Wnt/β-Catenin Signaling and Disease

The Metabolic and Molecular Bases of Inherited Disease

Scriver, R. C. (1995) · Medical Entomology and Zoology · Cited by 12,101

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

Sato, T., Vries, R. G., Snippert, H. J., van de Wetering, M., Barker, N., Stange, D. E., van Es, J. H., Abo, A., Kujala, P., Peters, P. J., et al. (2009) · Nature · doi:10.1038/nature07935 · Cited by 7,204

The metabolic and molecular bases of inherited disease

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Identification of stem cells in small intestine and colon by marker gene Lgr5

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Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

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Lessons from hereditary colorectal cancer

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Mutations affecting segment number and polarity in Drosophila

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Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

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Wnt signalling in stem cells and cancer

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Functional interaction of β-catenin with the transcription factor LEF-1

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RUNX1 prevents oestrogen-mediated AXIN1 suppression and β-catenin activation in ER-positive breast cancer

Chimge, N., Little, G. H., Baniwal, S. K., Adisetiyo, H., Xie, Y., Zhang, T., O’Laughlin, A. E., Liu, Z. Y., Ulrich, P. R., Martin, A., et al. (2016) · Nature Communications · doi:10.1038/ncomms10751 · Cited by 78

TRIM29 functions as an oncogene in gastric cancer and is regulated by miR-185.

Qiu, F., Xiong, J., Deng, J., & Xiang, X. (2015) · PubMed Central · Cited by 75

WWC3 regulates the Wnt and Hippo pathways via Dishevelled proteins and large tumour suppressor 1, to suppress lung cancer invasion and metastasis

Han, Q., Lin, X., Zhang, X., Jiang, G., Zhang, Y., Miao, Y., Rong, X., Zheng, X., Han, Y., Han, X., et al. (2017) · The Journal of Pathology · doi:10.1002/path.4919 · Cited by 76

Mutually exclusive signaling signatures define the hepatic and pancreatic progenitor cell lineage divergencePreprint

Rodríguez-Seguel, E. D. P., Mah, N., Naumann, H., Pongrac, I. M., Cerdá‐Esteban, N., Fontaine, J., Wang, Y., Chen, W., Andrade-Navarro, M. A., & Spagnoli, F. M. (2013) · Genes & Development · doi:10.1101/gad.220244.113 · Cited by 73

LGR5 regulates pro-survival MEK/ERK and proliferative Wnt/β-catenin signalling in neuroblastoma

Vieira, G. C., Chockalingam, S., Melegh, Z., Greenhough, A., Malik, S., Szemes, M., Park, J. H., Kaidi, A., Zhou, L., Catchpoole, D. R., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.5548 · Cited by 75

TLR4 Promotes Breast Cancer Metastasis via Akt/GSK3β/β‐Catenin Pathway upon LPS Stimulation

Li, J., Yin, J., Shen, W., Gao, R., Liu, Y., Chen, Y., Li, X., Liu, C., Xiang, R., & Luo, N. (2017) · The Anatomical Record · doi:10.1002/ar.23590 · Cited by 75

Thermodynamics in cancers: opposing interactions between PPAR gamma and the canonical WNT/beta‐catenin pathway

Lecarpentier, Y., CLAES, V. A., Vallée, A., & Hébert, J. (2017) · Clinical and Translational Medicine · doi:10.1186/s40169-017-0144-7 · Cited by 76

Dishevelled has a YAP nuclear export function in a tumor suppressor context-dependent manner

Lee, Y., Kim, N. H., Cho, E. S., Yang, J. H., Cha, Y. H., Kang, H. E., Yun, J. S., Cho, S. B., Lee, S.-H., Paclíková, P., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04757-w · Cited by 74

Targeting molecular pathways in cancer stem cells by natural bioactive compounds

Cianciosi, D., Varela‐López, A., Forbes-Hernández, T. Y., Gasparrini, M., Afrin, S., Reboredo‐Rodríguez, P., Zhang, J., Quiles, J. L., Nabavi, S. F., Battino, M. A., et al. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.08.006 · Cited by 75

