Wnt/β-catenin signaling and disease

Clevers, Hans, Nusse, Roel·2012·Cell

Cited by (1,023)

Items 701–800 of 1,023

  1. Andrographolide activates the canonical Wnt signalling pathway by a mechanism that implicates the non-ATP competitive inhibition of GSK-3β: autoregulation of GSK-3βin vivo
    Cheril Tapia‐Rojas, Andreas Schüller, Carolina B. Lindsay, Roxana C. Ureta, Cristóbal Mejías-Reyes, Juan L. Hancke, Francisco Melo, Nibaldo C. Inestrosa · 2014 · Biochemical Journal
  2. Signaling pathways regulating cartilage growth plate formation and activity
    William E. Samsa, Xin Zhou, Guang Dong Zhou · 2016 · Seminars in Cell and Developmental Biology
  3. Matrix Metalloproteinases-7 and Kidney Fibrosis
    Ben Ke, Chuqiao Fan, Liping Yang, Xiangdong Fang · 2017 · Frontiers in Physiology
  4. Wnt Signaling Regulates Multipolar-to-Bipolar Transition of Migrating Neurons in the Cerebral Cortex
    Boitard, Michael, Bocchi, Riccardo, Egervari, Kristof, Petrenko, Volodymyr, Viale, Beatrice, Gremaud, Stéphane, Zgraggen, Eloisa, Salmon, Patrick, Kiss, Jozsef Z. · 2015 · Cell Reports
  5. MiR-139-5p: promising biomarker for cancer
    He-da Zhang, Linhong Jiang, Dawei Sun, Jian Li, Jinhai Tang · 2015 · Tumor Biology
  6. Ligase IV inhibitor SCR7 enhances gene editing directed by CRISPR–Cas9 and ssODN in human cancer cells
    Zheng Mao Hu, Zhaoying Shi, Xiaogang Guo, Baishan Jiang, Guo Wang, Dixian Luo, Yonglong Chen, Yuan‐Shan Zhu · 2018 · Cell & Bioscience
  7. From genomics to metabolomics: emerging metastatic biomarkers in osteosarcoma
    Dylan C. Dean, Shen Shen, Francis John Hornicek, Zhenfeng Duan · 2018 · Cancer and Metastasis Reviews
  8. Long noncoding RNA CRNDE activates Wnt/β-catenin signaling pathway through acting as a molecular sponge of microRNA-136 in human breast cancer.
    Jinliang Huan, Xing Li, Qianhuang Lin, Hu Xui, Xianju Qin · 2017 · PubMed Central
  9. Regulation of Wnt Signaling Pathways at the Plasma Membrane and Their Misregulation in Cancer
    Yagmur Azbazdar, Mustafa Karabicici, Esra Erdal, Günes Özhan · 2021 · Frontiers in Cell and Developmental Biology
  10. Targeting the crosstalk between canonical Wnt/β-catenin and inflammatory signaling cascades: A novel strategy for cancer prevention and therapy
    Devesh Tewari, Sweta Bawari, Shikha Sharma, Lindsay K. DeLiberto, Anupam Bishayee · 2021 · Pharmacology & Therapeutics
  11. Integrated single-cell chromatin and transcriptomic analyses of human scalp identify gene-regulatory programs and critical cell types for hair and skin diseases
    Ober-Reynolds, Benjamin, Wang, Chen, Ko, Justin M., Rios, Eon J., Aasi, Sumaira Z., Davis, Mark M., Oro, Anthony E., Greenleaf, William J. · 2023 · Nature Genetics
  12. Hypoxic macrophages impair autophagy in epithelial cells through Wnt1: relevance in IBD
    D. Ortiz-Masiá, J. Cosín-Roger, S. Calatayud, C. Hernández, R. Alós, Joaquín Hinojosa, N. Apostolova, Ángeles Álvarez, M. Barrachina · 2013 · Mucosal Immunology
  13. Arl4c expression in colorectal and lung cancers promotes tumorigenesis and may represent a novel therapeutic target
    Shinsuke Fujii, Shinji Matsumoto, Satoshi Nojima, Eiichi Morii, Akira Kikuchi · 2014 · Oncogene
