005 · Cited by 209
Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53
Teufel, D. P., Freund, S. M. V., Bycroft, M., & Fersht, A. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702010104 · Cited by 207
p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism
Duan, W., Zhu, X., Ladenheim, B., Yu, Q., Guo, Z., Oyler, J. M., Cutler, R. G., Cadet, J. L., Greig, N. H., & Mattson, M. P. (2002) · Annals of Neurology · doi:10.1002/ana.10350 · Cited by 206
Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53‐dependent cellular senescence
Cosme‐Blanco, W., Shen, M., Lazar, A. J. F., Pathak, S., Lozano, G., Multani, A. S., & Chang, S. (2007) · The EMBO Reports · doi:10.1038/sj.embor.7400937 · Cited by 205
The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression
Minsky, N., & Oren, M. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.10.016 · Cited by 204
How important are post-translational modifications in p53 for selectivity in target-gene transcription and tumour suppression?
Olsson, A., Manzl, C., Strasser, A., & Villunger, A. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402196 · Cited by 204
Activation of p53 by MDM2 Antagonists Can Protect Proliferating Cells from Mitotic Inhibitors
Carvajal, D. M., Tovar, C., Yang, H. S., Vu, B. T., Heimbrook, D. C., & Vassilev, L. T. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3576 · Cited by 202
A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network
Toledo, F., Krummel, K. A., Lee, C. J., Liu, C.-W., Rodewald, L.-W., Tang, M., & Wahl, G. M. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.03.014 · Cited by 199 · cited 2×
“protected from spontaneous tumor development (Toledo et al., 2006).”
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p53 Linear Diffusion along DNA Requires Its C Terminus
McKinney, K. M., Mattia, M., Gottifredi, V., & Prives, C. L. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.09.032 · Cited by 194
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The dark side of a tumor suppressor: anti-apoptotic p53
Jänicke, R. U., Sohn, D., & Schulze‐Osthoff, K. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.33 · Cited by 193
MDM2 inhibits p300-mediated p53 acetylation and activation by forming a ternary complex with the two proteins
Kobet, E., Zeng, X., Zhu, Y., Keller, D., & Lu, H. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.23.12547 · Cited by 193
Activated p53 suppresses the histone methyltransferase EZH2 gene
Tang, X., Milyavsky, M., Shats, I., Erez, N., Goldfinger, N., & Rotter, V. (2004) · Oncogene · doi:10.1038/sj.onc.1207706 · Cited by 193
Intrinsic ubiquitination activity of PCAF controls the stability of the oncoprotein Hdm2
Linares, L. K., Kiernan, R. E., Triboulet, R., Chable-Bessia, C., Latreille, D., Cuvier, O., Lacroix, M., Cam, L. L., Coux, O., & Benkirane, M. (2007) · Nature Cell Biology · doi:10.1038/ncb1545 · Cited by 190
An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors
Brummelkamp, T. R., Fabius, A. W. M., Mullenders, J., Madiredjo, M., Velds, A., Kerkhoven, R. M., Bernards, R., & Beijersbergen, R. L. (2006) · Nature Chemical Biology · doi:10.1038/nchembio774 · Cited by 190
Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation
Rui, Y., Xu, Z., Lin, S., Li, Q., Rui, H., Luo, W., Hai‐Meng, Z. H. O. U., Cheung, P., Wu, Z., Ye, Z., et al. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600475 · Cited by 187
The C-terminal lysines fine-tune p53 stress responses in a mouse model, but are not required for stability control or transactivation
Krummel, K. A., Lee, C. J., Toledo, F., & Wahl, G. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503068102 · Cited by 187
Reactivation of mutant p53: molecular mechanisms and therapeutic potential
Selivanova, G., & Wiman, K. G. (2007) · Oncogene · doi:10.1038/sj.onc.1210295 · Cited by 186
Quaternary structures of tumor suppressor p53 and a specific p53–DNA complex
Tidow, H., Melero, R., Mylonas, E., Freund, S. M. V., Großmann, J., Carazo, J. M., Svergun, D. I., Valle, M., & Fersht, A. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705069104 · Cited by 185
Protein Kinase C δ Regulates Ser46 Phosphorylation of p53 Tumor Suppressor in the Apoptotic Response to DNA Damage
Yoshida, K., Liu, H., & Miki, Y. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m512074200 · Cited by 184
SnapShot: p53 Posttranslational Modifications
Kruse, J.-P., & Gu, W. J. (2008) · Cell · doi:10.1016/j.cell.2008.05.020 · Cited by 183
Suppression of tumorigenesis by the p53 target PUMA
Hemann, M. T., Zilfou, J. T., Zhao, Z., Burgess, D. J., Hannon, G. J., & Lowe, S. W. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403286101 · Cited by 183
