The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
The Amyloid State of Proteins in Human Diseases
Open accessAbstract
Amyloid fibers and oligomers are associated with a great variety of human diseases including Alzheimer’s disease and the prion conditions. Here we attempt to connect recent discoveries on the molecular properties of proteins in the amyloid state with observations about pathological tissues and disease states. We summarize studies of structure and nucleation of amyloid and relate these to observations on amyloid polymorphism, prion strains, co-aggregation of pathogenic proteins in tissues, and mechanisms of toxicity and transmissibility. Molecular studies have also led to numerous strategies for biological and chemical interventions against amyloid diseases.
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Metadata
- Authors
- Eisenberg, D., & Jucker, M.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 148
- Issue
- 6
- Pages
- 1188-1203
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2064367582
- Cited by
- 1,744
- References
- 27
- FWCI
- 45.89
- Type
- journal article
- Language
- en
- Open access
- bronze
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