Wnt/β-Catenin Signaling and Disease

Clevers, Hans, Nusse, Roel·2012·Cell

DOI 10.1016/j.cell.2012.05.012

Cited by (1,028)

Items 501–600 of 1,028

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Elena Fiorini, Lisa Veghini, Vincenzo Corbo · 2020 · Frontiers in Cell and Developmental Biology
CCT5 induces epithelial-mesenchymal transition to promote gastric cancer lymph node metastasis by activating the Wnt/β-catenin signalling pathway
Yun Li, Chenying Liu, Xin Zhang, Xiaodi Huang, Shujun Liang, Feiyue Xing, Han Tian · 2022 · British Journal of Cancer
Green tea polyphenol EGCG suppresses W nt/β‐catenin signaling by promoting GSK ‐3β‐ and PP2A ‐independent β‐catenin phosphorylation/degradation
Sangtaek Oh, Jungsug Gwak, Seo‐Young Park, Chung Shu Yang · 2014 · BioFactors
Inhibition of Wnt/β‐catenin signaling downregulates P‐glycoprotein and reverses multi‐drug resistance of cholangiocarcinoma
Dong‐Yan Shen, Wei Zhang, Xin Zeng, Changqin Liu · 2013 · Cancer Science
Wnt signaling in dendritic cells: its role in regulation of immunity and tolerance.
Daniel Swafford, Santhakumar Manicassamy · 2015 · PubMed
Wnt signaling and osteoporosis
Stavros C. Manolagas · 2014 · Maturitas
Molecular Role of RNF43 in Canonical and Noncanonical Wnt Signaling
Tadasuke Tsukiyama, Akimasa Fukui, Sayuri Terai, Yoichiro Fujioka, Keisuke Shinada, Hidehisa Takahashi, Terry P. Yamaguchi, Yusuke Ohba, Shigetsugu Hatakeyama · 2015 · Molecular and Cellular Biology
Endothelial to mesenchymal transition (EndoMT) in the pathogenesis of Systemic Sclerosis-associated pulmonary fibrosis and pulmonary arterial hypertension. Myth or reality?
Sergio A. Jiménez, Sonsoles Piera-Velázquez · 2016 · Matrix Biology
Role of cytonemes in Wnt transport
Eliana Stanganello, Steffen Scholpp · 2016 · Journal of Cell Science
The role of the Hes1 crosstalk hub in Notch-Wnt interactions of the intestinal crypt
Sophie Kate Kay, Heather A. Harrington, Sarah Shepherd, Keith R. Brennan, Trevor C. Dale, James M. Osborne, David J. Gavaghan, Helen Mary Byrne · 2017 · PLoS Computational Biology
Transcriptome 3′end organization by PCF11 links alternative polyadenylation to formation and neuronal differentiation of neuroblastoma
Anton Ogorodnikov, Michal Levin, Surendra Mohan Tattikota, Sergey V. Tokalov, Mainul Hoque, Denise Scherzinger, Fédérico Marini, Ansgar Poetsch, Harald Binder, Stephan Macher-Göppinger et al. · 2018 · Nature Communications
Advances in targeted therapy mainly based on signal pathways for nasopharyngeal carcinoma
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LRP5 Regulates Human Body Fat Distribution by Modulating Adipose Progenitor Biology in a Dose- and Depot-Specific Fashion
Nellie Y. Loh, Matt J. Neville, Kyriakoula Marinou, Sarah Hardcastle, Barbara A. Fielding, Emma L. Duncan, Mark I. McCarthy, Jonathan H. Tobias, Celia Louise Gregson, Fredrik Karpe et al. · 2015 · Cell Metabolism
Is Alzheimer's disease related to metabolic syndrome? A Wnt signaling conundrum
Juvenal A. Ríos, Pedro Cisternas, Marco A. Arrese, Salesa Barja Y., Nibaldo C. Inestrosa · 2014 · Progress in Neurobiology
Oriented divisions, fate decisions
Scott E. Williams, Elaine V. Fuchs · 2013 · Current Opinion in Cell Biology
Mangiferin exerts antitumor activity in breast cancer cells by regulating matrix metalloproteinases, epithelial to mesenchymal transition, and β-catenin signaling pathway