Niches for Skeletal Stem Cells of Mesenchymal Origin

Kurenkova, A. D., Medvedeva, E. V., Newton, P. T., & Chagin, A. S. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00592 · Cited by 74

Oxidative stress in hair follicle development and hair growth: Signalling pathways, intervening mechanisms and potential of natural antioxidants

Du, F., Li, J., Zhang, S., Zeng, X., Nie, J., & Li, Z. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18486 · Cited by 88

miR-942 promotes cancer stem cell-like traits in esophageal squamous cell carcinoma through activation of Wnt/β-catenin signalling pathway

Ge, C., Wu, S., Wang, W., Liu, Z., Zhang, J., Wang, Z., Li, R., Zhang, Z., Li, Z., Dong, S., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.3696 · Cited by 75

Hypoxia-Inducible Factors Modulate the Stemness and Malignancy of Colon Cancer Cells by Playing Opposite Roles in Canonical Wnt Signaling

Santoyo‐Ramos, P., Likhatcheva, M., García-Zepeda, E. A., Castañeda‐Patlán, M. C., & Robles‐Flores, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112580 · Cited by 75

Inhibition of cytoplasmic GSK-3β increases cisplatin resistance through activation of Wnt/β-catenin signaling in A549/DDP cells

Gao, Y., Liu, Z., Zhang, X., He, J., Pan, Y., Hao, F., Xie, L., Li, Q., Qiu, X., & Wang, E. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.05.005 · Cited by 75

Elevated Hepatic miR-22-3p Expression Impairs Gluconeogenesis by Silencing the Wnt-Responsive Transcription Factor Tcf7

Kaur, K., Vig, S., Srivastava, R., Mishra, A., Singh, V. P., Srivastava, R., & Datta, M. (2015) · Diabetes · doi:10.2337/db14-1924 · Cited by 75

A novel β-catenin signaling pathway activated by IL-1β leads to the onset of epithelial–mesenchymal transition in breast cancer cells

Pérez-Yépez, E. A., Ayala‐Sumuano, J., Lezama, R. A., & Meza, I. (2014) · Cancer Letters · doi:10.1016/j.canlet.2014.08.015 · Cited by 77

Wnt proteins synergize to activate β-catenin signaling

Alok, A., Lei, Z., Jagannathan, N. S., Kaur, S., Harmston, N., Rozen, S., Tucker-Kellogg, L., & Virshup, D. (2017) · Journal of Cell Science · doi:10.1242/jcs.198093 · Cited by 59

Diabetes-Induced Dysfunction of Mitochondria and Stem Cells in Skeletal Muscle and the Nervous System

Fujimaki, S., & Kuwabara, T. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18102147 · Cited by 77

Tumorigenic Cell Reprogramming and Cancer Plasticity: Interplay between Signaling, Microenvironment, and Epigenetics

Poli, V., Fagnocchi, L., & Zippo, A. (2018) · Stem Cells International · doi:10.1155/2018/4598195 · Cited by 81

Diminished WNT → β-catenin → c-MYC signaling is a barrier for malignant progression of BRAFV600E-induced lung tumorsPreprint

Juan, J. M., Muraguchi, T., Iezza, G., Sears, R. C., & McMahon, M. (2014) · Genes & Development · doi:10.1101/gad.233627.113 · Cited by 73

Epithelial WNT ligands are essential drivers of intestinal stem cell activation

Zou, W. Y., Blutt, S. E., Zeng, X.-L., Chen, M.-S., Lo, Y.-H., Castillo-Azofeifa, D., Klein, O. D., Shroyer, N. F., Donowitz, M., & Estes, M. K. (2018) · Cell Reports · doi:10.1016/j.celrep.2017.12.093 · Cited by 73

Synaptic Wnt/GSK3βSignaling Hub in Autism

Caracci, M. O., Ávila, M. E., & Ferrari, G. V. D. (2016) · Neural Plasticity · doi:10.1155/2016/9603751 · Cited by 78

Secreted AGR2 promotes invasion of colorectal cancer cells via Wnt11-mediated non-canonical Wnt signaling

