Wnt/β-catenin signaling and disease

Clevers, Hans, Nusse, Roel·2012·Cell

Cited by (1,023)

Items 201–300 of 1,023

  1. PAF and EZH2 Induce Wnt/β-Catenin Signaling Hyperactivation
    Hae‐Yun Jung, Sohee Jun, Moonsup Lee, Han-Cheon Kim, Xin Wang, Hong Long Ji, Pierre D. McCrea, Jae‐Il Park · 2013 · Molecular Cell
  2. β-Catenin Is Required for the Tumorigenic Behavior of Triple-Negative Breast Cancer Cells
    Jinhua Xu, Jenifer R. Prosperi, Noura J. Choudhury, Olufunmilayo Ibironke Olopade, Kathleen H. Goss · 2015 · PLoS ONE
  3. Inhibition of Wnt/β-catenin signaling ameliorates osteoarthritis in a murine model of experimental osteoarthritis
    Caressa Lietman, Brian Wu, Sarah Lechner, Andrew A. Shinar, Madhur Sehgal, Evgeny Rossomacha, Poulami Datta, Anirudh Sharma, Rajiv Gandhi, Mohit Kapoor et al. · 2018 · JCI Insight
  4. Notum Is Required for Neural and Head Induction via Wnt Deacylation, Oxidation, and Inactivation
    Xinjun Zhang, Seong-Moon Cheong, Nathália G. Amado, Alice H. Reis, Bryan T. MacDonald, Matthias Zebisch, E. Yvonne Jones, José G. Abreu, Xi He · 2015 · Developmental Cell
  5. Wnt Signalosome Assembly by DEP Domain Swapping of Dishevelled
    Melissa V. R. Gammons, Miha Renko, Christopher M. Johnson, Trevor J. Rutherford, Mariann Bienz · 2016 · Molecular Cell
  6. FOXM1 (Forkhead box M1) in Tumorigenesis
    Inken Wierstra · 2013 · Advances in cancer research
  7. Interaction of lncRNA MIR100HG with hnRNPA2B1 facilitates m6A-dependent stabilization of TCF7L2 mRNA and colorectal cancer progression
    Hao Liu, Danxiu Li, Lina Sun, Hongqiang Qin, Ahui Fan, Lingnan Meng, Ramona Graves‐Deal, Sarah E. Glass, Jeffrey L. Franklin, Qi Liu et al. · 2022 · Molecular Cancer
  8. APC Is an RNA-Binding Protein, and Its Interactome Provides a Link to Neural Development and Microtubule Assembly
    Nicolas Preitner, Jie Quan, Dan W. Nowakowski, Melissa Hancock, Jianhua Shi, Joseph Tcherkezian, Tracy L. Young‐Pearse, John G. Flanagan · 2014 · Cell
  9. Cellular Plasticity in Intestinal Homeostasis and Disease
    Felipe de Sousa e Melo, Frédéric J. de Sauvage · 2018 · Cell stem cell
  10. Identification of circular RNAs as a promising new class of diagnostic biomarkers for human breast cancer
    Lingshuang Lü, Jian Sun, Peiyi Shi, Weimin Kong, Kun Xu, Biyu He, Simin Zhang, Jianming Wang · 2017 · Oncotarget
  11. IQGAPs choreograph cellular signaling from the membrane to the nucleus
    Jessica M. Smith, Andrew C. Hedman, David B. Sacks · 2015 · Trends in Cell Biology
  12. Melanoma-Derived Wnt5a Promotes Local Dendritic-Cell Expression of IDO and Immunotolerance: Opportunities for Pharmacologic Enhancement of Immunotherapy
    Alisha Holtzhausen, Fei Linda Zhao, Kathy S. Evans, Masahito Tsutsui, Ciriana Orabona, Douglas S. Tyler, Brent Allen Hanks · 2015 · Cancer Immunology Research
  13. Intestinal Stem Cell Niche: The Extracellular Matrix and Cellular Components
