Polycomb-dependent regulatory contacts between distant Hox loci in Drosophila
Open accessAbstract
In Drosophila melanogaster, Hox genes are organized in an anterior and a posterior cluster, called Antennapedia complex and bithorax complex, located on the same chromosome arm and separated by 10 Mb of DNA. Both clusters are repressed by Polycomb group (PcG) proteins. Here, we show that genes of the two Hox complexes can interact within nuclear PcG bodies in tissues where they are corepressed. This colocalization increases during development and depends on PcG proteins. Hox gene contacts are conserved in the distantly related Drosophila virilis species and they are part of a large gene interaction network that includes other PcG target genes. Importantly, mutations on one of the loci weaken silencing of genes in the other locus, resulting in the exacerbation of homeotic phenotypes in sensitized genetic backgrounds. Thus, the three-dimensional organization of Polycomb target genes in the cell nucleus stabilizes the maintenance of epigenetic gene silencing.
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PcG complexes mediate chromatin loops between distal loci within Polycomb bodies.
“Within Polycomb bodies, PcG complexes were discovered to mediate chromatin loops between distal loci.”
From Transcriptional enhancers and their communication with gene promoters (2021) · cites this paper as [354]
Polycomb-mediated interactions have been previously reported in mouse ESs using a Capture-C approach and are a prominent feature in Drosophila.
“Polycomb-mediated interactions have been previously reported in mouse ESs using a Capture-C approach (Schoenfelder et al., 2015b) and are a prominent feature in Drosophila (Bantignies et al., 2011).”
From Multiscale 3D Genome Rewiring during Mouse Neural Development (2017) · cites this paper as Bantignies et al., 2011
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- Authors
- Bantignies, F., Roure, V., Comet, I., Leblanc, B., Schuettengruber, B., Bonnet, J., Tixier, V., Mas, A., & Cavalli, G.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Bantignies, Frédéric
- Cavalli, Giacomo
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 144
- Issue
- 2
- Pages
- 214-226
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1966015758
- Cited by
- 429
- References
- 67
- Citations by year
- 2026: 14 · 2025: 15 · 2024: 20 · 2023: 19 · 2022: 16 · 2021: 28 · 2020: 29 · 2019: 37 · 2018: 24 · 2017: 26 · 2016: 29 · 2015: 29 · 2014: 27 · 2013: 47 · 2012: 40
- FWCI
- 18.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 964 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- Centre National de la Recherche Scientifique
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- Polycomb group proteins, Hox genes, Antennapedia complex, bithorax complex, 3D nuclear organization, chromatin looping, epigenetic silencing, Drosophila melanogaster, Drosophila virilis, gene interaction networks
- MeSH terms
- Animals, Cell Nucleus, Drosophila, Drosophila melanogaster, Genes, Homeobox, Repressor Proteins, Gene Silencing, Drosophila Proteins, Regulatory Elements, Transcriptional, Antennapedia Homeodomain Protein, Polycomb-Group Proteins
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