Tian, S., Hu, J., Tao, K., Wang, J., Chu, Y., Li, J., Liu, Z., Ding, X., Xu, L., Li, Q., et al. (2018) · Experimental Cell Research · doi:10.1016/j.yexcr.2018.02.004 · Cited by 74

Translation Approach for Dentine Regeneration Using GSK-3 Antagonists

Zaugg, L. K., Banu, A., Walther, A. R., Chandrasekaran, D., Babb, R., Salzlechner, C., Hedegaard, M. A. B., Gentleman, E., & Sharpe, P. T. (2020) · Journal of Dental Research · doi:10.1177/0022034520908593 · Cited by 75

The Crosstalk between FAK and Wnt Signaling Pathways in Cancer and Its Therapeutic Implication

Wörthmüller, J., & Rüegg, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239107 · Cited by 74

Wnt/β-catenin signaling in colorectal cancer: Is therapeutic targeting even possible?

Disoma, C., Zhou, Y., Li, S., Peng, J., & Xia, Z. (2022) · Biochimie · doi:10.1016/j.biochi.2022.01.009 · Cited by 80

The Effect of Nanoparticle-Incorporated Natural-Based Biomaterials towards Cells on Activated Pathways: A Systematic Review

Fadilah, N. I. M., Isa, I. L. M., Zaman, W. S. W. K., Tabata, Y., & Fauzi, M. B. (2022) · Polymers · doi:10.3390/polym14030476 · Cited by 78

Cadherin signaling: keeping cells in touch

Klezovitch, O., & Vasioukhin, V. I. (2015) · F1000Research · doi:10.12688/f1000research.6445.1 · Cited by 75

Adamantinomatous craniopharyngioma: pathology, molecular genetics and mouse models

Martı́nez-Barberá, J. P., & Buslei, R. (2014) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem-2014-0442 · Cited by 74

Genetic regulation of murine pituitary development

Rizzoti, K. (2015) · Journal of Molecular Endocrinology · doi:10.1530/jme-14-0237 · Cited by 74

Resveratrol Protects SAMP8 Brain Under Metabolic Stress: Focus on Mitochondrial Function and Wnt Pathway

Palomera‐Ávalos, V., Griñán‐Ferré, C., Puigoriol‐Illamola, D., Camins, A., Sanfeliu, C., Canudas, A. M., & Pallàs, M. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9770-0 · Cited by 74

The Hippo-Salvador signaling pathway regulates renal tubulointerstitial fibrosis

Seo, E., Kim, W., Hur, J., Kim, H., Nam, S. A., Choi, A., Kim, Y., Park, S. H., Chung, C., Kim, J., et al. (2016) · Scientific Reports · doi:10.1038/srep31931 · Cited by 77

Different populations of Wnt-containing vesicles are individually released from polarized epithelial cells

Chen, Q., Takada, R., Noda, C., Kobayashi, S., & Takada, S. (2016) · Scientific Reports · doi:10.1038/srep35562 · Cited by 65

Quantifying β-catenin subcellular dynamics and cyclin D1 mRNA transcription during Wnt signaling in single living cells

Kafri, P., Hasenson, S. E., Kanter, I., Sheinberger, J., Kinor, N., Yunger, S., & Shav‐Tal, Y. (2016) · eLife · doi:10.7554/elife.16748 · Cited by 73

ASBEL –TCF3 complex is required for the tumorigenicity of colorectal cancer cells

Taniue, K., Kurimoto, A., Takeda, Y., Nagashima, T., Okada, M., Katou, Y., Shirahige, K., & Akiyama, T. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1605938113 · Cited by 73

TRIM65 triggers β-catenin signaling via ubiquitylation of Axin1 to promote hepatocellular carcinoma

Yang, Y.-F., Zhang, M., Tian, Q., & Zhang, C. Z. (2017) · Journal of Cell Science · doi:10.1242/jcs.206623 · Cited by 72

Activation of A2A Receptor by PDRN Reduces Neuronal Damage and Stimulates WNT/β-CATENIN Driven Neurogenesis in Spinal Cord Injury

Irrera, N., Arcoraci, V., Mannino, F., Vermiglio, G., Pallio, G., Minutoli, L., Bagnato, G., Anastasi, G., Mazzon, E., Bramanti, P., et al. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00506 · Cited by 74