    Laween Meran, Anna Baulies, Vivian Sze Wing Li · 2017 · Stem Cells International
  14. Wnt/β-Catenin Signaling: The Culprit in Pancreatic Carcinogenesis and Therapeutic Resistance
    Monish Ram Makena, Himavanth Reddy Gatla, Dattesh U. Verlekar, Sahithi Sukhavasi, Manoj Kumar Pandey, Kartick Chandra Pramanik · 2019 · International Journal of Molecular Sciences
  15. Tankyrase Inhibition Blocks Wnt/β-Catenin Pathway and Reverts Resistance to PI3K and AKT Inhibitors in the Treatment of Colorectal Cancer
    Oriol Arqués, Irene Chicote, Isabel Puig, Stephan P. Tenbaum, Guillem Argilés, Rodrigo Dienstmann, Natalia Fernández, Ginevra Caratù, Judit Matito, Daniel Silberschmidt et al. · 2015 · Clinical Cancer Research
  16. miR-139-5p is a regulator of metastatic pathways in breast cancer
    Keerthana Krishnan, Anita L Steptoe, Hilary C. Martin, Diwakar Ram Pattabiraman, Kátia Nones, Nicola Waddell, Mythily Mariasegaram, Peter T. Simpson, Sunil R. Lakhani, Alexander V. Vlassov et al. · 2013 · RNA
  17. Sexual Dimorphism in Colon Cancer
    Maria Abancens, Viviana Bustos, Harry Myles Harvey, Jean McBryan, Brian Joseph Harvey · 2020 · Frontiers in Oncology
  18. Significance of mechanical loading in bone fracture healing, bone regeneration, and vascularization
    Qianli Ma, Zahra Miri, Håvard Jostein Haugen, Amirhossein Moghanian, Dagnjia Loca · 2023 · Journal of Tissue Engineering
  19. The Transcription Factor FOXM1 (Forkhead box M1)
    Inken Wierstra · 2013 · Advances in cancer research
  20. Curcumin and obesity
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  21. The structural basis of R-spondin recognition by LGR5 and RNF43
    Po‐Han Chen, Xiaoyan Chen, Zhenghong Lin, Deyu Fang, Xiaolin L. He · 2013 · Genes & Development
  22. The Underappreciated Role of Allostery in the Cellular Network
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  23. Developmental pathways in colon cancer
    Fred E. Bertrand, C. William Angus, William J. Partis, George Sigounas · 2012 · Cell Cycle
  24. Noncanonical Functions of Telomerase: Implications in Telomerase-Targeted Cancer Therapies
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  25. Hormones and pathogenesis of uterine fibroids
    Fernando Marcos dos Reis, Enrrico Bloise, Tânia Maria Ortiga-Carvalho · 2015 · Best Practice & Research Clinical Obstetrics & Gynaecology
  26. Control of Wnt Receptor Turnover by R-spondin-ZNRF3/RNF43 Signaling Module and Its Dysregulation in Cancer
    Huai-Xiang Hao, Xiaomo Jiang, Feng Cong · 2016 · Cancers
  27. Endocytosis, Signaling, and Beyond
    Pier Paolo, M. von Zastrow · 2014 · Cold Spring Harbor Perspectives in Biology
  28. Targeting methyltransferase PRMT5 eliminates leukemia stem cells in chronic myelogenous leukemia
    Yanli Jin, Jingfeng Zhou, Fang Xu, Bei Jin, Lijing Cui, Yun Wang, Xin Du, Juan Li, Peng Li, Ruibao Ren et al. · 2016 · Journal of Clinical Investigation
