Cited by 561Circadian rhythm and melatoninGut microbiota and healthImmune Response and Inflammation

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Homeostasis in Intestinal Epithelium Is Orchestrated by the Circadian Clock and Microbiota Cues Transduced by TLRs

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Mukherji, Atish, Kobiita, Ahmad, Ye, Tao, Chambon, Pierre·2013·Cell

DOI 10.1016/j.cell.2013.04.020

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Abstract

Alterations of symbiosis between microbiota and intestinal epithelial cells (IEC) are associated with intestinal and systemic pathologies. Interactions between bacterial products (MAMPs) and Toll-like receptors (TLRs) are known to be mandatory for IEC homeostasis, but how TLRs may time homeostatic functions with circadian changes is unknown. Our functional and molecular dissections of the IEC circadian clock demonstrate that its integrity is required for microbiota-IEC dialog. In IEC, the antiphasic expression of the RORα activator and RevErbα repressor clock output regulators generates a circadian rhythmic TLR expression that converts the temporally arrhythmic microbiota signaling into circadian rhythmic JNK and IKKβ activities, which prevents RevErbα activation by PPARα that would disrupt the circadian clock. Moreover, through activation of AP1 and NF-κB, these activities, together with RORα and RevErbα, enable timing homeostatic functions of numerous genes with IEC circadian events. Interestingly, microbiota signaling deficiencies induce a prediabetic syndrome due to ileal corticosterone overproduction consequent to clock disruption.

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Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.211 · Cited by 35,890
Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
Cryan, J. F., & Dinan, T. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3346 · Cited by 4,572
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.033 · Cited by 4,554
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251
Mechanisms underlying the resistance to diet-induced obesity in germ-free mice
Bäckhed, F., Manchester, J. K., Semenkovich, C. F., & Gordon, J. I. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605374104 · Cited by 2,615
TLR signaling pathways
Takeda, K., & Akira, S. (2004) · Seminars in Immunology · doi:10.1016/j.smim.2003.10.003 · Cited by 2,528
IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer
Greten, F. R., Eckmann, L., Greten, T. F., Park, J. M., Li, Z.-W., Egan, L. J., Kagnoff, M. F., & Karin, M. (2004) · Cell · doi:10.1016/j.cell.2004.07.013 · Cited by 2,433
The mammalian circadian timing system: organization and coordination of central and peripheral clocks
Dibner, C., Schibler, U., & Albrecht, U. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135821 · Cited by 2,421
Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function.
Adachi, O., Kawai, T., Takeda, K., Matsumoto, M., Tsutsui, H., Sakagami, M., Nakanishi, K., & Akira, S. (1998) · Immunity · doi:10.1016/s1074-7613(00)80596-8 · Cited by 2,358
Molecular Analysis of Commensal Host-Microbial Relationships in the Intestine
Hooper, L. V., Wong, M. H., Thelin, A., Hansson, L., Falk, P. G., & Gordon, J. I. (2001) · Science · doi:10.1126/science.291.5505.881 · Cited by 2,202