No PUMA, no death
Yu, J., & Zhang, L. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00249-6 · Cited by 182
Tumor Suppressor p53 Slides on DNA with Low Friction and High Stability
Tafvizi, A., Huang, F. L., Leith, J. S., Fersht, A. R., Mirny, L. A., & van Oijen, A. M. (2008) · Biophysical Journal · doi:10.1529/biophysj.108.134122 · Cited by 181
MDM2-Regulated Degradation of HIPK2 Prevents p53Ser46 Phosphorylation and DNA Damage-Induced Apoptosis
Rinaldo, C., Prodosmo, A., Mancini, F., Iacovelli, S., Sacchi, A., Moretti, F., & Soddu, S. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.02.008 · Cited by 175
hCAS/CSE1L Associates with Chromatin and Regulates Expression of Select p53 Target Genes
Tanaka, T., Ohkubo, S., Tatsuno, I., & Prives, C. L. (2007) · Cell · doi:10.1016/j.cell.2007.08.001 · Cited by 173
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Loss of function of def selectively up-regulates Δ113p53 expression to arrest expansion growth of digestive organs in zebrafishPreprint
Chen, J., Ruan, H., Ng, S. M. E., Gao, C., Soo, H. M., Wu, W., Zhang, Z., Wen, Z., Lane, D. P., & Peng, J. (2005) · Genes & Development · doi:10.1101/gad.1366405 · Cited by 172
MDM2-Dependent Downregulation of p21 and hnRNP K Provides a Switch between Apoptosis and Growth Arrest Induced by Pharmacologically Activated p53
Enge, M., Bao, W., Hedström, E., Jackson, S. P., Moumen, A., & Selivanova, G. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.01.019 · Cited by 172
DNA Damage-Induced Downregulation of Cdc25C Is Mediated by p53 via Two Independent Mechanisms
Clair, S. S., Giono, L. E., Varmeh, S., Resnick‐Silverman, L., Liu, W.-J., Padi, A., Dastidar, J., DaCosta, A., Mattia, M., & Manfredi, J. J. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.11.002 · Cited by 168
Essential role of p53 phosphorylation by p38 MAPK in apoptosis induction by the HIV-1 envelope
Perfettini, J., Castedo, M., Nardacci, R., Ciccosanti, F., Boya, P., Roumier, T., Larochette, N., Piacentini, M., & Kroemer, G. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041502 · Cited by 167
The nuclear function of p53 is required for PUMA-mediated apoptosis induced by DNA damage
Wang, P., Yu, J., & Zhang, L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700020104 · Cited by 163
Transcription, apoptosis and p53: catch-22
Schüler, M., & Green, D. R. (2005) · Trends in Genetics · doi:10.1016/j.tig.2005.01.001 · Cited by 161
Hzf Determines Cell Survival upon Genotoxic Stress by Modulating p53 Transactivation
Das, S., Raj, L., Zhao, B., Kimura, Y., Bernstein, A., Aaronson, S. A., & Lee, S. W. (2007) · Cell · doi:10.1016/j.cell.2007.06.013 · Cited by 160
Transcriptional Repression by p53 through Direct Binding to a Novel DNA Element
Johnson, R. A., Ince, T. A., & Scotto, K. W. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100121200 · Cited by 158
The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP
Mantovani, F., Tocco, F., Girardini, J. E., Smith, P., Gasco, M., Lü, X., Crook, T., & Sal, G. D. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1306 · Cited by 155
A pivotal role for p53: balancing aerobic respiration and glycolysis
Ma, W., Sung, H. J., Park, J., Matoba, S., & Hwang, P. M. (2007) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-007-9083-0 · Cited by 153
p53‐repressed miRNAs are involved with E2F in a feed‐forward loop promoting proliferation
Brosh, R., Shalgi, R., Liran, A., Landan, G., Korotayev, K., Nguyen, G. H., Enerly, E., Johnsen, H., Buganim, Y., Solomon, H., et al. (2008) · Molecular Systems Biology · doi:10.1038/msb.2008.65 · Cited by 153
Selection against PUMA Gene Expression in Myc-Driven B-Cell Lymphomagenesis
Garrison, S. P., Jeffers, J. R., Yang, C., Nilsson, J. A., Hall, M. A., Rehg, J. E., Yue, W., Yu, J., Zhang, L., Onciu, M. M., et al. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00907-07 · Cited by 151
MED1/TRAP220 Exists Predominantly in a TRAP/ Mediator Subpopulation Enriched in RNA Polymerase II and Is Required for ER-Mediated Transcription
Zhang, X., Krutchinsky, A. N., Fukuda, A., Chen, W., Yamamura, S., Chait, B. T., & Roeder, R. G. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.05.015 · Cited by 147
p300 regulates p53-dependent apoptosis after DNA damage in colorectal cancer cells by modulation of PUMA/p21 levels
Iyer, N. G., Chin, S., Özdağ, H., Daigo, Y., Hu, D., Cariati, M., Brindle, K. M., Aparicio, S. A. J. R., & Caldas, C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401002101 · Cited by 147
The role of p53-induced apoptosis in cerebral ischemia: effects of the p53 inhibitor pifithrin ?