  29. The Role of Wnt Signalling in Angiogenesis.
    Jun Jun Olsen, Sebastian Pohl, Abhijeet P. Deshmukh, Malini Visweswaran, Natalie C. Ward, Frank Arfuso, Mark Agostino, Arun Dharmarajan · 2017 · Europe PMC (PubMed Central)
  30. LRP5 and LRP6 in Wnt Signaling: Similarity and Divergence
    Qian Ren, Jiongcheng Chen, Youhua Liu · 2021 · Frontiers in Cell and Developmental Biology
  31. Wnt Signaling Pathway Inhibitor Sclerostin Inhibits Angiotensin II–Induced Aortic Aneurysm and Atherosclerosis
    Smriti Murali Krishna, Sai Wang Seto, Roby J. Jose, Jiaze Li, Susan K. Morton, Erik Biroš, Yutang Wang, Vianne Nsengiyumva, Jan H.N. Lindeman, Gabriela G. Loots et al. · 2016 · Arteriosclerosis Thrombosis and Vascular Biology
  32. Tissue fibrosis induced by radiotherapy: current understanding of the molecular mechanisms, diagnosis and therapeutic advances
    Zuxiang Yu, Chaoyu Xu, Bin Song, Shihao Zhang, Chong Chen, Changlong Li, Shuyu Zhang · 2023 · Journal of Translational Medicine
  33. A collagen microchannel scaffold carrying paclitaxel-liposomes induces neuronal differentiation of neural stem cells through Wnt/β-catenin signaling for spinal cord injury repair
    Xiaoran Li, Caixia Fan, Zhifeng Xiao, Yannan Zhao, Haimin Zhang, Jie Sun, Yan Zhuang, Xianming Wu, Jiajia Shi, Yanyan Chen et al. · 2018 · Biomaterials
  34. circGSK3β promotes metastasis in esophageal squamous cell carcinoma by augmenting β-catenin signaling
    Xueting Hu, Duoguang Wu, Xiaotian He, Huiying Zhao, Zhanghai He, Jiatong Lin, Kefeng Wang, Wenjian Wang, Zihao Pan, Huayue Lin et al. · 2019 · Molecular Cancer
  35. Molecular mechanisms and therapeutic strategies in overcoming chemotherapy resistance in cancer
    Yixiang Gu, Ruifeng Yang, Yang Zhang, Miaomiao Guo, Kyle Takehiro, Ming Zhan, Linhua Yang, Hui Wang · 2025 · Molecular Biomedicine
  36. Stearoyl-CoA desaturase promotes liver fibrosis and tumor development in mice via a wnt positive-signaling loop by stabilization of low-density lipoprotein-receptor-related proteins 5 and 6
    Lai, Keane K.Y., Kweon, Soo-Mi, Chi, Feng, Hwang, Edward, Kabe, Yasuaki, Higashiyama, Reiichi, Qin, Lan, Yan, Rui, Wu, Raymond P., Lai, Keith et al. · 2017 · Gastroenterology
  37. Voluntary Running Attenuates Memory Loss, Decreases Neuropathological Changes and Induces Neurogenesis in a Mouse Model of A lzheimer's Disease
    Cheril Tapia‐Rojas, Florencia C. Aránguiz, Lorena Varela‐Nallar, Nibaldo C. Inestrosa · 2015 · Brain Pathology
  38. Signal integration in TGF-β, WNT, and Hippo pathways
    Liliana Attisano, Jeffrey L. Wrana · 2013 · F1000Prime Reports
  39. 2017 update on the relationship between diabetes and colorectal cancer: epidemiology, potential molecular mechanisms and therapeutic implications
    Nieves González, I. Prieto, Laura del Puerto‐Nevado, Sergio Portal‐Núñez, Juan Antonio Ardura, Marta Cortón, Beatriz Fernández‐Fernández, Óscar Aguilera, Carmen Gómez‐Guerrero, Sebastián Mas et al. · 2017 · Oncotarget
  40. Paving the Rho in cancer metastasis: Rho GTPases and beyond
    Sepp R. Jansen, Reinoud Gosens, Thomas Wieland, Martina Schmidt · 2017 · Pharmacology & Therapeutics
  41. Wnt/β-Catenin Signaling and Obesity
    Na Chen, Jiqiu Wang · 2018 · Frontiers in Physiology
  42. A tRNA fragment, 5′-tiRNAVal, suppresses the Wnt/β-catenin signaling pathway by targeting FZD3 in breast cancer
    Dongping Mo, Pan Jiang, Yining Yang, Xuelian Mao, Tan Xuyan, Xun Tang, Da Wei, Bing Li, Xiaoming Wang, Li Ping Tang et al. · 2019 · Cancer Letters
  43. Epithelial–mesenchymal transition: The history, regulatory mechanism, and cancer therapeutic opportunities
    Zhao Huang, Zhe Zhang, Chengwei Zhou, Lin Liu, Canhua Huang · 2022 · MedComm
  44. Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation
    Zhao, Chuntao, Deng, Yaqi, Liu, Lei, Yu, Kun, Zhang, Liguo, Wang, Haibo, He, Xuelian, Wang, Jincheng, Lu, Changqing, Wu, Laiman N et al. · 2016 · Nature Communications