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Parida, S., & Sharma, D. (2019) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2019.04.001 · Cited by 126
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Ieșanu, M. I., Zahiu, C. D. M., Dogaru, I.-A., Chiţimuș, D. M., Pîrcălăbioru, G. G., Voiculescu, S. E., Isac, S., Galoş, F., Pavel, B., O’Mahony, S. M., et al. (2022) · Antioxidants · doi:10.3390/antiox11112244 · Cited by 63
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Jacobs, J. P., & Braun, J. G. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.02.052 · Cited by 60
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Kabouridis, P. S., Lasrado, R., McCallum, S. E., Chng, S. H., Snippert, H. J. G., Clevers, H. C., Pettersson, S., & Pachnis, V. (2015) · Gut Microbes · doi:10.1080/19490976.2015.1109767 · Cited by 58
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The Oscillating Gut Microbiome and Its Effects on Host Circadian Biology
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Time of sample collection is critical for the replicability of microbiome analyses
Allaband, C., Lingaraju, A., Ramos, S. F., Kumar, T., Javaheri, H., Tiu, M. D., Machado, A. C. D., Richter, R. A., Elijah, E. O., Haddad, G. G., et al. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01064-1 · Cited by 61
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Paulose, J. K., & Cassone, V. M. (2016) · Gut Microbes · doi:10.1080/19490976.2016.1208892 · Cited by 56
Update on the Gastrointestinal Microbiome in Systemic Sclerosis
Bellocchi, C., & Volkmann, E. R. (2018) · Current Rheumatology Reports · doi:10.1007/s11926-018-0758-9 · Cited by 57
Intermittent fasting contributes to aligned circadian rhythms through interactions with the gut microbiome
Daas, M. C., & de Roos, N. M. (2021) · Beneficial Microbes · doi:10.3920/bm2020.0149 · Cited by 58
Lipid metabolites as metabolic messengers in inter-organ communication
Liu, S., Alexander, R., & Lee, C. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2014.05.002 · Cited by 57
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Chen, M., Lin, Y., Dang, Y., Xiao, Y., Zhang, F., Sun, G., Jiang, X., Zhang, L., Du, J., Duan, S., et al. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.04.040 · Cited by 51
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Singh, P., Kumar, M., & Khodor, S. A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01042 · Cited by 54
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Xiao, T., Langston, P. K., Muñoz-Rojas, A. R., Jayewickreme, T., Lazar, M. A., Benoist, C. O., & Mathis, D. J. (2022) · Science Immunology · doi:10.1126/sciimmunol.abl7641 · Cited by 54
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Burris, T. P., de Vera, I. M. S., Côté, I., Flaveny, C. A., Wanninayake, U. S., Chatterjee, A., Walker, J. K., Steinauer, N., Zhang, J., Coons, L. A., et al. (2023) · Pharmacological Reviews · doi:10.1124/pharmrev.121.000436 · Cited by 54
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Koboziev, I., Jones‐Hall, Y., Valentine, J. F., Webb, C. R., Furr, K. L., & Grisham, M. B. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000446 · Cited by 50
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Torres‐Fuentes, C., Suárez, M., Aragonès, G., Mulero, M., Ávila‐Román, J., Arola‐Arnal, A., Salvadó, M. J., Arola, L., Bravo, F. I., & Muguerza, B. (2022) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202100990 · Cited by 52
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Pontarollo, G., Kollar, B., Mann, A., Khuu, M. P., Kiouptsi, K., Bayer, F., Brandão, I., Zinina, V. V., Hahlbrock, J., Malinarich, F., et al. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00828-5 · Cited by 49
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Intestinal steroidogenesis
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Authors: Mukherji, A., Kobiita, A., Ye, T., & Chambon, P.
Affiliations: Centre National de la Recherche Scientifique (FR)
Corresponding author: Chambon, Pierre
ORCID: Mukherji, Atish
Ye, Tao
Chambon, Pierre
Venue: Cell
Publisher: Elsevier BV
Published: 2013-05
Volume: 153
Issue: 4
Pages: 812-827
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2013.04.020
OpenAlex: W2051984731
Cited by: 560
References: 61
Citations by year: 2026: 21 · 2025: 36 · 2024: 45 · 2023: 43 · 2022: 58 · 2021: 43 · 2020: 54 · 2019: 68 · 2018: 24 · 2017: 48 · 2016: 39 · 2015: 39 · 2014: 37 · 2013: 5
FWCI: 21.63
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 373 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Funders: Centre National de la Recherche Scientifique
Agence Nationale de la Recherche (07-Physio 002-01)
Institut National de la Santé et de la Recherche Médicale
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: intestinal epithelium, circadian clock, gut microbiota, Toll-like receptors, RORα, NR1D1, PPARα, JNK, IKKβ, NF-κB, AP-1, prediabetes, corticosterone, intestinal homeostasis
MeSH terms: Animals, Corticosterone, Ileum, Intestinal Mucosa, Male, Mice, Inbred C57BL, NF-kappa B, Toll-Like Receptors, Mice, Metagenome, Nuclear Receptor Subfamily 1, Group D, Member 1, Nuclear Receptor Subfamily 1, Group F, Member 1

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Homeostasis in Intestinal Epithelium Is Orchestrated by the Circadian Clock and Microbiota Cues Transduced by TLRs

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