Transfer RNA-derived small RNAs: potential applications as novel biomarkers for disease diagnosis and prognosis

Jia, Y., Tan, W., & Zhou, Y. (2020) · Annals of Translational Medicine · doi:10.21037/atm-20-2797 · Cited by 72

ERK1/2 inhibition reduces vascular calcification by activating miR-126-3p-DKK1/LRP6 pathway

Zeng, P., Yang, J. A., Liu, L., Yang, X., Yao, Z., Ma, C., Zhu, H., Su, J., Zhao, Q., Feng, K., et al. (2020) · Theranostics · doi:10.7150/thno.49771 · Cited by 76

Role of Wnt signaling pathways in type 2 diabetes mellitus

Chen, J., Ning, C., Mu, J., Li, D., Ma, Y., & Meng, X. (2021) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-021-04086-5 · Cited by 75

GPC2 Is a Potential Diagnostic, Immunological, and Prognostic Biomarker in Pan-Cancer

Chen, G., Luo, D., Zhong, N., Li, D., Zheng, J., Liao, H., Li, Z., Lin, X., Chen, Q., Zhang, C., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.857308 · Cited by 72

Lessons Learned from Past Cyclin-Dependent Kinase Drug Discovery Efforts

Xie, Z., Hou, S., Yang, X., Duan, Y., Han, J., Wang, Q., & Liao, C. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c02190 · Cited by 74

Porcn-dependent Wnt signaling is not required prior to mouse gastrulation

Biechele, S., Cockburn, K., Lanner, F., Cox, B., & Rossant, J. (2013) · Development · doi:10.1242/dev.094458 · Cited by 74

CDK5 activator protein p25 preferentially binds and activates GSK3β

Chow, H., Guo, D. S., Zhou, J., Zhang, G.-Y., Li, H., Herrup, K., & Zhang, J. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1402627111 · Cited by 78

Autocrine CSF-1R signaling drives mesothelioma chemoresistance via AKT activation

Cioce, M., Canino, C., Goparaju, C. M. V., Yang, H., Carbone, M., & Pass, H. I. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.136 · Cited by 71

ABC transporters in CSCs membranes as a novel target for treating tumor relapse

Zinzi, L., Contino, M., Cantore, M., Capparelli, E., Leopoldo, M., & Colabufo, N. A. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00163 · Cited by 79

WNT10A promotes an invasive and self-renewing phenotype in esophageal squamous cell carcinoma

Long, A., Giroux, V., Whelan, K. A., Hamilton, K. E., Tétreault, M.-P., Tanaka, K., Lee, J., Klein–Szanto, A. J., Nakagawa, H., & Rustgi, A. K. (2015) · Carcinogenesis · doi:10.1093/carcin/bgv025 · Cited by 76

Ginsenoside Rh2 inhibits hepatocellular carcinoma through β-catenin and autophagy

Yang, Z., Zhao, T., Liu, H., & Zhang, L. (2016) · Scientific Reports · doi:10.1038/srep19383 · Cited by 73

Feedback Activation of Basic Fibroblast Growth Factor Signaling via the Wnt/β-Catenin Pathway in Skin Fibroblasts

Wang, X., Zhu, Y., Sun, C. M., Wang, T., Shen, Y., Cai, W., Sun, J. T., Chi, L., Wang, H., Song, N., et al. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00032 · Cited by 73

Down-regulation of LRP1B in colon cancer promoted the growth and migration of cancer cells

Wang, Z., Sun, P., Gao, C., Chen, J., Li, J., Chen, Z., Xu, M., Shao, J., Zhang, Y., & Xie, J. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.04.010 · Cited by 73

Src- and confinement-dependent FAK activation causes E-cadherin relaxation and β-catenin activity

Gayrard, C., Bernaudin, C., Déjardin, T., Seiler, C., & Borghi, N. (2018) · The Journal of Cell Biology · doi:10.1083/jcb.201706013 · Cited by 73

miR-142-3pbalances proliferation and differentiation of mesenchymal cells during lung development