  45. Wnt your brain be inflamed? Yes, it Wnt!
    Bianca Marchetti, Stefano Pluchino · 2013 · Trends in Molecular Medicine
  46. Single-cell imaging of Wnt palmitoylation by the acyltransferase porcupine
    Xinxin Gao, Rami N. Hannoush · 2013 · Nature Chemical Biology
  47. Wnt/β-catenin links oxidative stress to podocyte injury and proteinuria
    Lili Zhou, Xiaowen Chen, Meizhi Lu, Qinyu Wu, Qian Yuan, Chengxiao Hu, Jinhua Miao, Yunfang Zhang, Hongyan Li, Fan Fan Hou et al. · 2019 · Kidney International
  48. CD44 functions in Wnt signaling by regulating LRP6 localization and activation
    M Schmitt, M Metzger, Dietmar Gradl, Gary R. Davidson, Véronique Orian‐Rousseau · 2014 · Cell Death and Differentiation
  49. Direct Targeting of β-Catenin by a Small Molecule Stimulates Proteasomal Degradation and Suppresses Oncogenic Wnt/β-Catenin Signaling
    So-Young Hwang, Xianming Deng, Sanguine Byun, Chan Lee, Seung-Joo Lee, Hyunsuk Suh, Jianming Zhang, Qiaofeng Kang, Ting Zhang, Kenneth D. Westover et al. · 2016 · Cell Reports
  50. Wnts in adult brain: from synaptic plasticity to cognitive deficiencies
    Oliva, Carolina A., Vargas, Jessica Y., Inestrosa, Nibaldo C. · 2013 · Frontiers in Cellular Neuroscience
  51. Wnt signaling: Essential roles in osteoblast differentiation, bone metabolism and therapeutic implications for bone and skeletal disorders
    Vlashi, Rexhina, Zhang, Xingen, Wu, Mengrui, Chen, Guiqian · 2023 · Genes & Diseases
  52. RNAi screens in mice identify physiological regulators of oncogenic growth
    Slobodan Beronja, Peter Janki, Evan Heller, Wen‐Hui Lien, Brice E. Keyes, Naoki Oshimori, Elaine V. Fuchs · 2013 · Nature
  53. Signaling pathway cross talk in Alzheimer’s disease
    Juan Alejandro Godoy, Juvenal A. Ríos, Juan Manuel Zolezzi, Nady Braidy, Nibaldo C. Inestrosa · 2014 · Cell Communication and Signaling
  54. Potential therapeutic targets of epithelial–mesenchymal transition in melanoma
    Ross L. Pearlman, Mary Katherine Montes de Oca, Harish Chandra Pal, Farrukh Afaq · 2017 · Cancer Letters
  55. Gut microbiota and cancer: How gut microbiota modulates activity, efficacy and toxicity of antitumoral therapy
    Stefania Gori, Alessandro Inno, Lorenzo Belluomini, Paolo Bocus, Zeno Bisoffi, Antonio Dello Russo, Guido Arcaro · 2019 · Critical Reviews in Oncology/Hematology
  56. Canonical Wnt signaling acts synergistically on BMP9-induced osteo/odontoblastic differentiation of stem cells of dental apical papilla (SCAPs)
    Hongmei Zhang, Jinhua Wang, Fang Deng, Enyi Huang, Zhengjian Yan, Zhongliang Wang, Youlin Deng, Qian Zhang, Zhonglin Zhang, Jixing Ye et al. · 2014 · Biomaterials
  57. A Novel Wnt Regulatory Axis in Endometrioid Endometrial Cancer
    Yu Fen Zhao, Yihua Yang, Jone Trovik, Kun Sun, Liang Zhou, Peiyong Jiang, Tat‐San Lau, Erling André Høivik, Helga Birgitte Salvesen, Hao Sun et al. · 2014 · Cancer Research
  58. Origins, Development, and Compartmentation of the Granule Cells of the Cerebellum
    G. Giacomo Consalez, Dan Goldowitz, Filippo Casoni, Richard B. Hawkes · 2021 · Frontiers in Neural Circuits
  59. The p53 Family Coordinates Wnt and Nodal Inputs in Mesendodermal Differentiation of Embryonic Stem Cells
    Qiong Wang, Yilong Zou, Sonja Nowotschin, Sang Yong Kim, Qing V. Li, Chew-Li Soh, Jie Su, Chao Zhang, Weiping Shu, Qiaoran Xi et al. · 2016 · Cell stem cell
  60. Dietary polyphenols suppress chronic inflammation by modulation of multiple inflammation-associated cell signaling pathways