  14. Physiological Role of β-Catenin/TCF Signaling in Neurons of the Adult Brain
    Marta Barbara Wisniewska · 2013 · Neurochemical Research
  15. The Wnt/β-catenin signaling pathway regulates the development of airway remodeling in patients with asthma
    Hyun Jung Kwak, Dong Won Park, Ji-Young Seo, Ji‐Yong Moon, Tae‐Hyung Kim, Jang Won Sohn, Dong Ho Shin, Ho Joo Yoon, Sung Soo Park, Sang‐Heon Kim · 2015 · Experimental & Molecular Medicine
  16. Discovery of Selective Small-Molecule Inhibitors for the β-Catenin/T-Cell Factor Protein–Protein Interaction through the Optimization of the Acyl Hydrazone Moiety
    Jonathan Leon Catrow, Yongqiang Zhang, Min Zhang, Haitao Ji · 2015 · Journal of Medicinal Chemistry
  17. Critical function of the necroptosis adaptor RIPK3 in protecting from intestinal tumorigenesis
    Dominique Bozec, Alina Cornelia Iuga, Giulia Roda, Stéphanie Dahan, Garabet Yeretssian · 2016 · Oncotarget
  18. Regulation of zonation and homeostasis in the adrenal cortex
    Emanuele Pignatti, Sining Leng, Diana L. Carlone, David T. Breault · 2016 · Molecular and Cellular Endocrinology
  19. The function of endocytosis in Wnt signaling
    Lucy H. Brunt, Steffen Scholpp · 2017 · Cellular and Molecular Life Sciences
  20. Hepatitis C virus core protein modulates several signaling pathways involved in hepatocellular carcinoma
    Shahab Mahmoudvand, Somayeh Shokri, Reza Taherkhani, Fatemeh Farshadpour · 2019 · World Journal of Gastroenterology
  21. The emerging role of exosomes in Wnt secretion and transport.
    Liang Zhang, J. Wrana · 2014 · Current Opinion in Genetics and Development
  22. Emodin represses TWIST1-induced epithelial–mesenchymal transitions in head and neck squamous cell carcinoma cells by inhibiting the β-catenin and Akt pathways
    Tzong‐Der Way, Jhen-Ting Huang, Chun-Hung Chou, Chi-Hung Huang, Muh‐Hwa Yang, Chi‐Tang Ho · 2013 · European Journal of Cancer
  23. SET7/9 regulates cancer cell proliferation by influencing β‐catenin stability
    Changchun Shen, Donglai Wang, Xiangyu Liu, Bo Gu, Yipeng Du, Fu‐Zheng Wei, Linlin Cao, Boyan Song, Xiaopeng Lu, Qiaoyan Yang et al. · 2015 · The FASEB Journal
  24. Involvement of FOXL2 and RSPO1 in Ovarian Determination, Development, and Maintenance in Mammals
    Maëlle Pannetier, Anne‐Amandine Chassot, Marie‐Christine Chaboissier, Éric Pailhoux · 2016 · Sexual Development
  25. β-catenin-mediated YAP signaling promotes human glioma growth
    Yan Wang, Peng Pan, Zhaohao Wang, Yu Zhang, Peng Xie, Decheng Geng, Yang Jiang, Rutong Yu, Xiuping Zhou · 2017 · Journal of Experimental & Clinical Cancer Research
  26. mTORC1 signaling suppresses Wnt/β-catenin signaling through DVL-dependent regulation of Wnt receptor FZD level
    Hao Zeng, Bo Lu, Raffaella Zamponi, Zinger Yang, Kristie Wetzel, Joseph Loureiro, Sina Mohammadi, Martin Beibel, Sebastian Bergling, John S. Reece-Hoyes et al. · 2018 · Proceedings of the National Academy of Sciences
  27. HIV-Associated Neurocognitive Impairment in the Modern ART Era: Are We Close to Discovering Reliable Biomarkers in the Setting of Virological Suppression?