Hongzhong Li, Jing Huang, Bing L. Yang, Tingxiu Xiang, Xuedong Yin, Weiyan Peng, Wei Cheng, Jingyuan Wan, Fuling Luo, Hongyuan Li et al. · 2013 · Toxicology and Applied Pharmacology
Activating the Wnt/β-Catenin Pathway for the Treatment of Melanoma – Application of LY2090314, a Novel Selective Inhibitor of Glycogen Synthase Kinase-3
Jennifer M. Atkinson, Kenneth B. Rank, Yi Arial Zeng, Andrew R. Capen, Vipin Yadav, Jason R. Manro, Thomas A. Engler, Marcio Chedid · 2015 · PLoS ONE
Synergistic anti-cancer effects of galangin and berberine through apoptosis induction and proliferation inhibition in oesophageal carcinoma cells
Kewei Ren, Wenzhe Zhang, Gang Wu, Jianzhuang Ren, Huibin Lu, Zong‐Ming Li, Xinwei Han · 2016 · Biomedicine & Pharmacotherapy
NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor
Laura Novellasdemunt, Anna Kucharska, Cara Jamieson, Maria Prange‐Barczynska, Anna Baulies, Pedro Antas, Jelte van der Vaart, Helmuth Gehart, Madelon M. Maurice, Vivian Sze Wing Li · 2019 · The EMBO Journal
Aberrant WNT/CTNNB1 Signaling as a Therapeutic Target in Human Breast Cancer: Weighing the Evidence
Emma H. van Schie, Renée van Amerongen · 2020 · Frontiers in Cell and Developmental Biology
Chemopreventive Activity of Plant Flavonoid Isorhamnetin in Colorectal Cancer Is Mediated by Oncogenic Src and β-Catenin
Shakir M. Saud, Matthew R. Young, Yava Jones‐Hall, Lilia V. Ileva, Moses O. Evbuomwan, Jennifer Wise, Nancy H. Colburn, Young Shin Kim, Gerd Bobe · 2013 · Cancer Research
Spatial and temporal aspects of Wnt signaling and planar cell polarity during vertebrate embryonic development
Sergei Y. Sokol · 2015 · Seminars in Cell and Developmental Biology
Wnt Signalling in Gastrointestinal Epithelial Stem Cells
Dustin James Flanagan, Chloe R. Austin, Elizabeth Vincan, Toby James Phesse · 2018 · Genes
Small-molecule-mediated reprogramming: a silver lining for regenerative medicine
Yohan Kim, Jaemin Jeong, Dongho Choi · 2020 · Experimental & Molecular Medicine
Wnt Signaling in Renal Cell Carcinoma
Xu, Qi, Krause, Mirja, Samoylenko, Anatoly, Vainio, Seppo · 2016 · Cancers
Disulfide Bond Requirements for Active Wnt Ligands
Bryan T. MacDonald, Annie Hien, Xinjun Zhang, Oladoyin Iranloye, David M. Virshup, Marian L. Waterman, Xi He · 2014 · Journal of Biological Chemistry
TET1 inhibits EMT of ovarian cancer cells through activating Wnt/β-catenin signaling inhibitors DKK1 and SFRP2
Hongying Duan, Zhiqiang Yan, Wei Chen, Yu Wu, Jinsong Han, Hongyan Guo, Jie Qiao · 2017 · Gynecologic Oncology
The therapeutic potential of targeting the endothelial-to-mesenchymal transition
Shirley Man, Gonzalo Sánchez‐Duffhues, Peter ten Dijke, David A. Baker · 2018 · Angiogenesis
Endometrial Cancer Stem Cells: Role, Characterization and Therapeutic Implications
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Walking the tight wire between cell adhesion and WNT signalling: a balancing act for β-catenin
Tanne van der Wal, Renée van Amerongen · 2020 · Open Biology
Wnt/β-catenin signalling regulates Sox17 expression and is essential for organizer and endoderm formation in the mouse
Silvia Engert, Ingo Burtscher, W. Perry Liao, Stanimir Dulev, Gunnar Schotta, Heiko Lickert · 2013 · Development
Epigenetic silencing ofSFRP1andSFRP5by hepatitis B virus X protein enhances hepatoma cell tumorigenicity through Wnt signaling pathway
Qing Mei Xie, Linlin Chen, Xuefeng Shan, Xiaoliang Shan, Jia Tang, Fan Zhou, Qingmei Chen, Huiqin Quan, Dan Nie, Wenlu Zhang et al. · 2013 · International Journal of Cancer