    Ibrahim Jantan, Md. Areeful Haque, Laiba Arshad, Hemavathy Harikrishnan, Abdi Wira Septama, Zeti‐Azura Mohamed‐Hussein · 2021 · The Journal of Nutritional Biochemistry
  61. Wnt signalling in neuronal differentiation and development
    Nibaldo C. Inestrosa, Lorena Varela‐Nallar · 2014 · Cell and Tissue Research
  62. USP7 Is a Tumor-Specific WNT Activator for APC-Mutated Colorectal Cancer by Mediating β-Catenin Deubiquitination
    Laura Novellasdemunt, Valentina Foglizzo, Laura Gómez-Cuadrado, Pedro Antas, Anna Kucharska, Vesela Encheva, Ambrosius P. Snijders, Vivian Sze Wing Li · 2017 · Cell Reports
  63. Non-canonical WNT signalling in cardiovascular disease: mechanisms and therapeutic implications
    Ioannis Akoumianakis, Murray Polkinghorne, Charalambos A. Antoniades · 2022 · Nature Reviews Cardiology
  64. Inhibition of Tankyrases Induces Axin Stabilization and Blocks Wnt Signalling in Breast Cancer Cells
    Ren-Yue Bao, Tania Y. Christova, Siyuan Song, Stéphane Angers, Xiaojun Yan, Liliana Attisano · 2012 · PLoS ONE
  65. Gene and protein expressions and metabolomics exhibit activated redox signaling and wnt/β-catenin pathway are associated with metabolite dysfunction in patients with chronic kidney disease
    Dan‐Qian Chen, Gang Cao, Hua Chen, Dan Liu, Wei Cheng Su, Xiao-Yong Yu, Nosratola D. Vaziri, Xiuhua Liu, Xu Bai, Li Zhang et al. · 2017 · Redox Biology
  66. Klotho Ameliorates Kidney Injury and Fibrosis and Normalizes Blood Pressure by Targeting the Renin-Angiotensin System
    Lili Zhou, Hongyan Mo, Jinhua Miao, Dong Feng Zhou, Roderick J. Tan, Fan Fan Hou, Youhua Liu · 2015 · American Journal Of Pathology
  67. Tumour suppressor TRIM33 targets nuclear β-catenin degradation
    Jianfei Xue, Yaohui Chen, Yamei Wu, Zhongyong Wang, Aidong Zhou, Sicong Zhang, Kangyu Lin, Kenneth Aldape, Sadhan Majumder, Zhimin Lu et al. · 2015 · Nature Communications
  68. TRIB2 Acts Downstream of Wnt/TCF in Liver Cancer Cells to Regulate YAP and C/EBPα Function
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  69. Glycogen synthase kinase‐3β is a pivotal mediator of cancer invasion and resistance to therapy
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  70. Interplay between Inflammation and Pathological Bone Resorption: Insights into Recent Mechanisms and Pathways in Related Diseases for Future Perspectives
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  71. Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo
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  72. Canonical and noncanonical Wnt signaling in neural stem/progenitor cells
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  73. Molecular Mechanisms of Chondrocyte Proliferation and Differentiation
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  74. Wnt pathway regulation of intestinal stem cells
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  75. Human Fibrotic Diseases: Current Challenges in Fibrosis Research
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  76. Uncoupling of macrophage inflammation from self-renewal modulates host recovery from respiratory viral infection
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  77. Alzheimer's disease, enzyme targets and drug discovery struggles: From natural products to drug prototypes
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  78. Control of Proliferation and Cancer Growth by the Hippo Signaling Pathway