    A. Bandera, L. Taramasso, G. Bozzi, A. Muscatello, J. Robinson, T. Burdo, A. Gori · 2019 · Frontiers in Aging Neuroscience
  28. How Tubular Epithelial Cell Injury Contributes to Renal Fibrosis
    Bi‐Cheng Liu, Tao‐Tao Tang, Lin‐Li Lv · 2019 · Advances in experimental medicine and biology
  29. Enhancing the Cell Permeability of Stapled Peptides with a Cyclic Cell-Penetrating Peptide
    Patrick G. Dougherty, Jin Wen, Xiaoyan Pan, Amritendu Koley, Jian-Guo Ren, Ashweta Sahni, Ruchira Basu, Heba Salim, George Appiah Kubi, Ziqing Qian et al. · 2019 · Journal of Medicinal Chemistry
  30. SNAIL1: Linking Tumor Metastasis to Immune Evasion
    Xiaolong Tang, Xue Sui, Liang Weng, Yongshuo Liu · 2021 · Frontiers in Immunology
  31. How the Wnt signaling pathway protects from neurodegeneration: the mitochondrial scenario
    Macarena S. Arrázola, Carmen Silva-Álvarez, Nibaldo C. Inestrosa · 2015 · Frontiers in Cellular Neuroscience
  32. DEP domains: structurally similar but functionally different
    Sarah V. Consonni, Madelon M. Maurice, Johannes L. Bos · 2014 · Nature Reviews Molecular Cell Biology
  33. Implications of biomarkers in human hepatocellular carcinoma pathogenesis and therapy
    Lili Han · 2014 · World Journal of Gastroenterology
  34. MiRNA-194 activates the Wnt/β-catenin signaling pathway in gastric cancer by targeting the negative Wnt regulator, SUFU
    Yin Peng, Xiaojing Zhang, Qiang Ma, Ruibin Yan, Ying� Qin, Yanqiu Zhao, Yulan Cheng, Mengting Yang, Qixiang Wang, Xianling Feng et al. · 2016 · Cancer Letters
  35. Molecular and cellular pathogenesis of adamantinomatous craniopharyngioma
    Juan Pedro Martı́nez-Barberá · 2015 · Neuropathology and Applied Neurobiology
  36. Biochemical and molecular mechanisms for the association between obesity, chronic Inflammation, and breast cancer
    David P. Rose, Linda C Vona-Davis · 2013 · BioFactors
  37. Presenilin Deficiency or Lysosomal Inhibition Enhances Wnt Signaling through Relocalization of GSK3 to the Late-Endosomal Compartment
    Radek Dobrowolski, Philipp Vick, Diego Ploper, Iwona Gumper, Harriet Snitkin, David D. Sabatini, Edward M. De Robertis · 2012 · Cell Reports
  38. GPC5, a novel epigenetically silenced tumor suppressor, inhibits tumor growth by suppressing Wnt/β-catenin signaling in lung adenocarcinoma
    Shuai Yuan, Zhigang Yu, Qingyun Liu, M Zhang, Y Xiang, Na Wu, Long Wu, Zhangxue Hu, Botao Xu, Tongjian Cai et al. · 2016 · Oncogene
  39. Bidirectional KCNQ1:β-catenin interaction drives colorectal cancer cell differentiation
    Raphaël Rapetti‐Mauss, Viviana Bustos, Warren Thomas, Jean McBryan, Harry Myles Harvey, Natalia Lajczak, Stephen F. Madden, Bernard Pellissier, Franck Borgèse, Olivier Soriani et al. · 2017 · Proceedings of the National Academy of Sciences
  40. The pathogenic roles of heparan sulfate deficiency in Hereditary Multiple Exostoses
    M. Pacifici · 2017 · Matrix Biology
  41. Deficient Wnt signalling triggers striatal synaptic degeneration and impaired motor behaviour in adult mice
    Soledad Galli, Douglas M. Lopes, Rachida Ammari, Jaakko J. Kopra, Sarah E. Millar, Alasdair J. Gibb, Patricia C. Salinas · 2014 · Nature Communications
  42. Polygonatum sibiricum polysaccharide inhibits osteoporosis by promoting osteoblast formation and blocking osteoclastogenesis through Wnt/β-catenin signalling pathway
    Li Du, Nong Meng-ni, Jinmin Zhao, Xiaoming Peng, Shaohui Zong, Gaofeng Zeng · 2016 · Scientific Reports
  43. TTL Proteins Scaffold Brassinosteroid Signaling Components at the Plasma Membrane to Optimize Signal Transduction in Arabidopsis