Carraro, G., Shrestha, A., Rostkovius, J., Contreras, A., Chao, C.-M., Agha, E. E., MacKenzie, B., Dilai, S., Guidolin, D., Taketo, M. M., et al. (2014) · Development · doi:10.1242/dev.105908 · Cited by 72

Discovery of Inhibitors of the Wnt and Hedgehog Signaling Pathways through the Catalytic Enantioselective Synthesis of an Iridoid‐Inspired Compound Collection

Takayama, H., Jia, Z., Kremer, L., Bauer, J. O., Carsten Strohmann, B., Ziegler, S., Antonchick, A. P., & Waldmann, H. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201306948 · Cited by 72

Activated renal tubular Wnt/β-catenin signaling triggers renal inflammation during overload proteinuria

Wong, D. W. L., Yiu, W. H., Chan, K. W., Li, Y., Ли, Б., Lok, S. W. Y., Taketo, M. M., Igarashi, P., Chan, L. Y. Y., Leung, J. C. K., et al. (2018) · Kidney International · doi:10.1016/j.kint.2017.12.017 · Cited by 71

Emerging Roles of SRSF3 as a Therapeutic Target for Cancer

Zhou, Z., Gong, Q., Lin, Z., Wang, Y., Li, M., Wang, L., Ding, H., & Li, P. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.577636 · Cited by 72

Wnt ligands regulate Tkv expression to constrain Dpp activity in the Drosophila ovarian stem cell niche

Luo, L., Wang, H., Fan, C., Liu, S., & Cai, Y. (2015) · The Journal of Cell Biology · doi:10.1083/jcb.201409142 · Cited by 72

High Glucose Induces Podocyte Injury via Enhanced (Pro)renin Receptor-Wnt-β-Catenin-Snail Signaling Pathway

Li, C., & Siragy, H. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089233 · Cited by 72

Esculetin Suppresses Proliferation of Human Colon Cancer Cells by Directly Targeting β-Catenin

Lee, S., Lim, T., Chen, H., Jung, S. K., Lee, H., Lee, M., Kim, D. J., Shin, A., Lee, K. W., Bode, A. M., et al. (2013) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-13-0241 · Cited by 76

Wnt/Rspondin/β-catenin signals control axonal sorting and lineage progression in Schwann cell development

Grigoryan, T., Stein, S., Qi, J., Wende, H., Garratt, A. N., Nave, K., Birchmeier, C., & Birchmeier, W. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1310490110 · Cited by 79

Transcription factor 7-like 1 is involved in hypothalamo–pituitary axis development in mice and humans

Gaston‐Massuet, C., McCabe, M. J., Scagliotti, V., Young, R., Carreno, G., Gregory, L. C., Jayakody, S. A., Pozzi, S., Gualtieri, A., Basu, B., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1503346113 · Cited by 72

Rational Design of Selective Small-Molecule Inhibitors for β-Catenin/B-Cell Lymphoma 9 Protein–Protein Interactions

Hoggard, L. R., Zhang, Y., Zhang, M., Panic, V., Wisniewski, J. A., & Ji, H. (2015) · Journal of the American Chemical Society · doi:10.1021/jacs.5b04988 · Cited by 72

Wnt/β-catenin signaling and renin–angiotensin system in chronic kidney disease

Zhou, L., & Liu, Y. (2016) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000205 · Cited by 74

Wnt5a and its signaling pathway in angiogenesis

Shi, Y., Zhu, N., Liu, C., Wu, H., Gui, Y., Liao, D., & Li, Q. (2017) · Clinica Chimica Acta · doi:10.1016/j.cca.2017.06.017 · Cited by 73

Wnt-Dependent Inactivation of the Groucho/TLE Co-repressor by the HECT E3 Ubiquitin Ligase Hyd/UBR5

Flack, J. E., Mieszczanek, J., Novcic, N., & Bienz, M. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.06.009 · Cited by 72

Angiopoietin-like 4 Is a Wnt Signaling Antagonist that Promotes LRP6 Turnover

Kirsch, N., Chang, L.-S., Koch, S., Glinka, A., Dolde, C. E., Colozza, G., Benitez, M. D. J., Robertis, E. M. D., & Niehrs, C. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.09.011 · Cited by 69