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  79. VGLL4 targets a TCF4–TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer
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  80. A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer
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  83. Lgr proteins in epithelial stem cell biology
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  84. Induction of intestinal stem cells by R-spondin 1 and Slit2 augments chemoradioprotection
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  85. TGFβ signaling and the control of myofibroblast differentiation: Implications for chronic inflammatory disorders
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  86. Inhibiting Glutamine-Dependent mTORC1 Activation Ameliorates Liver Cancers Driven by β-Catenin Mutations
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  87. Are Wnt/β-Catenin and PI3K/AKT/mTORC1 Distinct Pathways in Colorectal Cancer?
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  89. Activation of GLP-1 Receptor Promotes Bone Marrow Stromal Cell Osteogenic Differentiation through β-Catenin
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  90. Forkhead box Q1 promotes hepatocellular carcinoma metastasis by transactivating ZEB2 and VersicanV1 expression
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  91. Non-canonical Wnt signalling modulates the endothelial shear stress flow sensor in vascular remodelling
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  92. Interrelationship of canonical and non-canonical Wnt signalling pathways in chronic metabolic diseases
    Ian Ackers, Ramiro Malgor · 2017 · Diabetes and Vascular Disease Research
  93. Unraveling the signaling pathways promoting fibrosis in Dupuytren's disease reveals TNF as a therapeutic target
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  94. Role of Wnt Signaling in Adult Hippocampal Neurogenesis in Health and Disease
    Sebastian B. Arredondo, Daniela Valenzuela-Bezanilla, Muriel D. Mardones, Lorena Varela-Nallar · 2020 · Frontiers in Cell and Developmental Biology
  95. The signaling protein Wnt5a promotes TGFβ1-mediated macrophage polarization and kidney fibrosis by inducing the transcriptional regulators Yap/Taz
    Feng, Ye, Liang, Yan, Zhu, Xingwen, Wang, Mingjie, Gui, Yuan, Lu, Qingmiao, Gu, Mengru, Xue, Xian, Sun, Xiaoli, He, Weichun et al. · 2018 · Journal of Biological Chemistry
  96. Current Understanding on EGFR and Wnt/ -Catenin Signaling in Glioma and Their Possible Crosstalk
    Indranil Paul, S. Bhattacharya, A. Chatterjee, Mrinal K. Ghosh · 2013 · Genes & Cancer
  97. The CLK inhibitor SM08502 induces anti-tumor activity and reduces Wnt pathway gene expression in gastrointestinal cancer models
    Betty Y. Y. Tam, Kevin Chiu, Heekyung Chung, Carine Bossard, John D. Nguyen, Emily Creger, Brian W. Eastman, Chi Ching Mak, Maureen Ibanez, Abdullah Ghias et al. · 2019 · Cancer Letters
  98. A new link between diabetes and cancer: enhanced WNT/β-catenin signaling by high glucose
    García-Jiménez, Custodia, García-Martínez, Jose Manuel, Chocarro-Calvo, Ana, De la Vieja, Antonio · 2014 · Journal of Molecular Endocrinology
  99. The role of WNT signaling in adult ovarian folliculogenesis
    Jennifer A Hernandez Gifford · 2015 · Reproduction
  100. The RNA m6A writer WTAP in diseases: structure, roles, and mechanisms
    Qibo Huang, Jie Mo, Zhibin Liao, Xiaoping Chen, Bixiang Zhang · 2022 · Cell Death and Disease