Targeting β-catenin signaling for therapeutic intervention in MEN1-deficient pancreatic neuroendocrine tumours
Xiuli Jiang, Yanan Cao, Feng Li, Yutong Su, Yanli Li, Ying Hong Peng, Yulong Cheng, Chang Xian Zhang, Weiqing Wang, Guang Ning · 2014 · Nature Communications
Tyrosine kinase inhibitor–induced CD70 expression mediates drug resistance in leukemia stem cells by activating Wnt signaling
Carsten Riether, Christian M. Schürch, Christoph Flury, Magdalena Hinterbrandner, Linda Drück, Anne-Laure Huguenin, Gabriela Maria Baerlocher, Ramin Radpour, Adrian F. Ochsenbein · 2015 · Science Translational Medicine
Role of RAS/Wnt/β-catenin axis activation in the pathogenesis of podocyte injury and tubulo-interstitial nephropathy
Lin Chen, Dan‐Qian Chen, Ming Wang, Dan Liu, Hua Chen, Fang Dou, Nosratola D. Vaziri, Ying‐Yong Zhao · 2017 · Chemico-Biological Interactions
An Insight Into the Cancer Stem Cell Survival Pathways Involved in Chemoresistance in Triple-Negative Breast Cancer
Hina Qayoom, Nissar Ahmad Wani, Bader Alshehri, Manzoor Ahmad Mir · 2021 · Future Oncology
Interstitial Lung Disease in Scleroderma
Sara R. Schoenfeld, Flavia V. Castelino · 2015 · Rheumatic Disease Clinics of North America
The Cyclophilin A–CD147 complex promotes the proliferation and homing of multiple myeloma cells
Di Zhu, Zhongqiu Wang, Jianjun Zhao, Teresa Calimeri, Meng Jiang, Teru Hideshima, Mariateresa Fulciniti, Yue Kang, Scott B. Ficarro, Yu‐Tzu Tai et al. · 2015 · Nature Medicine
R-spondin1 is a novel hormone mediator for mammary stem cell self-renewal
Cheguo Cai, Qing Cissy Yu, Weimin Jiang, Wei Liu, Wenqian Song, Hua Yu, Lei Zhang, Ying Yang, Yi Arial Zeng · 2014 · Genes & Development
Wnt/β-Catenin Signaling in Alzheimer’s Disease
Ferrari, Giancarlo, Avila, Miguel, Medina, Matias, Perez-Palma, Eduardo, Bustos, Bernabe, Alarcon, Marcelo · 2014 · CNS & Neurological Disorders - Drug Targets
Tegavivint and the β-Catenin/ALDH Axis in Chemotherapy-Resistant and Metastatic Osteosarcoma
Nomura, Motonari, Rainusso, Nino, Lee, Yi-Chien, Dawson, Brian, Coarfa, Cristian, Han, Ruolan, Larson, Jeffrey L, Shuck, Ryan, Kurenbekova, Lyazat, Yustein, Jason T · 2019 · JNCI: Journal of the National Cancer Institute
The role of the non-canonical Wnt–planar cell polarity pathway in neural crest migration
Roberto Mayor, Eric Théveneau · 2013 · Biochemical Journal
Inhibition of WNT-CTNNB1 signaling upregulates SQSTM1 and sensitizes glioblastoma cells to autophagy blockers
Mireia Nàger, Marta Crespi Sallan, Anna Visa, Charumathi Pushparaj, Marı́a Santacana, Anna Macià, Andrée Yeramian, Carles Cantı́, Judit Herreros · 2018 · Autophagy
Mechanisms of Wnt signaling and control
Stephanie J. Grainger, Karl Willert · 2018 · WIREs Systems Biology and Medicine
Current perspectives on inhibitory SMAD7 in health and disease
Charlotte de Ceuninck van Capelle, Maureen Spit, Peter ten Dijke · 2020 · Critical Reviews in Biochemistry and Molecular Biology
The Key Role of the WNT/β-Catenin Pathway in Metabolic Reprogramming in Cancers under Normoxic Conditions
Alexandre Vallée, Yves Lecarpentier, Jean-Noël Vallée · 2021 · Cancers
Pgam5 released from damaged mitochondria induces mitochondrial biogenesis via Wnt signaling
Dominic B. Bernkopf, Kowcee Jalal, Martina Brückner, Karl Xaver Knaup, Marc Gentzel, Alexandra Schambony, Jürgen Behrens · 2018 · The Journal of Cell Biology
A Gene Expression Signature of Epithelial Tubulogenesis and a Role for ASPM in Pancreatic Tumor Progression