    Vítor Amorim‐Silva, Álvaro García-Moreno, Araceli G. Castillo, Naoufal Lakhssassi, Jessica Pérez‐Sancho, Yansha Li, Alicia Esteban del Valle, David Posé, Josefa Pérez‐Rodríguez, Jinxing Lin et al. · 2019 · The Plant Cell
  44. Structure, regulation, and (patho-)physiological functions of the stress-induced protein kinase CK1 delta (CSNK1D)
    Pengfei Xu, Chiara Ianes, Fabian Gärtner, Congxing Liu, Timo Burster, Vasiliy Alekseevich Bakulev, Najma Rachidi, Uwe Knippschild, Joachim Bischof · 2019 · Gene
  45. Genetics and signaling mechanisms of orofacial clefts
    Kurt Reynolds, Shuwen Zhang, Bo Hang Sun, Michael A. Garland, Yu Ji, Chengji J. Zhou · 2020 · Birth Defects Research
  46. Romosozumab in osteoporosis: yesterday, today and tomorrow
    Dong Wu, Lei Li, Zhun Wen, Guangbin Wang · 2023 · Journal of Translational Medicine
  47. A novel genome-wide in vivo screen for metastatic suppressors in human colon cancer identifies the positive WNT-TCF pathway modulators TMED3 and SOX12
    Arnaud Duquet, A. Melotti, Sonakshi Mishra, M. Malerba, Chandan Seth, Arwen Conod, A. R. I. Altaba · 2014 · EMBO Molecular Medicine
  48. Targeting Wnt signaling at the neuroimmune interface for dopaminergic neuroprotection/repair in Parkinson's disease
    Francesca L’Episcopo, Cataldo Tirolo, Salvatore Caniglia, Nunzio Testa, Maria C. Morale, Maria Francesca Serapide, Stefano Pluchino, Bianca Marchetti · 2014 · Journal of Molecular Cell Biology
  49. The Dishevelled Protein Family
    Marek Mlodzik · 2016 · Current topics in developmental biology/Current Topics in Developmental Biology
  50. Extracellular cues influencing oligodendrocyte differentiation and (re)myelination
    Natalie A. Wheeler, Babette Fuss · 2016 · Experimental Neurology
  51. Mismatch repair deficiency commonly precedes adenoma formation in Lynch Syndrome-Associated colorectal tumorigenesis
    Shigeki Sekine, Taisuke Mori, Reiko Ogawa, Masahiro Tanaka, Hiroshi Yoshida, Hirokazu Taniguchi, Takeshi Nakajima, Kokichi Sugano, Teruhiko Yoshida, Mamoru Kato et al. · 2017 · Modern Pathology
  52. Toward an integrated map of genetic interactions in cancer cells
    Benedikt Rauscher, Florian Heigwer, Luisa Henkel, Thomas Hielscher, Oksana Voloshanenko, Michael Boutros · 2018 · Molecular Systems Biology
  53. TGF‐β‐induced profibrotic signaling is regulated in part by the WNT receptor Frizzled‐8
    Anita I. R. Spanjer, Hoeke Abele Baarsma, Lisette M. Oostenbrink, Sepp R. Jansen, Christine C. Kuipers, Michael Lindner, Dirkje Sjoukje Postma, Herman Meurs, Irene H. Heijink, Reinoud Gosens et al. · 2016 · The FASEB Journal
  54. Degree of Tissue Differentiation Dictates Susceptibility to BRAF-Driven Colorectal Cancer
    Kevin Tong, Oscar Pellón-Cárdenas, Veerin R. Sirihorachai, Bailey N. Warder, Om A. Kothari, Ansu O. Perekatt, Emily E. Fokas, Robert L. Fullem, Anbo Zhou, Joshua K. Thackray et al. · 2017 · Cell Reports
  55. Ube2s stabilizes β-Catenin through K11-linked polyubiquitination to promote mesendoderm specification and colorectal cancer development
    Zhaoyan Li, Yan Wang, Yadan Li, Wanqi Yin, Libin Mo, Xianghao Qian, Yiran Zhang, Guifen Wang, Fan Bu, Zhiling Zhang et al. · 2018 · Cell Death and Disease
  56. Coordination of WNT signaling and ciliogenesis during odontogenesis by piezo type mechanosensitive ion channel component 1
    Aya Miyazaki, Asuna Sugimoto, Keigo Yoshizaki, Keita Kawarabayashi, Kokoro Iwata, Rika Kurogoushi, Takamasa Kitamura, Kunihiro Otsuka, Tomokazu Hasegawa, Yuki Akazawa et al. · 2019 · Scientific Reports
  57. The Emerging Role of Long Non-Coding RNAs in the Metastasis of Hepatocellular Carcinoma
    Xuejiao Chen, Feng Ru Tang, Frank Arfuso, Wen-Qi Cai, Zhaowu Ma, Jiyuan Yang, Gautam Sethi · 2019 · Biomolecules