Leker, R. R. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.01.030 · Cited by 145
Molecular Insights into Mechanisms of the Cell Death Program:Role in the Progression of Neurodegenerative Disorders
Culmsee, C., & Landshamer, S. (2006) · Current Alzheimer Research · doi:10.2174/156720506778249461 · Cited by 144
Prospective therapeutic applications of p53 inhibitors
Gudkov, A. V., & Komarova, E. A. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.03.153 · Cited by 142
Structure of the p53 Core Domain Dimer Bound to DNA
Ho, W. C., Fitzgerald, M. X., & Marmorstein, R. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603634200 · Cited by 142
Regulation of p53 tumour suppressor target gene expression by the p52 NF‐κB subunit
Schumm, K., Rocha, S., Caamaño, J., & Perkins, N. D. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601343 · Cited by 135
The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality
Johnson, T. M., Hammond, E. M., Giaccia, A. J., & Attardi, L. D. (2005) · Nature Genetics · doi:10.1038/ng1498 · Cited by 134
p53-dependent Down-regulation of Telomerase Is Mediated by p21
Shats, I., Milyavsky, M., Tang, X., Stambolsky, P., Erez, N., Brosh, R., Kogan, I., Braunstein, I., Tzukerman, M., Ginsberg, D., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402502200 · Cited by 133
The Arf/p53 Pathway in Cancer and Aging
Matheu, A., Maraver, A., & Serrano, M. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6851 · Cited by 132
p53 tumor suppressor protein regulates the levels of huntingtin gene expression
Feng, Z., Jin, S. V., Zupnick, A., Hoh, J., de Stanchina, E., Lowe, S. W., Prives, C. L., & Levine, A. J. (2005) · Oncogene · doi:10.1038/sj.onc.1209021 · Cited by 125
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A Chromatin-associated and Transcriptionally Inactive p53-Mdm2 Complex Occurs in mdm2 SNP309 Homozygous Cells
Arva, N. C., Gopen, T., Talbott, K. E., Campbell, L. E., Chicas, A., White, D. E., Bond, G. L., Levine, A. J., & Bargonetti, J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505203200 · Cited by 122
Skp2 suppresses p53-dependent apoptosis by inhibiting p300.
Kitagawa, M., Lee, S. H., & McCormick, F. (2008) · Molecules and Cells · doi:10.1016/j.molcel.2007.11.036 · Cited by 122
KLF5 Interacts with p53 in Regulating Survivin Expression in Acute Lymphoblastic Leukemia
Zhu, N., Gu, L., Findley, H. W., Chen, C., Dong, J., Yang, L. P. H., & Zhou, M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513810200 · Cited by 122
Neuronal Expression of p53 Dominant-Negative Proteins in Adult Drosophila melanogaster Extends Life Span
Bauer, J. H., Poon, P. C., Glatt-Deeley, H. R., Abrams, J., & Helfand, S. L. (2005) · Current Biology · doi:10.1016/j.cub.2005.10.051 · Cited by 121
Acetylation of Mouse p53 at Lysine 317 Negatively Regulates p53 Apoptotic Activities after DNA Damage
Chao, C., Wu, Z., Mazur, S. J., Borges, H. L., Rossi, M., Lin, T., Wang, J. Y. J., Anderson, C. W., Appella, E., & Xu, Y. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00062-06 · Cited by 119
Policing of oncogene activity by p53
Efeyan, A., García-Cao, I., Herranz, D., Velasco-Miguel, S., & Serrano, M. (2006) · Nature · doi:10.1038/443159a · Cited by 116
Quantitative analyses reveal the importance of regulated Hdmx degradation for p53 activation
Wang, Y. V., Wade, M., Wong, E., Li, Y.-C., Rodewald, L. W., & Wahl, G. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701497104 · Cited by 116
PCAF is an HIF-1α cofactor that regulates p53 transcriptional activity in hypoxia
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Authors: Vousden, K. H., & Prives, C.
Affiliations: Cancer Research UK Scotland Institute (GB)
Columbia University (US)
Corresponding author: Vousden, Karen H.
Prives, Carol
ORCID: Vousden, Karen H.
Prives, Carol
Venue: Cell
Publisher: Elsevier BV
Published: 2009-05
Volume: 137
Issue: 3
Pages: 413-431
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2009.04.037
OpenAlex: W2133959309
Semantic Scholar: 018e8ed8c8694d45cfd9ffaf967368345fe22af6
Cited by: 3,163
References: 232
Citations by year: 2026: 128 · 2025: 154 · 2024: 127 · 2023: 168 · 2022: 149 · 2021: 166 · 2020: 175 · 2019: 149 · 2018: 171 · 2017: 191 · 2016: 228 · 2015: 202 · 2014: 258 · 2013: 263 · 2012: 228
FWCI: 17.35
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1538 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
Funders: Cancer Research UK
National Cancer Institute (R01CA077742, CA77742)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords: p53, tumor suppressor, transcriptional activation, p53 activators, p53 inhibitors, p53 regulation
MeSH terms: Animals, Cell Survival, Cell Transformation, Neoplastic, Gene Expression Regulation, Humans, Mutation, Stress, Physiological, Transcriptional Activation, Tumor Suppressor Protein p53, Apoptosis, Cell Proliferation, Mice

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Blinded by the Light: The Growing Complexity of p53

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