Wnt/β-Catenin Signaling and Disease

The Metabolic and Molecular Bases of Inherited Disease

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Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

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The metabolic and molecular bases of inherited disease

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Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

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Lessons from hereditary colorectal cancer

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Mutations affecting segment number and polarity in Drosophila

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Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

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Wnt signalling in stem cells and cancer

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Functional interaction of β-catenin with the transcription factor LEF-1

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Wnt signaling in liver regeneration, disease, and cancer

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β-Arrestins promote podocyte injury by inhibition of autophagy in diabetic nephropathy

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Biphasic regulation of glutamine consumption by WNT during osteoblast differentiation

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Cadherins: cellular adhesive molecules serving as signalling mediators

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Allosteric Conformational Barcodes Direct Signaling in the Cell

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Circumventing senescence is associated with stem cell properties and metformin sensitivity

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GOLPH3/CKAP4 promotes metastasis and tumorigenicity by enhancing the secretion of exosomal WNT3A in non-small-cell lung cancer

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Osteocyte mechanotransduction in orthodontic tooth movement

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Allelic Imbalance in Regulation of ANRIL through Chromatin Interaction at 9p21 Endometriosis Risk Locus

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Direct targeting of β-catenin: Inhibition of protein–protein interactions for the inactivation of Wnt signaling

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Design of stapled α-helical peptides to specifically activate Wnt/β-catenin signaling

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p15RS/RPRD1A (p15INK4b-related Sequence/Regulation of Nuclear Pre-mRNA Domain-containing Protein 1A) Interacts with HDAC2 in Inhibition of the Wnt/β-Catenin Signaling Pathway

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Overexpression of protein phosphatase 2A in a murine model of chronic myocardial infarction leads to increased adverse remodeling but restores the regulation of β-catenin by glycogen synthase kinase 3β

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ROS Dependent Wnt/β-Catenin Pathway and Its Regulation on Defined Micro-Pillars—A Combined In Vitro and In Silico Study

Staehlke, S., Haack, F., Waldner, A.-C., Koczan, D., Moerke, C., Mueller, P., Uhrmacher, A. M., & Nebe, J. B. (2020) · Cells · doi:10.3390/cells9081784 · Cited by 36

Pyrvinium pamoate regulates MGMT expression through suppressing the Wnt/β-catenin signaling pathway to enhance the glioblastoma sensitivity to temozolomide

Li, H., Liu, S., Jin, R., Xu, H., Li, Y., Chen, Y., & Zhao, G. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00654-2 · Cited by 34

Building gut from scratch — progress and update of intestinal tissue engineering

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Computational Modeling of the Interplay between Cadherin-Mediated Cell Adhesion and Wnt Signaling Pathway

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Relating simulation studies by provenance—Developing a family of Wnt signaling models

Budde, K., Smith, J., Wilsdorf, P., Haack, F., & Uhrmacher, A. M. (2021) · PLOS Computational Biology · doi:10.1371/journal.pcbi.1009227 · Cited by 23

SOX 7 interferes with β‐catenin activity to promote neuronal apoptosis

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Exploring the mechanistic and temporal regulation of LRP6 endocytosis in canonical WNT signaling

Haack, F., Budde, K., & Uhrmacher, A. M. (2020) · Journal of Cell Science · doi:10.1242/jcs.243675 · Cited by 18

Wnts control membrane potential in mammalian cancer cells

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Telomeres, a busy platform for cell signaling.

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Osteocyte Wnt/β-catenin pathway activation upon mechanical loading is altered in ovariectomized mice

Jackson, E., Lara-Castillo, N., Akhter, M. P., Dallas, M., Scott, J. M., Ganesh, T., & Johnson, M. L. (2021) · Bone Reports · doi:10.1016/j.bonr.2021.101129 · Cited by 13

Single‐Cell Insights Into Macrophage Subtypes in Pulmonary Infections

Lin, Z., Zheng, Y., Zhong, Y., & Wang, H. (2026) · Advanced Science · doi:10.1002/advs.202510758 · Cited by 13

Human T2D-Associated Gene IMP2/IGF2BP2 Promotes the Commitment of Mesenchymal Stem Cells Into Adipogenic Lineage

Regué, L., Wang, W., Ji, F., Avruch, J., Wang, H., & Dai, N. (2023) · Diabetes · doi:10.2337/db21-1087 · Cited by 12

WNT/β-catenin pathway activation in hepatocellular carcinoma: a clinical perspective

Chua, M.-S., Ma, L., Wei, W., & So, S. (2014) · Gastrointestinal Cancer: Targets and Therapy · doi:10.2147/gictt.s44256 · Cited by 12

Wnt and β-Catenin Signaling and Skeletal Muscle Myogenesis in Response to Muscle Damage and Resistance Exercise and Training

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Analysis of Polymorphisms in the Mediator Complex Subunit 13-like (Med13L) Gene in the Context of Immune Function and Development of Experimental Arthritis

Sardar, S., Kanne, K., & Andersson, Å. (2018) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-018-0516-8 · Cited by 3

Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities

Nusse, R., & Clevers, H. (2017) · Cell · doi:10.1016/j.cell.2017.05.016 · Cited by 4,342

Wnt/β-Catenin Signaling in Development and Disease

Clevers, H. (2006) · Cell · doi:10.1016/j.cell.2006.10.018 · Cited by 5,568

A gust of WNT: analysis of the canonical WNT pathway.

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The way Wnt works: Components and mechanism

Saito‐Diaz, K., Chen, T. W., Wang, X., Thorne, C. A., Wallace, H. A., Page, A. W., & Lee, E. N. (2012) · Growth Factors · doi:10.3109/08977194.2012.752737 · Cited by 223

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

MacDonald, B. T., Tamai, K., & He, X. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.06.016 · Cited by 5,583