  58. Exosomal lncRNA DOCK9-AS2 derived from cancer stem cell-like cells activated Wnt/β-catenin pathway to aggravate stemness, proliferation, migration, and invasion in papillary thyroid carcinoma
    Dai, Wencheng, Jin, Xiaoxia, Han, Liang, Huang, Haijing, Ji, Zhenhua, Xu, Xinjiang, Tang, Mingming, Jiang, Bin, Chen, Weixian · 2020 · Cell Death & Disease
  59. The landscape of cancer-associated fibroblasts in colorectal cancer liver metastases
    Ambre Giguelay, Evgenia Turtoi, Lakhdar Khellaf, Guillaume Tosato, Ikrame Dadi, Tommy Chastel, Marie‐Alix Poul, Marine Pratlong, Stefan Nicolescu, Dany Séverac et al. · 2022 · Theranostics
  60. Stem cell-derived intestinal organoids: a novel modality for IBD
    Cheng‐mei Tian, Meifeng Yang, Haoming Xu, Min‐zheng Zhu, Ning-ning Yue, Yuan Zhang, Ruiyue Shi, Jun Yao, Lisheng Wang, Yu-jie Liang et al. · 2023 · Cell Death Discovery
  61. Regenerative Medicine: Charting a New Course in Wound Healing
    Geoffrey C. Gurtner, Mary Ann Chapman · 2015 · Advances in Wound Care
  62. Removal of SOST or blocking its product sclerostin rescues defects in the periodontitis mouse model
    Yinshi Ren, Xianglong Han, Sunita P. Ho, Stephen E. Harris, Zhengguo Cao, Aris N. Economides, Chunlin Qin, Hua-Zhu Ke, Min Liu, Jian Q. Feng · 2015 · The FASEB Journal
  63. Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation
    Xinwei Wang, Wei Liang, Julie M. Cramer, Brian J. Leibowitz, Colleen P. Judge-Golden, Michael W. Epperly, Joel S. Greenberger, Fengchao Wang, Linheng Li, Matthias G. Stelzner et al. · 2015 · Scientific Reports
  64. Wnt/β-catenin signaling induces the transcription of cystathionine-γ-lyase, a stimulator of tumor in colon cancer
    Kun Fan, Na Li, Jingjing Qi, Peng Yin, Chao Zhao, Liying Wang, Zengxia Li, Xiliang Zha · 2014 · Cellular Signalling
  65. WNT ‐3A and WNT ‐5A counteract lipopolysaccharide‐induced pro‐inflammatory changes in mouse primary microglia
    Carina Halleskog, Gunnar Schulte · 2013 · Journal of Neurochemistry
  66. Paracrine Wnt signaling both promotes and inhibits human breast tumor growth
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  67. Clathrin and AP2 are required for PtdIns(4,5)P2-mediated formation of LRP6 signalosomes
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  68. Regulation of Stem Cell Proliferation and Cell Fate Specification by Wingless/Wnt Signaling Gradients Enriched at Adult Intestinal Compartment Boundaries
    Ai Tian, Hassina Benchabane, Zhenghan Wang, Yashi F. Ahmed · 2016 · PLoS Genetics
  69. Granulocytic myeloid-derived suppressor cells maintain feto-maternal tolerance by inducing Foxp3 expression in CD4+CD25−T cells by activation of the TGF-β/β-catenin pathway
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  70. CRISPR-Barcoding for Intratumor Genetic Heterogeneity Modeling and Functional Analysis of Oncogenic Driver Mutations
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  71. Long non-coding RNA XIST promotes cell growth and metastasis through regulating miR-139-5p mediated Wnt/β-catenin signaling pathway in bladder cancer
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  72. Long noncoding RNA FEZF1-AS1 indicates a poor prognosis of gastric cancer and promotes tumorigenesis via activation of Wnt signaling pathway
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  73. TRIM14 promotes chemoresistance in gliomas by activating Wnt/β-catenin signaling via stabilizing Dvl2
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  74. Insulin/IGF-1R, SIRT1, and FOXOs Pathways—An Intriguing Interaction Platform for Bone and Osteosarcoma