E2‐mediated EMT by activation of β‐catenin/Snail signalling during the development of ovarian endometriosis

Xiong, W., Zhang, L., Liu, H., Li, N., Du, Y., He, H., Zhang, Z., & Liu, Y. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14668 · Cited by 71

WNK Kinases in Development and Disease

Rodan, A. R., & Jenny, A. (2016) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2016.08.004 · Cited by 70

A multitude of signaling pathways associated with Alzheimer's disease and their roles in AD pathogenesis and therapy

Gadhave, K., Kumar, D., Uversky, V. N., & Giri, R. (2020) · Medicinal Research Reviews · doi:10.1002/med.21719 · Cited by 71

Parkinson’s Disease: Potential Actions of Lithium by Targeting the WNT/β-Catenin Pathway, Oxidative Stress, Inflammation and Glutamatergic Pathway

Vallée, A., Vallée, J.-N., & Lecarpentier, Y. (2021) · Cells · doi:10.3390/cells10020230 · Cited by 71

RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state

Belenguer, G., Mastrogiovanni, G., Pacini, C., Hall, Z., Dowbaj, A. M., Arnes-Benito, R., Sljukic, A., Prior, N., Kakava, S., Bradshaw, C. R., et al. (2022) · Nature Communications · doi:10.1038/s41467-021-27923-z · Cited by 71

LEF1 and B9L Shield β-Catenin from Inactivation by Axin, Desensitizing Colorectal Cancer Cells to Tankyrase Inhibitors

de la Roche, M., Ibrahim, A. E. K., Mieszczanek, J., & Bienz, M. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-2682 · Cited by 71

β-Catenin-Independent Activation of TCF1/LEF1 in Human Hematopoietic Tumor Cells through Interaction with ATF2 Transcription Factors

Grumolato, L., Liu, G., Haremaki, T., Mungamuri, S. K., Mong, P. Y., Akiri, G., Lopez‐Bergami, P., Arita, A., Anouar, Y., Mlodzik, M., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003603 · Cited by 72

Monensin Inhibits Canonical Wnt Signaling in Human Colorectal Cancer Cells and Suppresses Tumor Growth in Multiple Intestinal Neoplasia Mice

Tůmová, L., Pombinho, A. R., Vojtěchová, M., Stančíková, J., Gradl, D., Krausová, M., Šloncová, E., Horázná, M., Křı́ž, V., Machoňová, O., et al. (2014) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-13-0625 · Cited by 71

Wnt/β-catenin signaling in bone marrow niche

Ahmadzadeh, A., Norozi, F., Shahrabi, S., Shahjahani, M., & Saki, N. (2015) · Cell and Tissue Research · doi:10.1007/s00441-015-2300-y · Cited by 73

AHNAK suppresses tumour proliferation and invasion by targeting multiple pathways in triple-negative breast cancer

Chen, B., Wang, J., Dai, D., Zhou, Q. S., Guo, X., Tian, Z., Huang, X., Yang, L., Tang, H., & Xie, X. (2017) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-017-0522-4 · Cited by 71

The emerging role of Wnt signaling dysregulation in the understanding and modification of age-associated diseases

García‐Velázquez, L., & Arias, C. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.06.001 · Cited by 70

Small-molecule Wnt agonists correct cleft palates in Pax9 mutant mice in utero

Jia, S., Zhou, J., Fanelli, C., Wee, Y., Bonds, J., Schneider, P., MUES, G. I., & D’Souza, R. N. (2017) · Development · doi:10.1242/dev.157750 · Cited by 71

Salvia miltiorrhiza protects against diabetic nephropathy through metabolome regulation and wnt/β-catenin and TGF-β signaling inhibition

Xiang, X., Cai, H.-D., Su, S., Dai, X., Zhu, K. Y., Guo, J., Yan, H., Guo, S., Gu, W., Qian, D., et al. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.10.030 · Cited by 71

Limited dishevelled/Axin oligomerization determines efficiency of Wnt/β-catenin signal transduction

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Role of Notch signaling pathway in pancreatic cancer.

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