Wei–Yu Wang, Chung‐Chi Hsu, Ting–Yun Wang, Chi–Rong Li, Ya‐Chin Hou, Jui–Mei Chu, Chung‐Ta Lee, Ming–Sheng Liu, Jimmy J.–M. Su, Kuan–Ying Jian et al. · 2013 · Gastroenterology
The Wnt Gatekeeper SFRP4 Modulates EMT, Cell Migration and Downstream Wnt Signalling in Serous Ovarian Cancer Cells
Caroline Elizabeth Ford, Eve Jary, Sean Si Qian Ma, Sheri Nixdorf, Viola A Heinzelmann-Schwarz, Robyn Lynne Ward · 2013 · PLoS ONE
Growth hormone is permissive for neoplastic colon growth
Vera Chesnokova, Svetlana Zonis, Cuiqi Zhou, Maria Victoria Recouvreux, Anat Ben-Shlomo, Takako Araki, Robert J. Barrett, Michael J. Workman, Kolja Wawrowsky, Vladimir A. Ljubimov et al. · 2016 · Proceedings of the National Academy of Sciences
Making, Exporting, and Modulating Wnts
Paul F. Langton, Satoshi Kakugawa, Jean‐Paul Vincent · 2016 · Trends in Cell Biology
Forces shaping the Drosophila wing
M. Carmen Díaz de la Loza, Barry J. Thompson · 2016 · Mechanisms of Development
Interactions between PPAR Gamma and the Canonical Wnt/Beta-Catenin Pathway in Type 2 Diabetes and Colon Cancer
Yves Lecarpentier, VICTOR A. CLAES, Alexandre Vallée, Jean‐Louis Hébert · 2017 · PPAR Research
Constitutive scaffolding of multiple Wnt enhanceosome components by Legless/BCL9
Laurens M. van Tienen, Juliusz Mieszczanek, Marc Fiedler, Trevor J. Rutherford, Mariann Bienz · 2017 · eLife
Targeting the PI3K /Akt signaling pathway in pancreatic β‐cells to enhance their survival and function: An emerging therapeutic strategy for type 1 diabetes
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Wnt Signaling in Heart Development and Regeneration
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Microbiota-derived I3A protects the intestine against radiation injury by activating AhR/IL-10/Wnt signaling and enhancing the abundance of probiotics
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Emerging regulatory mechanisms and functions of biomolecular condensates: implications for therapeutic targets
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Ying Feng, Kazuhiro Sentani, Alexandra B. Wiese, Evan Sands, Maranne E. Green, Guido T. Bommer, Kathleen R. Cho, Eric R. Fearon · 2013 · American Journal Of Pathology
Pre-clinical efficacy of combined therapy with novel β-catenin antagonist BC2059 and histone deacetylase inhibitor against AML cells
Warren C. Fiskus, Sachit Sharma, S Saha, Biren N. Shah, Santhana G.T. Devaraj, Baohua Sun, Stephen K. Horrigan, Christopher M. Leveque, Youli Zu, Swaminathan P. Iyer et al. · 2014 · Leukemia
Activating CAR and β-catenin induces uncontrolled liver growth and tumorigenesis
Dong, Bingning, Lee, Ju-Seog, Park, Yun-Yong, Yang, Feng, Xu, Ganyu, Huang, Wendong, Finegold, Milton J., Moore, David D. · 2015 · Nature Communications
Pathophysiology of New Bone Formation and Ankylosis in Spondyloarthritis
Rik Jozef Urbain Lories, Georg Andreas Schett · 2012 · Rheumatic Disease Clinics of North America
The metastasis suppressor, NDRG1, modulates β-Catenin phosphorylation and nuclear translocation by mechanisms involving FRAT1 and PAK4
Runsen Jin, Wensheng Liu, Sharleen V. Menezes, Fei Yue, Minhua Zheng, Žaklina Kovačević, Des Raymond Richardson · 2014 · Journal of Cell Science
USP20 positively regulates tumorigenesis and chemoresistance through β-catenin stabilization
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Fine-Tuning of Sox17 and Canonical Wnt Coordinates the Permeability Properties of the Blood-Brain Barrier