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  75. Palmitoyltransferase DHHC9 and acyl protein thioesterase APT1 modulate renal fibrosis through regulating β-catenin palmitoylation
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  76. β-catenin regulates Pax3 and Cdx2 for caudal neural tube closure and elongation
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  77. PIK3CA and APC mutations are synergistic in the development of intestinal cancers
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  78. Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt–β-catenin–mediated intestinal tumor growth and regeneration
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  79. A matrix metalloproteinase mediates long-distance attenuation of stem cell proliferation
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  82. Culturing human intestinal stem cells for regenerative applications in the treatment of inflammatory bowel disease
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  83. Dramatic dysbalancing of the Wnt pathway in breast cancers
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  88. A new WNT on the bone: WNT16, cortical bone thickness, porosity and fractures
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  89. An unexpected role for a Wnt-inhibitor: Dickkopf-1 triggers a novel cancer survival mechanism through modulation of aldehyde-dehydrogenase-1 activity
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  90. FOXC1-induced non-canonical WNT5A-MMP7 signaling regulates invasiveness in triple-negative breast cancer
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  91. Dioscin inhibits stem-cell-like properties and tumor growth of osteosarcoma through Akt/GSK3/β-catenin signaling pathway
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  92. Tbx20 acts upstream of Wnt signaling to regulate endocardial cushion formation and valve remodeling during mouse cardiogenesis
    Cai, Xiaoqiang, Zhang, Weijia, Hu, Jun, Zhang, Lu, Sultana, Nishat, Wu, Bingruo, Cai, Weibin, Zhou, Bin, Cai, Chen-Leng · 2013 · Development
  93. A Regulatory Network Involving β-Catenin, e-Cadherin, PI3k/Akt, and Slug Balances Self-Renewal and Differentiation of Human Pluripotent Stem Cells In Response to Wnt Signaling
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  94. TGIF Governs a Feed-Forward Network that Empowers Wnt Signaling to Drive Mammary Tumorigenesis
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  95. Long noncoding RNA DANCR is activated by SALL4 and promotes the proliferation and invasion of gastric cancer cells
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  96. Plasticity of Paneth cells and their ability to regulate intestinal stem cells
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  97. The gut microbiome and efficacy of cancer immunotherapy
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  98. Prognostic Significance of β-Catenin, E-Cadherin, and SOX9 in Colorectal Cancer: Results from a Large Population-Representative Series
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  99. Determination of mesenchymal stem cell fate by pigment epithelium‐derived factor (PEDF) results in increased adiposity and reduced bone mineral content
    Arijeet K. Gattu, E. Scott Swenson, Yasuko Iwakiri, Varman T. Samuel, Nancy W. Troiano, Ryan Berry, CHRISTOPHER D. CHURCH, Matthew S. Rodeheffer, Thomas O. Carpenter, Chuhan Chung · 2013 · The FASEB Journal
  100. Effects of quercetin, a natural phenolic compound, in the differentiation of human mesenchymal stem cells (MSC) into adipocytes and osteoblasts
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