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Systemic Elevation of PTEN Induces a Tumor-Suppressive Metabolic State
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“Mice with increased dosage of the tumor suppressor PTEN exhibit a general down-modulation of the IIS pathway and an increased energy expenditure that is associated with improved mitochondrial oxidative metabolism, as well as with an enhanced activity of the brown adipose tissue”
From The Hallmarks of Aging (2013) · cites this paper as Garcia-Cao et al., 2012
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Metadata
- Authors
- Garcia-Cao, I., Song, M. S., Hobbs, R. M., Laurent, G., Giorgi, C., de Boer, V. C. J., Anastasiou, D., Ito, K., Sasaki, A. T., Rameh, L., Carracedo, A., Vander Heiden, M. G., Cantley, L. C., Pinton, P., Haigis, M. C., & Pandolfi, P. P.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 149
- Issue
- 1
- Pages
- 49-62
- ISSN
- 0092-8674
- PMC
- PMC3319228
- Cited by
- 377
- References
- 15
- Language
- en
- Licence
- Funders
- Ministerio de Educación, Cultura y Deporte
- Associazione Italiana per la Ricerca sul Cancro
- National Institutes of Health (P01-CA089021, R01 CA-82328-09, R01-GM41890)
- Human Frontier Science Program
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