Cited by 5,554Wnt/β-catenin signaling in development and cancerSignaling Pathways in DiseaseHedgehog Signaling Pathway Studies

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Wnt/β-Catenin Signaling and Disease

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Clevers, Hans, Nusse, Roel·2012·Cell

DOI 10.1016/j.cell.2012.05.012

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Abstract

The WNT signal transduction cascade controls myriad biological phenomena throughout development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a wide range of pathologies in humans. In this Review, we provide an update of the core Wnt/β-catenin signaling pathway, discuss how its various components contribute to disease, and pose outstanding questions to be addressed in the future.

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Authors: Clevers, H., & Nusse, R.
Affiliations: Royal Netherlands Academy of Arts and Sciences (NL)
Corresponding author: Clevers, Hans
ORCID: Clevers, Hans
Venue: Cell
Publisher: Elsevier BV
Published: 2012-06
Volume: 149
Issue: 6
Pages: 1192-1205
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2012.05.012
OpenAlex: W2006419043
Cited by: 5,554
References: 180
Citations by year: 2026: 252 · 2025: 296 · 2024: 318 · 2023: 333 · 2022: 418 · 2021: 498 · 2020: 442 · 2019: 399 · 2018: 432 · 2017: 486 · 2016: 458 · 2015: 454 · 2014: 364 · 2013: 347 · 2012: 52
FWCI: 35.64
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 447 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (publishedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
Keywords: Wnt/β-catenin signaling, Wnt signaling, signal transduction, developmental biology, pathogenesis, aberrant signaling
MeSH terms: Animals, Disease, Humans, Wnt Proteins, beta Catenin, Wnt Signaling Pathway

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Wnt/β-Catenin Signaling and Disease

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