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AEG-1/MTDH/LYRIC
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Joseph Torresi, Bang Manh Tran, Dale Christiansen, Linda Earnest-Silveira, Renate Schwab, Elizabeth Vincan · 2019 · BMC Cancer
Neurodevelopmental Perspectives on Wnt Signaling in Psychiatry
Kimberly A. Mulligan, Benjamin N. R. Cheyette · 2016 · Complex Psychiatry
α-Catenin interacts with APC to regulate β-catenin proteolysis and transcriptional repression of Wnt target genes
Seung H. Choi, Conchi Estarás, James J. Moresco, John R. Yates, Katherine A. Jones · 2013 · Genes & Development
Signaling Pathways Involved in Mammalian Sex Determination and Gonad Development
Simon P. Windley, Dagmar Wilhelm · 2015 · Sexual Development
Transcriptional Regulation by ATOH1 and its Target SPDEF in the Intestine
Yuan‐Hung Lo, Eunah Chung, Zhaohui Li, Ying‐Wooi Wan, Maxime M. Mahé, Minshan Chen, Taeko K. Noah, Kristin N. Bell, Hari Krishna Yalamanchili, Tiemo Jürgen Klisch et al. · 2016 · Cellular and Molecular Gastroenterology and Hepatology
Role of Wnt/β‐catenin signaling regulatory microRNAs in the pathogenesis of colorectal cancer
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Deciphering the molecular morphology of the human hair cycle: Wnt signalling during the telogen–anagen transformation
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Wnt signaling mediates TLR pathway and promote unrestrained adipogenesis and metaflammation: Therapeutic targets for obesity and type 2 diabetes
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Yaoyao Zhu, Xia Li · 2023 · Cells
Identification of Key Residues and Regions Important for Porcupine-mediated Wnt Acylation
Jessica Rios-Esteves, Brittany Haugen, Marilyn D. Resh · 2014 · Journal of Biological Chemistry
Lineage tracing with Axin2 reveals distinct developmental and adult populations of Wnt/β-catenin–responsive neural stem cells
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S100A4 in Cancer Metastasis: Wnt Signaling-Driven Interventions for Metastasis Restriction
Mathias Dahlmann, Dennis Kobelt, Wolfgang Walther, Giridhar Mudduluru, Ulrike Stein · 2016 · Cancers
Noncanonical Wnt signaling plays an important role in modulating canonical Wnt-regulated stemness, proliferation and terminal differentiation of hepatic progenitors
Jiaming Fan, Qiang Wei, Junyi Liao, Yulong Zou, Dongzhe Song, Dongmei Xiong, Chao Ma, Xue Yu Hu, Xiangyang Qu, Liqun Chen et al. · 2017 · Oncotarget
Intersection of Hippo/YAP and Wnt/β-catenin signaling pathways
Konsavage, Wesley M., Yochum, Gregory S. · 2013 · Acta Biochimica et Biophysica Sinica
Regulation of the Wnt/β-Catenin Signaling Pathway by Human Papillomavirus E6 and E7 Oncoproteins
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FOXP1 potentiates Wnt/β-catenin signaling in diffuse large B cell lymphoma
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Intrinsic β-catenin signaling suppresses CD8+ T-cell infiltration in colorectal cancer
Junli Xue, Xuetao Yu, Liqiong Xue, Xiaoxiao Ge, Wei Zhao, Wei Peng · 2019 · Biomedicine & Pharmacotherapy
Dysfunctional Wnt/β-catenin signaling contributes to blood–brain barrier breakdown in Alzheimer’s disease
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Colon Macrophages Polarized by Commensal Bacteria Cause Colitis and Cancer through the Bystander Effect
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